{"id":518,"date":"2020-11-26T20:09:00","date_gmt":"2020-11-26T11:09:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=518"},"modified":"2022-05-26T20:12:42","modified_gmt":"2022-05-26T11:12:42","slug":"hsp47%e3%81%af%e3%81%8c%e3%82%93%e7%b4%b0%e8%83%9e%e3%81%ae%e5%a2%97%e6%ae%96%e3%82%84%e6%b5%b8%e6%bd%a4%e8%bb%a2%e7%a7%bb%e3%82%92%e4%bf%83%e9%80%b2%e3%81%99%e3%82%8b","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/hsp47%e3%81%af%e3%81%8c%e3%82%93%e7%b4%b0%e8%83%9e%e3%81%ae%e5%a2%97%e6%ae%96%e3%82%84%e6%b5%b8%e6%bd%a4%e8%bb%a2%e7%a7%bb%e3%82%92%e4%bf%83%e9%80%b2%e3%81%99%e3%82%8b\/","title":{"rendered":"HSP47\u306f\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3084\u6d78\u6f64\u8ee2\u79fb\u3092\u4fc3\u9032\u3059\u308b"},"content":{"rendered":"\n

\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.126\u3010\u5b66\u8853\u5831\u544a54\u3011<\/p>\n\n\n\n

\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c54<\/p>\n\n\n\n

HSP47<\/strong>\u306f\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3084\u6d78\u6f64\u8ee2\u79fb\u3092\u4fc3\u9032\u3059\u308b<\/strong><\/p>\n\n\n\n

\u5927\u585a\u5065\u4e09\uff08\u4e2d\u90e8\u5927\u5b66\uff09<\/p>\n\n\n\n

\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u6a5f\u80fd\u3092\u6301\u3064HSPs\uff08heat shock proteins\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3084\u305d\u306e\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308bHSF1\uff08heat shock transcription factor 1\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u8ee2\u5199\u56e0\u5b501\uff09\u304c\uff0c\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3084\u6d78\u6f64\u8ee2\u79fb\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u306f\uff0c\u4e00\u822c\u7684\u306b\u3082\u53d7\u3051\u5165\u308c\u3089\u308c\u3066\u304d\u3066\u3044\u308b\uff0eHSPs\u306e\u3046\u3061HSP70\u3084HSP90\u306e\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u4fc3\u9032\u52b9\u679c\u306a\u3069\u306b\u3064\u3044\u3066\u306f\u3088\u304f\u7814\u7a76\u3055\u308c\u3066\u304a\u308a\uff0c\u305d\u308c\u3089\u3092\u6a19\u7684\u3068\u3057\u305f\u963b\u5bb3\u5264\u306b\u3088\u308b\u304c\u3093\u6cbb\u7642\u306e\u7814\u7a76\u3082\u9032\u3093\u3067\u3044\u308b1)<\/sup>\uff0eHSP47\u306f\u5c0f\u80de\u4f53\u306b\u5c40\u5728\u3059\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u7279\u7570\u7684\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b2)<\/sup>\uff0e\u6700\u8fd1\uff0c\u305d\u306eHSP47\u304c\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3084\u8ee2\u79fb\u306b\u5bfe\u3057\u3066\u4fc3\u9032\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u3044\u304f\u3064\u304b\u306e\u8ad6\u6587\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u4ee5\u4e0b\u306b\u7d39\u4ecb\u3059\u308b3\u301c6)<\/sup>\uff0e\u3053\u308c\u307e\u3067HSP47\u306e\u767a\u73fe\u304c\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u60aa\u6027\u5ea6\u3084\u4e73\u304c\u3093\u306e\u4e88\u5f8c\u4e0d\u826f\u3068\u3088\u304f\u76f8\u95a2\u3059\u308b\u3053\u3068\u306a\u3069\u304c\u77e5\u3089\u308c\u3066\u3044\u305f\u304c\uff0c\u305d\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4e0d\u660e\u3067\u3042\u3063\u305f\uff0e<\/p>\n\n\n\n

