\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.150\u3010\u5b66\u8853\u5831\u544a68\u3011<\/p>\n\n\n\n
\u6700\u8fd1\u306e\u8a71\u984c68\uff082021\/07\/09\u914d\u4fe1\uff09<\/p>\n\n\n\n
\u3053\u308c\u304b\u3089\u306e\u5149\u6e29\u71b1\u6cbb\u7642\u958b\u767a\u306e\u65b9\u5411\u6027\u3000<\/p>\n\n\n\n
Direction for development of photothermal therapy<\/p>\n\n\n\n
\u91ce\u6751\u4fe1\u4ecb\uff0c\u8fbb\u672c\u5e83\u7d00\uff0c\u5b88\u672c\u7950\u53f8*\uff08\u9632\u885b\u533b\u79d1\u5927\u5b66\u6821\uff0c\u5916\u79d1\u5b66\u8b1b\u5ea7\uff0c*\u540c\uff0c\u751f\u7406\u5b66\u8b1b\u5ea7\uff09<\/p>\n\n\n\n
\u3000\u5149\u6e29\u71b1\u6cbb\u7642\uff08Photothermal Therapy: \u4ee5\u4e0bPTT\uff09\u3068\u306f\uff0c\u6700\u5927\u5438\u53ce\u6ce2\u9577\u304c700 nm\u304b\u30891,500 nm\u306e\u8fd1\u8d64\u5916\u9818\u57df\u306b\u3042\u308b\u5149\uff08\u30ec\u30fc\u30b6\u30fc\uff09\u3092\u8868\u5728\u6027\u306e\u816b\u760d\u306a\u3069\u3092\u5bfe\u8c61\u306b\u7167\u5c04\u3057\uff0c\u5149\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u5206\u5b50\u632f\u52d5\u30a8\u30cd\u30eb\u30ae\u30fc\u306b\u5909\u63db\u3055\u305b\u3066\uff0c\u816b\u760d\u7d30\u80de\u305d\u306e\u3082\u306e\u3084\u8fd1\u8d64\u5916\u5149\u5438\u53ce\u5264\u306e\u6e29\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u3067\u6297\u816b\u760d\u52b9\u679c\u3092\u5f97\u308b\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306e\u4e00\u7a2e\u3067\u3042\u308b\uff0e\u8fd1\u5e74\u306e\u85ac\u5264\u9001\u9054\u6280\u8853\u306b\u3088\u308aPTT\u306b\u304a\u3044\u3066\u3082\u8fd1\u8d64\u5916\u5149\u5438\u53ce\u5264\u3092\u816b\u760d\u306e\u307f\u306b\u96c6\u7a4d\u3055\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u3063\u305f\uff0e\u305d\u306e\u305f\u3081PTT\u306f\uff0c\u8fd1\u8d64\u5916\u5149\u306b\u3088\u308b\u5c40\u6240\u7167\u5c04\u304b\u3064\u8fd1\u8d64\u5916\u5149\u5438\u53ce\u5264\u306e\u816b\u760d\u3078\u306e\u96c6\u7a4d\u306b\u3088\u308a\uff0c\u6e29\u5ea6\u4e0a\u6607\u3092\u816b\u760d\u306e\u307f\u306b\u7d5e\u308a\u8fbc\u3080\u30c0\u30d6\u30eb\u30bf\u30fc\u30b2\u30c3\u30c6\u30a3\u30f3\u30b0\u52b9\u679c\u3067\uff0c\u6b63\u5e38\u7d44\u7e54\u3078\u306e\u71b1\u640d\u50b7\u3092\u5c40\u9650\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u4f4e\u4fb5\u8972\u6cbb\u7642\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n
\u3000\u8fd1\u5e74\uff0cPark\u3089\u306f\uff0cICG\uff08\u30a4\u30f3\u30c9\u30b7\u30a2\u30cb\u30f3\u30b0\u30ea\u30fc\u30f3\uff09\u3092\u642d\u8f09\u3057\u305fPEG\uff08\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\uff09\u5316\u9280\u30ca\u30ce\u7c92\u5b50(PEG-BSA\uff08\u30a6\u30b7\u8840\u6e05\u30a2\u30eb\u30d6\u30df\u30f3\uff09-AgNPs\/ICG)*\u3092\u958b\u767a\u3057\uff0c\u62c5\u764c\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\uff0cPEG-BSA-AgNPs\/ICG\u306e\u9ad8\u3044\u816b\u760d\u96c6\u7a4d\u6027\uff0c\u5149-\u71b1\u5909\u63db\u52b9\u7387\u304a\u3088\u3073PEG-BSA-AgNPs\/ICG\u3092\u7528\u3044\u305fPTT\u306e\u9ad8\u3044\u6cbb\u7642\u52b9\u679c\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u305f1)\uff0e\u7d4c\u9759\u8108\u6295\u4e0e\uff14\u6642\u9593\u5f8c\u306b\u306f\uff0cICG\u86cd\u5149\u306b\u3088\u308b\u816b\u760d\u3078\u306e\u9ad8\u5ea6\u306a\u86cd\u5149\u96c6\u7a4d\u3092\u78ba\u8a8d\u3057\uff0c\u305d\u306e\u5f8c\uff0c\u8d64\u5916\u7dda\u30ab\u30e1\u30e9\u3067\u30e2\u30cb\u30bf\u30fc\u3057\u306a\u304c\u30890.95 