{"id":1298,"date":"2022-02-14T16:46:58","date_gmt":"2022-02-14T07:46:58","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=1298"},"modified":"2022-02-14T16:46:59","modified_gmt":"2022-02-14T07:46:59","slug":"%e6%97%a5%e6%9c%ac%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc%e3%83%9f%e3%82%a2%e5%ad%a6%e4%bc%9a%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9no-161%e3%80%90%e5%ad%a6%e8%a1%93%e5%a0%b1%e5%91%8a72","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e6%97%a5%e6%9c%ac%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc%e3%83%9f%e3%82%a2%e5%ad%a6%e4%bc%9a%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9no-161%e3%80%90%e5%ad%a6%e8%a1%93%e5%a0%b1%e5%91%8a72\/","title":{"rendered":"\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.161\u3010\u5b66\u8853\u5831\u544a72\u3011"},"content":{"rendered":"\n

\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.161\u3010\u5b66\u8853\u5831\u544a72\u3011<\/p>\n\n\n\n

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\u30e6\u30d3\u30ad\u30c1\u30f3\u3084\u30e6\u30d3\u30ad\u30c1\u30f3\u7d4c\u8def\u20204<\/sup>\u306b\u95a2\u308f\u308b\u56e0\u5b50\u306f\u30b9\u30c8\u30ec\u30b9\u9846\u7c92 (\u3053\u3053\u3067\u306f\u7d30\u80de\u8cea\u3092\u6307\u3059) \u306e\u5185\u5074\u306b\u5b58\u5728\u3057\uff0c\u30e6\u30d3\u30ad\u30c1\u30f3\u5206\u89e3\u9175\u7d20\u304c\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306e\u52d5\u614b\u5236\u5fa1\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\uff0e\u3055\u3089\u306b\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u54c1\u8cea\u7ba1\u7406\u304c\u7834\u7dbb\u3059\u308b\u3068\uff0c\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3055\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306b\u84c4\u7a4d\u3057\uff0c\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306e\u6a5f\u80fd\u3092\u963b\u5bb3\u3059\u308b\uff0e\u3057\u304b\u3057\u306a\u304c\u3089\uff0c\u3053\u308c\u3089\u306b\u95a2\u3059\u308b\u5148\u884c\u7814\u7a76\u3067\u306f\u8af8\u8aac\u3042\u308a\uff0c\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u3088\u308b\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5236\u5fa1\u6a5f\u69cb\u306b\u3064\u3044\u3066\u306f\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u6b8b\u3055\u308c\u3066\u3044\u308b\uff0e\u6700\u8fd1\uff0cJ Paul Taylor\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\uff0c\u69d8\u3005\u306a\u7a2e\u985e\u306e\u7d30\u80de\u30b9\u30c8\u30ec\u30b9\u8ca0\u8377\u3092\u8907\u6570\u306e\u7d30\u80de\u7a2e\u306b\u5bfe\u3057\u3066\u884c\u3044\uff0c\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u7b54\u3057\u3066\u5f62\u6210\u3055\u308c\u308b\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7db2\u7f85\u7684\u60c5\u5831\u3067\u3042\u308b\u300c\u30e6\u30d3\u30ad\u30c1\u30ce\u30fc\u30e0\u300d\u3092\u69cb\u7bc9\u3057\u305f4)<\/sup>\uff0e\u6e29\u71b1\u51e6\u7406\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u308b\u30e6\u30d3\u30ad\u30c1\u30ce\u30fc\u30e0\u306b\u306f\uff0c\u6838\u7d30\u80de\u8cea\u9593\u8f38\u9001\u3084\u7ffb\u8a33\u306e\u3088\u3046\u306b\u6e29\u71b1\u51e6\u7406\u306b\u3088\u3063\u3066\u4f4e\u4e0b\u3059\u308b\u7d30\u80de\u6a5f\u80fd\u3084\uff0c\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306e\u69cb\u6210\u56e0\u5b50\u304c\u542b\u307e\u308c\u3066\u3044\u305f\uff0e\u307e\u305f\uff0c\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306f\uff0c\u6838\u7d30\u80de\u8cea\u9593\u8f38\u9001\u3084\u7ffb\u8a33\u306e\u6a5f\u80fd\u4f4e\u4e0b, \u304a\u3088\u3073\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306e\u5f62\u6210\u306b\u306f\u5fc5\u8981\u3067\u306f\u306a\u3044\u304c\uff0c\u3053\u308c\u3089\u306e\u6a5f\u80fd\u56de\u5fa9\u3084\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306e\u6d88\u5931\u306b\u304a\u3044\u3066\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\uff0e\u3055\u3089\u306b\uff0c\u540c\u3058\u53f7\u306b\u63b2\u8f09\u3055\u308c\u305f\u540c\u3058\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u306e\u5225\u306e\u8ad6\u6587\u3067\u306f\uff0c\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306eRNA-\u30bf\u30f3\u30d1\u30af\u8cea\u9593\u76f8\u4e92\u4f5c\u7528\u306b\u304a\u3051\u308b\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u62c5\u3046G3BP1 (Ras GTPase-activating protein-binding protein 1) \u306e\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u304c\uff0c\u6e29\u71b1\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u306e\u56de\u5fa9\u904e\u7a0b\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u306a\u3063\u305f5)<\/sup>\uff0e<\/p>\n\n\n\n

