{"id":506,"date":"2021-03-16T20:06:00","date_gmt":"2021-03-16T11:06:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=506"},"modified":"2022-05-26T20:09:34","modified_gmt":"2022-05-26T11:09:34","slug":"hsf1%e3%81%af%e7%b4%b0%e8%83%9e%e3%81%ae%e3%82%a8%e3%83%8d%e3%83%ab%e3%82%ae%e3%83%bc%e4%bb%a3%e8%ac%9d%e3%81%a8mtorc1%e3%81%ae%e6%b4%bb%e6%80%a7%e5%8c%96%e3%82%92%e5%88%b6%e5%be%a1%e3%81%99%e3%82%8b","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/hsf1%e3%81%af%e7%b4%b0%e8%83%9e%e3%81%ae%e3%82%a8%e3%83%8d%e3%83%ab%e3%82%ae%e3%83%bc%e4%bb%a3%e8%ac%9d%e3%81%a8mtorc1%e3%81%ae%e6%b4%bb%e6%80%a7%e5%8c%96%e3%82%92%e5%88%b6%e5%be%a1%e3%81%99%e3%82%8b\/","title":{"rendered":"HSF1\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3068mTORC1\u306e\u6d3b\u6027\u5316\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067T\u7d30\u80de\u6025\u6027\u767d\u8840\u75c5\u306e\u9032\u884c\u3092\u4fc3\u9032\u3059\u308b"},"content":{"rendered":"\n

\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.133\u3010\u5b66\u8853\u5831\u544a60\u3011<\/p>\n\n\n\n

\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c60<\/p>\n\n\n\n

HSF1\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3068mTORC1\u306e\u6d3b\u6027\u5316\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067T\u7d30\u80de\u6025\u6027\u767d\u8840\u75c5\u306e\u9032\u884c\u3092\u4fc3\u9032\u3059\u308b<\/p>\n\n\n\n

\u5927\u585a\u5065\u4e09\uff08\u4e2d\u90e8\u5927\u5b66\uff09<\/p>\n\n\n\n

\u3000HSF1\uff08heat shock transcription factor 1\uff09\u306f\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\uff08\u591a\u304f\u306eheat shock proteins\uff09\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u751f\u5b58\u56e0\u5b50\u306e\u8ee2\u5199\u3092\u4ea2\u9032\u3059\u308b\u3053\u3068\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u6052\u5e38\u6027\u7dad\u6301\u306b\u5bc4\u4e0e\u3057\uff0c\u3055\u307e\u3056\u307e\u306a\u816b\u760d\u7d30\u80de\u306e\u767a\u751f\u3084\u9032\u5c55\uff0c\u8ee2\u79fb\u306a\u3069\u3092\u4fc3\u9032\u3057\u3066\u3044\u308b1)<\/sup>\uff0e\u3068\u3053\u308d\u304c\u6700\u8fd1\uff0cHSF1\u304cPGC-1a*\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u751f\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\u8ee2\u5199\u56e0\u5b50\uff09\u306e\u8ee2\u5199\u3092\u4ea2\u9032\u3059\u308b\u3053\u3068\u3067\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u306b\u95a2\u308f\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b2)<\/sup>\uff0e\u3064\u307e\u308a\uff0cHSF1\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u6052\u5e38\u6027\u306e\u307f\u306a\u3089\u305a\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3082\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u7d30\u80de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u305f\uff0e<\/p>\n\n\n\n

