{"id":522,"date":"2020-10-16T20:10:00","date_gmt":"2020-10-16T11:10:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=522"},"modified":"2022-05-26T20:13:27","modified_gmt":"2022-05-26T11:13:27","slug":"hsf1%e3%81%afampk%e3%82%92%e6%8a%91%e5%88%b6%e3%81%99%e3%82%8b%e3%81%93%e3%81%a8%e3%81%ab%e3%82%88%e3%82%8a%e3%83%a1%e3%83%a9%e3%83%8e%e3%83%bc%e3%83%9e%e3%81%ae%e5%a2%97%e6%ae%96%e3%82%92%e4%bf%83","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/hsf1%e3%81%afampk%e3%82%92%e6%8a%91%e5%88%b6%e3%81%99%e3%82%8b%e3%81%93%e3%81%a8%e3%81%ab%e3%82%88%e3%82%8a%e3%83%a1%e3%83%a9%e3%83%8e%e3%83%bc%e3%83%9e%e3%81%ae%e5%a2%97%e6%ae%96%e3%82%92%e4%bf%83\/","title":{"rendered":"HSF1\u306fAMPK\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u30e1\u30e9\u30ce\u30fc\u30de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b"},"content":{"rendered":"\n<p><strong>\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.123\u3010\u5b66\u8853\u5831\u544a52\u3011<\/strong><\/p>\n\n\n\n<p><strong>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c52<\/strong>\uff082020\/10\/16\u914d\u4fe1\uff09<\/p>\n\n\n\n<p><strong>HSF1<\/strong><strong>\u306fAMPK\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u30e1\u30e9\u30ce\u30fc\u30de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b<\/strong><\/p>\n\n\n\n<p>\u5927\u585a\u5065\u4e09\uff08\u4e2d\u90e8\u5927\u5b66\u30fb\u540d\u8a89\u6559\u6388\uff09<\/p>\n\n\n\n<p>\u71b1\u30b7\u30e7\u30c3\u30af\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u6bd2\u6027\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306e\u30de\u30b9\u30bf\u30fc\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308bHSF1\uff08heat shock transcription factor 1\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u8ee2\u5199\u56e0\u5b501\uff09\u306f\uff0c\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u6a5f\u80fd\u3092\u6301\u3064\u591a\u304f\u306eHSPs\uff08heat shock proteins\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u7fa4\uff09\u3092\u8ee2\u5199\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u7d30\u80de\u306e\u751f\u5b58\u3092\u4fc3\u9032\u3059\u308b\u3088\u3046\u306b\u50cd\u3044\u3066\u3044\u308b\uff0e\u3068\u3053\u308d\u304c\uff0c\u304c\u3093\u7d30\u80de\u306f\u3053\u306eHSF1\u306e\u6a5f\u80fd\u3092\u3046\u307e\u304f\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u81ea\u8eab\u306e\u751f\u5b58\u3092\u6709\u5229\u306b\u3057\u3066\u3044\u308b\uff0e\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306fHSF1\u306f\u304c\u3093\u767a\u751f\u306e\u591a\u304f\u306e\u904e\u7a0b\uff08\u5f62\u8cea\u8ee2\u63db\uff0c\u7d30\u80de\u5897\u6b96\uff0c\u6d78\u6f64\u8ee2\u79fb\uff0c\u85ac\u5264\u8010\u6027\u306a\u3069\uff09\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<sup>1\uff09<\/sup>\uff0e\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u306e\u306f\uff0cHSF1\u306e\u65b0\u305f\u306a\u6a5f\u80fd\u3068\u3057\u3066\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u3064\u304b\u3055\u3069\u308bAMPK\uff08AMP-activated protein