{"id":1313,"date":"2022-03-16T15:15:54","date_gmt":"2022-03-16T06:15:54","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=1313"},"modified":"2022-05-27T15:42:07","modified_gmt":"2022-05-27T06:42:07","slug":"1313","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/1313\/","title":{"rendered":"HSP40\u30d5\u30a1\u30df\u30ea\u30fc\u306eDNAJA1\u306f\u5909\u7570\u578bp53\u3068\u306e\u4f1a\u5408\u3092\u4ecb\u3057\u3066\u304c\u3093\u306e\u8ee2\u79fb\u3092\u4fc3\u9032\u3059\u308b"},"content":{"rendered":"\n

\u5b66\u8853\u7d39\u4ecb\uff1aNO.74<\/p>\n\n\n\n

HSP40\u30d5\u30a1\u30df\u30ea\u30fc\u306eDNAJA1\u306f\u5909\u7570\u578bp53\u3068\u306e\u4f1a\u5408\u3092\u4ecb\u3057\u3066\u304c\u3093\u306e\u8ee2\u79fb\u3092\u4fc3\u9032\u3059\u308b<\/h2>\n\n\n\n

\u5927\u585a\u5065\u4e09*<\/p>\n\n\n\n

\u4e2d\u90e8\u5927\u5b66\u3000\u5fdc\u7528\u751f\u7269\u5b66<\/p>\n\n\n\n

\u3053\u308c\u307e\u3067\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u6a5f\u80fd\u3092\u6301\u3064\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea\uff08heat shock proteins\uff0cHSPs\uff09\uff08\u5177\u4f53\u7684\u306b\u306fHSP90\u3084HSP70\u306a\u3069\uff09\u3084\u305d\u306e\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308bHSF1\u304c\uff0c\u304c\u3093\u306e\u767a\u751f\u3084\u9032\u5c55\uff0c\u8ee2\u79fb\u306a\u3069\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u306f\u591a\u304f\u5831\u544a\u3055\u308c\u3066\u304d\u3066\u3044\u308b\uff0e\u4e00\u65b9\uff0c\u30b7\u30e3\u30da\u30ed\u30f3\u88dc\u52a9\u56e0\u5b50\uff08co-chaperone\uff09\u3067\u3042\u308bHSP40\u30d5\u30a1\u30df\u30ea\u30fc\u20201<\/sup>\u306e\u30e1\u30f3\u30d0\u30fc\u306b\u3064\u3044\u3066\u306f\uff0cDNAJA3\/Tid1\u306f\u304c\u3093\u306b\u5bfe\u3057\u3066\u6291\u5236\u7684\u306b\u50cd\u304d\uff0cDNAJB8\u306f\u304c\u3093\u306b\u5bfe\u3057\u3066\u4fc3\u9032\u7684\u306b\u6a5f\u80fd\u3057\u3066\u3044\u308b\u3053\u3068\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b1, 2<\/sup>\uff09<\/sup>\uff0e\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u306e\u306f\uff0c\u305d\u306eHSP40\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u5225\u306e\u30e1\u30f3\u30d0\u30fc\u3067\u3042\u308bDNAJA1\u304c\uff0c\u5909\u7570p53\uff08mp53\uff09\u20202<\/sup>\u3068\u4f1a\u5408\u3057\u3066\u5b89\u5b9a\u5316\u3059\u308b\u3053\u3068\u3067\u304c\u3093\u306e\u8ee2\u79fb\u3092\u4fc3\u9032\u3059\u308b\u3068\u3044\u3046Kaida\u3089\u306e\u5831\u544a\u3067\u3042\u308b3)<\/sup>\uff0emp53\u306e\u7d30\u80de\u5185\u3067\u306e\u5b89\u5b9a\u5316\u304c\uff0c\u304c\u3093\u7d30\u80de\u306e\u9032\u5c55\u306b\u5927\u304d\u304f\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u306f\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u540c\u3058\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u5148\u884c\u7814\u7a76\u3068\u3057\u3066\uff0c\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u85ac\u5264\u3067\u3042\u308b\u30b9\u30bf\u30c1\u30f3\uff08statin\uff09\u20203<\/sup>\u304cmp53\uff08\u7acb\u4f53\u69cb\u9020\u5909\u7570\u578b\uff09\u306e\u5206\u89e3\u3092\u7279\u7570\u7684\u306b\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3066\u3044\u308b4<\/sup>\uff09<\/sup>\uff0e\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u691c\u8a0e\u3057\u305f\u3068\u3053\u308d\uff0c\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u3063\u3066\u30e1\u30d0\u30ed\u30f3\u9178\u4ee3\u8b1d\u7d4c\u8def\u306e\u9175\u7d20\uff08HMG-CoA reductase\uff09\u304c\u963b\u5bb3\u3055\u308c\u3066\u4e2d\u9593\u4ee3\u8b1d\u7523\u7269\u306e\u30e1\u30d0\u30ed\u30f3\u9178-5-\u30ea\u30f3\u9178\uff08MVP\uff09\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3067\uff0cmp53\u3068DNAJA1\u3068\u306e\u4f1a\u5408\u304c\u640d\u306a\u308f\u308c\uff0c\u305d\u306e\u7d50\u679cmp53\u304c\u4e0d\u5b89\u5b9a\u306b\u306a\u3063\u3066\u30e6\u30d3\u30ad\u30c1\u30f3-\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u7cfb\u306b\u3088\u3063\u3066\u5206\u89e3\u3055\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u306e\u3067\u3042\u308b\uff0e\u306a\u304a\uff0c\u30e1\u30d0\u30ed\u30f3\u9178-5-\u30ea\u30f3\u9178\u3068mp53-DNAJA1\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u306f\u672a\u89e3\u660e\u3067\u3042\u308b\uff0e\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u8ad6\u6587\u3067\u306fmp53\u306e\u5b89\u5b9a\u5316\u306b\u95a2\u308f\u308bDNAJA1\u306e\u6a5f\u80fd\u3092\u3055\u3089\u306b\u8a73\u3057\u304f\u89e3\u6790\u3057\u3066\u3044\u308b3<\/sup>\uff09<\/sup>\uff0e<\/p>\n\n\n\n