\u30d2\u30c8T\u7d30\u80de\u6025\u6027\u767d\u8840\u75c5\uff08T cell acute lymphoblastic leukemia, T-ALL\uff09\u306e\u75c5\u56e0\u306e\u7279\u5fb4\u306e\u4e00\u3064\u304c\uff0cPI3K\u2192AKT\u2192mTORC1\u7d4c\u8def*\u306e\u5236\u5fa1\u4e0d\u80fd\u306a\u6d3b\u6027\u5316\u3067\u3042\u308b\uff0e\u3053\u306e\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306e\u4fc3\u9032\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u306e\u6291\u5236\uff0c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u6291\u5236\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3067\u7d30\u80de\u306e\u5897\u6b96\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\uff0ePTEN*\u306fPI3K\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3053\u306e\u7d4c\u8def\u3092\u6291\u5236\u3057\uff0c\u7d30\u80de\u306e\u5897\u6b96\u3092\u8ca0\u306b\u5236\u5fa1\u3057\u3066\u3044\u308b\uff0eT-ALL\u306e10\u301c20\uff05\u306fPTEN\u306e\u6b20\u5931\u3084\u5909\u7570\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\uff0e\u305d\u306e\u7d50\u679c\uff0cPI3K\u2192AKT\u2192mTORC1\u7d4c\u8def\u304c\u7570\u5e38\u306b\u6d3b\u6027\u5316\u3055\u308c\u3066\u816b\u760d\u7d30\u80de\u306e\u5897\u6b96\u304c\u4ea2\u9032\u3059\u308b3)<\/sup>\uff0e<\/p>\n\n\n\n

\u3000\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u306e\u306f\uff0cHSF1\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3068mTORC1\u306e\u6d3b\u6027\u5316\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067T-ALL\u306e\u9032\u884c\u3092\u4fc3\u9032\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u3067\u3042\u308b4)<\/sup>\uff0e\u5b9f\u9a13\u7cfb\u3068\u3057\u3066\u306f\uff0cPTEN\u6b20\u640d\u306b\u3088\u3063\u3066\u767a\u75c7\u3057\u305f\u30de\u30a6\u30b9T-ALL\u816b\u760d\u3068\uff0c\u30d2\u30c8T-ALL\u7d30\u80de\u682a\u3092\u7528\u3044\u3066\u89e3\u6790\u3057\u3066\u3044\u308b\uff0e\u307e\u305a\uff0c\u30de\u30a6\u30b9T-ALL\u816b\u760d\u306b\u304a\u3044\u3066\uff0cHSF1\u3092\u6b20\u5931\u3055\u305b\u308b\u3068\uff08\u3064\u307e\u308aPTEN\u3068HSF1\u306e\u30c0\u30d6\u30eb\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\uff09\u80f8\u817a\u3067\u306e\u816b\u760d\u91cd\u91cf\u304c\u6e1b\u5c11\u3057\uff0c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u5897\u52a0\u3057\uff0c\u751f\u5b58\u7387\u3082\u5411\u4e0a\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff0e\u305d\u306e\u816b\u760d\u3067\u306fMAPK\/ERK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u6291\u5236\u3055\u308c\u3066\u304a\u308a\uff0cmTORC1\u6d3b\u6027\u3068\u305d\u306e\u4e0b\u6d41\u306e\u56e0\u5b50\uff08p70S6K*\u30684E-BP*\uff09\u306e\u30ea\u30f3\u9178\u5316\u3082\u4f4e\u4e0b\u3057\u3066\u3044\u305f\uff0e\u30d2\u30c8T-ALL\u7d30\u80de\u682a\u3067\u3082HSF1\u306e\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u306b\u3088\u308amTORC1\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u6291\u5236\u3055\u308c\u3066\u3044\u305f\uff0e\u3055\u3089\u306b\u89e3\u6790\u3092\u9032\u3081\u308b\u3068\uff0c\u30d2\u30c8T-ALL\u7d30\u80de\u3067\u306fATP\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\uff0c\u591a\u304f\u306e\u30a2\u30df\u30ce\u9178\u6fc3\u5ea6\u3082\u6e1b\u5c11\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u80fd\u3082\u4f4e\u4e0b\uff0c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u306e\u6307\u6a19\u3067\u3042\u308b\u9178\u7d20\u6d88\u8cbb\u7387\u3082\u4f4e\u4e0b\u3057\u3066\u3044\u305f\uff0eHSF1\u304c\u6b20\u640d\u3059\u308b\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3067ATP\u30ec\u30d9\u30eb\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u306e\u30672, 5)<\/sup>\uff0cT-ALL\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306e\u3053\u3068\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u3068\u8457\u8005\u3089\u306f\u8ff0\u3079\u3066\u3044\u308b\uff0eATP\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\u3059\u308b\u3068mTORC1\u6d3b\u6027\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u308b\uff0e\u305d\u306e\u7d50\u679c\uff0c\u4e0b\u6d41\u306e\u56e0\u5b50\uff08p70S6K\u30684E-BP\uff09\u306e\u30ea\u30f3\u9178\u5316\u304c\u6e1b\u5c11\u3057\u3066\u7ffb\u8a33\uff08\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\uff09\u3082\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u306b\u306a\u308a\uff0c\u305d\u308c\u306b\u3088\u3063\u3066T-ALL\u816b\u760d\u306e\u5897\u6b96\u304c\u4e0d\u5229\u306b\u306a\u308b\uff0e\u3057\u305f\u304c\u3063\u3066\uff0c\u30bf\u30a4\u30c8\u30eb\u306b\u3082\u3042\u308b\u3088\u3046\u306b\uff0cHSF1\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3068mTORC1\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067T-ALL\u7d30\u80de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3057\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308b\uff0e<\/p>\n\n\n\n

