{"id":512,"date":"2021-02-04T20:08:00","date_gmt":"2021-02-04T11:08:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=512"},"modified":"2022-05-26T20:10:53","modified_gmt":"2022-05-26T11:10:53","slug":"%e6%b8%a9%e7%86%b1%e3%82%b9%e3%83%88%e3%83%ac%e3%82%b9%e3%81%ab%e3%82%88%e3%82%8b%e3%83%8d%e3%82%af%e3%83%ad%e3%83%88%e3%83%bc%e3%82%b7%e3%82%b9%e2%80%95%e6%b4%bb%e6%80%a7%e9%85%b8%e7%b4%a0%e3%81%ae","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e6%b8%a9%e7%86%b1%e3%82%b9%e3%83%88%e3%83%ac%e3%82%b9%e3%81%ab%e3%82%88%e3%82%8b%e3%83%8d%e3%82%af%e3%83%ad%e3%83%88%e3%83%bc%e3%82%b7%e3%82%b9%e2%80%95%e6%b4%bb%e6%80%a7%e9%85%b8%e7%b4%a0%e3%81%ae\/","title":{"rendered":"\u6e29\u71b1\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u2015\u6d3b\u6027\u9178\u7d20\u306e\u95a2\u4e0e\u3068\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u2015"},"content":{"rendered":"\n

\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.130<\/p>\n\n\n\n

\u6700\u8fd1\u306e\u8a71\u984c57\uff082021\u5e74\/2\/4\u914d\u4fe1\uff09<\/p>\n\n\n\n

\u6e29\u71b1\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u2015\u6d3b\u6027\u9178\u7d20\u306e\u95a2\u4e0e\u3068\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u2015<\/p>\n\n\n\n

\u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\uff09<\/p>\n\n\n\n

\u3000\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u30fb\u71b1\u30b9\u30c8\u30ec\u30b9\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u95a2\u9023\u3092\u5831\u544a\u3059\u308b\u8ad6\u6587\u306f\u591a\u3044\uff0e\u6700\u8fd1\uff0c\u65b0\u305f\u306a\u7d30\u80de\u6b7b\u306b\u95a2\u3059\u308b\u8ad6\u6587\u304c\u6570\u591a\u304f\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3082\u3042\u308a\uff0cThe Society of Toxicologic Pathology(STP)\u306eThe Nomenclature Committee on Cell Death\u306f\u5b9a\u671f\u7684\u306b\u7d30\u80de\u6b7b\u306e\u5b9a\u7fa9\u3092\u516c\u8868\u3057\u3066\u304a\u308a\uff0c2018\u5e74\u306b\u306f\u7d30\u80de\u6b7b\u309212\u7a2e\u985e*\u306b\u5206\u985e\u3057\u3066\u3044\u308b\uff11\uff09<\/sup>\uff0e<\/p>\n\n\n\n

