{"id":510,"date":"2021-03-11T20:07:00","date_gmt":"2021-03-11T11:07:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=510"},"modified":"2022-05-26T20:10:32","modified_gmt":"2022-05-26T11:10:32","slug":"hsp90%e9%98%bb%e5%ae%b3%e5%89%a4%e3%81%8a%e3%82%88%e3%81%b3hspa12a%e3%81%ab%e3%82%88%e3%82%8b%e3%82%a8%e3%83%b3%e3%83%89%e3%83%88%e3%82%ad%e3%82%b7%e3%83%b3%e8%aa%98%e7%99%ba%e3%83%91%e3%82%a4","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/hsp90%e9%98%bb%e5%ae%b3%e5%89%a4%e3%81%8a%e3%82%88%e3%81%b3hspa12a%e3%81%ab%e3%82%88%e3%82%8b%e3%82%a8%e3%83%b3%e3%83%89%e3%83%88%e3%82%ad%e3%82%b7%e3%83%b3%e8%aa%98%e7%99%ba%e3%83%91%e3%82%a4\/","title":{"rendered":"HSP90\u963b\u5bb3\u5264\u304a\u3088\u3073HSPA12A\u306b\u3088\u308b\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u8a98\u767a\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u6291\u5236"},"content":{"rendered":"\n<p>\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.131\u3010\u5b66\u8853\u5831\u544a58\u3011<\/p>\n\n\n\n<p>\u6700\u8fd1\u306e\u8a71\u984c58<\/p>\n\n\n\n<p>&nbsp;\u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\uff09\uff0c\u670d\u90e8\u88d5\u4e00\uff08\u5317\u6d77\u9053\u533b\u7642\u5927\u5b66\uff09<\/p>\n\n\n\n<p>\u3000\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9(pyroptosis)*\u306f\u708e\u75c7\u306b\u95a2\u9023\u3057\u305f\u907a\u4f1d\u5b50\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6b7b(regulated cell death\uff0cRCD)\u306e\u4e00\u7a2e\u3067\u3042\u308b\uff0e\u3059\u3067\u306b\uff0c\u71b1\u4e2d\u75c7\u306a\u3069\u304c\u8981\u56e0\u3068\u306a\u308b\u71b1\u30b9\u30c8\u30ec\u30b9\u304c\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u767a\u3059\u308b\u3053\u3068\u306f\u30e9\u30c3\u30c8\u306e\u809d\u7d30\u80de<sup>\uff11\uff09<\/sup>\u3084\u30d2\u30c8\u81cd\u5e2f\u9759\u8108\u5185\u76ae\u7d30\u80de<sup>2<\/sup><sup>\uff09<\/sup>\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0e\u6700\u8fd1\uff0cHSP90\u963b\u5bb3\u5264<sup>3<\/sup><sup>\uff09<\/sup>\u304a\u3088\u3073\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8ceaHSPA12A<sup>4<\/sup><sup>\uff09<\/sup>*\u304c\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3059\u308b\u77e5\u898b\u304c\u5831\u544a\u3055\u308c\u305f\u306e\u3067\u7d39\u4ecb\u3059\u308b\uff0e<\/p>\n\n\n\n<p>Zhou\u3089<sup>3)<\/sup>\u306f\uff0c\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u3067\u3042\u308b\u83cc\u4f53\u69cb\u6210\u6210\u5206\u30ea\u30dd\u30dd\u30ea\u30b5\u30c3\u30ab\u30e9\u30a4\u30c9(LPS) *\u3042\u308b\u3044\u306f<em>Streptomyces