\u6700\u8fd1\uff0cHSF1\u306fNAD+<\/sup>\u306e\u751f\u5408\u6210\u7d4c\u8def\u306e\u9175\u7d20\u3067\u3042\u308bNAMPT*\u306e\u8ee2\u5199\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u7d30\u80de\u5185NAD+<\/sup>\u6fc3\u5ea6\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b5)<\/sup>\uff0eNAD+<\/sup>\u306f\u89e3\u7cd6\u7cfb\u3084\u30af\u30a8\u30f3\u9178\u56de\u8def\u306e\u9178\u5316\u9084\u5143\u9175\u7d20\u306e\u88dc\u9175\u7d20\u3068\u3057\u3066\u7570\u5316\u4ee3\u8b1d\u3092\u4ea2\u9032\u3057\uff0cATP\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067\u7d30\u80de\u306e\u5897\u6b96\u306b\u5bc4\u4e0e\u3059\u308b\uff0e\u307e\u305f\uff0c\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3*\u3084PARP*\u306a\u3069\u306e\u9175\u7d20\u306fNAD+<\/sup>\u3092\u57fa\u8cea\u3068\u3057\u3066\u304a\u308a\uff0cNAD+<\/sup>\u306f\u3053\u308c\u3089\u306e\u9175\u7d20\u3092\u6d3b\u6027\u5316\u3059\u308b6)<\/sup>\uff0e\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u3084PARP\u306f\u3044\u305a\u308c\u3082\u7d30\u80de\u306e\u751f\u5b58\u306b\u6709\u5229\u306b\u306a\u308b\u3088\u3046\u306b\u50cd\u3044\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

\u4eca\u56de\u53d6\u308a\u4e0a\u3052\u305f\u8ad6\u6587\u306fHSF1\u306e\u65b0\u305f\u306a\u5074\u9762\u3092\u793a\u3057\u3066\u304a\u308a\uff0cHSF1\u3092\u6a19\u7684\u3068\u3057\u305f\u304c\u3093\u6cbb\u7642\u6cd5\u304c\u6709\u671b\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

  1. Alasady MJ, Mendillo ML. The multifaced role of HSF1 in tumorigenesis. In Mendillo et al. (eds), HSF1 and Molecular Chaperones in Biology and Cancer, Advances in Experimental Medicine and Biology 1243, Springer Nature Switzerland AG, pp. 69-85, 2020.<\/li>
  2. Ma X, et al. Celastrol protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1a transcriptional axis. Cell Metab, 22: 695-708, 2015.<\/li>
  3. Girardi T, et al. The genetics and molecular biology of T-ALL. Blood, 129: 1113-23, 2017.<\/li>
  4. Eroglu B, et al. HSF1-mediated control of cellular energy metabolism and mTORC1 activation drive T cell lymphoblastic leukemia progression. Mol Cancer Res, 18: 463-76, 2020.<\/li>
  5. Qiao A, et al. The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. J Cell Biol, 216: 723-41, 2017.<\/li>
  6. Rajman L, et al. Therapeutic potential of NAD-boosting molecules: The in vivo evidence. Cell Metab, 27: 529-47, 2018.<\/li><\/ol>\n\n\n\n