\u3000\u307e\u305a\uff0c\u5317\u6d77\u9053\u5927\u5b66\u306e\u7530\u6751\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u3067\u3042\u308b3)<\/sup>\uff0e\u5f7c\u3089\u306f\u6700\u521d\u306b\u3044\u304f\u3064\u304b\u306e\u4e73\u304c\u3093\u7d30\u80de\u682a\u306b\u3064\u3044\u3066HSP47\u767a\u73fe\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\uff0c\u9ad8\u8ee2\u79fb\u6027\u306e\u7d30\u80de\u3067\u306fHSP47\u767a\u73fe\u7d30\u80de\u306e\u5272\u5408\u306f\u6570\uff05\u3067\u3042\u3063\u305f\uff0e\u3068\u3053\u308d\u304c\uff0c\u305d\u306e\u9ad8\u8ee2\u79fb\u6027\u4e73\u304c\u3093\u7d30\u80de\u3092\u30de\u30a6\u30b9\u306b\u79fb\u690d\u3057\u3066\u5f62\u6210\u3055\u308c\u305f\u816b\u760d\u7d44\u7e54\u3067\u306fHSP47\u767a\u73fe\u7d30\u80de\u304c20\uff05\u8fd1\u304f\u306b\u307e\u3067\u5897\u52a0\u3057\u305f\uff0e\u307e\u305f\uff0c\u540c\u3058\u7d30\u80de\u3092\u5c3e\u9759\u8108\u306b\u6ce8\u5165\u3057\u3066\u3067\u304d\u305f\u80ba\u8ee2\u79fb\u5de3\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\uff0cHSP47\u767a\u73fe\u7d30\u80de\u304c\u7d0490\uff05\u306b\u307e\u3067\u5897\u52a0\u3057\u305f\uff0e\u305d\u3053\u3067\uff0c\u79fb\u690d\u816b\u760d\u304b\u3089\u5358\u96e2\u3057\u305fHSP47\u9ad8\u767a\u73fe\u7d30\u80de\u306b\u3064\u3044\u3066\uff0cHSP47\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3059\u308b\u3068\u904a\u8d70\u80fd\u3084\u6d78\u6f64\u80fd\u304c\u4f4e\u4e0b\u3057\uff0c\u5c3e\u9759\u8108\u306b\u6ce8\u5165\u3057\u305f\u3068\u3053\u308d\u80ba\u3067\u306e\u8ee2\u79fb\u5de3\u3082\u6e1b\u5c11\u3057\u305f\uff0e\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u816b\u760d\u306e\u5fae\u5c0f\u74b0\u5883\u304c\uff0c\u4e73\u304c\u3093\u7d30\u80de\u306bHSP47\u3092\u8a98\u5c0e\u3057\uff0c\u305d\u306e\u7d50\u679c\uff0c\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3084\u8ee2\u79fb\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\uff0e\u305d\u3053\u3067\uff0cHSP47\u3068\u7d50\u5408\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\uff0c\u5c0f\u80de\u4f53\u5185\u306eHSP47\u306f\u5c0f\u80de\u4f53\u819c\u306b\u5c40\u5728\u3059\u308bIRE1a\uff08unfolded protein response [UPR]\u306b\u95a2\u4e0e\u3059\u308b\u56e0\u5b50\u306e\u4e00\u3064\uff09*\u3092\u4ecb\u3057\u3066\u7d30\u80de\u8cea\u306eNMIIA\uff08\u975e\u7b4b\u8089\u30df\u30aa\u30b7\u30f3IIA\uff09\u3068\u7d50\u5408\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\uff0eHSP47\u9ad8\u767a\u73fe\u7d30\u80de\u3067\u306f\u78ba\u304b\u306b\u30a2\u30af\u30c1\u30f3\u30b9\u30c8\u30ec\u30b9\u30d5\u30a1\u30a4\u30d0\u30fc\u304c\u89b3\u5bdf\u3055\u308c\uff0c\u7d30\u80de\u5468\u8fba\u90e8\u306b\u8449\u72b6\u4eee\u8db3\uff08lamellipodia\uff09\u304c\u591a\u304f\u5f62\u6210\u3055\u308c\u3066\u3044\u305f\uff0e\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u30df\u30aa\u30b7\u30f3\u3068\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306e\u7d50\u5408\u306b\u3088\u308b\u53ce\u7e2e\u529b\u306e\u5897\u5f37\u3092\u610f\u5473\u3057\uff0c\u3053\u308c\u306b\u3088\u308a\u7d30\u80de\u306e\u904a\u8d70\u80fd\u304c\u5411\u4e0a\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\uff0e\u904a\u8d70\u80fd\u306e\u5411\u4e0a\u306f\u304c\u3093\u7d30\u80de\u306e\u8ee2\u79fb\u306b\u3064\u306a\u304c\u308b\uff0e\u4ee5\u4e0a\u306e\u6210\u7e3e\u306f\uff0c\u3053\u308c\u307e\u3067\u77e5\u3089\u308c\u3066\u3044\u306a\u304b\u3063\u305fHSP47\u306e\u65b0\u305f\u306a\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3057\uff0cHSP47\u304c\u4e73\u304c\u3093\u7d30\u80de\u306e\u8ee2\u79fb\u306e\u4fc3\u9032\u56e0\u5b50\u3068\u3057\u3066\u50cd\u304f\u3053\u3068\u3092\u793a\u3057\u305f\uff0e<\/p>\n\n\n\n

