{"id":494,"date":"2021-06-22T20:02:00","date_gmt":"2021-06-22T11:02:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=494"},"modified":"2022-05-26T20:06:57","modified_gmt":"2022-05-26T11:06:57","slug":"%e3%81%8c%e3%82%93%e3%81%ae%e5%85%8d%e7%96%ab%e3%83%81%e3%82%a7%e3%83%83%e3%82%af%e3%83%9d%e3%82%a4%e3%83%b3%e3%83%88%e9%98%bb%e5%ae%b3%e5%8a%b9%e6%9e%9c%e3%82%92%e6%94%b9%e5%96%84%e3%81%99%e3%82%8b","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e3%81%8c%e3%82%93%e3%81%ae%e5%85%8d%e7%96%ab%e3%83%81%e3%82%a7%e3%83%83%e3%82%af%e3%83%9d%e3%82%a4%e3%83%b3%e3%83%88%e9%98%bb%e5%ae%b3%e5%8a%b9%e6%9e%9c%e3%82%92%e6%94%b9%e5%96%84%e3%81%99%e3%82%8b\/","title":{"rendered":"\u304c\u3093\u306e\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u52b9\u679c\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306e\u5149\u6e29\u71b1\u7642\u6cd5"},"content":{"rendered":"\n

\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.146\u3010\u5b66\u8853\u5831\u544a66\u3011<\/p>\n\n\n\n

\u6700\u8fd1\u306e\u8a71\u984c66<\/p>\n\n\n\n

\u304c\u3093\u306e\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u52b9\u679c\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306e\u5149\u6e29\u71b1\u7642\u6cd5<\/p>\n\n\n\n

\u5897\u6c38\u3000\u614e\u4e00\u90ce \uff08\u962a\u548c\u7b2c\u4e8c\u6cc9\u5317\u75c5\u9662\uff0c\u5927\u962a\u5e9c\u7acb\u5927\u5b66 \uff09 <\/p>\n\n\n\n