    \u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n

    *PGC-1a\uff08peroxisome proliferator-activated receptor g coactivator-1a\uff09\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3084\u30d1\u30fc\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u306e\u751f\u6210\u3092\u4fc3\u3059\u8ee2\u5199\u56e0\u5b50\uff0e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u304c\u5897\u5f37\u3059\u308b\u306e\u3067ATP\u306e\u5408\u6210\u304c\u4fc3\u9032\u3055\u308c\u3066\u7d30\u80de\u306e\u751f\u5b58\u3084\u5897\u6b96\u306b\u6709\u5229\u306b\u50cd\u304f\uff0e<\/p>\n\n\n\n

    *PI3K\u2192AKT\u2192mTORC1\u7d4c\u8def\uff1a\u30ea\u30f3\u9178\u5316\u306b\u3088\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u4e00\u3064\uff0e\u7d30\u80de\u5916\u304b\u3089\u306e\u4fe1\u53f7\u306b\u3088\u308a\u53d7\u5bb9\u4f53\u578b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\uff08RTK\uff09\u304c\u6d3b\u6027\u5316\u3059\u308b\u3068\uff0cPI3K\uff08phosphatidylinositol-3 kinase\uff09\u304c\u30ea\u30f3\u9178\u5316\u3055\u308c\u3066\u6d3b\u6027\u5316\u3057\uff0c\u3064\u3044\u3067PDK1\uff08phosphoinositide-dependent kinase 1\uff09\uff0cAKT\uff08protein kinase B\uff09\uff0c\u6b21\u306bmTORC1\uff08mammalian target of rapamycin complex 1\uff09\u304c\u30ea\u30f3\u9178\u5316\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\uff0e\u6d3b\u6027\u5316\u3055\u308c\u305fmTORC1\u306f\u4e0b\u6d41\u306ep70S6K\u30844E-BP\u3092\u3055\u3089\u306b\u30ea\u30f3\u9178\u5316\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u7ffb\u8a33\u3092\u4fc3\u9032\u3057\uff0c\u7d30\u80de\u5897\u6b96\u306b\u5bc4\u4e0e\u3059\u308b\uff0e<\/p>\n\n\n\n

    *PTEN\uff08phosphatase and tensin homolog\uff09\uff1aPI3K\u306e\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067PI3K\u2192AKT\u2192mTORC1\u7d4c\u8def\u3092\u6291\u5236\u3057\uff0c\u7d30\u80de\u5897\u6b96\u3092\u8ca0\u306b\u5236\u5fa1\u3057\u3066\u3044\u308b\uff0ePTEN\u306e\u5909\u7570\u3084\u6b20\u640d\u304c\u3053\u306e\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\uff0c\u7d30\u80de\u5897\u6b96\u304c\u7570\u5e38\u306b\u4ea2\u9032\u3059\u308b\uff0e\u3057\u305f\u304c\u3063\u3066\uff0cPTEN\u306f\u304c\u3093\u6291\u5236\u56e0\u5b50\u306e\u4e00\u3064\u3067\u3042\u308b\uff0e<\/p>\n\n\n\n

    *p70S6K\u30684E-BP\uff1ap70S6K \u306f40S\u30ea\u30dc\u30bd\u30fc\u30e0\u306e\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306e\u4e00\u3064\u3067\u3042\u308bS6\u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\u30ad\u30ca\u30fc\u30bc\uff0870 kDa\u306e\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3067\u3042\u308a\uff0cmTORC1\u306b\u3088\u3063\u3066\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u3068\u6d3b\u6027\u5316\u3057\u3066\u7ffb\u8a33\u3092\u4fc3\u9032\u3059\u308b\uff0e\u307e\u305f\uff0c4E-BP\u304cmTORC1\u306b\u3088\u3063\u3066\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u3068\u7ffb\u8a33\u958b\u59cb\u56e0\u5b50\uff08eIF-4E\uff09\u304b\u3089\u89e3\u96e2\u3057\u3066\u7ffb\u8a33\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n