hygroscopicus<\/em>\u306b\u7531\u6765\u3059\u308b\u6297\u751f\u7269\u8cea\u30cb\u30b2\u30ea\u30b7\u30f3*\u3067\u8a98\u767a\u3057\u305f\u30d2\u30c8\u6025\u6027\u5358\u7403\u6027\u767d\u8840\u75c5THP-1\u7d30\u80de\u306e\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u5bfe\u3057\u3066\uff0c155\u7a2e\u985e\u306e\u5316\u5b66\u7269\u8cea\u3092\u5bfe\u8c61\u306b\u6291\u5236\u7269\u8cea\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u305f\uff0e\u305d\u306e\u7d50\u679c\uff0cHSP90\u963b\u5bb3\u5264\u3067\u3042\u308b\u30b2\u30eb\u30c0\u30ca\u30de\u30a4\u30b7\u30f3\u306f\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3057\u305f\uff0e\u4ed6\u306eHSP90\u963b\u5bb3\u5264\u3067\u3042\u308b\u30e9\u30c7\u30a3\u30b7\u30b3\u30fc\u30eb*\uff0c17-DMAG*\uff0c\u304a\u3088\u307317-AAG*\u3082\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u304a\u3051\u308b\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0*\/\u30ab\u30b9\u30d1\u30fc\u30bc-\uff11\/GSDMD(\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D)\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306b\u5bfe\u3057\u3066\u963b\u5bb3\u7684\u306b\u50cd\u304f\u3053\u3068\u306b\u3088\u308a\uff0c\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3057\u305f\uff0eHSP90\u963b\u5bb3\u5264\u3067\u51e6\u7406\u3059\u308b\u3068\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u91cd\u8981\u56e0\u5b50\u3067\u3042\u308bNLRP3\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4e0d\u5b89\u5b9a\u3068\u306a\u308a\uff0c\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u306b\u3088\u308b\u5206\u89e3\u304c\u4fc3\u9032\u3055\u308c\u305f\uff0eHSP90\u306e\u963b\u5bb3\u306b\u3088\u3063\u3066HSP70\u306e\u767a\u73fe\u304c\u4e0a\u6607\u3059\u308b\u304c\uff0c\u3053\u308c\u3082HSP90\u963b\u5bb3\u5264\u306b\u3088\u308b\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u6291\u5236\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u306a\u3044\uff0e\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\uff0c\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u304c\u95a2\u4fc2\u3059\u308b\u708e\u75c7\u6027\u75be\u60a3\u306e\u6cbb\u7642\u306b\u304a\u3051\u308bHSP90\u963b\u5bb3\u306e\u6709\u7528\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>\u6557\u8840\u75c7\u306f\uff0c\u611f\u67d3\u75c7\u3078\u306e\u53cd\u5fdc\u304c\u5236\u5fa1\u4e0d\u80fd\u306b\u9665\u308b\u3053\u3068\u3067\u809d\uff0c\u814e\uff0c\u80ba\u306a\u3069\u4e3b\u8981\u306a\u81d3\u5668\u306b\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u751f\u547d\u3092\u8105\u304b\u3059\u81d3\u5668\u6a5f\u80fd\u969c\u5bb3\u304c\u751f\u3058\u308b\u81e8\u5e8a\u75c7\u5019\u7fa4\u3067\u3042\u308b\uff0e\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u6d3b\u6027\u5316\u306b\u5bfe\u3059\u308b\u30ab\u30b9\u30d1\u30fc\u30bc-4\/5\/11*\u306b\u3088\u308b\u7d30\u80de\u8ceaLPS\u30bb\u30f3\u30b7\u30f3\u30b0\u304c\u6557\u8840\u75c7\u9032\u884c\u306e\u4e3b\u8981\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u60f3\u5b9a\u3055\u308c\uff0c\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3068\u5185\u76ae\u7d30\u80de\u306b\u304a\u3051\u308b\u7814\u7a76\u304b\u3089\u306fLPS\u304c\u30a2\u30b7\u30ed\u30