W\uff0c20\u5206\u9593\u306e\u8fd1\u8d64\u5916\u5149\u7167\u5c04\u3092\u884c\u3063\u305f\uff0e\u816b\u760d\u306e\u8868\u9762\u6e29\u5ea6\u306f49\u2103\u306b\u307e\u3067\u9054\u3057\uff0c\u7167\u5c04\u7fcc\u65e5\u4ee5\u964d\uff0c\u816b\u760d\u306e\u6d88\u5931\u3092\u78ba\u8a8d\u3057\uff0c\u512a\u308c\u305f\u6cbb\u7642\u52b9\u679c\u3092\u793a\u3057\u305f\uff0e<\/p>\n\n\n\n
\u3000\u7b46\u8005\u306e\u7814\u7a76\u5ba4\u306b\u304a\u3044\u3066\u3082\uff0c\u816b\u760d\u96c6\u7a4d\u6027\u306e\u3042\u308b\u30ca\u30ce\u30ad\u30e3\u30ea\u30a2\u306b\u8fd1\u8d64\u5916\u5149\u5438\u53ce\u5264\u3068\u3057\u3066\u306eICG\u3092\u642d\u8f09\u3057\u305fICG\u30e9\u30af\u30c8\u30bd\u30fc\u30e0\u3068\u3044\u3046\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\uff0c\u7d4c\u9759\u8108\u6295\u4e0e\u3057\u3066\uff0c\u8fd1\u8d64\u5916\u5149\u7167\u5c04\u3092\u884c\u3063\u305f2)\uff0e\u3059\u308b\u3068\uff0c\u6e29\u5ea6\u4e0a\u6607\u304c43\u2103\u672a\u6e80\u306e\u62c5\u764c\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306e\u816b\u760d\u30b5\u30a4\u30ba\u306f\u4e0d\u5909\u306a\u3044\u3057\u306f\u5897\u5927\u50be\u5411\u3067\u3042\u3063\u305f\u3082\u306e\u306e\uff0c43\u2103\u4ee5\u4e0a\u306b\u6e29\u5ea6\u4e0a\u6607\u3057\u305f\u816b\u760d\u3067\u306f\u78ba\u5b9f\u306a\u816b\u760d\u6d88\u5931\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0e\u3053\u306e\u69d8\u306b\uff0c\u3053\u308c\u307e\u3067\u306ePTT\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\uff0c\u5f93\u6765\u306e\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306e\u3088\u3046\u306b\u4e8b\u524d\u306b\u52a0\u6e29\u88c5\u7f6e\u306e\u6e29\u5ea6\u3092\u8a2d\u5b9a\u3057\u3066\u52a0\u6e29\u7dad\u6301\u3059\u308b\u306e\u3067\u306f\u306a\u304f\uff0c\u4e00\u5b9a\u306e\u7167\u5c04\u5f37\u5ea6\u3067\u8fd1\u8d64\u5916\u5149\u7167\u5c04\u3057\u3066\u3044\u305f\uff0e\u305d\u306e\u305f\u3081\uff0c\u7167\u5c04\u4e2d\u306e\u816b\u760d\u6e29\u5ea6\u306f\u672a\u6e2c\u5b9a\uff0c\u307e\u305f\u306f\u6e29\u5ea6\u8a08\u6e2c\u306f\u8a18\u9332\u3068\u3057\u3066\u5b9f\u65bd\u3059\u308b\u306b\u3068\u3069\u307e\u3063\u3066\u3044\u305f3, 4)\uff0e<\/p>\n\n\n\n
\u3000\u305d\u3053\u3067\u7b46\u8005\u3089\u306f\uff0c\u816b\u760d\u6e29\u5ea6\u3092\u76ee\u6a19\u6e29\u5ea6\u306b\u7dad\u6301\u3057\u306a\u304c\u3089\u7167\u5c04\u3057\u7d9a\u3051\u3089\u308c\u308b\u3088\u3046\u306b\u30ec\u30fc\u30b6\u30fc\u672c\u4f53\u3068\u8d64\u5916\u7dda\u30ab\u30e1\u30e9\u306a\u3069\u306e\u975e\u63a5\u89e6\u578b\u306e\u6e29\u5ea6\u6e2c\u5b9a\u88c5\u7f6e\u3068\u3092\u63a5\u7d9a\u3057\uff0c\u7167\u5c04\u5f37\u5ea6\u3092\u81ea\u52d5\u8abf\u7bc0\u3067\u304d\u308b\u6e29\u5ea6\u5236\u5fa1\u578b\u5149\u6e29\u71b1\u6cbb\u7642\uff08temperature-controlled