\u3000 CTLA-4\u3084PD1\/PDL1\u306a\u3069\u306e\u514d\u75ab\u300c\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u300d\u306b\u5bfe\u3059\u308b\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3092\u542b\u3080\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\uff08Immune checkpoint blockade, ICB\uff09\u306f\uff0c\u304c\u3093\u60a3\u8005\u306e\u81e8\u5e8a\u8ee2\u5e30\u3092\u5287\u7684\u306b\u6539\u5584\u3057\u305f\u304c\uff0c\u518d\u767a\u7387\u306e\u9ad8\u3044\u5e83\u7bc4\u56f2\u306b\u6e21\u308b\u56fa\u5f62\u816b\u760d\u306b\u5bfe\u3057\u3066\u306f\u5fc5\u305a\u3057\u3082\u826f\u597d\u306a\u594f\u52b9\u7387\u3092\u793a\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u306f\u8a00\u3048\u305a\uff0c\u3053\u306e\u70b9\u304cICB\u6cbb\u7642\u306e\u554f\u984c\u70b9\u3068\u3055\u308c\u3066\u3044\u308b1,2)<\/sup>\uff0e\u4ed6\u65b9\uff0c\u5149\u6e29\u71b1\u7642\u6cd5\uff08Photothermal therapy, PTT\uff09\u306f\uff0c\u6ce2\u9577\u304c\u4e00\u81f4\u3059\u308b\u30ec\u30fc\u30b6\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u305f\u5149\u5fdc\u7b54\u6027\u30ca\u30ce\u7c92\u5b50\u3092\u5229\u7528\u3059\u308b\u5c40\u6240\u7684\u306a\u71b1\u713c\u707c\u6cbb\u7642\u3067\u3042\u308a\uff0c\u591a\u304f\u306ein vitro<\/em>\u7814\u7a76\u304a\u3088\u3073\u524d\u81e8\u5e8ain vivo<\/em>\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\uff0c\u816b\u760d\u7d30\u80de\u306e\u7a2e\u985e\u306b\u5fdc\u3058\u3066\u3055\u307e\u3056\u307e\u306a\u71b1\u91cf\u9818\u57df\u306b\u304a\u3044\u3066\uff0cPTT\u306b\u3088\u3063\u3066\u767a\u751f\u3057\u305f\u71b1\u304c\u816b\u760d\u5168\u4f53\u306e\u7834\u58ca\u3092\u5f15\u304d\u8d77\u3053\u3059\u3068\u3055\u308c\u3066\u3044\u308b\uff0e\u3057\u304b\u3057\u306a\u304c\u3089\uff0cPTT\u306e\u307f\u306b\u3088\u308b\u5358\u72ec\u6cbb\u7642\u306f\uff0c\u4e0d\u5747\u4e00\u306a\u71b1\u5206\u5e03\u3068\u6700\u9069\u3067\u306f\u306a\u3044\u514d\u75ab\u5fdc\u7b54\u306e\u305f\u3081\u306b\uff0c\u816b\u760d\u3092\u5b8c\u5168\u306b\u306f\u6392\u9664\u3057\u5f97\u305a\uff0c\u5c40\u6240\u518d\u767a\u3084\u8ee2\u79fb\u3092\u5f15\u304d\u8d77\u3053\u3059\u5834\u5408\u3082\u3088\u304f\u3042\u308b3)<\/sup>\uff0e\u3059\u306a\u308f\u3061\uff0cICB\u6cbb\u7642\u306f\u304c\u3093\u306e\u514d\u75ab\u539f\u6027\u3092\u6539\u5584\u3059\u308b\u304c\uff0c\u5f37\u529b\u306a\u6297\u816b\u760d\u7d30\u80de\u6bd2\u6027\u3092\u5f15\u304d\u8d77\u3053\u305b\u306a\u3044\uff0e\u30ca\u30ce\u7c92\u5b50\u30d9\u30fc\u30b9\u306ePTT\u306f\uff0c\u6a19\u7684\u5316\u304a\u3088\u3073\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6bd2\u6027\u3092\u8a98\u767a\u3057\u5f97\u308b\u304c\uff0c\u9577\u671f\u7684\u306a\u514d\u75ab\u539f\u6027\u8a18\u61b6\u306b\u95a2\u3057\u3066\u306f\u6700\u9069\u3067\u306f\u306a\u3044\uff0e\u3057\u305f\u304c\u3063\u3066\uff0c\u3053\u306e\u4e8c\u3064\u306e\u6cbb\u7642\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u4e8b\u306b\u3088\u3063\u3066\uff0c\u88dc\u5b8c\u7684\u3067\u76f8\u4e57\u7684\u306a\u6297\u816b\u760d\u52b9\u679c\u3092\u63d0\u4f9b\u3057\u5f97\u3048\u308b\u6cbb\u7642\u6cd5\u304c\u671f\u5f85\u3067\u304d\u308b4)<\/sup>\uff0e<\/p>\n\n\n\n

\u3000\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u8ad6\u6587\u3067\u306f\uff0cPTT\u3067\u4f7f\u7528\u3055\u308c\u308b\u4e09\u3064\u306e\u30af\u30e9\u30b9\u306e\u30ca\u30ce\u7c92\u5b50\uff08\u91d1\u5c5e\u7121\u6a5f\u30ca\u30ce\u7c92\u5b50\uff0c\u70ad\u7d20\u30d9\u30fc\u30b9\u306e\u30ca\u30ce\u7c92\u5b50\uff0c\u6709\u6a5f\u67d3\u6599\uff09\u306e\u6709\u7528\u6027\u3092\u793a\u3057\uff0c\u524d\u81e8\u5e8a\u30e2\u30c7\u30eb\u3068\u3057\u3066\uff0cICB\u306e\u52b9\u679c\u3092\u5f37\u5316\u3059\u308b\u30ca\u30ce\u7c92\u5b50\u30d9\u30fc\u30b9\u306ePTT\u6cbb\u7642\u4f75\u7528\u306e\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u308b4,5)<\/sup>\uff0e\u306a\u304a\uff0cICB\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u30ca\u30ce\u7c92\u5b50\u30d9\u30fc\u30b9\u306ePTT\u6cbb\u7642\u3092\u6700\u9069\u5316\u3059\u308b\u969b\u306e\u91cd\u8981\u306a\u56e0\u5b50\u306f\uff0c\u9069\u5207\u306a\u71b1\u91cf\uff08\u30b5\u30fc\u30de\u30eb\u30a6\u30a3\u30f3\u30c9\u30a6\uff09\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\uff0e\u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b\u306f\uff0c\u816b\u760d\u7d30\u80de\u306e\u7a2e\u985e\u306b\u5fdc\u3058\u3066\uff0c\u7279\u5b9a\u306e\u30b5\u30fc\u30de\u30eb\u30a6\u30a3\u30f3\u30c9\u30a6\u306b\u304a\u3044\u3066\u6700\u3082\u52b9\u7387\u3088\u304f\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b6)<\/sup>\uff0e<\/p>\n\n\n\n