\u3000\u307e\u305a\uff0c\u982d\u9838\u90e8\u6241\u5e73\u4e0a\u76ae\u304c\u3093\uff08head and neck squamous cell carcinoma\uff0cHNSCC\uff09\u306e\u7d30\u80de\u682a\u304a\u3088\u3073\u7d44\u7e54\u3067\u306f\u6b63\u5e38\u7d30\u80de\u3084\u6b63\u5e38\u7d44\u7e54\u306b\u6bd4\u3079\u3066DNAJA1\u304c\u9ad8\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u305f\uff0e\u6b21\u3044\u3067\uff0c\u7acb\u4f53\u69cb\u9020\u5909\u7570\u578bmp53\u3092\u767a\u73fe\u3057\u3066\u3044\u308bHNSCC\u7d30\u80de\u306b\u304a\u3044\u3066DNAJA1\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3059\u308b\u3068mp53\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\uff0c\u904a\u8d70\u80fd\u3082\u4f4e\u4e0b\uff0c\u904a\u8d70\u80fd\u306b\u95a2\u308f\u308bCDC42\/RAC1\u20204<\/sup>\u306e\u6d3b\u6027\u578b\u304a\u3088\u3073\u30d5\u30a3\u30ed\u30dd\u30c7\u30a3\u30a2\/\u30e9\u30e1\u30ea\u30dd\u30c7\u30a3\u30a2\u5f62\u6210\u3082\u8457\u3057\u304f\u4f4e\u4e0b\u3057\u305f\uff0e\u3057\u304b\u3057\uff0c\u3053\u308c\u3089\u306e\u52b9\u679c\u306fDNA\u63a5\u89e6\u578bmp53\u3084\u91ce\u751f\u578bp53\u3092\u6301\u3064\u7d30\u80de\u3067\u306f\u89b3\u5bdf\u3055\u308c\u306a\u304b\u3063\u305f\uff0e\u307e\u305f\uff0cDNAJA1\u306f\u7acb\u4f53\u69cb\u9020\u5909\u7570\u578bmp53\u3068\u306e\u307f\u7279\u7570\u7684\u306b\u4f1a\u5408\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u78ba\u8a8d\u3055\u308c\u305f\uff0e\u3055\u3089\u306b\uff0c\u7acb\u4f53\u69cb\u9020\u5909\u7570\u578bmp53\u3092\u6301\u3064 HNSCC\u306e\u79fb\u690d\u816b\u760d\u306b\u304a\u3044\u3066\u3082DNAJA1\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3059\u308b\u3068\uff0c\u816b\u760d\u306e\u5897\u6b96\u304c\u6291\u5236\u3055\u308c\u308b\u3068\u3068\u3082\u306b\u30ea\u30f3\u30d1\u7bc0\u3084\u80ba\u3078\u306e\u8ee2\u79fb\u3082\u963b\u5bb3\u3055\u308c\u305f\uff0e\u3053\u308c\u3089\u306e\u7d50\u679c\u306fDNAJA1\u304cmp53\u306e\u5909\u7570\u578b\u306b\u4f9d\u5b58\u3057\u3066HNSCC\u306e\u8ee2\u79fb\u3092\u4fc3\u9032\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u304a\u308a\uff0c\u7acb\u4f53\u69cb\u9020\u5909\u7570\u578bmp53\u3092\u4fdd\u6709\u3059\u308b\u304c\u3093\u7d30\u80de\u306b\u304a\u3044\u3066DNAJA1\u304c\u6cbb\u7642\u306e\u6a19\u7684\u306b\u306a\u308a\u3046\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\uff0e\u3000<\/p>\n\n\n\n

