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Gy\uff0c\u816b\u760d\u306b\u306f40 Gy\u306e\u521d\u671f\u7167\u5c04\u7dda\u91cf\u3092\u8a2d\u5b9a\u3057\uff0c30\u65e5\u5f8c\u306b\u518d\u7167\u5c04\u3092\u5b9f\u65bd\u3057\u305f\uff0e\u6e29\u71b1\u7642\u6cd5\u306f42.5\u2103\u30671\u6642\u9593\uff0c\u518d\u7167\u5c0430\u5206\u5f8c\u3088\u308a\u958b\u59cb\u3057\u305f\uff0e\u76ae\u819a\u53cd\u5fdc\u306f\u6025\u6027\u76ae\u819a\u6bd2\u6027\u30b9\u30b3\u30a2\uff080.5-3.5\uff09\u3067\u8a55\u4fa1\u3057\uff0c\u816b\u760d\u5236\u5fa1\u306f90\u65e5\u9593\u306e\u89b3\u5bdf\u671f\u9593\u3067\u5224\u5b9a\u3057\u305f\uff0e\u7d50\u679c\u306f\uff0c\u518d\u7167\u5c04\u306b\u3088\u308b\u76ae\u819a\u969c\u5bb3\u306eMedian Damaging Dose(MDD)\u2085\u2080<sup>#9<\/sup>\u306f25 Gy\u3067\u3042\u3063\u305f\u304c\uff0c\u6e29\u71b1\u7642\u6cd5\u4f75\u7528\u306b\u3088\u308a18 Gy\u306b\u6e1b\u5c11\u3057\uff0c\u71b1\u5897\u5f37\u6bd4\uff08TER\uff091.4\u3092\u793a\u3057\u305f\uff0e\u3053\u308c\u306b\u5bfe\u3057\uff0c\u816b\u760d\u5236\u5fa1\u3067\u306f\uff0cTumor Control Dose (TCD)\u2085\u2080<sup>#10<\/sup>\u304c\u518d\u7167\u5c04\u5358\u72ec\u306e49 Gy\u304b\u3089\u6e29\u71b1\u7642\u6cd5\u4f75\u7528\u306729 Gy\u306b\u8457\u660e\u306b\u6e1b\u5c11\u3057\uff0cTER 1.7\u3092\u9054\u6210\u3057\u305f\uff0e\u3053\u308c\u306b\u3088\u308aTGF 1.2\u304c\u5f97\u3089\u308c\uff0c\u6e29\u71b1\u7642\u6cd5\u304c\u816b\u760d\u306b\u3088\u308a\u9078\u629e\u7684\u306b\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff0e\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\uff0c\u5358\u56de\u7167\u5c04\u306eTCD\u2085\u2080\u306f54 Gy\u3067\u3042\u3063\u305f\u306e\u3067\uff0c\u518d\u7167\u5c04\u306e\u65b9\u304c\u52b9\u7387\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\uff0e\u3057\u304b\u3057\u306a\u304c\u3089\uff0c\u91cd\u8981\u306a\u8ab2\u984c\u3068\u3057\u3066\uff0c\u6e29\u71b1\u7642\u6cd5\u4f75\u7528\u7fa447\u5339\u4e2d23\u5339\uff0848.9%\uff09\u304c\u6cbb\u7642\u95a2\u9023\u6bd2\u6027\u306b\u3088\u308a\u7814\u7a76\u304b\u3089\u9664\u5916\u3055\u308c\u305f\u70b9\u304c\u6319\u3052\u3089\u308c\u308b\uff0e\u3053\u306e\u3046\u30616\u5339\u304c\u6b7b\u4ea1\uff0c13\u5339\u304c\u91cd\u7be4\u306a\u76ae\u819a\u53cd\u5fdc\u307e\u305f\u306f20%\u4ee5\u4e0a\u306e\u4f53\u91cd\u6e1b\u5c11\u306b\u3088\u308a\u5b89\u697d\u6b7b\u3068\u306a\u3063\u305f\uff0e\u3053\u306e\u9ad8\u3044\u8131\u843d\u7387\u306b\u3088\u308a\u9ad8\u7dda\u91cf\u57df\u3067\u306e\u5b8c\u5168\u306a\u7dda\u91cf\u53cd\u5fdc\u66f2\u7dda\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u304b\u3063\u305f\uff0e\u307e\u305f\uff0c30\u65e5\u9593\u9694\u3067\u306e\u8a55\u4fa1\u306e\u305f\u3081\uff0c\u6b63\u5e38\u7d44\u7e54\u306e\u5b8c\u5168\u306a\u56de\u5fa9\u306f\u8a55\u4fa1\u3055\u308c\u3066\u304a\u3089\u305a\uff0c\u3088\u308a\u9577\u671f\u306e\u89b3\u5bdf\u304c\u5fc5\u8981\u3067\u3042\u308b\uff0e\u7d50\u8ad6\u3068\u3057\u3066\uff0c\u6e29\u71b1\u7642\u6cd5\u306f\u518d\u7167\u5c04\u306e\u6cbb\u7642\u52b9\u679c\u3092\u6709\u610f\u306b\u5897\u5f37\u3057\uff0c\u7279\u306b\u816b\u760d\u306b\u5bfe\u3057\u3066\u3088\u308a\u5927\u304d\u306a\u5897\u611f\u52b9\u679c\u3092\u793a\u3059\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u305f\uff0e\u672c\u7814\u7a76\u306f\u518d\u7167\u5c04\u3068\u6e29\u71b1\u7642\u6cd5\u4f75\u7528\u306e\u5f71\u97ff\u3092\u6b63\u5e38\u7d44\u7e54\u3068\u816b\u760d\u306e\u4e21\u9762\u304b\u3089\u521d\u3081\u3066\u8a55\u4fa1\u3057\u305f\u70b9\u3067\u9ad8\u3044\u65b0\u898f\u6027\u304c\u8a8d\u3081\u3089\u308c\u308b\uff0e\u4ed6\u65b9\u3067\uff0c\u81e8\u5e8a\u5fdc\u7528\u306b\u306f\u614e\u91cd\u306a\u7dda\u91cf\u6700\u9069\u5316\u3068\u53b3\u5bc6\u306a\u5b89\u5168\u6027\u76e3\u8996\u304c\u4e0d\u53ef\u6b20\u3068\u306a\u308b\uff0e\u307e\u305f\uff0c\u5358\u4e00\u816b\u760d\u30e2\u30c7\u30eb\u3067\u306e\u77e5\u898b\u306e\u305f\u3081\uff0c\u7d44\u7e54\u578b\u306e\u9055\u3044\u3092\u542b\u3081\u305f\u691c\u8a3c\u3084\u5206\u5272\u7167\u5c04\u30fb\u514d\u75ab\u7642\u6cd5\u4f75\u7528\u306a\u3069\u81e8\u5e8a\u306b\u5373\u3057\u305f\u524d\u81e8\u5e8a\u7814\u7a76\u3082\u6c42\u3081\u3089\u308c\u308b\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Hill S.A., Denekamp J.: The response of six mouse tumours to combined heat and X rays: implications for therapy. Br J Radiol, 52: 209-218, 1979.<\/li>\n\n\n\n<li>Folefac C.A., Sinha P.M., Bassler N., Sitarz M.K., Mortensen D., Busk M., Qian H., Krawczyk P.M., Oei A.L., Elming P.B., Horsman M.R.: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40878477\/\">Pre-clinical studies investigating the combination of hypofractionated\u00a0radiation\u00a0with\u00a0hyperthermia\u00a0in a murine tumor and normal skin.<\/a> Int J Hyperthermia, 42: 2545400, 2025.<\/li>\n\n\n\n<li>Folefac C.A., Sinha P.M., Bassler N., S\u00f8rensen B.S., Horsman M.R.: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40714862\/\">Preclinical study of reirradiation with\u00a0hyperthermia\u00a0in recurrent murine tumors and normal mouse skin.<\/a> Acta Oncol, 64: 972-978, 2025.<\/li>\n<\/ol>\n\n\n\n<p>\u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n<p><sup>#1<\/sup>\u5be1\u5206\u5272\u7167\u5c04: \u5f93\u6765\u306e30-33\u5206\u5272\uff081.8-2 Gy\/\u56de\uff09\u3088\u308a\u5c11\u306a\u3044\u5206\u5272\u6570\u3067\u9ad8\u7dda\u91cf\u3092\u6295\u4e0e\u3059\u308b\u653e\u5c04\u7dda\u6cbb\u7642\u6cd5\uff0e\u6280\u8853\u9032\u6b69\u306b\u3088\u308a\u7cbe\u5bc6\u7167\u5c04\u304c\u53ef\u80fd\u3068\u306a\u308a\u63a1\u7528\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p><sup>#2 <\/sup>\u816b\u760d\u5897\u6b96\u9045\u5ef6\uff08Tumor Growth Delay\uff09: \u6cbb\u7642\u5f8c\u306e\u816b\u760d\u304c\u521d\u671f\u4f53\u7a4d\u306e3\u500d\u306b\u5230\u9054\u3059\u308b\u307e\u3067\u306e\u6642\u9593\uff0e\u653e\u5c04\u7dda\u6cbb\u7642\u52b9\u679c\u306e\u524d\u81e8\u5e8a\u8a55\u4fa1\u3067\u6a19\u6e96\u7684\u306b\u4f7f\u7528\u3055\u308c\u308b\u6307\u6a19.