ad\u30b7\u30a2\u30b7\u30eb\u30d2\u30c9\u30ed\u30e9\u30fc\u30bc(AOAH) *\u3067\u4e0d\u6d3b\u5316\u3055\u308c\u3001\u305d\u306e\u3053\u3068\u304cLPS\u306b\u5bfe\u3059\u308b\u30ab\u30b9\u30d1\u30fc\u30bc-4\/5\/11\u306e\u8131\u611f\u4f5c\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0eLiu\u3089<sup>4)<\/sup>\u306f\uff0c\u809d\u7d30\u80de\u306b\u304a\u3044\u3066LPS\u304cHSP70\u30d5\u30a1\u30df\u30ea\u30fc\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea12A(HSPA12A)\u306e\u6838\u79fb\u884c\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u3068\uff0cHSPA12A\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8(KO)\u3057\u305f\u30de\u30a6\u30b9\u3067\u306fLPS\u8a98\u767a\u6025\u6027\u809d\u969c\u5bb3\u304c\u5897\u60aa\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\uff0e\u307e\u305f\uff0cLPS\u304c\u8a98\u5c0e\u3059\u308b\u30ab\u30b9\u30d1\u30fc\u30bc-11*\u306e\u6d3b\u6027\u5316\u3068\u3001\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D\u306e\u5207\u65ad\u306b\u3088\u308b\u819c\u5b54\u3092\u5f62\u6210\u3059\u308bGSDMD<sup>Nterm<\/sup>\uff08\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u6307\u6a19\uff09\u306e\u751f\u6210\u304c\u3001\u91ce\u751f\u30de\u30a6\u30b9\u3088\u308a\u3082HSPA12A-KO\u30de\u30a6\u30b9\u3067\u9855\u8457\u3067\u3042\u3063\u305f\uff0e\u521d\u4ee3\u809d\u7d30\u80de\u3092\u7528\u3044\u3066\u6a5f\u80fd\u306e\u55aa\u5931\u30fb\u7372\u5f97\u5b9f\u9a13\u3092\u3057\u305f\u3068\u3053\u308d\uff0cHSPA12A\u3092\u6b20\u640d\u3055\u305b\u308b\u3068\uff0c\u7d30\u80de\u8ceaLPS\u306e\u84c4\u7a4d\u3084\uff0c\u30ab\u30b9\u30d1\u30fc\u30bc-11\u6d3b\u6027\u5316\uff0cGSDMD<sup>Nterm<\/sup>\u751f\u6210\u304c\u4fc3\u9032\u3055\u308c\uff0cHSPA12A\u3092\u904e\u5270\u767a\u73fe\u3055\u305b\u308b\u3068\u305d\u308c\u3089\u306f\u963b\u5bb3\u3055\u308c\u305f\uff0e\u307e\u305f\uff0cLPS\u8a98\u767aAOAH\u767a\u73fe\u306fHSPA12A\u6b20\u640d\u3067\u6291\u5236\u3055\u308c\u305f\uff0e\u4e00\u65b9\uff0cAOAH\u904e\u5270\u767a\u73fe\u306fHSPA12A\u6b20\u640d\u306b\u3088\u308b\u809d\u7d30\u80de\u306e\u30ab\u30b9\u30d1\u30fc\u30bc-11\u304c\u4ecb\u5728\u3059\u308b\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u4fc3\u9032\u3092\u9006\u8ee2\u3055\u305b\u305f\uff0e\u3055\u3089\u306b\u5206\u5b50\u6a5f\u69cb\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\uff0cHSPA12A\u306fPGC-1\u03b1 (peroxisome proliferator-activated receptor \u03b3 coactivator-1\u03b1) *\u3068\u76f4\u63a5\u76f8\u4e92\u4f5c\u7528\u3057\u3066\uff0c\u305d\u306e\u6838\u79fb\u884c\u3092\u4fc3\u9032\u3057\uff0c\u305d\u308c\u306b\u3088\u3063\u3066\u7d30\u80de\u8ceaLPS\u3092\u4e0d\u6d3b\u6027\u5316\u3059\u308bAOAH\u767a\u73fe\u3092\u5897\u3084\u3057\uff0c\u6700\u7d42\u7684\u306b\u809d\u7d30\u80de\u306e\u30ab\u30b9\u30d1\u30fc\u30bc-11\u4ecb\u5728\u6027\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3057\u305f\uff0e\u3059