\u3000\u540c\u3058\u7530\u6751\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\uff0cHSP47\u304cIRE1a\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067ROS\uff08\u6d3b\u6027\u9178\u7d20\u7a2e\uff09\u306e\u767a\u751f\u3092\u6291\u5236\u3057\uff0c\u305d\u306e\u7d50\u679c\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u5831\u544a\u3057\u3066\u3044\u308b4)<\/sup>\uff0e<\/p>\n\n\n\n

\u3000\u307e\u305f\uff0cXiong\u3089\u306fHSP47\u304c\u5225\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u304c\u3093\u7d30\u80de\u306e\u8ee2\u79fb\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f5)<\/sup>\uff0e\u305d\u308c\u306b\u3088\u308b\u3068\uff0c\u8840\u6db2\u4e2d\u3092\u5faa\u74b0\u3057\u3066\u3044\u308b\u304c\u3093\u7d30\u80de\u306fHSP47\u3092\u9ad8\u767a\u73fe\u3059\u308b\u3053\u3068\u3067\u30b3\u30e9\u30fc\u30b2\u30f3type I\u306e\u7d30\u80de\u5916\u3078\u306e\u5206\u6ccc\u304c\u4ea2\u9032\u3057\u3066\u304a\u308a\uff0c\u305d\u306e\u3053\u3068\u306b\u3088\u308a\u304c\u3093\u7d30\u80de\u3068\u8840\u5c0f\u677f\u306e\u7d50\u5408\u304c\u5897\u52a0\u3057\u3066\u304c\u3093\u7d30\u80de\u540c\u58eb\u304c\u96c6\u5408\u3057\u3066\u30af\u30e9\u30b9\u30bf\u30fc\u3092\u5f62\u6210\u3057\uff0c\u305d\u306e\u7d50\u679c\u304c\u3093\u7d30\u80de\u306e\u8840\u7ba1\u5916\u3078\u306e\u6ea2\u51fa\uff08extravasation\uff09\u304c\u4fc3\u9032\u3055\u308c\u308b\u3068\u3044\u3046\uff0e\u3053\u308c\u3082\u304c\u3093\u7d30\u80de\u306e\u8ee2\u79fb\u3092\u4fc3\u3059\u3053\u3068\u306b\u306a\u308b\uff0e<\/p>\n\n\n\n

