{"id":508,"date":"2021-03-15T20:07:00","date_gmt":"2021-03-15T11:07:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=508"},"modified":"2022-05-26T20:10:12","modified_gmt":"2022-05-26T11:10:12","slug":"%e6%b8%a9%e5%ba%a6%e6%84%9f%e5%8f%97%e6%80%a7%e3%83%aa%e3%83%9d%e3%82%bd%e3%83%bc%e3%83%a0%e5%8c%85%e5%9f%8b%e5%9e%8b%e3%83%89%e3%82%ad%e3%82%bd%e3%83%ab%e3%83%93%e3%82%b7%e3%83%b3%e3%81%af%e5%be%93","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e6%b8%a9%e5%ba%a6%e6%84%9f%e5%8f%97%e6%80%a7%e3%83%aa%e3%83%9d%e3%82%bd%e3%83%bc%e3%83%a0%e5%8c%85%e5%9f%8b%e5%9e%8b%e3%83%89%e3%82%ad%e3%82%bd%e3%83%ab%e3%83%93%e3%82%b7%e3%83%b3%e3%81%af%e5%be%93\/","title":{"rendered":"\u6e29\u5ea6\u611f\u53d7\u6027\u30ea\u30dd\u30bd\u30fc\u30e0\u5305\u57cb\u578b\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u306f\u5f93\u6765\u306e\u6295\u4e0e\u6cd5\u3088\u308a\u9ad8\u6fc3\u5ea6\u3067\u8180\u80f1\u306b\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u3092\u96c6\u7a4d\u3055\u305b\u308b-\u7b4b\u5c64\u6d78\u6f64\u8180\u80f1\u764c\u6cbb\u7642\u3078\u306e\u767a\u5c55"},"content":{"rendered":"\n

\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.131\u3010\u5b66\u8853\u5831\u544a59\u3011<\/p>\n\n\n\n

\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c59<\/p>\n\n\n\n

\u6e29\u5ea6\u611f\u53d7\u6027\u30ea\u30dd\u30bd\u30fc\u30e0\u5305\u57cb\u578b\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u306f\u5f93\u6765\u306e\u6295\u4e0e\u6cd5\u3088\u308a\u9ad8\u6fc3\u5ea6\u3067\u8180\u80f1\u306b\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u3092\u96c6\u7a4d\u3055\u305b\u308b-\u7b4b\u5c64\u6d78\u6f64\u8180\u80f1\u764c\u6cbb\u7642\u3078\u306e\u767a\u5c55<\/p>\n\n\n\n

\u6cb3\u5408\u3000\u61b2\u5eb7\uff08\u540d\u53e4\u5c4b\u5e02\u7acb\u5927\u5b66\u5927\u5b66\u533b\u5b66\u7814\u7a76\u79d1\u3000\u814e\u30fb\u6ccc\u5c3f\u5668\u79d1\u5b66\u5206\u91ce\uff09<\/p>\n\n\n\n

\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306e\u9818\u57df\u306b\u304a\u3044\u3066\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\u305f\u6cbb\u7642\u6cd5\u3082\u958b\u767a\u3055\u308c\u3066\u3044\u308b\uff0e\u4ee3\u8868\u7684\u306a\u3082\u306e\u306b\u91d1\u30ca\u30ce\u30ed\u30c3\u30c9\u3068\u8fd1\u8d64\u5916\u7dda\u7167\u5c04\u306b\u3088\u308bphotothermal therapy1)<\/sup>\u3084\uff0c\u30de\u30b0\u30cd\u30bf\u30a4\u30c8(Fe3<\/sub>O4<\/sub> )\u304b\u3089\u306a\u308b\u78c1\u6027\u30ca\u30ce\u7c92\u5b50\u304c\u4ea4\u6d41\u78c1\u5834\u306b\u3088\u308b\u30d2\u30b9\u30c6\u30ea\u30b7\u30b9\u640d\u5931\u3067\u767a\u71b1\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7528\u3044\u305f\u78c1\u5834\u8a98\u5c0e\u7d44\u7e54\u5185\u52a0\u6e29\u6cd5\u304c\u3042\u308b2) <\/sup>\uff0e\u307e\u305f\uff0c\u52a0\u6e29\u306b\u3088\u308a\u6297\u764c\u5264\u3092\u653e\u51fa\u3059\u308b\u30ea\u30dd\u30bd\u30fc\u30e0\u3092\u7528\u3044\u305fDrug delivery system (DDS)\u3082\u958b\u767a\u3055\u308c\u3066\u3044\u308b\uff0e\u3053\u306eDDS\u306e\u7814\u7a76\u306e\u4e2d\u3067, \u5c3f\u8def\u7cfb\u306e\u69cb\u9020\u304c\u30d2\u30c8\u306b\u985e\u4f3c\u3057\u3066\u3044\u308b\u5927\u578b\u52d5\u7269\u3067\u3042\u308b\u30d6\u30bf\u3092\u7528\u3044\u305f\u7b4b\u5c64\u6d78\u6f64\u6027\u8180\u80f1\u764c\u306b\u5bfe\u3059\u308b\u8180\u80f1\u6e29\u5b58\u6cbb\u7642\u306b\u7d50\u3073\u3064\u304f\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30ca\u30eb\u7814\u7a76\u306b\u3064\u3044\u3066\u8a73\u7d30\u3092\u5831\u544a\u3059\u308b3)<\/sup>\uff0e<\/p>\n\n\n\n