kinase\uff09*\u3068\u76f4\u63a5\u7d50\u5408\u3057\uff0c\u305d\u306e\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u304c\u3093\u7d30\u80de\uff08\u30e1\u30e9\u30ce\u30fc\u30de\uff09\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\uff0c\u3068\u3044\u3046Su\u3089\u306e\u8ad6\u6587\u3067\u3042\u308b<sup>2\uff09<\/sup>\uff0e<\/p>\n\n\n\n<p>AMPK\u306f3\u3064\u306e\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\uff08\u89e6\u5a92\u6d3b\u6027\u3092\u6301\u3064\u03b1\uff0c\u5236\u5fa1\u6027\u306e\u03b2\u3068\u03b3\uff09\u304b\u3089\u306a\u308a\uff0c\u03b1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306b\u306fATP\u304c\uff0c\u03b3\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306b\u306fAMP\u304c\u7d50\u5408\u3059\u308b\uff0e\u7d30\u80de\u5185\u306eATP\u30ec\u30d9\u30eb\u304c\u6e1b\u5c11\u3057\u3066AMP\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u3088\u3046\u306a\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u308b\u3068\uff0cAMPK\u306f\uff0c\u03b3\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3078\u306eAMP\u306e\u7d50\u5408\u3084\uff0c\u03b1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8Thr172\u306e\u816b\u760d\u6291\u5236\u56e0\u5b50LKB1\uff08liver kinase B1\uff09*\u306b\u3088\u308b\u30ea\u30f3\u9178\u5316\u3092\u53d7\u3051\u3066\u6d3b\u6027\u5316\u3059\u308b\uff0e\u6d3b\u6027\u5316\u3055\u308c\u305fAMPK\u306f\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u7570\u5316\u904e\u7a0b\u306b\u95a2\u4e0e\u3059\u308b\uff08ATP\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\uff09\u56e0\u5b50\u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\u3053\u3068\u3067\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\uff0e\u307e\u305f\uff0c\u03b1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8Thr172\u306e\u30ea\u30f3\u9178\u57fa\u304c\u8131\u30ea\u30f3\u9178\u5316\u9175\u7d20\uff08PP2A*\uff09\u306b\u3088\u3063\u3066\u5916\u3055\u308c\u308b\u3068AMPK\u306f\u5931\u6d3b\u3059\u308b<sup>3, 4)<\/sup>\uff0e\u3000<\/p>\n\n\n\n<p>\u3000Su\u3089\u306e\u8ad6\u6587<sup>2)<\/sup>\u3067\u306f\uff0c\u307e\u305aHSF1<sup>wt(1-529)<\/sup>\u304cAMPK\u03b1\uff08\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\uff09\u3068\u76f4\u63a5\u4f1a\u5408\u3057\uff0cLKB1\u306b\u3088\u308bAMPK\u03b1Thr172\u306e\u30ea\u30f3\u9178\u5316\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\uff0e\u3068\u3053\u308d\u304c\uff0cHSF1\u306e\u8ee2\u5199\u6d3b\u6027\u306e\u306a\u3044\u5909\u7570\u4f53\uff08HSF1<sup>1-323<\/sup>\uff1aC\u672b\u7aef\u306e\u30c8\u30e9\u30f3\u30b9\u6d3b\u6027\u5316\u30c9\u30e1\u30a4\u30f3\u3092\u6b20\u640d\uff0c\u304a\u3088\u3073HSF1<sup>324-529<\/sup>\uff1aN\u672b\u7aef\u306eDNA\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\u3092\u6b20\u640d\uff09\u3067\u3082AMPK\u03b1Thr172\u306e\u30ea\u30f3\u9178\u5316\u3092\u963b\u5bb3\u3057\u305f\u306e\u3067\u3042\u308b\uff0e\u307e\u305f\uff0cHSF1<sup>wt<\/sup>\u306f\uff0cATP\u306e\u03b1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3078\u306e\u7d50\u5408\u3084AMP\u306e\u03b3\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3078\u306e\u7d50\u5408\u3082\u6291\u5236\u3057\u305f\uff0e\u3055\u3089\u306b\uff0cHSF1<sup>wt<\/sup>\u306fPP2A\u3068AMPK\u306e\u7d50\u5408\u3092\u5897\u5f37\u3057\u3066\uff0cAMPK\u03b1Thr172\u306e\u8131\u30ea\u30f3\u9178\u5316\u3092\u4fc3\u9032\u3057\u3066AMPK\u3092