{"id":1412,"date":"2022-07-15T15:36:00","date_gmt":"2022-07-15T06:36:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=1412"},"modified":"2022-10-26T16:42:11","modified_gmt":"2022-10-26T07:42:11","slug":"%e6%97%a5%e6%9c%ac%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc%e3%83%9f%e3%82%a2%e5%ad%a6%e4%bc%9a%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9no-163%e3%80%90%e5%ad%a6%e8%a1%93%e5%a0%b1%e5%91%8a75","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e6%97%a5%e6%9c%ac%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc%e3%83%9f%e3%82%a2%e5%ad%a6%e4%bc%9a%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9no-163%e3%80%90%e5%ad%a6%e8%a1%93%e5%a0%b1%e5%91%8a75\/","title":{"rendered":"\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.169\u3010\u5b66\u8853\u5831\u544a76\u3011"},"content":{"rendered":"\n<p>\u5b66\u8853\u7d39\u4ecb\uff1a76<\/p>\n\n\n\n<h2 class=\"is-style-vk-heading-double_black wp-block-heading\">\u30bf\u30f3\u30d1\u30af\u8cea\u6bd2\u6027\u306b\u304a\u3051\u308bHsp70-Bag3\u8907\u5408\u4f53\u306e\u5f79\u5272<\/h2>\n\n\n\n<p>\u7530\u6e15\u3000\u572d\u7ae0<sup>1,<\/sup>*\u30fb\u67da\u6728\u3000\u9054\u4e5f<sup>2<\/sup><\/p>\n\n\n\n<p><sup>1<\/sup>\u5bcc\u5c71\u5927\u5b66\u7814\u7a76\u63a8\u9032\u6a5f\u69cb\u907a\u4f1d\u5b50\u5b9f\u9a13\u65bd\u8a2d<\/p>\n\n\n\n<p><sup>2<\/sup>\u5bcc\u5c71\u5927\u5b66\u5b66\u8853\u7814\u7a76\u90e8\uff08\u533b\u5b66\u7cfb\uff09\u773c\u79d1\u5b66<\/p>\n\n\n\n<p>\u7d30\u80de\u5185\u306b\u306f\u591a\u7a2e\u591a\u69d8\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5b58\u5728\u3057\uff0c\u305d\u306e\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u306b\u3088\u308a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30db\u30e1\u30aa\u30b9\u30bf\u30b7\u30b9\u304c\u53b3\u5bc6\u306b\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b (\u30d7\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9<sup>\u2628<\/sup><sup>1<\/sup>)\uff0e\u3057\u304b\u3057\u306a\u304c\u3089\uff0c\u71b1\u3092\u542b\u3080\u69d8\u3005\u306a\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308a\u7d30\u80de\u5185\u306b\u69cb\u9020\u7684\u306b\u7570\u5e38\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u84c4\u7a4d\u3059\u308b\u3068\u7d30\u80de\u306e\u6a5f\u80fd\u7570\u5e38\u3084\u7d30\u80de\u6b7b\u304c\u8a98\u5c0e\u3055\u308c\u308b (<a>\u30bf\u30f3\u30d1\u30af\u8cea\u6bd2\u6027<\/a><sup>\u2628<\/sup><sup>2<\/sup>)\uff0e\u4e00\u65b9\u3067\uff0c\u71b1\u30b9\u30c8\u30ec\u30b9\u306b\u66dd\u3055\u308c\u305f\u6642\uff0c\u71b1\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u304c\u8d77\u308a\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u7fa4 (HSPs) \u306f\u901f\u3084\u304b\u306b\u8ee2\u5199\u30fb\u7ffb\u8a33\u3055\u308c\uff0c\u305d\u308c\u3089\u306e\u30b7\u30e3\u30da\u30ed\u30f3\u6a5f\u80fd\u7b49\u306b\u3088\u308a\u7d30\u80de\u4fdd\u8b77\u7684\u306b\u6a5f\u80fd\u3059\u308b\uff0eHSPs\u306e\u4e3b\u8981\u306a\u30e1\u30f3\u30d0\u30fcHsp70\u306f\uff0c\u305d\u306e\u30b3\u30b7\u30e3\u30da\u30ed\u30f3Hsp40\u3068\u5354\u8abf\u3057\u3066\u30b7\u30e3\u30da\u30ed\u30f3\u6a5f\u80fd\u3092\u62c5\u3044\uff0c\u307e\u305f\uff0cHsp70\u306b\u52a0\u3048\u3066\u6570\u591a\u304f\u306eHSPs\u3068\u69cb\u9020\u7570\u5e38\u30bf\u30f3\u30d1\u30af\u8cea\u84c4\u7a4d\u304c\u95a2\u4e0e\u3059\u308b\u75be\u60a3\u3068\u306e\u9593\u306e\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<sup>1)<\/sup>\uff0eBAG\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