\u3053\u3053\u3067\u306f\uff0c\u305d\u306e\u3046\u3061\u306e\u4e00\u3064\u65b0\u898f\u7d30\u80de\u6b7b\u3067\u3042\u308b\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u6e29\u71b1\u306b\u95a2\u3059\u308b2\u7de8\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3059\u308b\uff0e\u5c0f\u8178\u304c\u71b1\u4e2d\u75c7\u306e\u7f79\u60a3\u7387\u304a\u3088\u3073\u6b7b\u4ea1\u7387\u306e\u4e3b\u8981\u56e0\u5b50\u306b\u306a\u308b\u3053\u3068\u306f\u793a\u3055\u308c\u3066\u3044\u305f\u304c\uff0c\u305d\u306e\u6a5f\u5e8f\u306f\u4e0d\u660e\u3067\u3042\u3063\u305f\uff0e\u71b1\u4e2d\u75c7\u304c\u5c0f\u8178\u306e\u640d\u50b7\u3092\u4fc3\u9032\u3059\u308b\u6a5f\u5e8f\u89e3\u660e\u306e\u305f\u3081\u306b\u30e9\u30c3\u30c8\u5c0f\u8178\u7531\u6765IEC-6\u7d30\u80de\u3068C57BL\/6\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066in vitro<\/em> \u304a\u3088\u3073in vivo<\/em>\u306e\u5b9f\u9a13\u7cfb\u3067\u691c\u8a0e\u3057\u305f\uff0eIEC-6\u7d30\u80de\u306b\u306f39, 41, 43\u306845o<\/sup>C, 2 \u6642\u9593\u51e6\u7406\u3092\u884c\u3044\uff0c\u30de\u30a6\u30b9\u306f\u76f4\u8178\u6e29\u5ea642o<\/sup>C\u307e\u3067\u6052\u6e29\u7bb1\u3067\u4f53\u6e29\u3092\u4e0a\u3052\uff0c\u5c0f\u8178\u3092\u53d6\u308a\u51fa\u3057\u8abf\u3079\u305f\uff0e\u7d30\u80de\u6b7b\uff0c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\uff0c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u6307\u6a19\u3067\u3042\u308b\u30de\u30ed\u30f3\u30b8\u30a2\u30eb\u30c7\u30d2\u30c9\uff0cSOD\uff0c\u304a\u3088\u3073\u7d44\u7e54\u5b66\u7684\u5909\u5316\u3092\u5e38\u6cd5\u306b\u5f93\u3063\u3066\u8abf\u3079\u305f\uff0e\u307e\u305f\uff0c\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u95a2\u4fc2\u3059\u308bRIPK1 (receptor-interacting protein kinase 1), RIPK3 (receptor-interacting protein kinase 3), \u30ea\u30f3\u9178\u5316MLKL (mixed lineage kinase domain-like protein)\u306b\u3064\u3044\u3066\u306f\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u3067\u8abf\u3079\u305f\uff0e\u71b1\u51e6\u7406\u306fin vitro<\/em> \u304a\u3088\u3073in vivo<\/em>\u7cfb\u3068\u3082\u30db\u30e1\u30aa\u30b9\u30bf\u30b7\u30b9\u306e\u7834\u7dbb\uff0c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\uff0c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u640d\u50b7\u3092\u8a98\u767a\u3057\u305f\uff0eRIPK1\u963b\u5bb3\u5264\u3067\u3042\u308b\u30cd\u30af\u30ed\u30b9\u30bf\u30c1\u30f3-1 \u3042\u308b\u3044\u306f RIPK3\u306e\u5316\u5b66\u7684\u963b\u5bb3\u5264 GSK872\u3067\u51e6\u7406\u3059\u308b\u3068\u3059\u3079\u3066\u306e\u6307\u6a19\u3067\u6539\u5584\u52b9\u679c\u3092\u793a\u3057\u305f\uff0e\u307e\u305f\uff0c\u6297\u9178\u5316\u5264N-\u30a2\u30bb\u30c1\u30eb\u30b7\u30b9\u30c6\u30a4\u30f3(NAC)\u51e6\u7406\u306f\u71b1\u8a98\u767a RIPK1\/RIPK3-\u4f9d\u5b58\u6027\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u5f62\u6210\u3092\u6291\u5236\u3057\u305f\uff0e\u30de\u30a6\u30b9\u3092NAC\uff08100 mg\/kg,i.p.\uff09\u51e6\u7406\u3059\u308b\u3068\u71b1\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u3092\u4e0b\u3052\u305f\uff0e\u4ee5\u4e0a\u3088\u308a\uff0c\u6d3b\u6027\u9178\u7d20\u306e\u9664\u53bb\u306b\u3088\u308a\uff0c\u71b1\u30b9\u30c8\u30ec\u30b9\u8a98\u767a\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u9632\u3050\u3068\u5c0f\u8178\u640d\u50b7\u304c\u8efd\u6e1b\u3057\uff0c\u6b7b\u4ea1\u7387\u3082\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f2)<\/sup>\uff0e<\/p>\n\n\n\n