PTT: \u4ee5\u4e0btecPTT\uff09\u30b7\u30b9\u30c6\u30e0\u3092\u958b\u767a\u3057\u305f5)\uff0e\u62c5\u764c\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\uff0c40\u2103\u304b\u308943\u2103\u307e\u30671\u2103\u305a\u3064\u8a2d\u5b9a\u6e29\u5ea6\u3092\u5909\u3048\u3066\u7167\u5c04\u3057\u3066\u3082\uff0c43\u2103\u3067\u78ba\u5b9f\u306b\u816b\u760d\u6d88\u5931\u3092\u8a98\u5c0e\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u305f2)\uff0e\u4eca\u5f8c\u306ePTT\u7814\u7a76\u3067\u306f\uff0ctecPTT\u306e\u51fa\u73fe\u306b\u3088\u308a\u76ee\u6a19\u6e29\u5ea6\u5230\u9054\u53ca\u3073\u7dad\u6301\u304c\u53ef\u80fd\u3068\u306a\u3063\u305f\u3053\u3068\u304b\u3089\u816b\u760d\u96c6\u7a4d\u6027\uff0c\u816b\u760d\u9078\u629e\u6027\u306e\u9ad8\u3044\u8fd1\u8d64\u5916\u5149\u5438\u53ce\u5264\u306e\u958b\u767a\u304c\u671b\u307e\u308c\u308b\uff0etecPTT\u306fPTT\u3092\u81e8\u5e8a\u5fdc\u7528\u3078\u3068\u767a\u5c55\u3055\u305b\u308b\u8db3\u304c\u304b\u308a\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u308b\uff0e<\/p>\n\n\n\n
\u3000\u7e70\u308a\u8fd4\u3057\u306b\u306a\u308b\u304cPTT\u306e\u6cbb\u7642\u5bfe\u8c61\u306f\uff0c\u5149\uff08\u30ec\u30fc\u30b6\u30fc\uff09\u6cbb\u7642\u306e\u7279\u6027\u4e0a\uff0c\u8868\u5728\u6027\u306e\u816b\u760d\u304c\u826f\u3044\u9069\u5fdc\u3068\u8003\u3048\u3089\u308c\u308b\uff0etecPTT\u306e\u3088\u3046\u306b\u78ba\u5b9f\u306a\u6cbb\u7642\u52b9\u679c\u304c\u62c5\u4fdd\u3055\u308c\u308c\u3070\uff0c\u4f8b\u3048\u3070\uff0c\u5149\u6cbb\u7642\u306e\u4ee3\u8868\u3067\u3042\u308b\u5149\u7dda\u529b\u5b66\u7642\u6cd5\u306e\u9069\u5fdc\u75c7\u4f8b\u3067\u3042\u308b\u653e\u5c04\u7dda\u3042\u308b\u3044\u306f\u5316\u5b66\u653e\u5c04\u7dda\u7642\u6cd5\u5f8c\u306e\u5c40\u6240\u907a\u6b8b\u518d\u767a\u98df\u9053\u764c\u75c7\u4f8b\u3084\u30ac\u30a4\u30c9\u30ef\u30a4\u30e4\u30fc\u304c\u901a\u904e\u3057\u306a\u3044\u7ba1\u8154\u5185\u5360\u62e0\u6027\u306e\u6d88\u5316\u5668\u764c\u3084\u80ba\u764c\u75c7\u4f8b\u304c\u6cbb\u7642\u5bfe\u8c61\u306e\u5019\u88dc\u3068\u3057\u3066\u6319\u304c\u308b\u3060\u308d\u3046\uff0e\u52a0\u3048\u3066\uff0c\u5927\u8178\u764c\u3084\u5375\u5de3\u764c\u306e\u64ad\u7a2e\u6027\u75c5\u5909\u306e\u3088\u3046\u306a\u6e1b\u91cf\u5207\u9664\u306e\u610f\u7fa9\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u75c5\u5909\u306b\u304a\u3044\u3066\u3082\uff0c\u3042\u308b\u7a0b\u5ea6\u306e\u9650\u5c40\u7684\u306a\u8868\u5728\u6027\u75c5\u5909\u3067\u3042\u308c\u3070\uff0c\u3053\u306etecPTT\u306b\u3088\u308b\u816b\u760d\u91cf\u6e1b\u91cf\u304c\u3088\u3044\u9069\u5fdc\u306b\u306a\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u671f\u5f85\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n
\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n
1) Park T, et al. ICG-loaded PEGylated BSA-silver nanoparticles for effective photothermal cancer therapy. Int J Nanomedicine 15: 5459-71, 2020.<\/p>\n\n\n\n
2) Nomura S, et al. Highly reliable, targeted photothermal cancer therapy combined with thermal dosimetry using a near-infrared absorbent. Sci Rep. 10: 1-7, 2020.<\/p>\n\n\n\n
