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Yu F-X,&nbsp;<em>et al.<\/em>&nbsp;Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell 163: 811-28, 2015.<\/p>\n\n\n\n<p>2) Harvey K,&nbsp;<em>et al<\/em>. The Hippo pathway and human cancer. Nat Rev Cancer 13: 246-57, 2013.<\/p>\n\n\n\n<p>3) Nguyen C,&nbsp;<em>et al<\/em>. YAP\/TAZ signaling and resistance to cancer therapy. Trends in Cancer 5: 283-96, 2019.<\/p>\n\n\n\n<p>4) Luo M,&nbsp;<em>et al.<\/em>&nbsp;Heat stress activates YAP\/TAZ to induce the heat shock transcriptome.<\/p>\n\n\n\n<p>Nat Cell Biol. 22: 1447-59, 2020.<\/p>\n\n\n\n<p>5) Calses PC,&nbsp;<em>et al<\/em>. Hippo pathway in cancer: Aberrant regulation and therapeutic opportunities. Trends in Cancer 5: 297-307, 2019.<\/p>\n\n\n\n<p>\u8a9e\u53e5\u89e3\u8aac<\/p>\n\n\n\n<p>*Hippo\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\uff1a\u6700\u521d\u306f\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306eWarts\uff08Wts\uff09\u907a\u4f1d\u5b50\u306e\u6b20\u640d\u306b\u3088\u3063\u3066\u591a\u304f\u306e\u5668\u5b98\u3067\u7570\u5e38\u306a\u5897\u6b96\uff08abnormal outgrowth\uff09\u304c\u898b\u3089\u308c\u305f\u306e\u304c\u304d\u3063\u304b\u3051\u3067\u3042\u308b\uff0e\u305d\u306e\u5f8c\uff0cHippo\uff08Hpo\uff09\u306a\u3069\u306e\u3044\u304f\u3064\u304b\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3067\u3082\u540c\u3058\u3088\u3046\u306b\u7570\u5e38\u306a\u5897\u6b96\u304c\u898b\u3089\u308c\uff0c\u3053\u308c\u3089\u306e\u56e0\u5b50\u304c\u907a\u4f1d\u7684\u306b\u3082\u7269\u7406\u7684\u306b\u3082\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\uff0c\u65b0\u3057\u3044\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3068\u3057\u3066Hippo\u7d4c\u8def\u3068\u540d\u3065\u3051\u3089\u308c\u305f\uff0eHippo\u306e\u7531\u6765\u306f\uff0c\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u591a\u304f\u306e\u5668\u5b98\u304c\u7570\u5e38\u306a\u5927\u304d\u3055\u306b\u306a\u308a\uff0c\u305d\u308c\u304cHippopotamus\uff08\u30ab\u30d0\uff09\u306e\u5f62\u614b\u306b\u4f3c\u3066\u3044\u305f\u3053\u3068\u304b\u3089\u3068\u8a00\u308f\u308c\u3066\u3044\u308b\uff0eHippo\u7d4c\u8def\u306f\u30b3\u30f3\u30bf\u30af\u30c8\u30a4\u30f3\u30d2\u30d3\u30b7\u30e7\u30f3\u306b\u3082\u95a2\u4e0e\u3057\u3066\u304a\u308a\uff0c\u7d30\u80de\u540c\u58eb\u304c\u63a5\u7740\u3059\u308b\u3068\u63a5\u7740\u90e8\u4f4d\u306e\u7d30\u80de\u8cea\u5074\u306bYAP\/TAZ\u304c\u4fdd\u6301\u3055\u308c\u3066\u7d30\u80de\u5897\u6b96\u304c\u6291\u5236\u3055\u308c\u308b\uff0e\u307e\u305f\u7d30\u80de\u9aa8\u683c\u7cfb\u306b\u3088\u3063\u3066\u3082LATS1\/2\u6d3b\u6027\u304c\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>*NF2\/merlin\uff1aneurofibromin 2\uff0e\u816b\u760d\u6291\u5236\u56e0\u5b50\u3067\u3042\u308b\uff0e\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u3067\u306fmerlin\u3068\u547c\u3070\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>* MST1\/2\uff1amammalian Ste20-like kinase 1 and 2\uff0e\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306eHippo\uff08Hpo\uff09\u306e\u30aa\u30fc\u30bd\u30ed\u30fc\u30b0\uff0eLAST1\/2\u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\uff0e<\/p>\n\n\n\n<p>* LATS1\/2\uff1alarge tumor suppressor 1 and 2\uff0e\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306eWarts\uff08Wts\uff09\u306e\u30aa\u30fc\u30bd\u30ed\u30fc\u30b0\uff0eYAP\/TAZ \u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\u3053\u3068\u3067\u4e0d\u6d3b\u6027\u5316\u3059\u308b\uff0e<\/p>\n\n\n\n<p>* YAP\/TAZ\uff1aYAP\u306fyes-associated protein.TAZ\u306ftranscriptional co-activator with PDZ-binding motif. YAP\u3068TAZ\u306f\uff0c\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308bTEADs\u306e\u30b3\u30a2\u30af\u30c6\u30a3\u30d9\u30fc\u30bf\u30fc\u3068\u3057\u3066\u50cd\u304f\uff0e<\/p>\n\n\n\n<p>* TEADs\uff1aTEA domain transcription factors. \u8ee2\u5199\u56e0\u5b50\u30671\u301c4\u307e\u3067\u5b58\u5728\u3059\u308b\uff0e\u901a\u5e38\u306f\u4e0d\u6d3b\u6027\u3060\u304c\uff0c\u6d3b\u6027\u578b\uff08\u8131\u30ea\u30f3\u9178\u5316\u578b\uff09\u306eYAP\/TAZ\u304c\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u6d3b\u6027\u5316\u3057\uff0c\u7d30\u80de\u306e\u5897\u6b96\u3084\u751f\u5b58\u306a\u3069\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u3092\u8ee2\u5199\u3059\u308b\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.143\u3010\u5b66\u8853\u5831\u544a64\u3011 \u6700\u8fd1\u306e\u8a71\u984c64 Hippo\u7d4c\u8def\u3068\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2 \u5927\u585a\u5065\u4e09\uff08\u4e2d\u90e8\u5927\u5b66\uff09 \u3000Hippo\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def*\uff08\u4ee5\u4e0b\uff0cHippo\u7d4c\u8def\u3068\u7565\uff09\u306f\uff0c\u591a\u7d30\u80de\u751f\u7269\u306b\u304a\u3044\u3066 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-498","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/498","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=498"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/498\/revisions"}],"predecessor-version":[{"id":499,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/498\/revisions\/499"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=498"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=498"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}