\u306a\u308f\u3061\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\uff0cHSPA12A\u304cLPS\u8a98\u767a\u809d\u969c\u5bb3\u306b\u5bfe\u3059\u308b\u91cd\u8981\u56e0\u5b50\u3067\u3042\u308a\uff0cHSPA12A\u3092\u6a19\u7684\u3068\u3057\u3066\u6557\u8840\u75c7\u60a3\u8005\u306e\u809d\u81d3\u306e\u7ba1\u7406\u3059\u308b\u3053\u3068\u306f\u53ef\u80fd\u306a\u6226\u7565\u306b\u306a\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>\u751f\u7269\u304c\u7d30\u83cc\u611f\u67d3\u3084\u640d\u50b7\u3067\u7d44\u7e54\u50b7\u5bb3\u3092\u53d7\u3051\u308b\u3068\u708e\u75c7\u304c\u8d77\u3053\u308b\uff0e\u3053\u306e\u6642\uff0c\u611f\u67d3\u3084\u50b7\u5bb3\u3092\u53d7\u3051\u305f\u514d\u75ab\u62c5\u5f53\u7d30\u80de\u3067\u306f\uff0c\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306b\u3088\u3063\u3066\u30ab\u30b9\u30d1\u30fc\u30bc1\u304c\u6d3b\u6027\u5316\u3055\u308c\uff0c\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5206\u6ccc\u3084\u7d30\u80de\u6b7b\u304c\u8a98\u767a\u3055\u308c\u308b\uff0e\u95a2\u4fc2\u3059\u308b\u7d30\u80de\u6b7b\u3068\u3057\u3066\uff0c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3070\u304b\u308a\u3067\u306a\u304f\uff0c\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3082\u5f79\u5272\u3092\u679c\u305f\u3059\u3068\u8003\u3048\u3089\u308c\uff0c\u4eca\u5f8c\u3055\u3089\u306a\u308b\u7d30\u80de\u6b7b\u306e\u8a73\u7d30\u306a\u6a5f\u69cb\u89e3\u660e\u304c\u9032\u3080\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e\u5c1a\uff0c\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u304a\u3088\u3073\u708e\u75c7\u306b\u4fc2\u308b\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u306b\u95a2\u3057\u3066\u306fJorgensen \u3089\u306e\u7dcf\u8aac<sup>5, 6)<\/sup>\u304c\u3042\u308a\uff0c\u53c2\u8003\u306b\u3055\u308c\u305f\u3044\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p>1.&nbsp;Geng Y&nbsp;<em>et al<\/em>. Heatstroke induces liver injury via IL-1\u03b2 and HMGB1-induced pyroptosis. J Hepatol 63: 622-33, 2015.<\/p>\n\n\n\n<p>2. Pei Y&nbsp;<em>et al<\/em>. Pyroptosis of HUVECs can be induced by heat stroke. Biochem Biophys Res Commun 506: 626-31, 2018.<\/p>\n\n\n\n<p>3. Zhou Z&nbsp;<em>et al<\/em>. Heat shock protein 90 inhibitors suppress pyroptosis in THP-1 cells. Biochem J 477: 3923-34, 2020.<\/p>\n\n\n\n<p>4. Liu J&nbsp;<em>et al<\/em>. HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1\u03b1-dependent acyloxyacyl hydrolase expression. Cell Death Differ 27: 2651-67, 2020.<\/p>\n\n\n\n<p>5. Jorgensen&nbsp;<em>et al.<\/em>&nbsp;Pyroptotic cell death defends against intracellular pathogens. Immunol Rev 265: 130-42, 2015.<\/p>\n\n\n\n<p>6. Jorgensen&nbsp;<em>et al.<\/em>&nbsp;Programmed cell death as a defence against infection. Nat Rev Immunol 17:151-64, 2017.