\u80ba\u306e\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3092\u5bfe\u8c61\u306b\u3057\u305f\u7814\u7a76\u3067\u306f\uff0c43o<\/sup>C\u306e\u71b1\u51e6\u7406\u306f\u6642\u9593\u4f9d\u5b58\u6027\u306b\u30ad\u30ca\u30fc\u30bc\u306e\u53d7\u5bb9\u4f53\u5171\u5f79\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bRIP3\u306e\u767a\u73fe\u3092\u5909\u3048\u305a\u306bRIP1\u304a\u3088\u3073MLKL\u306e\u767a\u73fe\u3092\u5897\u3084\u3057\u305f\uff0e\u514d\u75ab\u5171\u6c88\u5b9f\u9a13\u306b\u3088\u308aRIP1\u306f RIP3\u306b\u7d50\u5408\u3057\uff0c\u30cd\u30af\u30ed\u30bd\u30fc\u30e0\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\uff0e\u30cd\u30af\u30ed\u30b9\u30bf\u30c1\u30f3-1\u3067\u524d\u51e6\u7406\u3059\u308b\u3068\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3059\u308b\u3068\u3068\u3082\u306b\uff0c\u7d30\u80de\u6838\u304b\u3089\u306e\u7d30\u80de\u8cea\u3078\u306eHMGB1\uff08high mobility group box protein 1\uff09\u306e\u79fb\u884c\u3092\u963b\u5bb3\u3057\u305f\uff0e\u540c\u69d8\u306bPD98059\u306b\u3088\u308bERK\u963b\u5bb3, BAY11-7082\u306b\u3088\u308bNF-\u03baB\u963b\u5bb3\uff0c\u304a\u3088\u3073 c-Jun peptide \u306b\u3088\u308bc-Jun\u306e\u963b\u5bb3\u306fHMGB1\u306e\u79fb\u884c\u3092\u963b\u5bb3\u3057\u305f\uff0esiRNA\u306b\u3088\u308b RIP1\/RIP3 \u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u5b9f\u9a13\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u71b1\u51e6\u7406\u306b\u3088\u308b\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u904e\u7a0b\u3092\u963b\u5bb3\u3059\u308b\u3068\u3068\u3082\u306bERK\u304a\u3088\u3073 c-Jun \u306e\u30ea\u30f3\u9178\u5316\u3092\u6291\u5236\u3057\u305f\uff0e\u4ee5\u4e0a\u3088\u308a\uff0c\u71b1\u30b9\u30c8\u30ec\u30b9\u306f\u80ba\u306e\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u304a\u3044\u3066MAPK, NF-\u03baB, \u304a\u3088\u3073 c-Jun\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u4ecb\u3057\u3066RIP1\/RIP3\u4f9d\u5b58\u6027\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u767a\u3059\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\uff0e<\/p>\n\n\n\n

\u304c\u3093\u6cbb\u7642\u306b\u95a2\u3059\u308b\u7814\u7a76\u3067\u306f\u30e1\u30e9\u30ce\u30fc\u30de\u306e\u91d1\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\u305f\u5149\u6e29\u71b1\u6cbb\u7642\u306b\u304a\u3044\u3066\u3082\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u95a2\u4e0e\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b4<\/sup>\uff09<\/sup>\uff0e\u307e\u305f\uff0c\u304c\u3093\u6cbb\u7642\u306b\u304a\u3044\u3066\u3082\u975e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u6a19\u7684\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u308b5<\/sup>\uff09<\/sup>\uff0e\u307e\u3060\uff0c\u71b1\u306b\u3088\u308b\u7d30\u80de\u6b7b\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u306a\u3044\u69d8\u5f0f\u3082\u3042\u308a\uff0c\u4eca\u5f8c\u306e\u6e29\u71b1\u8a98\u5c0e\u7d30\u80de\u6b7b\u306e\u7814\u7a76\u304c\u767a\u5c55\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n\n\n\n

1) Galluzzi L, et al<\/em>. Molecular mechanisms of cell death: recommendations of the Nomenclature \u3000Committee on Cell Death 2018. Cell Death Differ, 25: 486\u2013541, 2018.<\/p>\n\n\n\n

2) Li L, et al. Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury. Int J Hyperthermia, 37: 517-30,<\/strong><\/p>\n\n\n\n

3) Wei H,et al<\/em>. Heat stress induces RIP1\/RIP3-dependent necroptosis through the MAPK, NF-\u03baB, and c-Jun signaling pathways in pulmonary vascular endothelial cells. Biochem Biophys Res Commun, 528: 206-12, 2020.<\/p>\n\n\n\n

4) Zhang Y, et al<\/em>. Temperature-dependent cell death patterns induced by functionalized gold nanoparticle photothermal therapy in melanoma cells. Sci Rep, 8: 8720, 2018.<\/p>\n\n\n\n

5) Sepand MR, et al<\/em>. Targeting non-apoptotic cell death in cancer treatment by nanomaterials: Recent advances and future outlook. 29:102243,\u30002020.<\/p>\n\n\n\n