\u4e0d\u6d3b\u6027\u5316\u3055\u305b\u305f\uff0e\u3053\u308c\u3089\u306e\u52b9\u679c\u306f\u3044\u305a\u308c\u3082HSF1\u306e\u8ee2\u5199\u6d3b\u6027\u306e\u306a\u3044\u5909\u7570\u4f53\u308424\u30a2\u30df\u30ce\u9178\u306e\u30da\u30d7\u30c1\u30c9\u65ad\u7247\u3067\u3082\u89b3\u5bdf\u3055\u308c\u305f\uff0e\u3064\u307e\u308a\uff0cHSF1\u306b\u3088\u308bAMPK\u306e\u963b\u5bb3\u52b9\u679c\u306f\uff0cHSF1\u306e\u8ee2\u5199\u6d3b\u6027\u3068\u306f\u95a2\u4fc2\u306a\u304f\uff0cHSF1\u3068AMPK\u306e\u76f4\u63a5\u7684\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff0e<\/p>\n\n\n\n<p>\u3000AMPK\u306f\uff0c\u307e\u305f\u8102\u8cea\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\u8ee2\u5199\u56e0\u5b50SREBP1\uff08sterol regulatory element binding protein 1\uff09*\u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\u3053\u3068\u3067\u305d\u306e\u6d3b\u6027\u3092\u6291\u5236\u3059\u308b\uff0e\u305d\u306e\u7d50\u679c\uff0c\u8102\u8cea\u5408\u6210\u306f\u6291\u5236\u3055\u308c\uff0c\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5408\u6210\u3082\u963b\u5bb3\u3055\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u308b<sup>3)<\/sup>\uff0eHSF1\u306f\u4e0a\u8ff0\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3067AMPK\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067SREBP1\u306e\u8ee2\u5199\u6d3b\u6027\u304c\u4fc3\u9032\u3055\u308c\uff0c\u305d\u306e\u7d50\u679c\uff0c\u8102\u8cea\u5408\u6210\u3084\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5408\u6210\u304c\u5897\u52a0\u3057\u305f\uff0e\u30de\u30a6\u30b9\u500b\u4f53\u30ec\u30d9\u30eb\u3067\u3082\uff0cHSF1\u904e\u5270\u767a\u73fe\u500b\u4f53\u3067\u306fAMPK\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u304c\u6291\u5236\u3055\u308c\u3066\u304a\u308a\uff0c\u8102\u8cea\u91cf\u3060\u3051\u3067\u306a\u304f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30ec\u30d9\u30eb\u3082\u5897\u52a0\u3057\uff0c\u305d\u306e\u3053\u3068\u304c\u30e1\u30e9\u30ce\u30fc\u30de\u7d30\u80de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3057\u305f\uff0e\u304c\u3093\u7d30\u80de\u306f\u5897\u6b96\u306e\u305f\u3081\u306e\u71c3\u6599\u3092\u88dc\u7d66\u3059\u308b\u305f\u3081\u306b\u5927\u91cf\u306e\u8102\u8cea\u3092\u5fc5\u8981\u3068\u3059\u308b\u304c\uff0cHSF1\u306b\u3088\u308b\u8102\u8cea\u5408\u6210\u4fc3\u9032\u52b9\u679c\u306f\u304c\u3093\u7d30\u80de\u306b\u3068\u3063\u3066\u597d\u90fd\u5408\u306a\u306e\u304b\u3082\u3057\u308c\u306a\u3044\uff0e\u3053\u306e\u3088\u3046\u306a\u3053\u3068\u304b\u3089\uff0cHSF1\u306f\u305d\u306e\u8ee2\u5199\u6d3b\u6027\u3068\u306f\u95a2\u4fc2\u306a\u304fAMPK\u6d3b\u6027\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u816b\u760d\u4fc3\u9032\u56e0\u5b50\u3068\u3057\u3066\u306e\u5f79\u5272\u3092\u6301\u3064\u3053\u3068\u304c\u793a\u3055\u308c\u305f<sup>2)<\/sup>\uff0e<\/p>\n\n\n\n<p>\u3000\u300c\u6700\u8fd1\u306e\u5831\u544a11\u300d\u3067\u3082\u7d39\u4ecb\u3057\u305f\u3088\u3046\u306b\uff0cAMPK\u306fHSF1Ser121\u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\u3053\u3068\u3067\u4e0d\u6d3b\u6027\u5316\u3057\uff0c\u816b\u760d\u306e\u5897\u6b96\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<sup>5)<\/sup>\uff0e\u3053\u306e\u3