    *NAMPT\uff08nicotinamide phosphoribosyl transferase\uff09\uff1aNAM\uff08nicotinamide\uff09\u304b\u3089NAD+<\/sup>\uff08nicotinamide adenine dinucleotide\uff09\u306e\u524d\u99c6\u4f53\u3067\u3042\u308bNMN\uff08nicotinamide mononucleotide\uff09\u3092\u5408\u6210\u3059\u308b\u9175\u7d20\u3067\uff0cNAD+<\/sup>\u6fc3\u5ea6\u3092\u5897\u52a0\u3055\u305b\u308b\uff0e<\/p>\n\n\n\n

    *\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\uff08sirtuin\uff09\uff1a\u9577\u5bff\u907a\u4f1d\u5b50\u306e\u7523\u7269\u3067\uff0e\u30d2\u30c8\u3067\u306fSIRT1\u304b\u3089SIRT7\u307e\u3067\u306e7\u3064\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b\uff0e\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306fNAD+<\/sup>\u3092\u57fa\u8cea\u3068\u3059\u308b\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u3067\u3042\u308a\uff0c\u30d2\u30b9\u30c8\u30f3\u3084\u3055\u307e\u3056\u307e\u306a\u8ee2\u5199\u56e0\u5b50\u306a\u3069\u306e\u30a2\u30bb\u30c1\u30eb\u57fa\u3092\u5916\u3059\u3053\u3068\u3067\uff0c\u30b9\u30c8\u30ec\u30b9\u6761\u4ef6\u4e0b\u3067\u3082\u7d30\u80de\u304c\u751f\u5b58\u3067\u304d\u308b\u3088\u3046\u306b\u6a5f\u80fd\u3057\u3066\uff0c\u8001\u5316\u9045\u5ef6\u3084\u5bff\u547d\u5ef6\u9577\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\uff0e\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306f\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3084\uff0c\u9069\u5ea6\u306a\u904b\u52d5\uff0c\u30e1\u30c8\u30db\u30eb\u30df\u30f3\uff0c\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff0c\u307e\u305fNAD+<\/sup>\u306e\u524d\u99c6\u4f53\u3067\u3042\u308bNMN\u306a\u3069\u306b\u3088\u3063\u3066\u3082\u6d3b\u6027\u5316\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n

    *PARP\uff08poly-ADP-ribose polymerase\uff09\uff1aNAD+<\/sup>\u3092\u57fa\u8cea\u3068\u3057\u3066\u6a19\u7684\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306bADP-\u30ea\u30dc\u30fc\u30b9\u3092\u4ed8\u52a0\u3057\u3066\u3044\u304f\u9175\u7d20\uff0ePARP\u306fDNA\u4fee\u5fa9\u3092\u306f\u3058\u3081\u3068\u3057\u3066\uff0c\u8ee2\u5199\uff0c\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\uff0c\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\uff0c\u7d30\u80de\u306e\u751f\u5b58\u3092\u52a9\u3051\u308b\u3088\u3046\u306b\u50cd\u3044\u3066\u3044\u308b\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.133\u3010\u5b66\u8853\u5831\u544a60\u3011 \u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c60 HSF1\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3068mTORC1\u306e\u6d3b\u6027\u5316\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067T\u7d30\u80de\u6025\u6027\u767d\u8840\u75c5\u306e\u9032\u884c\u3092\u4fc3\u9032\u3059\u308b \u5927\u585a\u5065\u4e09\uff08 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-506","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=506"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/506\/revisions"}],"predecessor-version":[{"id":507,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/506\/revisions\/507"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}