\u306a\u304a\uff0c\u3053\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u306f\u6700\u8fd1HSP40\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u306b\u3088\u308b\u816b\u760d\u6291\u5236\u56e0\u5b50\u3067\u3042\u308bp53\u306e\u5236\u5fa1\u306b\u95a2\u3059\u308b\u7dcf\u8aac\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b5<\/sup>\uff09<\/sup>\uff0e<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

  1. Nishizawa S., Hirohashi Y., Torigoe T., Takahashi A., Tamura Y., Mori T., Kanaseki T., Kamiguchi K., Asanuma H., Morita R., Sokolovskaya A., Matsuzaki J., Yamada R., Fujii R., Kampinga H.H., Kondo T., Hasegawa T., Hara I., Sato N.: HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells. Cancer Res, 72: 2844\u20132854, 2012.<\/li>
  2. Chen C-Y., Jan C-I., Lo J-F., Yang S-C., Chang Y-L., Pan S-H., Wang W-L., Hong T-M., Yang P-C.: Tid1-L inhibits EGFR signaling in lung adenocarcinoma by enhancing EGFR ubiquitinylation and degradation. Cancer Res, 73: 4009\u20134019, 2013.<\/li>
  3. Kaida A., Yamamoto S., Parrales A., Young E.D., Ranjan A., Alalem M.A., Morita K-I., Oikawa Y., Harada H., Ikeda T., Thomas S.M., Diaz F.J., Iwakuma T.: DNAJA1 promotes cancer metastasis through interaction with mutant p53. Oncogene,40: 5013\u20135025, 2021.<\/li>
  4. Parrales A., Ranjan A., Iyer S.V., Padhye S., Weir S.J., Roy A., Iwakuma T.: DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. Nat Cell Biol, 18: 1233-1243, 2016.            <\/li>
  5. Kaida A., Iwakuma T.: Regulation of p53 and cancer signaling by heat shock protein 40\/J-domain protein family members. Int J Mol Sci, 22: 13527, 2021.<\/li><\/ol>\n\n\n\n