\u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n

*12\u7a2e\u985e\u306e\u7d30\u80de\u6b7b<\/p>\n\n\n\n

  1. Intrinsic apoptosis (\u5185\u56e0\u6027\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9)\uff1a\u7d30\u80de\u5185\u5916\u306e\u5fae\u5c0f\u74b0\u5883\u306e\u4e71\u308c\u306b\u3088\u308a\u59cb\u52d5\u3055\u308c\uff0c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5916\u819c\u900f\u904e\u6027\u3067\u753b\u5b9a\u3055\u308c\u308bRCD(Regulated cell death:\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6b7b\uff09\u306e\u69d8\u5f0f\uff0e\u5b9f\u884c\u56e0\u5b50\u306f\u30ab\u30b9\u30d1\u30fc\u30bc<\/li>
  2. Extrinsic apoptosis\uff08\u5916\u56e0\u6027\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff09\uff1a\u7d30\u80de\u819c\u53d7\u5bb9\u4f53\u3067\u691c\u51fa\u3055\u308c\u308b\u7d30\u80de\u5916\u306e\u5fae\u5c0f\u74b0\u5883\u306e\u4e71\u308c\u306b\u3088\u308a\u59cb\u52d5\u3055\u308c\uff0c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5916\u819c\u900f\u904e\u6027\u3067\u753b\u5b9a\u3055\u308c\u308bRCD\u306e\u69d8\u5f0f\uff0e\u30ab\u30b9\u30d1\u30fc\u30bc8\u304c\u4fc3\u9032\u56e0\u5b50\u3067\uff0c\u4e3b\u305f\u308b\u5b9f\u884c\u56e0\u5b50\u306f\u30ab\u30b9\u30d1\u30fc\u30bc3\uff0e<\/li>
  3. Mitochondrial permeability transition (MPT)-driven necrosis (\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u900f\u904e\u6027\u79fb\u884c\u99c6\u52d5\u30cd\u30af\u30ed\u30fc\u30b7\u30b9)\uff1a\u7d30\u80de\u5185\u5fae\u5c0f\u74b0\u5883\u306e\u4e71\u308c\u306b\u3088\u308a\u59cb\u52d5\u3055\u308c\u308bRCD\u306e\u7279\u7570\u578b\uff0e\u30b7\u30af\u30ed\u30d5\u30a3\u30ea\u30f3D<\/strong>\u4f9d\u5b58\u7684\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u900f\u904e\u6027\u306e\u4ea2\u9032\u306b\u3088\u308b\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\uff0e<\/li>
  4. Necroptosis (\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9)\uff1aMLKL (Mixed lineage kinase domain-like),RIPK1(Receptor-interacting kinase\uff11)\u304a\u3088\u3073 RIPK3 (Receptor-interacting kinase 3)\u306b\u4f9d\u5b58\u3057\u305f\u7d30\u80de\u5185\u5916\u306e\u30db\u30e1\u30aa\u30b9\u30bf\u30b7\u30b9\u306e\u5909\u52d5\u306b\u3088\u308a\u59cb\u52d5\u3055\u308c\u308bRCD\u306e\u4e00\u69d8\u5f0f\uff0e\u7d30\u80de\u306e\u81a8\u5f35\u304b\u3089\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306a\u3069\u306e\u7d30\u80de\u5c0f\u5668\u5b98\u306e\u5d29\u58ca\u3084\u6838\u878d\u89e3\u3092\u7d4c\u3066\u7d30\u80de\u819c\u306e\u5d29\u58ca\u3078\u3068\u81f3\u308b\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u3068\u540c\u69d8\u306e\u5909\u5316\u3092\u793a\u3059\u907a\u4f1d\u7684\u306b\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6b7b\uff0e\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u521d\u671f\u6bb5\u968e\u306b\u3042\u308b\u7d30\u80de\u306f\uff0cRIP3\u306e\u30ea\u30f3\u9178\u5316\u3068\uff0c\u4e00\u822c\u7684\u306b\u306f\u30cd\u30af\u30ed\u30bd\u30fc\u30e0\uff08necrosome\uff09\u3068\u3057\u3066\u77e5\u3089\u308c\u308bRIP1\u3068\u03b2\u30a2\u30df\u30ed\u30a4\u30c9\u69d8\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u03b2-amyloid-like protein\uff09\u8907\u5408\u4f53\u306e\u5f62\u6210\u306b\u3088\u3063\u3066\u7279\u5fb4\u3065\u3051\u3089\u308c\u308b\uff0e\u30cd\u30af\u30ed\u30b9\u30bf\u30c1\u30f31\u306f\u9078\u629e\u7684\u963b\u5bb3\u5264\uff0e<\/li>
