{"id":516,"date":"2021-01-18T20:09:00","date_gmt":"2021-01-18T11:09:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=516"},"modified":"2022-05-26T20:12:05","modified_gmt":"2022-05-26T11:12:05","slug":"%e5%85%8d%e7%96%ab%e7%b3%bb%e3%81%ab%e8%aa%8d%e8%ad%98%e3%81%95%e3%82%8c%e3%82%84%e3%81%99%e3%81%84%e5%85%8d%e7%96%ab%e5%8e%9f%e6%80%a7%e7%b4%b0%e8%83%9e%e6%ad%bb%e3%82%92%e3%83%8f%e3%82%a4%e3%83%91","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e5%85%8d%e7%96%ab%e7%b3%bb%e3%81%ab%e8%aa%8d%e8%ad%98%e3%81%95%e3%82%8c%e3%82%84%e3%81%99%e3%81%84%e5%85%8d%e7%96%ab%e5%8e%9f%e6%80%a7%e7%b4%b0%e8%83%9e%e6%ad%bb%e3%82%92%e3%83%8f%e3%82%a4%e3%83%91\/","title":{"rendered":"\u514d\u75ab\u7cfb\u306b\u8a8d\u8b58\u3055\u308c\u3084\u3059\u3044\u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b\u3092\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u3067\u8a98\u5c0e\u3059\u308b"},"content":{"rendered":"\n

\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.127\u3010\u5b66\u8853\u5831\u544a55\u3011<\/p>\n\n\n\n

\u6700\u8fd1\u306e\u8a71\u984c55<\/p>\n\n\n\n

\u514d\u75ab\u7cfb\u306b\u8a8d\u8b58\u3055\u308c\u3084\u3059\u3044\u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b\u3092\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u3067\u8a98\u5c0e\u3059\u308b<\/p>\n\n\n\n

\u4e95\u85e4\u3000\u5f70\uff08\u540d\u53e4\u5c4b\u5927\u5b66 \u5927\u5b66\u9662\u5de5\u5b66\u7814\u7a76\u79d1 \u5316\u5b66\u30b7\u30b9\u30c6\u30e0\u5de5\u5b66\u5c02\u653b\uff09<\/p>\n\n\n\n

\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306e\u9b45\u529b\u306f\uff0c(1) \u5316\u5b66\u7642\u6cd5\u3068\u7570\u306a\u308a\u7269\u7406\u7684\u306a\u6cbb\u7642\u6cd5\u306a\u306e\u3067\u526f\u4f5c\u7528\u304c\u5c11\u306a\u3044\u3053\u3068\uff0c(2) \u5916\u79d1\u624b\u8853\u3068\u7570\u306a\u308a\u4fb5\u8972\u6027\u304c\u4f4e\u3044\u3053\u3068\u306b\u52a0\u3048\u3066\uff0c(3) \u304c\u3093\u7d30\u80de\u6b7b\u304c\u4f53\u5185\u3067\u8a98\u5c0e\u3055\u308c\u308b\u70b9\u306b\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\uff0e\u4f53\u5185\u3067\u304c\u3093\u7d30\u80de\u304c\u6b7b\u306c\u3068\uff0c\u304c\u3093\u7d30\u80de\u306e\u6297\u539f\u304c\u6297\u539f\u63d0\u793a\u7d30\u80de\u3067\u3042\u308b\u6a39\u72b6\u7d30\u80de\u306b\u3088\u3063\u3066\u53d6\u308a\u8fbc\u307e\u308c\u3066\uff0c\u6297\u816b\u760d\u514d\u75ab\u304c\u8a98\u5c0e\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e\u6cbb\u7642\u306b\u6d3b\u304b\u3059\u305f\u3081\u306b\uff0c\u5982\u4f55\u306b\u52b9\u7387\u3088\u304f\u514d\u75ab\u7cfb\u306b\u8a8d\u8b58\u3055\u305b\u308b\u304b\u3092\u691c\u8a0e\u3059\u308b\u969b\u306b\u306f\uff0c\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u91cd\u8981\u306b\u306a\u3063\u3066\u304f\u308b\uff0e<\/p>\n\n\n\n