\u3000\u3055\u3089\u306b\uff0cChern\u3089\u306f\u7d50\u8178\u76f4\u8178\u304c\u3093\u306b\u304a\u3044\u3066\uff0cHSP47\u304c\u4e0a\u3067\u8ff0\u3079\u305f\u306e\u3068\u306f\u7570\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u816b\u760d\u306e\u751f\u5b58\u3084\u85ac\u5264\u6cbb\u7642\u62b5\u6297\u6027\u3092\u4ea2\u9032\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u308b6)<\/sup>\uff0e\u5f7c\u3089\u306f\u307e\u305aHSP47\u304c\u7d30\u80de\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306eAKT\u306e\u30ea\u30f3\u9178\u5316\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u4fc3\u9032\u30845-FU\u306b\u5bfe\u3059\u308b\u62b5\u6297\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u793a\u3057\u305f\uff0e\u3053\u306eAKT\u306e\u30ea\u30f3\u9178\u5316\u4fc3\u9032\u306e\u539f\u56e0\u306f\uff0cHSP47\u304cAKT\u7279\u7570\u7684\u306a\u8131\u30ea\u30f3\u9178\u5316\u9175\u7d20\uff08PHLPP1\uff0cPH-domain leucine-rich-repeat-containing protein phosphatase\uff09\u3068\u7d50\u5408\u3057\u3066\u4e0d\u5b89\u5b9a\u5316\u3059\u308b\u3053\u3068\u3067\uff0c\u305d\u306e\u5206\u89e3\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u3042\u3063\u305f\uff0e<\/p>\n\n\n\n

\u3000\u4ee5\u4e0a\uff0c\u3053\u3053\u3067\u7d39\u4ecb\u3057\u305f\u3088\u3046\u306b\uff0cHSP47\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u7279\u7570\u7684\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u306e\u6a5f\u80fd\u306e\u307b\u304b\u306b\uff0c\u3044\u304f\u3064\u304b\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3084\u6d78\u6f64\u30fb\u8ee2\u79fb\u3092\u4ea2\u9032\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u305f\uff0e\u4eca\u5f8c\uff0cHSP47\u3092\u6a19\u7684\u3068\u3057\u305f\u304c\u3093\u6cbb\u7642\u306e\u7814\u7a76\u3082\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n\n\n\n

  1. Workman P. Reflections and outlook on targeting HP90, HSP70 and HSF1 in cancer: A personal perspective. In Mendillo et al<\/em>. (eds), HSF1 and Molecular Chaperones in Biology and Cancer, Advances in Experimental Medicine and Biology 1243, Springer Nature Switzerland AG, pp. 69-85, 2020.<\/li>
  2. Ito S., et al<\/em>. Roles of the endoplasmic reticulum-resident, collagen-specific molecular chaperone Hsp47 in vertebrate cells and human disease. J Biol Chem, 294: 2133-41, 2019<\/li>
  3. Yoneda A., et al<\/em>. HSP47 promotes metastasis of breast cancer by interacting with myosin IIA via the unfolded protein response transuducer IRE1a. Oncogene, 39: 4519-37, 2020.<\/li>
  4. Yoneda A., et al<\/em>. Heat shock protein 47 maintains cancer cell growth by inhibiting the unfolded protein response transducer IRE1a. Mol Cancer Res, 18: 847-58, 2020.<\/li>
  5. Xiong G., et al<\/em>. Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction. Proc Natl Acad Sci USA, 117: 3748-58, 2020.<\/li>
  6. Chern Y., et al<\/em>. Heat shock protein 47 promotes tumor survival and therapy resistance by modulationg AKT signaling via PHLPP1 in colorectal cancer. Cancer Biol Med, 17: 343-56, 2020.<\/li><\/ol>\n\n\n\n

    \u7528\u8a9e\u89e3\u8aac<\/strong><\/p>\n\n\n\n

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