  5. Ferroptosis (\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9)\uff1a\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc4\u306b\u3088\u308a\u69cb\u6210\u7684\u306b\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u5185\u5fae\u5c0f\u74b0\u5883\u306e\u9178\u5316\u7684\u969c\u5bb3\u306b\u3088\u308b\u59cb\u52d5\u3055\u308c\u308bRCD\u306e\u4e00\u69d8\u5f0f\uff0e\u9244\u30a4\u30aa\u30f3\u30ad\u30ec\u30fc\u30bf\u3084\u8102\u8cea\u6297\u9178\u5316\u5264\u3067\u963b\u5bb3\u3055\u308c\u308b\uff0e\u30d5\u30a7\u30ed\u30b9\u30bf\u30c1\u30f31\u304c\u963b\u5bb3\u5264\uff0e<\/li>
  6. Pyroptosis (\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9)\uff1a\u30ac\u30b9\u30c0\u30fc\u30df\u30f3\uff08\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u306b\u3088\u308b\u7d30\u80de\u819c\u306e\u201d\u5b54\u201d\u5f62\u6210\u306b\u4f9d\u5b58\u3057\u305fRCD\u306e\u4e00\u69d8\u5f0f\uff0e\u591a\u304f\u306f\u708e\u75c7\u306b\u4f34\u3046\u30ab\u30b9\u30d1\u30fc\u30bc\u985e\u306e\u6d3b\u6027\u5316\u306e\u7d50\u679c\u3068\u3057\u3066\u8d77\u304d\u308b\uff0e\u3053\u308c\u306f\uff0c1992\u5e74\u306bZychlinsky\u3089\u306b\u3088\u3063\u3066\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3068\u3057\u3066\u6700\u521d\u306b\u8a18\u8f09\u3055\u308c\u305fRCD<\/a>\u306e\u4e00\u7a2e\u3067\u3042\u308a\uff0c\u708e\u75c7\u8a98\u5c0e\u6027\u306e\u7d30\u80de\u6b7b\u3067\u3042\u308b\u3053\u3068\u304b\u3089\uff0c2001\u5e74\u306bCookson\u3068Brennan\u306b\u3088\u3063\u3066\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u547d\u540d\u3055\u308c\u305f\uff0e\u81ea\u7136\u514d\u75ab\u7cfb\u306b\u304a\u3051\u308b\u7d30\u80de\u5185\u5916\u306e\u6052\u5e38\u6027\u306e\u4e71\u308c\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\uff0e<\/li>
  7. Parthanatos (\u30d1\u30fc\u30bf\u30ca\u30c8\u30b9)\uff1aPARP-1\uff08\u30dd\u30eaADP\u30ea\u30dc\u30fc\u30b9\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc-1\uff09\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u3067\u958b\u59cb\u3055\u308cAIF(\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u8a98\u5c0e\u56e0\u5b50)\u4f9d\u5b58\u6027\u304a\u3088\u3073MIF(\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u904a\u8d70\u963b\u6b62\u56e0\u5b50)\u4f9d\u5b58\u6027DNA\u5206\u89e3\u306b\u95a2\u4fc2\u3057\u305f\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u7834\u7dbb\u306b\u3088\u308a\u4fc3\u9032\u3055\u308c\u308bRCD\u306e\u4e00\u69d8\u5f0f\uff0e<\/li>
  8. Entotic cell death (\u30a8\u30f3\u30c8\u30fc\u30b7\u30b9\u69d8\u7d30\u80de\u6b7b)\uff1a\u30a2\u30af\u30c8\u30df\u30aa\u30b7\u30f3\u4f9d\u5b58\u7684\u306a\u7d30\u80de-\u7d30\u80de\u5185\u5305\u3092\u8d77\u6e90\u3068\u3057\u3066\u30ea\u30bd\u30bd\u30fc\u30e0\u3067\u5b9f\u884c\u3055\u308c\u308bRCD\u306e\u4e00\u69d8\u5f0f\uff0e2007\u5e74\u306bOverholtzer\u3089\u306b\u3088\u3063\u3066\u547d\u540d\u3055\u308c\u305f\u7d30\u80de\u6b7b\u3067\u30ab\u30b9\u30d1\u30fc\u30bc\u306f\u5fc5\u8981\u306a\u304f\uff0c\u7d30\u80de\u306f\u96a3\u63a5\u3059\u308b\u7d30\u80de\u306b\u8caa\u98df\u3055\u308c\u308b\u3053\u3068\u306b\u3088\u308a\u6b7b\u306c\uff0e<\/li>