\u7d30\u80de\u6b7b\u306e\u5f62\u5f0f\u306f\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u5927\u5225\u3055\u308c\u308b\uff0e\u7b46\u8005\u3089\u306f\uff0c\u6297\u816b\u760d\u514d\u75ab\u8ce6\u6d3b\u306b\u91cd\u8981\u306a\u5206\u5b50\u3068\u3057\u3066\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea (HSP) \u306b\u7740\u76ee\u3057\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u304d\u305f1)<\/sup>\uff0eHSP70\u306f\u6e29\u71b1\u8010\u6027\u3092\u8a98\u5c0e\u3059\u308b\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\uff0e\u307e\u305f\uff0c\u514d\u75ab\u7cfb\u306b\u3068\u3063\u3066Danger signal\u3067\u3042\u308bHSP\u306f\uff0c\u7d30\u80de\u5916\u306b\u653e\u51fa\u3055\u308c\u308b\u3068\u81ea\u7136\u514d\u75ab\u7cfb\u3092\u6d3b\u6027\u5316\u3059\u308b\u3068\u3068\u3082\u306b\uff0cHSP\u306b\u30b7\u30e3\u30da\u30ed\u30f3\u3055\u308c\u305f\u816b\u760d\u6297\u539f\u30da\u30d7\u30c1\u30c9\u304c\u6a39\u72b6\u7d30\u80de\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3066\u6297\u816b\u760d\u514d\u75ab\u3092\u8a98\u5c0e\u3059\u308b\uff0e\u7b46\u8005\u3089\u306f\uff0c\u7279\u306b\u78c1\u6027\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\u305f\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u304a\u3044\u3066\uff0cHSP70\u767a\u73fe\u3092\u4ecb\u3057\u305f\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u3092\u304c\u3093\u7d30\u80de\u306b\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\uff0c\u6297\u816b\u760d\u514d\u75ab\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u305f\uff0e<\/p>\n\n\n\n

\u4e00\u65b9\uff0c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u304a\u3044\u3066\u514d\u75ab\u7cfb\u306b\u8a8d\u8b58\u3055\u308c\u3084\u3059\u3044\u7d30\u80de\u6b7b\u306f\u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b(Immunogenic cell death: ICD)\u3068\u3088\u3070\u308c\u3066\u304a\u308a\uff0c\u305d\u306e\u5b9a\u7fa9\u306f (1) Calreticulin*\u3084HSP70\u304a\u3088\u3073HSP90\u304c\u7d30\u80de\u819c\u4e0a\u306b\u73fe\u308c\u308b\u3053\u3068\uff0c(2) High mobility group box1 (HMGB1)*\u3084\u708e\u75c7\u7cfb\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u7d30\u80de\u5916\u306b\u653e\u51fa\u3055\u308c\u308b\u3053\u3068\uff0c(3) ATP\u3084DNA\u304a\u3088\u3073RNA\u304c\u7d42\u672b\u671f\u5206\u89e3\u56e0\u5b50\u3068\u3057\u3066\u73fe\u308c\u308b\u3053\u3068\uff0c\u3068\u3055\u308c\u3066\u3044\u308b2)<\/sup>\uff0e\u6700\u8fd1\uff0c\u30ca\u30ce\u30e1\u30c7\u30a3\u30b7\u30f3\u3068\u3057\u3066\u306e\u5149\u6e29\u71b1\u6cbb\u7642 (Photothermal therapy) \u3067ICD\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0eWen\u3089\u306f\uff0c\u8fd1\u8d64\u5916\u7dda\u3067\u767a\u71b1\u3059\u308b\u30d1\u30e9\u30b8\u30a6\u30e0\u3068\u6297\u304c\u3093\u5264\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u304b\u3089\u306a\u308b\u30ca\u30ce\u7c92\u5b50\u3092\u8abf\u88fd\u3057\u3066\u5149\u6e29\u71b1\u5316\u5b66\u6cbb\u7642\u3092CT26\u62c5\u304c\u3093\u30de\u30a6\u30b9\u306b\u884c\u3063\u305f\u3068\u3053\u308d\uff0cCalreticulin\u306e\u7d30\u80de\u819c\u3067\u306e\u767a\u73fe\uff0cHMGB1\uff0cATP\uff0cTNF-\u03b1\uff0cIFN-\u03b3\u306e\u653e\u51fa\uff0c\u816b\u760d\u6d78\u6f64CD8\u967d\u6027T\u7d30\u80de\u306e\u5897\u52a0\u3068Foxp3\u967d\u6027T\u7d30\u80de\u306e\u6e1b\u5c11\uff0c\u816b\u760d\u30b5\u30a4\u30ba\u306e\u6e1b\u5c11\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u305f3)<\/sup>\uff0e<\/p>\n\n\n\n