    \u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n

    \u20201<\/sup>HSP40\u30d5\u30a1\u30df\u30ea\u30fc\uff1aHSP40\u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u5927\u8178\u83cc\u306eDnaJ\u3068\u76f8\u540c\u6027\u304c\u3042\u308b\u306e\u3067J\u30c9\u30e1\u30a4\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3082\u547c\u3070\u308c\u3066\u3044\u308b\uff0e\u54fa\u4e73\u985e\u3067\u306f\u7d0450\u500b\u306e\u30e1\u30f3\u30d0\u30fc\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\uff0c\u30c9\u30e1\u30a4\u30f3\u69cb\u9020\u306b\u3088\u3063\u3066DNAJA\uff0cDNAJB\uff0cDNAJC \u306e3\u3064\u306e\u30af\u30e9\u30b9\u306b\u5206\u985e\u3055\u308c\u308b\uff0e\u5927\u8178\u83ccDnaJ\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306f\u30a2\u30df\u30ce\u672b\u7aef\u306b\u7d0470\u30a2\u30df\u30ce\u9178\u304b\u3089\u306a\u308bJ\u30c9\u30e1\u30a4\u30f3\u304c\u3042\u308a\uff0c\u3053\u306e\u30c9\u30e1\u30a4\u30f3\u306f\u4ed6\u306e\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u306e\u3059\u3079\u3066\u306b\u5171\u901a\u3057\u3066\u5b58\u5728\u3057\u3066\u3044\u308b\uff0eJ\u30c9\u30e1\u30a4\u30f3\u306e\u6b21\u306b\u30b0\u30ea\u30b7\u30f3\u3068\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u306e\u591a\u3044G\/F\u30c9\u30e1\u30a4\u30f3\uff0c\u4e2d\u592e\u4ed8\u8fd1\u306b\u30b7\u30b9\u30c6\u30a4\u30f3\u306e\u591a\u3044C\u30c9\u30e1\u30a4\u30f3\u304c\u3042\u308b\uff0eHSP40\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u306e\u4e2d\u3067\uff0c\u3053\u308c\u30893\u3064\u306e\u30c9\u30e1\u30a4\u30f3\uff08J\uff0cG\/F\uff0cC\uff09\u3092\u6301\u3064\u306e\u304cDNAJA\uff0cJ\u30c9\u30e1\u30a4\u30f3\u3068G\/F\u30c9\u30e1\u30a4\u30f3\u3092\u6301\u3064\u306e\u304cDNAJB\uff0cJ\u30c9\u30e1\u30a4\u30f3\u306e\u307f\u3092\u6301\u3064\u306e\u304cDNAJC\u3068\u30af\u30e9\u30b9\u5206\u3051\u3055\u308c\u3066\u3044\u308b\uff0e\u305d\u308c\u305e\u308c\u306e\u30af\u30e9\u30b9\u306e\u30e1\u30f3\u30d0\u30fc\u306f\u307e\u305f\u756a\u53f7\u306b\u3088\u3063\u3066\u533a\u5225\u3055\u308c\u308b\uff0eHSP40\u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u81ea\u8eab\u306b\u306f\u30b7\u30e3\u30da\u30ed\u30f3\u6a5f\u80fd\u306f\u306a\u304f\uff0cJ\u30c9\u30e1\u30a4\u30f3\u3092\u4ecb\u3057\u3066HSP70\u3068\u4f1a\u5408\u3059\u308b\u3053\u3068\u3067\u305d\u306e\u30b7\u30e3\u30da\u30ed\u30f3\u6a5f\u80fd\u3092\u4fc3\u9032\u3059\u308b\u88dc\u52a9\u56e0\u5b50\uff08co-chaperone\uff09\u3068\u3057\u3066\u50cd\u304f\uff0e<\/p>\n\n\n\n

    \u20202<\/sup>\u5909\u7570p53\uff08mp53\uff09\uff1a\u816b\u760d\u6291\u5236\u56e0\u5b50\u3067\u3042\u308bp53\u306f\u591a\u304f\u306e\u304c\u3093\u3067\u5909\u7570\u3057\u3066\u3044\u308b\u3053\u3068\u306f\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\uff0c\u305d\u306e\u5909\u7570\u306e\u591a\u304f\u306f\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u3067\u3042\u308a\uff0c\u5927\u307e\u304b\u306b2\u7a2e\u985e\u306b\u5206\u3051\u3089\u308c\u308b\uff0e\u30bf\u30a4\u30d7I\u306fDNA\u63a5\u89e6\u578b\u3067\u3042\u308a\uff0cp53\u306eDNA\u7d50\u5408\u90e8\u4f4d\u306e\u30a2\u30df\u30ce\u9178\u306e\u5909\u7570\u3067\u3042\u308b\uff0e\u30bf\u30a4\u30d7II\u306fp53\u30bf\u30f3\u30d1\u30af\u8cea\u5168\u4f53\u306e\u7acb\u4f53\u69cb\u9020\u5168\u4f53\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u30a2\u30df\u30ce\u9178\u5909\u7570\uff08\u7acb\u4f53\u69cb\u9020\u5909\u7570\u578b\uff0cconformational\/unfolded type\uff09\u3067\u3042\u308b\uff0e\u3000<\/p>\n\n\n\n