\u8180\u80f1\u764c\u306f\u5927\u304d\u304f\u5206\u3051\u3066\u65e9\u671f\u764c\u3067\u3042\u308b\u975e\u7b4b\u5c64\u6d78\u6f64\u6027\u8180\u80f1\u764c\uff08\u8868\u5728\u6027\u764c\uff09\u3068\u9032\u884c\u764c\u3067\u3042\u308b\u7b4b\u5c64\u6d78\u6f64\u6027\u8180\u80f1\u764c(muscle-invasive bladder cancer: MIBC)\u306b\u5206\u3051\u3089\u308c\u308b\uff0eMIBC\u306e\u6cbb\u7642\u306e\u539f\u5247\u306f\u8180\u80f1\u5168\u6458\u9664\u8853\uff0b\u5c3f\u8def\u5909\u66f4\u8853\u3067\u3042\u308b\u304c\uff0c\u3053\u308c\u306f\u60a3\u8005\u306eQOL\u3092\u4e0b\u3052\u308b\u3053\u3068\u306b\u306a\u308b\uff0e\u6297\u764c\u5264\u306e\u7d4c\u9759\u8108\u7684\u306a\u5168\u8eab\u6295\u4e0e\u306f\u526f\u4f5c\u7528\u3092\u6291\u3048\u308b\u305f\u3081\u8180\u80f1\u306b\u304a\u3051\u308b\u6297\u764c\u5264\u306e\u6fc3\u5ea6\u304c\u4f4e\u304f\u306a\u3089\u3056\u308b\u3092\u5f97\u305a\uff0c\u6cbb\u7642\u52b9\u679c\u306f\u6e80\u8db3\u306e\u3044\u304f\u3082\u306e\u3067\u306f\u306a\u3044\uff0e\u4eca\u307e\u3067\u3082\u30ea\u30dd\u30bd\u30fc\u30e0\u3092\u7528\u3044\u305f\u6297\u764c\u5264\u306eDDS\u306f\u5b58\u5728\u3057\u305f\u304c\uff0cEPR\u52b9\u679c\u306b\u3088\u308b\u6d88\u6975\u7684\u306a\u9001\u9054\u3067\u3042\u3063\u305f\uff0e\u307e\u305f\uff0c\u53e4\u5178\u7684\u306a\u6e29\u5ea6\u611f\u53d7\u6027\u30ea\u30dd\u30bd\u30fc\u30e0\u3082\u5b58\u5728\u3057\uff0c\u809d\u81d3\u764c\u306b\u5bfe\u3059\u308b\u81e8\u5e8a\u8a66\u9a13\u3082\u884c\u308f\u308c\u305f\u304c\uff0c\u6cbb\u7642\u52b9\u679c\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f4)<\/sup>\uff0e<\/p>\n\n\n\n

