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infrared photoimmunotherapy(NIR-PIT)\uff08\u8fd1\u8d64\u5916\u5149\u7dda\u514d\u75ab\u7642\u6cd5\uff09\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u8868\u9762\u306e\u6297\u539f\u306b\u7279\u7570\u7684\u306a\u6297\u4f53\u306b\u8fd1\u8d64\u5916\u7dda\u306b\u53cd\u5fdc\u3059\u308bprobe\u3092\u3064\u3051\uff0c\u8fd1\u8d64\u5916\u7dda\u3092\u7167\u5c04\u3059\u308b\u3053\u3068\u3067\u6cbb\u7642\u3092\u884c\u3046\u304c\u3093\u5149\u514d\u75ab\u7642\u6cd5\u3067\u3042\u308b1, 2\uff09\uff0eNIR-PIT\u306f\u8fd1\u8d64\u5916<br>\u306e\u6c34\u6eb6\u6027\u30b7\u30ea\u30b3\u30f3\u30d5\u30bf\u30ed\u30b7\u30a2\u30cb\u30f3\u8a98\u5c0e\u4f53\u3067\u3042\u308bIRdye700DX\uff08IR700\uff09\u3068\u304c\u3093\u7d30\u80de\u306e\u8868\u9762\u306b\u767a\u73fe\u3057\u305f\u6297\u539f\u3092\u6a19\u7684\u3068\u3059\u308b\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\uff08mAb\uff09\u3092\u6295\u4e0e\u3059\u308b\u304c\u3093\u306e\u5206\u5b50\u6a19\u7684\u5149\u7dda\u7642\u6cd5\u3067\u3042\u308b\uff0e\u305d\u306e\u5f8c\u306e\u8fd1\u8d64\u5916\u5149\u7dda\u3078\u306e\u5c40\u6240\u66dd\u9732\u306b\u3088\u308a\uff0c\u3053\u306e\u5149\u5316\u5b66\u7684\u300c\u6b7b\u300d\u306e\u30b9\u30a4\u30c3\u30c1\u304c\u5165\u308a\uff0c\u305d\u306e\u7d50\u679c\u6a19\u7684\u3068\u306a\u308b\u304c\u3093\u7d30\u80de\u306e\u8fc5\u901f\u304b\u3064\u9ad8\u5ea6\u306b\u9078\u629e\u7684\u306aimmuno-genic cell death\uff08ICD: 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BioBlade\u24c7 \u30ec\u30fc\u30b6\u30b7\u30b9\u30c6\u30e0\u3092\u7528<br>\u3044\u305f\u6ce2\u9577 690 nm \u306e\u30ec\u30fc\u30b6\u5149\u3092\u7167\u5c04\u3059\u308b\uff0e\u305d\u308c\u306b\u3088\u3063\u3066\u672c\u85ac\u54c1\u306b\u7d50\u5408\u3057\u3066\u3044\u308b 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4\u4f8b\uff0813.3%\uff09\u304c\u5b8c<br>\u5168\u594f\u52b9\uff0c9\u4f8b\uff0830.0%\uff09\u304c\u90e8\u5206\u594f\u52b9\u3067\u3042\u3063\u305f\uff0e\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u306f19\u4f8b\uff0863.3%\uff09\u306b\u30b0\u30ec\u30fc\u30c93\u4ee5\u4e0a\u306e\u6709\u5bb3\u4e8b\u8c61\u3092\u8a8d\u3081\u305f\uff0e\u305d\u306e\u5f8c\u5207\u9664\u4e0d\u80fd\u306a\u5c40\u6240\u518d\u767a\u306e\u65e5\u672c\u4eba\u982d\u9838\u90e8\u6241\u5e73\u4e0a\u76ae\u764c\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u56fd\u5185\u7b2c\u2160\u76f8\u8a66\u9a13\u304c\u884c\u308f\u308c\u305f\uff0e\u3053\u308c\u3089\u4e8c\u3064\u306e\u8a66\u9a13\u306b\u3088\u308a\uff0c\u5207\u9664\u4e0d\u80fd\u306a\u5c40\u6240\u9032\u884c\u307e\u305f\u306f\u5c40\u6240\u518d\u767a\u306e\u982d\u9838\u90e8\u764c\u60a3\u8005\u306b\u5bfe\u3059\u308b\u672c\u6cbb\u7642\u306e\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3068\u6709\u52b9\u6027\u304c\u793a\u3055\u308c\u305f\uff0e\u982d\u9838\u90e8\u764c\u5149\u514d\u75ab\u7642\u6cd5\u306f\u65e5\u672c\u56fd\u5185\u306e62\u65bd\u8a2d\uff082022\u5e744\u670815\u65e5\u6642\u70b9\uff09\u3067\u6cbb\u7642\u304c\u53ef\u80fd\u3068\u306a\u308a\uff0c\u982d\u9838\u90e8\u764c\u4ee5\u5916\u3067\u3082\u98df\u9053\u764c\u306a\u3069\u3067\u81e8\u5e8a\u8a66\u9a13\u304c\u5b9f\u65bd\u3001\u3042\u308b\u3044\u306f\u4e88\u5b9a\u3055\u308c\u3066\u3044\u308b\uff0e\u3053\u306e\u3088\u3046\u306b\u5149\u514d\u75ab\u7642\u6cd5\u306f\u3055\u307e\u3056\u307e\u306a\u304c\u3093\u7a2e\u3084\u6cbb\u7642\u30bb\u30c3\u30c6\u30a3\u30f3\u30b0\u3078\u306e\u5fdc\u7528\u304c\u53ef\u80fd\u3068\u306a\u308a\uff0c\u81e8\u5e8a\u8a66\u9a13\u3092\u542b\u3081\u305f\u4eca\u5f8c\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e<br>1)&nbsp; &nbsp; Kobayashi H, Choyke P.L.: Near infrared photoimmunotherapy of cancer.