    \u20203<\/sup>\u30b9\u30bf\u30c1\u30f3\uff08statin\uff09\uff1a\u30b9\u30bf\u30c1\u30f3\u306f\u809d\u81d3\u3067\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5408\u6210\u3092\u963b\u5bb3\u3057\u3066\u8840\u6db2\u4e2d\u306e\u60aa\u7389\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u547c\u3070\u308c\u308bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\uff0c\u52d5\u8108\u786c\u5316\u3092\u4e88\u9632\u3059\u308b\u85ac\u3068\u3057\u3066\u4e16\u754c\u4e2d\u3067\u51e6\u65b9\u3055\u308c\u3066\u3044\u308b\uff0e\u30b9\u30bf\u30c1\u30f3\u3068\u3044\u3046\u306e\u306f\u3044\u304f\u3064\u304b\u306e\u85ac\u5264\u306e\u7dcf\u79f0\u3067\u3042\u308a\uff0c\u30d7\u30e9\u30d0\u30b9\u30bf\u30c1\u30f3\uff0c\u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f3\uff0c\u30ed\u30d0\u30b9\u30bf\u30c1\u30f3\u306a\u3069\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u30a2\u30bb\u30c1\u30eb-CoA\u304b\u3089\u59cb\u307e\u308b\u30e1\u30d0\u30ed\u30f3\u9178\u7d4c\u8def\u3067\u5408\u6210\u3055\u308c\u308b\uff0e\u3053\u306e\u7d4c\u8def\u306e\u9014\u4e2d\u3067\u30e1\u30d0\u30ed\u30f3\u9178\uff08MVA\uff09\u3092\u5408\u6210\u3059\u308b\u9175\u7d20\u304cHMG-CoA reductase\uff08hydroxy methyl glutaryl-CoA\u9084\u5143\u9175\u7d20\uff09\u3067\u3042\u308a\uff0c\u3053\u306e\u9175\u7d20\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u306e\u304c\u30b9\u30bf\u30c1\u30f3\u3067\u3042\u308b\uff0e\u30e1\u30d0\u30ed\u30f3\u9178\uff08MVA\uff09\u306f\u30e1\u30d0\u30ed\u30f3\u9178\u30ad\u30ca\u30fc\u30bc\u306b\u3088\u3063\u3066\u30ea\u30f3\u9178\u5316\u3055\u308c\u3066\u30e1\u30d0\u30ed\u30f3\u9178-5-\u30ea\u30f3\u9178\uff08MVP\uff09\u306b\u306a\u308b\uff0e<\/p>\n\n\n\n

    \u20204<\/sup>CDC42\/RAC1\uff1a\u7d30\u80de\u304c\u304c\u3093\u5316\u3059\u308b\u3068\u7d30\u80de\u5185\u306e\u30a2\u30af\u30c1\u30f3\u7dda\u7dad\u306a\u3069\u304c\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306b\u7d44\u307f\u66ff\u3048\u3089\u308c\u3066\u7d30\u80de\u8868\u5c64\u3067\u30d5\u30a3\u30ed\u30dd\u30c7\u30a3\u30a2\/\u30e9\u30e1\u30ea\u30dd\u30c7\u30a3\u30a2\u304c\u591a\u6570\u5f62\u6210\u3055\u308c\u3066\u904a\u8d70\u80fd\u304c\u6d3b\u767a\u306b\u306a\u308b\uff0e\u3053\u306e\u904e\u7a0b\u3092\u5236\u5fa1\u3059\u308b\u306e\u304cRho\u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3067GTPase\u6d3b\u6027\u3092\u6301\u3064CDC42\u3068RAC1\u3067\u3042\u308b\uff0e<\/p>\n\n\n\n

    \u5229\u76ca\u76f8\u53cd\u306b\u95a2\u3059\u308b\u958b\u793a\uff1a<\/p>\n\n\n\n

    \u3000\u8457\u8005\u306b\u5229\u76ca\u76f8\u53cd\u72b6\u614b\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff0e<\/p>\n\n\n\n

    Mini-review:<\/p>\n\n\n\n

    HSP40 Family Member DNAJA1 Promotes Cancer Metastasis through Interaction with Mutant p53<\/p>\n\n\n\n

    KENZO OHTSUKA*<\/p>\n\n\n\n

    College of Bioscience and Biotechnology, Chubu University, Kasugai, Aichi 478-8501, Japan<\/p>\n\n\n\n

    *Corresponding author: kohtsuka\uff08\u30a2\u30c3\u30c8\u30de\u30fc\u30af\uff09isc.chubu.ac.jp<\/a><\/p>\n\n\n\n

    Key Words: HSP40 family, DNAJA1, mutant p53, metastasis<\/p>\n\n\n\n

    Received: 28 February, 2022<\/p>\n\n\n\n

    Accepted: 4 March, 2022<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u5b66\u8853\u7d39\u4ecb\uff1aNO.74 HSP40\u30d5\u30a1\u30df\u30ea\u30fc\u306eDNAJA1\u306f\u5909\u7570\u578bp53\u3068\u306e\u4f1a\u5408\u3092\u4ecb\u3057\u3066\u304c\u3093\u306e\u8ee2\u79fb\u3092\u4fc3\u9032\u3059\u308b \u5927\u585a\u5065\u4e09* \u4e2d\u90e8\u5927\u5b66\u3000\u5fdc\u7528\u751f\u7269\u5b66 \u3053\u308c\u307e\u3067\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u6a5f\u80fd\u3092\u6301\u3064\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea\uff08heat shock p […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-1313","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/1313","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=1313"}],"version-history":[{"count":5,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/1313\/revisions"}],"predecessor-version":[{"id":1389,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/1313\/revisions\/1389"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=1313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=1313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=1313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}