\u5168\u3066\u306e\u304c\u3093\u7d30\u80de\u3067\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u8a98\u5c0e\u3055\u308c\u308b\u304b\u306f\u5206\u304b\u3089\u306a\u3044\u3057\uff0c\u6297\u816b\u760d\u514d\u75ab\u304c\u8a98\u5c0e\u3055\u308c\u308b\u304b\u306f\u4e0d\u660e\u3067\u3042\u308b\u304c\uff0c\u6297\u816b\u760d\u514d\u75ab\u306e\u3082\u305f\u3089\u3059\u6cbb\u7642\u52b9\u679c\u306f\u591a\u5927\u3060\u3068\u8003\u3048\u3089\u308c\u308b\uff0e\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u304a\u3044\u3066\u3082\u514d\u75ab\u7cfb\u306b\u8a8d\u8b58\u3055\u308c\u3084\u3059\u3044\u304c\u3093\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u30d7\u30ed\u30c8\u30b3\u30eb\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u306f\u610f\u7fa9\u304c\u3042\u308b\u3060\u308d\u3046\uff0e<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

  1. Ito A, et al<\/em>. Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: A novel concept of \u201cheat-controlled necrosis\u201d with heat shock protein expression. Cancer Immunol Immunother, 55: 320-8, 2006.<\/li>
  2. Asadzadeh Z, et al<\/em>. Current approaches for combination therapy of cancer: The role of immunogenic cell death. Cancers, 12: 1047, 2020.<\/li>
  3. Wen Y, et al<\/em>. Photothermal-chemotherapy integrated nanoparticles with tumor microenvironment response enhanced the induction of immunogenic cell death for colorectal cancer efficient treatment. ACS Appl Mater Interfaces, 11: 43393-408, 2019.<\/li><\/ol>\n\n\n\n

    \u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n

    *<\/sup>Calreticulin\uff1a\u30ab\u30eb\u30ec\u30c6\u30a3\u30ad\u30e5\u30ea\u30f3\u306f\uff0c\u7d30\u80de\u5185Ca2<\/sup>\uff0b<\/sup>\u306e\u6052\u5e38\u6027\u304a\u3088\u3073\u5c0f\u80de\u4f53 (ER) \u306eCa2<\/sup>\uff0b<\/sup>\u5bb9\u91cf\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\uff0eCalnexin (\u30ab\u30eb\u30cd\u30ad\u30b7\u30f3) \u3084ERp57\u3068\u5171\u306bCalreticulin \/ Calnexin\u30b5\u30a4\u30af\u30eb\u3092\u69cb\u6210\u3057\uff0c\u65b0\u3057\u304f\u5408\u6210\u3055\u308c\u305f\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u305f\u305f\u307f\u3068\u54c1\u8cea\u7ba1\u7406\u3092\u62c5\u3063\u3066\u3044\u308b\uff0eCalreticulin\u306f\uff0cER\u5185\u5916\u3067\u591a\u304f\u306e\u751f\u4f53\u5185\u30b7\u30b9\u30c6\u30e0\u3067\u5f79\u5272\u3092\u679c\u305f\u3059\u30de\u30eb\u30c1\u30d7\u30ed\u30bb\u30b9\u5206\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\uff0e\u6700\u8fd1\uff0cCalreticulin\u306f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308b\u816b\u760d\u7d30\u80de\u306e\u53d6\u308a\u8fbc\u307f\u3092\u4fc3\u9032\u3057\uff0c\u98df\u4f5c\u7528\u3092\u5897\u5927\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

    *<\/sup>High mobility group box1 (HMGB1)\uff1a\u672c\u5206\u5b50\u306f\uff0c\u640d\u50b7\u3084\u611f\u67d3\uff0c\u708e\u75c7\u6027\u523a\u6fc0\u3092\u53d7\u3051\u3066\u7523\u751f\u3055\u308c\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4e00\u7a2e\u3067\uff0c\u6d3b\u6027\u5316\u3057\u305f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304a\u3088\u3073\u6210\u719f\u3057\u305f\u6a39\u72b6\u7d30\u80de\uff0c\u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\u7d30\u80de\u306b\u3088\u3063\u3066\u5206\u6ccc\u3055\u308c\u308b\uff0eHMGB1\u306f\u307e\u305f\uff0cV(D)J\u907a\u4f1d\u5b50\u518d\u69cb\u6210\u306b\u3082\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.127\u3010\u5b66\u8853\u5831\u544a55\u3011 \u6700\u8fd1\u306e\u8a71\u984c55 \u514d\u75ab\u7cfb\u306b\u8a8d\u8b58\u3055\u308c\u3084\u3059\u3044\u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b\u3092\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u3067\u8a98\u5c0e\u3059\u308b \u4e95\u85e4\u3000\u5f70\uff08\u540d\u53e4\u5c4b\u5927\u5b66 \u5927\u5b66\u9662\u5de5\u5b66\u7814\u7a76\u79d1 \u5316\u5b66\u30b7\u30b9\u30c6\u30e0\u5de5\u5b66\u5c02\u653b\uff09 \u30cf\u30a4\u30d1 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-516","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/516","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=516"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/516\/revisions"}],"predecessor-version":[{"id":517,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/516\/revisions\/517"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=516"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=516"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=516"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}