<\/p>\n\n\n\n<p>\u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n<p>\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9(pyroptosis)\uff1a\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u3082\u79f0\u3059\u308b\uff0e\u907a\u4f1d\u5b50\u5236\u5fa1\u3055\u308c\u308b\u7d30\u80de\u6b7b(regulated cell death, RCD)\u306f\u73fe\u5728\uff0c12\u7a2e\u985e\u306b\u5206\u985e\u3055\u308c\u3066\u304a\u308a\uff0c\u305d\u306e\u4e00\u69d8\u5f0f\u3067\u3042\u308b\uff0e\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306f\uff0c\u8d64\u75e2\u83cc\u611f\u67d3\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3067\u8a8d\u3081\u3089\u308c\u308b\u201c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u201d\u3068\u3057\u3066\u5831\u544a\u3055\u308c\u305f\uff0e\u4f46\u3057\uff0c\u7d30\u80de\u819c\u306e\u7834\u58ca\u3092\u4f34\u3046\u7d30\u80de\u6b7b\u3067\u3042\u3063\u305f\uff0e\u305d\u306e\u5f8c\uff0c\u30b5\u30eb\u30e2\u30cd\u30e9\u83cc\u306b\u3088\u308b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u7d30\u80de\u6b7b\u3067\u30ab\u30b9\u30d1\u30fc\u30bc-1\u306e\u95a2\u4e0e\u304c\u5831\u544a\u3055\u308c\uff0cCookson BT\u3068Brennan MA\u306b\u3088\u308a\uff0c2001 \u5e74\u306bpyroptosis\u3068\u547d\u540d\u3055\u308c\u305f\uff0e\u3053\u308c\u306f\u708e\u75c7\u8a98\u5c0e\u6027\u7d30\u80de\u6b7b\u3068\u3057\u3066\u77e5\u3089\u308c\uff0c\u514d\u75ab\u62c5\u5f53\u7d30\u80de(\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\uff0c\u6a39\u72b6\u7d30\u80de\uff0cT\u7d30\u80de\u306a\u3069)\u304c\u75c5\u539f\u5fae\u751f\u7269\u306a\u3069\u306b\u611f\u67d3\u3059\u308b\u3068\uff0c\u30ab\u30b9\u30d1\u30fc\u30bc-1\u304c\u6d3b\u6027\u5316\u3057\uff0c\u7d30\u80de\u8cea\u306e\u5909\u6027\u3092\u4f34\u3044\uff0c\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u306b\u985e\u4f3c\u3057\u305f\u5f62\u614b\u5b66\u7684\u7279\u5fb4(\u7d30\u80de\u819c\u306e\u5b54\u5f62\u6210\uff0c\u7d30\u80de\u306e\u81a8\u6f64\u3068\u7834\u88c2)\u3092\u793a\u3059\uff0e\u3053\u306e\u904e\u7a0b\u3067\u306f\uff0c\u30ab\u30b9\u30d1\u30fc\u30bc-1\u306e\u57fa\u8cea\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D\uff08GDDMD\uff09\u304c\u77e5\u3089\u308c\uff0c\u3053\u308c\u306f\u975e\u523a\u6fc0\u6642\u306b\u306f\uff0c\u7d30\u80de\u8cea\u5185\u3067\u4e0d\u6d3b\u6027\u578b\u524d\u99c6\u4f53\u3068\u3057\u3066\u5b58\u5728\u3059\u308b\u304c\uff0c\u611f\u67d3\u5f8c\uff0c\u30ab\u30b9\u30d1\u30fc\u30bc\u3067\u5207\u65ad\u3055\u308c\u308b\u3068\uff0c\u6d3b\u6027\u578b\u306eN\u672b\u7aef\u65ad\u7247\uff08GSDMD<sup>Nterm<\/sup>\uff09\u304c\u591a\u91cf\u4f53\u5316\u3057\uff0c\u7d30\u80de\u819c\u306b\u633f\u5165\uff0c\u201c\u5b54\u201d\u3092\u5f62\u6210\u3057\uff0c\u7d30\u80de\u819c\u3092\u7834\u58ca\u3059\u308b\uff0e<\/p>\n\n\n\n<p>HSPA12A\uff1a\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8ceaA (HSPA) \u30d5\u30a1\u30df\u30ea\u30fc\u3092\u69cb\u6210\u3059\u308b\u907a\u4f1d\u5b50\u306e\u4e00\u3064\uff0e\u67d3\u8272\u4f5310\uff51.26.12\u306b\u4f4d\u7f6e\u3059\u308b\uff0e<\/p>\n\n\n\n<p>\u30ea\u30dd\u30dd\u30ea\u30b5\u30c3\u30ab\u30e9\u30a4\u30c9 (LPS)\uff1a\u30b0\u30e9\u30e0\u9670\u6027\u83cc\u306e\u7d30\u80de\u58c1\u5916\u819c\u306e\u69cb\u6210\u6210\u5206\u3067\u3042\u308a\uff0c\u8102\u8cea\u53ca\u3073\u591a\u7cd6\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u7cd6\u8102\u8cea\u3067\u3042\u308b\uff0eLPS\u306f\u5185\u6bd2\u7d20\uff08\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\uff09\u3067\u3042\u308a\uff0c\u591a\u5f69\u306a\u751f\u7269\u6d3b\u6027\u3092\u767a\u73fe\u3059\u308b\uff0eLPS\u306e\u751f<\/p>\n\n\n\n<p>\u30cb\u30b2\u30ea\u30b7\u30f3 (nigericin)\uff1a<em>Streptomyces hygroscopicus<\/em>&nbsp;\u306b\u7531\u6765\u3059\u308b \u6297\u751f\u7269\u8cea\uff0eH+\uff0cK+ \u306e\u30a2\u30f3\u30c1\u30dd\u30fc\u30bf\u30fc\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b\uff0e\u30b0\u30e9\u30e0\u967d\u6027\u83cc\u306b\u5bfe\u3059\u308b\u6297\u751f\u7269\u8cea\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u3044\u305f\uff0e\u307e\u305f\uff0c\u771f\u6838\u751f\u7269\u306e\u7d30\u80de\u3067\u30b4\u30eb\u30b8\u4f53\u306e\u6a5f\u80fd\u3092\u963b\u5bb3\u3059\u308b\uff0e\u6297HIV\u6d3b\u6027\u3082\u793a\u3059\uff0e\u7406\u4f5c\u7528\u767a\u73fe\u306f\uff0c\u5bbf\u4e3b\u7d30\u80de\u306e\u7d30\u80de\u819c\u8868\u9762\u306b\u5b58\u5728\u3059\u308bToll\u69d8\u53d7\u5bb9\u4f534 (TLR4) \u3092\u4ecb\u3057\u3066\u884c\u308f\u308c\u308b\uff0e<\/p>\n\n\n\n<p>\u30e9\u30c7\u30a3\u30b7\u30b3\u30fc\u30eb (radicicol)\uff1a \u5225\u540d\u30e2\u30ce\u30eb\u30c7\u30f3(monorden)\uff0cHSP90\u963b\u5bb3\u5264\uff0e<\/p>\n\n\n\n<p>17-DMAG\uff1a 17-[2-(dimethylamino)ethyl]amino-17-desmethoxygeldanamycin\u306e\u7565\u3067HSP90\u963b\u5bb3\u5264\u306e\u4e00\u3064\uff0e<\/p>\n\n\n\n<p>17-AAG\uff1a\u5225\u540d\u306ftanepcimycin\uff0cHSP90\u963b\u5bb3\u5264\uff0e<\/p>\n\n\n\n<p>\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0(inflammasome)\uff1a\u75c5\u539f\u4f53\u6210\u5206\u3084\u5185\u56e0\u6027\u306e\u6210\u5206\u306b\u3088\u308a\u6d3b\u6027\u5316\u3055\u308c\u308b\uff0cNLR\uff08Nod-like receptor\uff09\uff0cASC(Apoptosis-associated speck-like protein containing caspase recruitment domain)\uff0c\u304a\u3088\u3073\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3088\u308a\u69cb\u6210\u3055\u308c\u308b\u7d30\u80de\u5185\u86cb\u767d\u8cea\u8907\u5408\u4f53\uff0e<\/p>\n\n\n\n<p>\u30a2\u30b7\u30ed\u30ad<strong>\u30b7<\/strong>\u30a2\u30b7\u30eb\u30d2\u30c9\u30ed\u30e9\u30fc\u30bc(acyloxyacyl hydrolase, AOAH)\uff1a\u9846\u7c92\u7403\u5185\u306b\u5b58\u5728\u3059\u308b\u30ea\u30d4\u30c9\uff21\u306e\u679d\u5225\u308c\u8102\u80aa\u9178\u5074\u9396(\u30a2\u30b7\u30ed\u30ad\u30b7\u30a2\u30b7\u30eb\u8102\u80aa\u9178)\u3092\u5206\u65ad\u3059\u308b\u9175\u7d20\uff0e<\/p>\n\n\n\n<p>\u30ab\u30b9\u30d1\u30fc\u30bc-11(caspase<strong>&#8211;<\/strong>11)\uff1a \u30ab\u30b9\u30d1\u30fc\u30bc-1\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066IL-1\u03b2\u3084IL-18\u306e\u6d3b\u6027\u5316\u306b\u95a2\u4e0e\u3059\u308b\u30ab\u30b9\u30d1\u30fc\u30bc\uff0e\u30ab\u30b9\u30d1\u30fc\u30bc-11\u306f\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3068\u76f8\u540c\u6027\u304c\u3042\u308b\u3053\u3068\u304b\u3089\uff0c\u708e\u75c7\u8a98\u5c0e\u6027\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u305f\u304c\uff0c\u69d8\u3005\u306a\u75c5\u539f\u6027\u30b0\u30e9\u30e0\u9670\u6027\u7d30\u83cc\u306b\u3088\u308b\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u6d3b\u6027\u5316\u306b\u30ab\u30b9\u30d1\u30fc\u30bc-11\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u6301\u3064\u3053\u3068\u304c\u5831\u544a\u3055\u308c\uff0c\u30ea\u30dd\u591a\u7cd6\u306e\u6bd2\u6027\u304c\uff0c\u4ee5\u524d\u306b\u8003\u3048\u3089\u308c\u3066\u3044\u305f\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3067\u306f\u306a\u304f\uff0c\u30ab\u30b9\u30d1\u30fc\u30bc-11\u306b\u4f9d\u5b58\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\uff0e\u3053\u308c\u306b\u3088\u308a\uff0c\u7d30\u83cc\u611f\u67d3\u306b\u5bfe\u3059\u308b\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u3067\u306e\u30ab\u30b9\u30d1\u30fc\u30bc-11\u306e\u708e\u75c7\u8a98\u5c0e\u6027\u306e\u5f79\u5272\u304c\u660e\u78ba\u306b\u306a\u3063\u305f\uff0e<\/p>\n\n\n\n<p>PGC-1\u03b1 (peroxisome proliferator-activated receptor coactivator-1\u03b1)\uff1a\u6804\u990a\u72b6\u614b\u306b\u5fdc\u7b54\u3057\u305f\u4ee3\u8b1d\u8abf\u7bc0\u306b\u95a2\u308f\u308b\u8ee2\u5199\u5236\u5fa1\u56e0\u5b50\u3067\uff0c\u304a\u3082\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3084\u30d1\u30fc\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u306e\u751f\u6210\u306b\u95a2\u308f\u308b\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.131\u3010\u5b66\u8853\u5831\u544a58\u3011 \u6700\u8fd1\u306e\u8a71\u984c58 &nbsp;\u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\uff09\uff0c\u670d\u90e8\u88d5\u4e00\uff08\u5317\u6d77\u9053\u533b\u7642\u5927\u5b66\uff09 \u3000\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9(pyroptosis)*\u306f\u708e\u75c7\u306b\u95a2\u9023\u3057\u305f\u907a\u4f1d\u5b50\u5236\u5fa1\u3055\u308c\u305f [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-510","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/510","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=510"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/510\/revisions"}],"predecessor-version":[{"id":511,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/510\/revisions\/511"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=510"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=510"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=510"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}