\u672c\u7814\u7a763)<\/sup>\u3067\u306f\u30ea\u30dd\u30bd\u30fc\u30e0\u3068\u3057\u3066phosphatidyldiglycerol-based thermosensitive liposomes (DPPG2<\/sub>-TSL)\u3092\u7528\u3044\u305f\uff0e\u3053\u308c\u306f\u8840\u6f3f\u4e2d\u3067\u308260\u5206\u9593\u306f\u5b89\u5b9a\u3057\u3066\u304a\u308a\uff0c40-42\u2103\u306e\u52a0\u6e29\u3067\u901f\u3084\u304b\u306b\u5185\u5305\u3059\u308b\u6297\u764c\u5264\u3092\u653e\u51fa\u3059\u308b\u6027\u8cea\u304c\u3042\u308b\uff0e\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\uff0eDPPG2<\/sub>-TSL\u3067\u6297\u764c\u5264\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3(DOX)\u3092\u5305\u57cb\u3057\u305fDPPG2<\/sub>-TSL-DOX\u3092\u30d6\u30bf\u306b\u9759\u8108\u6ce8\u5c04\u3092\u884c\u3046\uff0e\u8180\u80f1\u306fSynergo system\u3092\u7528\u3044\u3066\u52a0\u6e29\u3057\u305f\uff0e\u7d4c\u5c3f\u9053\u7684\u306b\u8180\u80f1\u5185\u306b\u30a2\u30d7\u30ea\u30b1\u30fc\u30bf\u30fc\u3092\u633f\u5165\u3057\uff0c915 MHz\u306e\u30e9\u30b8\u30aa\u6ce2\u3092\u7167\u5c04\u3057\u8180\u80f1\u5185\u9762\u304b\u3089\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u3092\u5b9f\u65bd\uff0c\u8180\u80f1\u5185\u309260-90\u5206\u959343\u2103\u3067\u7dad\u6301\u3059\u308b\uff0e\u8180\u80f1\u58c1\u306f\u52a0\u6e29\u3055\u308c\u308b\u305f\u3081\uff0c\u9759\u8108\u6ce8\u5c04\u306b\u3088\u3063\u3066\u5168\u8eab\u306b\u884c\u304d\u308f\u305f\u3063\u305fDPPG2<\/sub>-TSL-DOX\u304b\u3089\uff0c\u52a0\u6e29\u306b\u3088\u3063\u3066\u8180\u80f1\u58c1\u3067\u306e\u307fDOX\u304c\u653e\u51fa\u3055\u308c\u308b\uff0e\u7d50\u679c\u3068\u3057\u3066\u8180\u80f1\u58c1\u306b\u306f\u9ad8\u6fc3\u5ea6\u306eDOX\u304c\u96c6\u7a4d\u3059\u308b\u304c\uff0c\u4ed6\u81d3\u5668\u306b\u306fDOX\u306f\u96c6\u7a4d\u3057\u306a\u3044\u3068\u3044\u3046\u3082\u306e\u3067\u3042\u308b\uff0e\u65b9\u6cd5\u3068\u7d50\u679c\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\uff0e<\/p>\n\n\n\n

21\u5339\u306e\u30d6\u30bf\u3092\u7528\u3044\u3066\uff0c3\u5339\u305a\u3064\u4ee5\u4e0b\u306e7\u7fa4\u306b\u5206\u3051\u305f\uff0e<\/p>\n\n\n\n

  1. (\u9759\u6ce8)DPPG2<\/sub>-TSL-DOX (20 mg\/m2<\/sup>)+60\u5206\u52a0\u6e29\uff0c<\/li>
  2. (\u9759\u6ce8)DPPG2<\/sub>-TSL-DOX (20 mg\/m2<\/sup>)+90\u5206\u52a0\u6e29\uff0c<\/li>
  3. (\u9759\u6ce8)DPPG2<\/sub>-TSL-DOX (20 mg\/m2<\/sup>)(\u52a0\u6e29\u306a\u3057)\uff0c<\/li>
  4. (\u9759\u6ce8)DOX (20 mg\/m2<\/sup>) +60\u5206\u52a0\u6e29\uff0c<\/li>
  5. (\u9759\u6ce8)DPPG2<\/sub>-TSL-DOX (60 mg\/m2<\/sup>) +60\u5206\u52a0\u6e29\uff0c<\/li>
  6. (\u8180\u80f1\u5185\u6ce8\u5165)DOX (50 mg\/50ml)(\u52a0\u6e29\u306a\u3057)\uff0c<\/li>
  7. (\u8180\u80f1\u5185\u6ce8\u5165)DOX (50 mg\/50ml) +60\u5206\u52a0\u6e29\uff0e<\/li><\/ol>\n\n\n\n