<br>Acc Chem Res, 52: 2332-2339, 2019.<br>2)&nbsp; &nbsp; Cognetti DM, Johnson JM, Curry JM, et al.: Phase 1\/2a, open- label,<br>multicenter study of RM\uff0d1929 photoimmunotherapy in patients with<br>locoregional, recurrent head and neck squamous cell carcinoma. Head &amp; Neck,<br>43: 3875-3887, 2021.<br>3)&nbsp; &nbsp; \u4f50\u85e4 \u548c\u79c0: \u8fd1\u8d64\u5916\u5149\u7dda\u514d\u75ab\u7642\u6cd5\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e. \u65e5\u30ec\u533b\u8a8c (JJSLSM),<br>41: 104-109, 2020.<br>4)&nbsp; &nbsp; \u698e\u7530 \u667a\u5f18, \u7530\u539f \u4fe1\uff1a\u5149\u514d\u75ab\u7642\u6cd5\uff0e\u304c\u3093\u5206\u5b50\u6a19\u7684\u6cbb\u7642, 19: 196-200, 2022.<br>5)&nbsp; &nbsp; \u82b1\u4e95 \u4fe1\u5e83\uff1a\u982d\u9838\u90e8\u304c\u3093\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u3000\u304c\u3093\u5149\u514d\u75ab\u7642\u6cd5\uff0e\u65e5\u8033\u9f3b, 125:<br>492-493, 2022.<\/p>\n\n\n\n<p>\u7528\u8a9e\u89e3\u8aac<br>\u26281 immuno-genic cell death\uff08ICD: \u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b\uff09\uff1a\u3042\u308b\u7a2e\u306e\u6297\u304c\u3093\u85ac\u306f\uff0c\u901a\u5e38\u306e\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u3084\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u6bd4\u3079\u514d\u75ab\u5fdc\u7b54\u3092\u60f9\u8d77\u3057\u3084\u3059\u3044\u5f62\u3067\uff0c\u304c\u3093\u7d30\u80de\u3092\u6bba\u50b7\u3059\u308b\uff0e\u3053\u306e\u7d30\u80de\u6b7b\u3092\u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b\u3068\u3088\u3076\uff0e<br>\u5229\u76ca\u76f8\u53cd\u306b\u95a2\u3059\u308b\u958b\u793a<br>\u8457\u8005\u306b\u5229\u76ca\u76f8\u53cd\u72b6\u614b\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f<\/p>\n\n\n\n<p>Mini-review:<br>Photoimmunotherapy for Head and Neck Cancer<br>KENJI MITSUDO*<br>Department of Oral and Maxillofacial Surgery, Yokohama City University<br>Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa<br>236-0004, Japan<br>*Corresponding author:&nbsp;<a href=\"mailto:mitsudo@yokohama-cu.ac.jp\" target=\"_blank\" rel=\"noreferrer noopener\">mitsudo@yokohama-cu.ac.jp<\/a><br>Key Words: photoimmunotherapy, head and neck cancer, RM-1926\/ASP1929<br>Received: 16 August, 2022<br>Accepted: 31 October, 2022<br>Thermal Medicine\u3000 Vol.38(4)\u63b2\u8f09\u4e88\u5b9a<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u982d\u9838\u90e8\u764c\u306b\u5bfe\u3059\u308b\u5149\u514d\u75ab\u7642\u6cd5 \u5149\u85e4\u5065\u53f8\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u3000\u984e\u9854\u9762\u53e3\u8154\u6a5f\u80fd\u5236\u5fa1\u5b66 \u624b\u8853\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\uff0c\u5316\u5b66\u7642\u6cd5\u304c\u764c\u306b\u5bfe\u3059\u308b3\u5927\u6cbb\u7642\u3068\u8a00\u308f\u308c\uff0c\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306e\u5c0e\u5165\u306b\u3088\u308a\u3001\u514d\u75ab\u6cbb\u7642\u3092\u542b\u3081\u305f\u3082\u306e\u304c\u7b2c4\u306e\u6cbb\u7642\u3068\u3044 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[2],"tags":[],"class_list":["post-2065","post","type-post","status-publish","format-standard","hentry","category-newsletter"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/2065","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=2065"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/2065\/revisions"}],"predecessor-version":[{"id":2066,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/2065\/revisions\/2066"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=2065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=2065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=2065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}