u306eBag3<sup>\u2628<\/sup><sup>3<\/sup>\u306f\uff0c\u71b1\u8a98\u5c0e\u6027\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3067Hsp70\u306e\u30b3\u30b7\u30e3\u30da\u30ed\u30f3\u3067\u3082\u3042\u308b\uff0e\u8fd1\u5e74\uff0c<a>Hsp70-Bag3<\/a>\u8907\u5408\u4f53\u304c\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3084\u304c\u3093\u7b49\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u6f14\u3058\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u3063\u3066\u304d\u305f<sup>2)<\/sup>\uff0e\u4eca\u56de\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u6bd2\u6027\u306b\u304a\u3051\u308b<a>Hsp70-Bag3<\/a>\u8907\u5408\u4f53\u306e\u5f79\u5272\u3092\u793a\u3057\u305fSherman\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u5831\u544a<sup>3, 4)<\/sup>\u3092\u7d39\u4ecb\u3059\u308b\uff0e<\/p>\n\n\n\n<p>\u3000\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0<sup>\u2628<\/sup><sup>4<\/sup>\u306f\uff0c\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3055\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5206\u89e3\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u3067\u3042\u308b\uff0e\u305d\u306e\u963b\u5bb3\u5264MG-132\u3067\u7d30\u80de\u3092\u51e6\u7406\u3059\u308b\u3068\uff0c\u7d30\u80de\u5185\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6\u4f53\u304c\u751f\u6210\u3057\uff0c\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54<sup>\u2628<\/sup><sup>5<\/sup>\u3092\u4f34\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u6bd2\u6027\u304c\u8a98\u5c0e\u3055\u308c\u308b\uff0e\u30d2\u30c8\u4e73\u304c\u3093\u7d30\u80de\u682aMCF10A\u306b\u304a\u3044\u3066\uff0cMG-132\u6dfb\u52a0\u3067\u751f\u6210\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6\u4f53\u306fHsp70\u3084Bag3\u306e\u6a5f\u80fd\u963b\u5bb3\uff0c\u307e\u305f\u306f\uff0c<a>Hsp70-Bag3<\/a>\u306e\u76f8\u4e92\u4f5c\u7528\u6291\u5236\u5264YM-1<sup>\u2628<\/sup><sup>6<\/sup>\u51e6\u7406\u306b\u3088\u308a\u6709\u610f\u306b\u6e1b\u5c11\u3057\u305f\uff0e\u307e\u305f\uff0c\u3053\u306e\u6642\uff0c\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3055\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3068Hsp70-Bag3\u3068\u306e\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0e\u3053\u308c\u3089\u306e\u7d50\u679c\u7b49\u304b\u3089\uff0cHsp70-Bag3\u8907\u5408\u4f53\u304c<a>\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6<\/a>\u3092\u611f\u77e5\u3059\u308b\u30bb\u30f3\u30b5\u30fc\u3068\u3057\u3066\u5bc6\u63a5\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f<sup>3)<\/sup>\uff0e<\/p>\n\n\n\n<p>\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u304c\u8a98\u5c0e\u3055\u308c\u305f\u6642\uff0c\u5c0f\u80de\u4f53\u306e\u30bb\u30f3\u30b5\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u8d77\u70b9\u3068\u3057\u305f\u4e3b\u306b3\u7a2e\u985e\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\uff0cIRE1\u7d4c\u8def<sup>\u2628<\/sup><sup>5<\/sup>\uff0cPERK\u7d4c\u8def<sup>\u2628<\/sup><sup>5<\/sup>\u3068ATF6 \u7d4c\u8def<sup>\u2628<\/sup><sup>5<\/sup>\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b<sup>5)<\/sup>\uff0eHsp70-Bag3\u8907\u5408\u4f53\u306e\u95a2\u4e0e\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u3092<a><\/a><a>Hsp70-Bag3<\/a>\u306e\u76f8\u4e92\u4f5c\u7528\u6291\u5236\u5264JG-98<sup>\u2628<\/sup><sup>6<\/sup>\u3092\u7528\u3044\u3066\u8abf\u3079\u305f\u7d50\u679c\uff0cIRE1\u7d4c\u8def\u3068ATF6\u7d4c\u8def\u3067\u306f\u306a\u304fPERK\u7d4c\u8def\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u5224\u3063\u305f\uff0ePERK\u306f\uff0c\u7ffb\u8a33\u958b\u59cb\u56e0\u5b50eIF2\u03b1\uff0c\u8ee2\u5199\u56e0\u5b50ATF4\u306e\u9806\u306b\u6d3b\u6027\u5316\u3057\uff0c\u3055\u3089\u306b\u8ee2\u5199\u56e0\u5b50CHOP\u306e\u767a\u73fe\u3092\u4e0a\u6607\u3055\u305b\u308b (\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u8a98\u5c0e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def<sup>\u2628<\/sup><sup>5<\/sup>)\uff0eMCF10A\u7d30\u80de\u306b\u304a\u3044\u3066\uff0cJG-98\u306fCHOP\u4f9d\u5b58\u7684\u306a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3057\u305f\uff0e\u3057\u304b\u3057\u306a\u304c\u3089\uff0cJG-98\u51e6\u7406\u7d30\u80de\u306b\u304a\u3044\u3066PERK\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3057\u3066\u3082eIF2\u03b1\u4ee5\u964d\u306e\u5fdc\u7b54\u306f\u6291\u5236\u3055\u308c\u306a\u304b\u3063\u305f\uff0eHsp70-Bag3\u8907\u5408\u4f53\u306e\u95a2\u4e0e\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u304c\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3068\u306f\u7570\u306a\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\uff0e\u8a73\u7d30\u306a\u5b9f\u9a13\u6210\u7e3e\u306f\u5272\u611b\u3057\u305f\u304c\uff0cSherman\u3089\u306fHsp70-Bag3\u8907\u5408\u4f53\u304c\u5c0f\u80de\u4f53\u3067\u306f\u306a\u304f\u7d30\u80de\u8cea\u306b\u304a\u3051\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u6bd2\u6027\u306e\u30bb\u30f3\u30b5\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u7d50\u8ad6\u3057\u305f<sup>6)<\/sup>\uff0e<\/p>\n\n\n\n<p>\u5f15\u304d\u7d9a\u304d\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u6bd2\u6027\uff0c\u71b1\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3084\u304c\u3093\u6e29\u71b1\u7642\u6cd5\u7b49\u306b\u304a\u3044\u3066\uff0cHsp70-Bag3\u8907\u5408\u4f53\u304c\u95a2\u4e0e\u3059\u308b\u7814\u7a76\u306e\u52d5\u5411\u306b\u6ce8\u76ee\u3057\u305f\u3044\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p>1) Brehme M., Voisine C.: Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity. Dis Model Mech, 9: 823-838, 2016.<\/p>\n\n\n\n<p>2) K\u00f6gel D., Linder B., Brunschweiger A., Chines S., Behl C.: At the crossroads of apoptosis and autophagy: Multiple roles of the co-chaperone BAG3 in stress and therapy resistance of cancer. Cells, 9: 574, 2020.<\/p>\n\n\n\n<p>3) Meriin A.B., Narayanan A., Meng L., Alexandrov I., Varelas X., Ciss\u00e9 I.I., Sherman M.Y.: Hsp70-Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation. Proc Natl Acad Sci U S A, 115: E7043-E7052, 2018.<\/p>\n\n\n\n<p>4) Patel S., Kumar S., Baldan S., Hesin A., Yaglom J., Sherman M.Y.: Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2\u03b1 via the Hsp70-Bag3 module. iScience, 25: 104282, 2022.<\/p>\n\n\n\n<p>5) Mori K.: The unfolded protein response: the dawn of a new field. Proc Jpn Acad Ser B Phys Biol Sci, 91: 469-480, 2015.<\/p>\n\n\n\n<p>6) Sherman M.Y., Gabai V.: The role of Bag3 in cell signaling. J Cell Biochem, 123: 43-53, 2022.