    \u6cbb\u7642\u5f8c\u76f4\u3061\u306b\u81d3\u5668\u3092\u6458\u51fa\u3057\uff0c\u7d44\u7e54\u5185\u306eDOX\u6fc3\u5ea6\u306fHPLC\u3067\u6e2c\u5b9a\uff0e\u7d44\u7e54\u5185\u306e\u5206\u5e03\u306f\u86cd\u5149\u514d\u75ab\u67d3\u8272\u3067\u691c\u8a0e\u3057\u305f\uff0e\u8180\u80f1\u58c1\u5185\u306eDOX\u6fc3\u5ea6\u306f\uff0cDOX\u5358\u72ec\u2463\u3088\u308aDPPG2<\/sub>-TSL-DOX (20 mg\/m2<\/sup>)\u52a0\u6e29\u3042\u308a\u7fa4\u2460\u2461\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u305f\uff0e\u307e\u305f\uff0cDPPG2<\/sub>-TSL-DOX (60 mg\/m2<\/sup>)\uff0b\u52a0\u6e29\u3042\u308a\u7fa4\u2464\u306f\uff0cDPPG2<\/sub>-TSL-DOX(20 mg\/m2<\/sup>)\uff0b\u52a0\u6e29\u3042\u308a\u7fa4\u2460\u2461\u3088\u308a7\u500d\u9ad8\u3044\u6fc3\u5ea6\u3067\u3042\u3063\u305f\uff0e\u52a0\u6e29\u6642\u9593\u306b\u3088\u308b\u5dee\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff0e\u8180\u80f1\u58c1\u5185\u3067\u306f\u7c98\u819c\uff0c\u7b4b\u5c64\uff0c\u6f3f\u819c\u3068\u5747\u7b49\u306bDOX\u306f\u5206\u5e03\u3057\u3066\u3044\u305f\uff0e\u3069\u306e\u7fa4\u3067\u3082\u5fc3\u81d3\uff0c\u814e\u81d3\uff0c\u809d\u81d3\uff0c\u813e\u81d3\uff0c\u80ba\u3067\u306fDOX\u306e\u96c6\u7a4d\u306f\u5c11\u306a\u304b\u3063\u305f\uff0e\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089DPPG2<\/sub>-TSL-DOX\uff0b\u6e29\u71b1\u6cbb\u7642\u306f\uff0c\u5f93\u6765\u306eDOX\u5358\u72ec\u6295\u4e0e\u3088\u308a\u6297\u764c\u4f5c\u7528\u304c\u5927\u304d\u3044\u3068\u8003\u3048\u3089\u308c\u308b\uff0e\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\uff0cMIBC\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u691c\u8a0e\u3059\u308b\u4fa1\u5024\u304c\u3042\u308b\u3068\u601d\u308f\u308c\u308b\uff0e\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306e\u4e2d\u3067\uff0c\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\u305f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u81e8\u5e8a\u5fdc\u7528\u3055\u308c\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

    \u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

    1) De Matteis V, et al<\/em>. Engineered gold nanoshells killing tumor cells: New perspectives. Curr Pharm Des, 25: 1477-89, 2019.<\/p>\n\n\n\n

    2) Ito A, et al<\/em>. Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: A novel concept of \u201cheat-controlled necrosis\u201d with heat shock protein expression. Cancer Immunol Immunother, 55: 320-8, 2006.<\/p>\n\n\n\n

    3) van Valenberg F, et al.<\/em> Dppg2-based thermosensitive liposomes with encapsulated doxorubicin combined with hyperthermia lead to higher doxorubicin concentrations in the bladder compared to conventional application in pigs: A rationale for the treatment of muscle-invasive bladder cancer, Int J Nanomedicine, 16: 75-88, 2021.<\/p>\n\n\n\n

    4) Tak W, et al<\/em>. Phase III HEAT study adding lyso-thermosensitive liposomal doxorubicin to radiofrequency ablation in patients with unresectable hepatocellular carcinoma lesions. Clin Cancer Res, 24: 73-83, 2018.<\/p>\n","protected":false},"excerpt":{"rendered":"

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