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\u5927\u585a\u5065\u4e09*<\/p>\n\n\n\n

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\u3000\u3053\u306e\u3088\u3046\u306b\u4f5c\u7528\u6a5f\u4f5c\u306e\u308f\u304b\u3063\u3066\u3044\u308b\u65e2\u77e5\u306e\u85ac\u5264\u3067\u3082\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u4e88\u671f\u3057\u306a\u3044\u53cd\u5fdc\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u304c\u3093\u7d30\u80de\u306b\u5bfe\u3057\u3066\u6bba\u7d30\u80de\u52b9\u679c\u3092\u5f15\u304d\u8d77\u3053\u3059\u5834\u5408\u304c\u3042\u308b\uff0e\u4eca\u5f8c\u306f\u3055\u307e\u3056\u307e\u306a\u85ac\u5264\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3088\u308a\u6709\u52b9\u306a\u304c\u3093\u6cbb\u7642\u6cd5\u304c\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027\u306b\u671f\u5f85\u3057\u305f\u3044\uff0e<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

  1. Dixon<\/a>\u00a0S.J.,\u00a0Lemberg<\/a> K.M.,\u00a0Lamprecht<\/a> M.R.,\u00a0Skouta<\/a> R.,\u00a0Zaitsev<\/a> E.M.,\u00a0Gleason<\/a> C.E.,\u00a0Patel<\/a> D.N.,\u00a0Bauer<\/a> A.J.,\u00a0Cantley<\/a> A.M.,\u00a0Yang<\/a> W.S.,\u00a0Morrison B.,<\/a> Stockwell<\/a> B.R.: Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell, 149: 1060-1072, 2012.<\/li>
  2. Mou Y., Wang J., Wu J., He D., Zhang C., Duan C., Li B.: Ferroptosis, a new form of cell death: opportunities and challenges in cancer. J Hematol Oncol, 12: 34, 2019.<\/li>
  3. Westerheide<\/a> S.D.,\u00a0Bosman<\/a> J.D.,\u00a0Mbadugha<\/a> B.N.A.,\u00a0Kawahara<\/a> T.L.A.,\u00a0Matsumoto<\/a> G.,\u00a0Kim<\/a> S.,\u00a0Gu<\/a> W.,\u00a0Devlin<\/a> J.P., Silverman<\/a> R.B.,\u00a0Morimoto<\/a> R.I.: Celastrols as inducers of the heat shock response and cytoprotection. J Biol Chem, 279: 56053\u201356060, 2004.<\/li>
  4. Salminen<\/a> A.,\u00a0Lehtonen<\/a> M.,\u00a0Paimela<\/a> T.,\u00a0Kaarniranta<\/a> K.: Cerastrol: Molecular targets of Thunder God Vine. Biochem Biophys Res Commun, 394: 439-442, 2010.<\/li>
  5. Kashyap D., Sharma A., Tuli H.S., Sak K., Mukherjee T., Bishayee A.: Molecular targets of celastrol in cancer: recent trends and advancements. Crit Rev Oncol Hematol, 128: 70\u201381, 2018.<\/li>
  6. Liu<\/a>\u00a0M.,\u00a0Fan<\/a>\u00a0Y.,\u00a0Li<\/a>\u00a0D.,\u00a0Han<\/a>\u00a0B.,\u00a0Meng<\/a>\u00a0Y.,\u00a0Chen<\/a>\u00a0F.,\u00a0Liu<\/a>\u00a0T.,\u00a0Song<\/a>\u00a0Z.,\u00a0Han<\/a>\u00a0Y.,\u00a0Huang<\/a>\u00a0L.,\u00a0Chang<\/a>\u00a0Y.,\u00a0Cao<\/a>\u00a0P.,\u00a0Nakai<\/a>\u00a0A.,\u00a0Tan<\/a> K.: Ferroptpsis inducer erastin sensitizes NSCLC cells to cerastrol through activation of ROS-mitochondrial fission-mitophagy axis. Mol Oncol, 15: 2084-2105, 2021.<\/li><\/ol>\n\n\n\n

    \u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n

    \u20201<\/sup>\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\uff1a\u9244\u30a4\u30aa\u30f3\u4f9d\u5b58\u7684\u306a\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6b7b\u306e\u4e00\u30641<\/sup>\uff09<\/sup>\uff0e\u7d30\u80de\u5185\u306e\u904a\u96e2\u9244\u306b\u3088\u308b\u6d3b\u6027\u9178\u7d20\u7a2e\u3068\u904e\u9178\u5316\u8102\u8cea\u306e\u84c4\u7a4d\u306b\u3088\u308a\u7d30\u80de\u6b7b\u304c\u8a98\u5c0e\u3055\u308c\u308b\uff0e\u30a8\u30e9\u30b9\u30c1\u30f3\u306f\u7279\u7570\u7684\u306a\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\u8a98\u5c0e\u5264\u3067\u3042\u308b\uff0e\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u3088\u308b\u7d30\u80de\u6b7b\u306f\u9244\u30ad\u30ec\u30fc\u30bf\u30fc\u3084\u6297\u9178\u5316\u5264\u306eferrostatin-1\u3067\u963b\u5bb3\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n

    \u20202<\/sup>Cerastrol\uff1a\u6f22\u65b9\u85ac\u306eThunder God Vine\uff08Tripterygium wilfordii<\/em>, \u30af\u30ed\u30c5\u30eb\uff0c\u30cb\u30b7\u30ad\u30ae\u79d1\u306e\u3064\u308b\u6027\u4f4e\u6728\uff09\u306e\u6210\u5206\u306e\u4e00\u3064\uff0e<\/p>\n\n\n\n

    \u5229\u76ca\u76f8\u53cd\u306b\u95a2\u3059\u308b\u958b\u793a\uff1a<\/p>\n\n\n\n

    \u8457\u8005\u306b\u5229\u76ca\u76f8\u53cd\u72b6\u614b\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff0e<\/p>\n\n\n\n

    Mini-review:<\/p>\n\n\n\n

    Anti-tumor effect of the combinational treatment with erastin and cerastrol<\/p>\n\n\n\n

    KENZO OHTSUKA*<\/p>\n\n\n\n

    College of Bioscience and Biotechnology, Chubu University, Kasugai, Aichi 478-8501, Japan<\/p>\n\n\n\n

    *Corresponding author: kohtsuka@isc.chubu.ac.jp<\/a><\/p>\n\n\n\n

    Key Words: erastin, cerastrol, ROS-dependent autophagy, mitophagy<\/p>\n\n\n\n

    Received: 28 December, 2021<\/p>\n\n\n\n

    Accepted: 28 January, 2022<\/p>\n\n\n\n

    Vol.38 (1)\u63b2\u8f09\u4e88\u5b9a<\/p>\n\n\n\n

    \n\n\n\n

    <\/a><\/p>\n\n\n\n

    <\/a><\/p>\n\n\n\n

    <\/a><\/p>\n\n\n\n

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