<\/p>\n\n\n\n<p>\u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n<p><sup>\u26281<\/sup>\u30d7\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9 (proteostasis)\uff1a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6052\u5e38\u6027\u3092\u7dad\u6301\u3059\u308b\u4e00\u9023\u306e\u904e\u7a0b\uff0e\u7d30\u80de\u5185\u306e\u5168\u3066\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u751f\u6210\u304b\u3089\u305d\u306e\u5206\u89e3\u307e\u3067\u306e\u904e\u7a0b\u304c\u542b\u307e\u308c\uff0c\u91cf\u7684\uff0c\u8cea\u7684\u3055\u3089\u306b\u4f4d\u7f6e\u7684\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6b63\u5e38\u6a5f\u80fd\u3092\u7dad\u6301\u3059\u308b\u72b6\u614b\u3067\u3042\u308b\uff0e<\/p>\n\n\n\n<p><sup>\u26282<\/sup>\u30bf\u30f3\u30d1\u30af\u8cea\u6bd2\u6027 (proteotoxicity)\uff1a\u7d30\u80de\u5185\u306b\u7570\u5e38\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u751f\u6210\u3057\uff0c\u7d30\u80de\u6bd2\u6027\u3092\u793a\u3059\u72b6\u614b\uff0e\u7570\u5e38\u30bf\u30f3\u30d1\u30af\u304c\u84c4\u7a4d\u3059\u308b\u3053\u3068\u306b\u3088\u308a\uff0c\u7cd6\u5c3f\u75c5\uff0c\u5404\u7a2e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7b49\uff0c\u69d8\u3005\u306a\u75c5\u614b\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p><sup>\u26283<\/sup><strong> <\/strong>BAG3 (BAG cochaperone 3)\uff1aBAG (Bcl-2 associated athanogene) \u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u306eBag3\u306f\uff0c\u81ea\u3089\u306eBAG\u30c9\u30e1\u30a4\u30f3\u3068Hsp70 \u306eATPase\u30c9\u30e1\u30a4\u30f3\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308bHsp70\u306e\u30b3\u30b7\u30e3\u30da\u30ed\u30f3\u3067\u3042\u308b\uff0eBag3\u306f\uff0c\u6e29\u71b1\uff0c\u91cd\u91d1\u5c5e\u7b49\uff0c\u7a2e\u3005\u306e\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\uff0c\u7d30\u80de\u5897\u6b96\uff0c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3084\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u7b49\u306e\u69d8\u3005\u306a\u7d30\u80de\u6a5f\u80fd\u306e\u5236\u5fa1\u306b\u95a2\u4e0e\u3059\u308b\uff0e\u307e\u305f\uff0cBag3\u306f\uff0c\u304c\u3093\uff0c\u52a0\u9f62\u306b\u4f34\u3046\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7b49\uff0c\u591a\u69d8\u306a\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<sup>2)<\/sup>\uff0e<\/p>\n\n\n\n<p><sup>\u26284<\/sup>\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0 (proteasome)<strong>\uff1a<\/strong><a>\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3055\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5206\u89e3\u3059\u308b\u30bf\u30f3\u30d1\u30af<\/a>\u8cea\u8907\u5408\u4f53\uff0e\u771f\u6838\u751f\u7269\u306b\u306f\u30e6\u30d3\u30ad\u30c1\u30f3\/\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u30b7\u30b9\u30c6\u30e0\u3068\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\/\u30ea\u30bd\u30bd\u30fc\u30e0\u30b7\u30b9\u30c6\u30e0\u306e2\u7a2e\u985e\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u30b7\u30b9\u30c6\u30e0\u304c\u3042\u308b\uff0eMG132\u306f\u5f37\u529b\u306a\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u963b\u5bb3\u5264\u3067\uff0c\u5e83\u304f\u7814\u7a76\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p><sup>\u26285<\/sup>\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54 (endoplasmic reticulum (ER) stress response)\uff1a\u5c0f\u80de\u4f53\u5185\u306b\u69cb\u9020\u7570\u5e38\u30bf\u30f3\u30d1\u30af\u304c\u84c4\u7a4d\u3059\u308b\u3068<a>\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54<\/a>\u304c\u8d77\u3053\u308b\uff0e\u3053\u308c\u306f\uff0cUPR (unfolded protein response) \u3068\u3082\u547c\u3070\u308c\u3066\u3044\u308b\uff0e<a>\u3053\u306e\u30b7\u30b0\u30ca\u30eb\u7cfb\u306b\u306f\uff0c\u5c0f\u80de\u4f53\u306e\u30bb\u30f3\u30b5\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u8d77\u70b9\u3068\u3057\u305f\u4e3b\u306b<\/a>IRE1 (inositol requiring enzyme-1) \u7d4c\u8def\uff0cPERK (protein kinase R-like ER kinase) \u7d4c\u8def\u3068ATF6 (activating transcription factor 6) \u7d4c\u8def\u304c\u3042\u308b\uff0e\u5c1a\uff0cPERK \u2192 eIF2\u03b1 (eukaryotic initiation factor 2\u03b1) \u2192 ATF4 (activating transcription factor 4) \u2192 CHOP (C\/EBP homologous protein) \u7d4c\u8def\u306f\uff0c<a>\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u8a98\u5c0e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u3068\u3057\u3066\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b<\/a><sup>5)<\/sup>\uff0e<\/p>\n\n\n\n<p><sup>\u26286<\/sup>Hsp70-Bag3\u306e\u76f8\u4e92\u4f5c\u7528\u6291\u5236\u5264<strong>\uff1a<\/strong>\u6700\u521d\u306b\uff0cHsp70-Bag3\u306e\u76f8\u4e92\u4f5c\u7528\u6291\u5236\u5264YM-1\u304c\u958b\u767a\u3055\u308c\u305f\uff0eYM-1\u306f\uff0cHsp70\u306eATPase\u30c9\u30e1\u30a4\u30f3\u306b\u7d50\u5408\u3057\u3066Bag3\u3068\u306e\u7d50\u5408\u3092\u963b\u5bb3\u3059\u308b\uff0eJG-98\u306f\uff0cYM-1\u306e\u8a98\u5c0e\u4f53\u3067YM-1\u3088\u308a\u3082\u4f4e\u6fc3\u5ea6\u3067\u52b9\u679c\u304c\u3042\u308b\u7b2c\u4e8c\u4e16\u4ee3\u306e\u672c\u4f5c\u7528\u6291\u5236\u5264\u3067\u3042\u308b<sup>6)<\/sup>\uff0e<\/p>\n\n\n\n<p>\u5229\u76ca\u76f8\u53cd\u306b\u95a2\u3059\u308b\u958b\u793a\uff1a<\/p>\n\n\n\n<p>\u3000\u8457\u8005\u306b\u5229\u76ca\u76f8\u53cd\u72b6\u614b\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff0e<\/p>\n\n\n\n<p>Mini-review<\/p>\n\n\n\n<p>Role of Hsp70-Bag3 Complex for <a>Proteotoxicity<\/a><\/p>\n\n\n\n<p>YOSHIAKI TABUCHI<sup>1,<\/sup>*, TATSUYA YUNOKI<sup>2<\/sup><\/p>\n\n\n\n<p><sup>1<\/sup>Division of Molecular Genetics, Life Science Research Center, University of Toyama, Toyama 930-0194, Japan<\/p>\n\n\n\n<p><sup>2<\/sup>Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan<\/p>\n\n\n\n<p>*Corresponding author: ytabu@cts.u-toyama.ac.jp<\/p>\n\n\n\n<p>Key Words: Hsp70, Bag3, proteotoxicity<\/p>\n\n\n\n<p>Received: 18 June, 2022<\/p>\n\n\n\n<p>Accepted: 1 July, 2022<\/p>\n\n\n\n<p>Thermal Medicine Vol.38(3) \u63b2\u8f09\u4e88\u5b9a<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5b66\u8853\u7d39\u4ecb\uff1a76 \u30bf\u30f3\u30d1\u30af\u8cea\u6bd2\u6027\u306b\u304a\u3051\u308bHsp70-Bag3\u8907\u5408\u4f53\u306e\u5f79\u5272 \u7530\u6e15\u3000\u572d\u7ae01,*\u30fb\u67da\u6728\u3000\u9054\u4e5f2 1\u5bcc\u5c71\u5927\u5b66\u7814\u7a76\u63a8\u9032\u6a5f\u69cb\u907a\u4f1d\u5b50\u5b9f\u9a13\u65bd\u8a2d 2\u5bcc\u5c71\u5927\u5b66\u5b66\u8853\u7814\u7a76\u90e8\uff08\u533b\u5b66\u7cfb\uff09\u773c\u79d1\u5b66 \u7d30\u80de\u5185\u306b\u306f\u591a\u7a2e\u591a\u69d8\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5b58\u5728\u3057\uff0c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[2],"tags":[],"class_list":["post-1412","post","type-post","status-publish","format-standard","hentry","category-newsletter"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/1412","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=1412"}],"version-history":[{"count":2,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/1412\/revisions"}],"predecessor-version":[{"id":1416,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/1412\/revisions\/1416"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=1412"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=1412"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=1412"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}