\u3000PTT\u6cbb\u7642\u306b\u3088\u3063\u3066\u640d\u50b7\u3092\u53d7\u3051\u6b7b\u306b\u304b\u3051\u3066\u3044\u308b\u7d30\u80de\u304b\u3089\u751f\u6210\u3055\u308c\u305f\u6297\u539f\u306f\u30ef\u30af\u30c1\u30f3\u3068\u3057\u3066\u3082\u6a5f\u80fd\u3057\uff0cICB\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\uff0c\u514d\u75ab\u5fdc\u7b54\u3092\u3055\u3089\u306b\u6d3b\u6027\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff0eICB\u3068\u7d44\u307f\u5408\u308f\u305b\u305fPTT\u306f\uff0c\u9577\u671f\u306b\u6e21\u308b\u514d\u75ab\u8a18\u61b6\u3092\u8a98\u5c0e\u3057\u3064\u3064\uff0c\u539f\u767a\u6027\u304a\u3088\u3073\u8ee2\u79fb\u6027\u816b\u760d\u3092\u52b9\u7387\u7684\u306b\u6839\u7d76\u3057\u5f97\u308b\u3068\u3044\u3046\u5f37\u529b\u306a\u6297\u816b\u760d\u7d30\u80de\u52b9\u679c\u3092\u60f9\u8d77\u3067\u304d\u308b\uff0e\u30ca\u30ce\u7c92\u5b50\u30d9\u30fc\u30b9\u306ePTT\u3068ICB\u514d\u75ab\u7642\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u624b\u6cd5\u306f\uff0c\u304c\u3093\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u4e92\u3044\u306e\u9650\u754c\u3092\u76f8\u4e57\u7684\u306b\u88dc\u5b8c\u3057\u3042\u3046\u3053\u3068\u306b\u3088\u3063\u3066\uff0c\u816b\u760d\u306e\u7e2e\u5c0f\u3068\u9577\u671f\u306e\u7121\u75c5\u751f\u5b58\u3092\u76ee\u6307\u3059\u6709\u529b\u306a\u304c\u3093\u6cbb\u7642\u6cd5\u306e\u4e00\u3064\u3068\u306a\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u308b4)<\/sup>\uff0e <\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

1)   Haslam A, et al<\/em>. Estimation of the percentage of US patients with cancer who are eligible for and respond to checkpoint inhibitor immunotherapy drugs. JAMA Netw Open, 2: e192535, 2019.<\/p>\n\n\n\n

2)   Hamid O, et al<\/em>. Five-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001. Ann Oncol, 30: 582-8, 2019.<\/p>\n\n\n\n

3)   Nam J, et al<\/em>. Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer. Nat Commun, 9: 1074, 2018.<\/p>\n\n\n\n

4)   Balakrishnan PB, et al.<\/em> Photothermal therapies to improve immune checkpoint blockade for cancer. Int J Hyperthermia, 37: 24-49, 2020.<\/p>\n\n\n\n

5)   Ledezma DK, et al<\/em>. Indocyanine green-nexturastat A-PLGA nanoparticles combine photothermal and epigenetic therapy for melanoma. Nanomaterials, 10: 161, 2020.<\/p>\n\n\n\n

6)   Sweeney EE, et al<\/em>. Photothermal therapy generates a thermal window of immunogenic cell death in neuroblastoma. Small, 14: 1800678, 2018.<\/p>\n","protected":false},"excerpt":{"rendered":"

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