3) Tsujimoto H, et al. Photodynamic therapy using nanoparticle loaded with indocyanine green for experimental peritoneal dissemination of gastric cancer. Cancer Sci. 105: 1626-30, 2014.<\/p>\n\n\n\n
4) Tsujimoto H, et al. Theranostic photosensitive nanoparticles for lymph node metastasis of gastric cancer. Annals Surgical Oncol. 22: 923-8, 2015.<\/p>\n\n\n\n
5) Nomura S, et al. Thermal sensor circuit using thermography for temperature-controlled laser hyperthermia. J Sensors 2017: 1-7, 2017.<\/p>\n\n\n\n
\u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n
*PEG\u5316\u9280\u30ca\u30ce\u7c92\u5b50(PEG-BSA-AgNPs\/ICG)\uff1a100 nm\u5f84\u306b\u8a2d\u8a08\u3055\u308c\u305fPEG\u5316\u9280\u30ca\u30ce\u7c92\u5b50\u306b\u5149\u5438\u53ce\u5264\u304b\u3064\u86cd\u5149\u7269\u8cea\u3067\u3042\u308bICG\u304c\u642d\u8f09\u3055\u308c\u305f\u5316\u5408\u7269\uff0ePEG\u5316\u306b\u3088\u308b\u51dd\u96c6\u6027\u306e\u4f4e\u4e0b\uff0c\u6eb6\u89e3\u5ea6\u306e\u5411\u4e0a\u3060\u3051\u3067\u306a\u304f\uff0cPEG\u9396\u306b\u3088\u308b\u7acb\u4f53\u969c\u5bb3\u3067\uff0c\u7c92\u5b50\u8868\u9762\u3078\u306e\u30aa\u30d7\u30bd\u30cb\u30f3\u5316\u3092\u6291\u5236\u3057\uff0c\u7d30\u7db2\u5185\u76ae\u7cfb\u306b\u3042\u308b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\uff08\u8caa\u98df\u7d30\u80de\uff09\u304b\u3089\u306e\u6355\u6349\u3092\u514d\u308c\uff0c\u30ca\u30ce\u7c92\u5b50\u306e\u8840\u4e2d\u6ede\u7559\u6027\u5411\u4e0a\u3092\u3082\u305f\u3089\u3059\u305f\u3081\uff0cPEG-BSA-AgNPs\/ICG\u306e\u816b\u760d\u96c6\u7a4d\u6027\u304c\u5897\u3059\uff0e\u3055\u3089\u306b\uff0cICG\u642d\u8f09\u306b\u3088\u308aPEG-BSA-AgNPs\/ICG\u306e\u816b\u760d\u3078\u306e\u96c6\u7a4d\u304c\u86cd\u5149\u89b3\u5bdf\u3055\u308c\uff0c\u540c\u90e8\u4f4d\u306b\u5bfe\u3059\u308b\u8fd1\u8d64\u5916\u5149\u7167\u5c04\u306b\u3088\u308aICG\u306f\u52a0\u71b1\u3055\u308c\uff0c\u816b\u760d\u6e29\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u305f\u3081\u52b9\u7387\u7684\u306b\u5149\u6e29\u71b1\u52b9\u679c\u304c\u767a\u63ee\u3055\u308c\u308b\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"
\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.150\u3010\u5b66\u8853\u5831\u544a68\u3011 \u6700\u8fd1\u306e\u8a71\u984c68\uff082021\/07\/09\u914d\u4fe1\uff09 \u3053\u308c\u304b\u3089\u306e\u5149\u6e29\u71b1\u6cbb\u7642\u958b\u767a\u306e\u65b9\u5411\u6027\u3000 Direction for development of phototh […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-1243","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/1243","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=1243"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/1243\/revisions"}],"predecessor-version":[{"id":1244,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/1243\/revisions\/1244"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=1243"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=1243"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=1243"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}