  9. NETotic cell death (\u30cd\u30c8\u30fc\u30b7\u30b9\u69d8\u7d30\u80de\u6b7b\uff09\uff1aNET (Neutrophil extracellular traps\uff0c\u597d\u4e2d\u7403\u7d30\u80de\u5916\u30c8\u30e9\u30c3\u30d7)\u5f62\u6210\u306b\u95a2\u4fc2\u3057\u305f\u9020\u8840\u7d30\u80de\u8a98\u5c0e\u306b\u9650\u5b9a\u3055\u308c\u305f\u6d3b\u6027\u9178\u7d20\u4f9d\u5b58\u6027RCD\u306e\u4e00\u69d8\u5f0f\uff0e\u597d\u4e2d\u7403\u304c\u4e3b\u3067\u3042\u308b\u304c\uff0c\u597d\u5869\u57fa\u7403\uff0c\u597d\u9178\u7403\u3067\u3082\u8a8d\u3081\u3089\u308c\u308b\uff0e<\/li>
  10. Lysosome-dependent cell death (\u30ea\u30bd\u30bd\u30fc\u30e0\u4f9d\u5b58\u6027\u7d30\u80de\u6b7b)\uff1a\u30ab\u30c6\u30d7\u30b7\u30f3\u3067\u4fc3\u9032\u3055\u308c\uff0c\u521d\u671f\u306e\u30ea\u30bd\u30bd\u30fc\u30e0\u819c\u900f\u904e\u6027\u3067\u753b\u5b9a\u3055\u308c\u308bRCD\u306e\u4e00\u69d8\u5f0f\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5916\u819c\u900f\u904e\u6027\u304a\u3088\u3073\u30ab\u30b9\u30d1\u30fc\u30bc\u985e\u304c\u95a2\u4fc2\u3059\u308b\u5834\u5408\u304c\u3042\u308b\uff0e<\/li>
  11. ADCD:autophagy-dependent cell death (\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u4f9d\u5b58\u6027\u7d30\u80de\u6b7b)\uff1a\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u4f9d\u5b58\u3057\u305fRCD\u306e\u4e00\u69d8\u5f0f\uff0e<\/li>
  12. Immunogenic cell death (ICD, \u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b)\uff1a\u514d\u75ab\u5fdc\u7b54\u6027\u5bbf\u4e3b\u306b\u304a\u3051\u308b\u7372\u5f97\u514d\u75ab\u5fdc\u7b54\u3092\u6d3b\u6027\u5316\u3059\u308b\u306b\u5341\u5206\u306aRCD\u306e\u4e00\u69d8\u5f0f\uff0e\u304c\u3093\u7d30\u80de\u304c\u653e\u5c04\u7dda\u3084\u6297\u304c\u3093\u5264\u306b\u3088\u3063\u3066\uff0c\u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u3068\u81ea\u7136\u514d\u75ab\u306b\u304a\u3051\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3084\u6297\u816b\u760d\u80fd\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\uff0ccalreticulin\u5206\u5b50\u306e\u7d30\u80de\u819c\u8868\u9762\u3078\u306e\u9732\u51fa\u306a\u3069\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.130 \u6700\u8fd1\u306e\u8a71\u984c57\uff082021\u5e74\/2\/4\u914d\u4fe1\uff09 \u6e29\u71b1\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u2015\u6d3b\u6027\u9178\u7d20\u306e\u95a2\u4e0e\u3068\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u2015 \u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\uff09 \u3000\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u30fb\u71b1\u30b9\u30c8\u30ec\u30b9\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-512","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/512","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=512"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/512\/revisions"}],"predecessor-version":[{"id":513,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/512\/revisions\/513"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=512"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=512"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}