<\/p>\n\n\n\n<p><sup>#3 <\/sup>\u6e7f\u6027\u843d\u5c51\uff08Moist Desquamation\uff09: \u653e\u5c04\u7dda\u306b\u3088\u308b\u6025\u6027\u76ae\u819a\u53cd\u5fdc\u306e\u91cd\u5ea6\u306a\u75c7\u72b6\uff0e\u8868\u76ae\u306e\u5b8c\u5168\u5265\u96e2\u306b\u3088\u308a\u771f\u76ae\u304c\u9732\u51fa\u3057\uff0c\u6ef2\u51fa\u6db2\u3092\u4f34\u3046\u72b6\u614b\u3067\u6b63\u5e38\u7d44\u7e54\u8010\u5bb9\u6027\u306e\u6307\u6a19.<\/p>\n\n\n\n<p><sup>#4<\/sup> \u03b3-H2AX\u30d5\u30a9\u30fc\u30ab\u30b9: DNA\u4e8c\u91cd\u9396\u5207\u65ad\u304c\u751f\u3058\u305f\u969b\u306b\u5f62\u6210\u3055\u308c\u308b\u4fee\u5fa9\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u96c6\u7a4d\u70b9\uff0e\u653e\u5c04\u7dda\u306b\u3088\u308bDNA\u640d\u50b7\u306e\u5b9a\u91cf\u7684\u8a55\u4fa1\u306b\u7528\u3044\u3089\u308c\u308b\u91cd\u8981\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff0e<\/p>\n\n\n\n<p><sup>#5<\/sup>\u30d4\u30e2\u30cb\u30c0\u30be\u30fc\u30eb\u67d3\u8272: \u4f4e\u9178\u7d20\u74b0\u5883\u3067\u306e\u307f\u4ee3\u8b1d\u3055\u308c\u308b\u5316\u5408\u7269\u3092\u7528\u3044\u305f\u7d44\u7e54\u5316\u5b66\u67d3\u8272\u6cd5\uff0e\u816b\u760d\u5185\u306e\u4f4e\u9178\u7d20\u9818\u57df\u3092\u53ef\u8996\u5316\u3057, \u4f4e\u9178\u7d20\u5206\u753b\u306e\u5b9a\u91cf\u7684\u8a55\u4fa1\u306b\u4f7f\u7528\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n<p><sup>#6 <\/sup>TER\uff08Thermal Enhancement Ratio, \u71b1\u5897\u5f37\u6bd4\uff09: \u6e29\u71b1\u7642\u6cd5\u306a\u3057\u306e\u52b9\u679c\u7dda\u91cf\u3092\u6e29\u71b1\u7642\u6cd5\u4f75\u7528\u6642\u306e\u52b9\u679c\u7dda\u91cf\u3067\u5272\u3063\u305f\u5024\uff0e1\u3088\u308a\u5927\u304d\u3044\u307b\u3069\u6e29\u71b1\u7642\u6cd5\u306e\u4f75\u7528\u306b\u3088\u308b\u5897\u611f\u52b9\u679c\u304c\u9ad8\u3044.<\/p>\n\n\n\n<p><sup>#7 <\/sup>TGF\uff08Therapeutic Gain Factor, \u6cbb\u7642\u52b9\u679c\u6bd4\uff09: \u816b\u760d\u306eTER\u3092\u6b63\u5e38\u7d44\u7e54\u306eTER\u3067\u5272\u3063\u305f\u5024\uff0e1\u3088\u308a\u5927\u304d\u3044\u969b\u306b\u306f\u3001\u816b\u760d\u9078\u629e\u7684\u306a\u6cbb\u7642\u52b9\u679c\u3092\u793a\u3059\uff0e<\/p>\n\n\n\n<p><sup>#8<\/sup>\u518d\u7167\u5c04\uff08Re-irradiation\uff09: \u904e\u53bb\u306b\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u305f\u90e8\u4f4d\u306b\u5bfe\u3057\u3066\u518d\u5ea6\u884c\u3046\u653e\u5c04\u7dda\u6cbb\u7642\uff0e\u6b63\u5e38\u7d44\u7e54\u306e\u653e\u5c04\u7dda\u8a18\u61b6\u306b\u3088\u308a\u8010\u5bb9\u7dda\u91cf\u304c\u4f4e\u4e0b\u3059\u308b\u305f\u3081\uff0c\u614e\u91cd\u306a\u7dda\u91cf\u8a2d\u5b9a\u304c\u5fc5\u8981\uff0e<\/p>\n\n\n\n<p><sup>#9 <\/sup>MDD<sub>50<\/sub>\uff08Median Damaging Dose 50\uff09: 50%\u306e\u52d5\u7269\u306b\u7279\u5b9a\u30ec\u30d9\u30eb\u4ee5\u4e0a\u306e\u76ae\u819a\u969c\u5bb3\uff08\u672c\u7814\u7a76\u3067\u306f\u22652.5\u30b9\u30b3\u30a2\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u653e\u5c04\u7dda\u91cf\uff0e\u6b63\u5e38\u7d44\u7e54\u306e\u653e\u5c04\u7dda\u8010\u5bb9\u6027\u306e\u6307\u6a19\uff0e<\/p>\n\n\n\n<p><sup>#10<\/sup> TCD<sub>50<\/sub>\uff08Tumor Control Dose 50\uff09: 50%\u306e\u816b\u760d\u3067\u5b8c\u5168\u5236\u5fa1\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u653e\u5c04\u7dda\u91cf\uff0e\u816b\u760d\u306e\u653e\u5c04\u7dda\u611f\u53d7\u6027\u3092\u793a\u3059\u91cd\u8981\u306a\u6307\u6a19\uff0e<\/p>\n\n\n\n<p>\u5229\u76ca\u76f8\u53cd\u306b\u95a2\u3059\u308b\u958b\u793a\uff1a<br>\u3000\u8457\u8005\u306b\u5229\u76ca\u76f8\u53cd\u72b6\u614b\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff0e<\/p>\n\n\n\n<p>Mini-review:<br>Recent Preclinical Studies on the Combination of Radiation and Hyperthermia<\/p>\n\n\n\n<p>MAKOTO ITO*<\/p>\n\n\n\n<p>Department of Radiology, Aichi Medical University Hospital<\/p>\n\n\n\n<p>*Corresponding author: <a href=\"mailto:itou.makoto.292@mail.aichi-med-u.ac.jp\">itou.makoto.292\uff08\u30a2\u30c3\u30c8\u30de\u30fc\u30af\uff09mail.aichi-med-u.ac.jp<\/a><br>Key Words: Hyperthermia, hypofractionated radiation, proton therapy, combination, preclinical study<\/p>\n\n\n\n<p>Received: 6 October, 2025<\/p>\n\n\n\n<p>Accepted: 8 October, 2025<\/p>\n\n\n\n<p>Thermal Medicine2025.41(4)\u63b2\u8f09\u4e88\u5b9a<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n","protected":false},"excerpt":{"rendered":"<p>\u5b66\u8853\u7d39\u4ecb \u653e\u5c04\u7dda\u3068\u4f75\u7528\u3057\u305f\u6e29\u71b1\u7642\u6cd5\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u524d\u81e8\u5e8a\u7814\u7a76 \u4f0a\u85e4\u3000\u8aa0* \u611b\u77e5\u533b\u79d1\u5927\u5b66\u3000\u653e\u5c04\u7dda\u79d1 \u6e29\u71b1\u7642\u6cd5(Hyperthermia)\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u4f75\u7528\u306e\u6709\u7528\u6027\u306f\u53e4\u304f\u304b\u3089\u77e5\u3089\u308c\u305f\u3068\u3053\u308d\u3067\u3042\u308b1)\uff0e\u4e21\u8005\u306e\u4f75\u7528\u306f\u2460\u653e\u5c04\u7dda\u62b5\u6297\u6027 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-3229","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/3229","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=3229"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/3229\/revisions"}],"predecessor-version":[{"id":3230,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/3229\/revisions\/3230"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=3229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=3229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=3229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}