\u6e29\u71b1\u51e6\u7406\u306b\u3088\u3063\u3066\uff0cDNA\u4fee\u5fa9\u56e0\u5b50\u3067\u3042\u308bNBS1\/MRE11\/RAD50\u8907\u5408\u4f53\u304c\u7d30\u80de\u8cea\u3078\u6838\u5916\u8f38\u9001\u3055\u308c\u308b6)<\/sup>\u304c\uff0c\u56de\u5fa9\u671f\u306b\u306f\u518d\u3073\u6838\u5185\u3078\u8f38\u9001\u3055\u308c\u308b7)<\/sup>\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u3053\u308c\u3089\u306e\u73fe\u8c61\u306f\uff0c\u6e29\u71b1\u51e6\u7406\u306b\u3088\u308b\u653e\u5c04\u7dda\u5897\u611f\u6a5f\u5e8f\u3092\u8aac\u660e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u305f\u304c\uff0c\u4eca\u56de\u306e\u30e6\u30d3\u30ad\u30c1\u30ce\u30fc\u30e0\u7814\u7a76\u306e\u6210\u679c\u304b\u3089\uff0c\u3053\u306e\u4e00\u9023\u306e\u53cd\u5fdc\u306b\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u904e\u7a0b\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\uff0e\u5b9f\u969b\uff0cJ Paul Taylor\u3089\u306e\u6210\u679c\u306e\u4e2d\u3067\uff0cDNA\u4fee\u5fa9\u30fb\u9178\u5316\u9084\u5143\u3084\u7d30\u80de\u9aa8\u683c\u306b\u95a2\u308f\u308b\u56e0\u5b50\u3082\uff0c\u6e29\u71b1\u8a98\u5c0e\u30e6\u30d3\u30ad\u30c1\u30ce\u30fc\u30e0\u306b\u542b\u307e\u308c\u3066\u3044\u305f4)<\/sup>\uff0e\u4eca\u56de\u306e\u4e00\u9023\u306e\u7814\u7a76\u6210\u679c\u304b\u3089\uff0c\u6e29\u71b1\u306b\u3088\u308b\u653e\u5c04\u7dda\u5897\u611f\u306e\u6cbb\u7642\u6226\u7565\u3068\u3057\u3066\uff0c\u30e6\u30d3\u30ad\u30c1\u30f3\u7d4c\u8def\u304c\u518d\u3073\u7740\u76ee\u3055\u308c\u308b\u304d\u3063\u304b\u3051\u3068\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

  1. Kose S., Furuta M., Imamoto N.: Hikeshi, A nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage. Cell, 149: 578-589, 2012.<\/li>
  2. Ninomiya K., Iwakiri J., Aly M.K., Sakaguchi Y., Adachi S., Natsume T., Terai G., Asai K., Suzuki T., Hirose T.: m6<\/sup> A modification of HSATIII lncRNAs regulates temperature-dependent splicing. EMBO J, e107976, 2021.<\/li>
  3. Onoguchi-Mizutani R., Kirikae Y., Ogura Y., Gutschner T., Diederichs S., Akimitsu N.: Identification of a heat-inducible novel nuclear body containing the long noncoding RNA MALAT1<\/em>. J Cell Sci, 134: jcs253559, 2021.<\/li>
  4. Maxwell B.A., Gwon Y., Mishra A., Peng J., Nakamura H., Zhang K., Kim H.J., Taylor J.P.: Ubiquitination is essential for recovery of cellular activities after heat shock. Science, 372: eabc3593, 2021.<\/li>
  5. Gwon Y., Maxwell B.A., Kolaitis R., Zhang P., Kim H.J., Taylor J.P.: Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner. Science, 372: eabf6548, 2021.<\/li>
  6. Seno J.D., Dynlacht J.R.: Intracellular redistribution and modification of proteins of the Mre11\/Rad50\/Nbs1 DNA repair complex following irradiation and heat-shock. J Cell Physiol, 199: 157-170, 2004.<\/li>
  7. Takahashi A., Mori E., Ohnishi T.: The foci of DNA double strand break-recognition proteins localize with \u03b3H2AX after heat treatment. J Radiat Res, 51: 91-95, 2010.<\/li><\/ol>\n\n\n\n

    \u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n

    \u20201<\/sup>\u7ffb\u8a33\u6a5f\u80fd\uff1a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5408\u6210\u3059\u308b\u4ed5\u7d44\u307f\u3084\u80fd\u529b\uff0e<\/p>\n\n\n\n

    \u20202<\/sup>\u30dd\u30ea\u30bd\u30fc\u30e0\uff1amRNA\u5206\u5b50\u306b\u6570\u73e0\u7389\u72b6\u306b\u7d50\u5408\u3057\u305f\u30ea\u30dc\u30bd\u30fc\u30e0\u306e\u96c6\u5408\u4f53\uff0e<\/p>\n\n\n\n

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    \u5229\u76ca\u76f8\u53cd\u306b\u95a2\u3059\u308b\u958b\u793a<\/p>\n\n\n\n

    \u3000\u8457\u8005\u306b\u5229\u76ca\u76f8\u53cd\u72b6\u614b\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff0e<\/p>\n\n\n\n

    Mini Review<\/p>\n\n\n\n

    Alternative role of ubiquitination for recovery from heat shock<\/p>\n\n\n\n

    YOSUKE NAKAGAWA1<\/sup>, TADAAKI KIRITA1<\/sup>, EIICHIRO MORI2,<\/sup>*<\/p>\n\n\n\n

    Departments of 1<\/sup>Oral and Maxillofacial Surgery, and 2<\/sup>Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan<\/p>\n\n\n\n

    *Corresponding author: emori@naramed-u.ac.jp<\/a><\/p>\n\n\n\n

    Key Words: recovery from heat stress, heat shock response, ubiquitination, stress granules<\/p>\n\n\n\n

    Received: 21 July, 2021<\/p>\n\n\n\n

    Accepted: 14 January, 2022<\/p>\n\n\n\n

    Vol.38 (1)\u63b2\u8f09\u4e88\u5b9a<\/p>\n","protected":false},"excerpt":{"rendered":"

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