053\u3068\u306f\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306e\u5236\u5fa1\u56e0\u5b50HSF1\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u30bb\u30f3\u30b5\u30fcAMPK\u304c\u4e92\u3044\u306b\u6291\u5236\u3057\u5408\u3046\u3053\u3068\u3067\u7d30\u80de\u5185\u306e\u6052\u5e38\u6027\u304c\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\uff0e\u6b63\u5e38\u7d30\u80de\u3067\u306fAMPK\u304c\u512a\u52e2\u3067\u7d30\u80de\u5897\u6b96\u304c\u6b63\u5e38\u306b\u9032\u884c\u3057\u3066\u3044\u308b\u306e\u3060\u304c\uff0c\u304c\u3093\u7d30\u80de\u3067\u306fHSF1\u304c\u512a\u52e2\u3068\u306a\u308a<sup>1)<\/sup>\uff0c\u81ea\u8eab\u306e\u5897\u6b96\u306b\u6709\u5229\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u306a\u3044\uff0e<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Alasady MJ, Mendillo ML. The multifaced role of HSF1 in tumorigenesis. In Mendillo et al. (eds), HSF1 and Molecular Chaperones in Biology and Cancer, Advances in Experimental Medicine and Biology 1243, Springer Nature Switzerland AG, pp. 69-85, 2020.<\/li><li>Su K-H,&nbsp;<em>et al<\/em>. Heat shock factor 1 is a direct antagonist of AMP-activated protein kinase. Mol Cell, 76: 546-61, 2019.<\/li><li>Hardie DG,&nbsp;<em>et al<\/em>. AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol, 13: 251-62, 2012.<\/li><li>Carling D. AMPK signaling in health and disease. Curr Opin Cell Biol, 45: 31-7, 2017.<\/li><li>Dai S,&nbsp;<em>et al<\/em>. Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK. EMBO J, 34:275-93, 2015.<\/li><\/ul>\n\n\n\n<p><strong>\u7528\u8a9e\u89e3\u8aac<\/strong><\/p>\n\n\n\n<p>*<strong>AMPK<\/strong><strong>\uff08AMP-activated protein kinase\uff09<\/strong>\uff1a\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u30bb\u30f3\u30b5\u30fc\u3068\u3082\u547c\u3070\u308c\uff0c\u7d30\u80de\u5185\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u30ec\u30d9\u30eb\uff08ATP\u30ec\u30d9\u30eb\uff09\u3092\u4e00\u5b9a\u306b\u4fdd\u3064\u3088\u3046\u306b\u6a5f\u80fd\u3057\u3066\u3044\u308b\uff0eATP\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\u3057\u3066\uff0cAMP\u3068ADP\u30ec\u30d9\u30eb\u304c\u5897\u52a0\u3059\u308b\u3068\u6d3b\u6027\u5316\u3055\u308c\uff0cATP\u6d88\u8cbb\u7d4c\u8def\uff08\u540c\u5316\u904e\u7a0b\uff09\u306e\u56e0\u5b50\u3092\u6291\u5236\u3059\u308b\u3068\u3068\u3082\u306b\uff0cATP\u5408\u6210\u7d4c\u8def\uff08\u7570\u5316\u904e\u7a0b\uff09\u306e\u56e0\u5b50\u3092\u6d3b\u6027\u5316\u3057\u3066ATP\u30ec\u30d9\u30eb\u3092\u4fdd\u3061\uff0c\u30a8\u30cd\u30eb\u30ae\u30fc\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3059\u308b\u3088\u3046\u306b\u50cd\u3044\u3066\u3044\u308b\uff0eAMPK\u306f\u4e0a\u6d41\u306e\u30ad\u30ca\u30fc\u30bc\uff08LKB1\u306a\u3069\uff09\u306b\u3088\u308b\u30ea\u30f3\u9178\u5316\u3068\uff0cAMP\u306e\u03b3\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3078\u306e\u7d50\u5408\u306b\u3088\u308b\u30a2\u30ed\u30b9\u30c6\u30ea\u30c3\u30af\u52b9\u679c\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n<p>*<strong>LKB1<\/strong><strong>\uff08liver kinase B1\uff09<\/strong>\uff1a\u6d88\u5316\u7ba1\u306b\u826f\u6027\u306e\u30dd\u30ea\u30fc\u30d7\u3092\u591a\u767a\u3059\u308bPeutz-Jegher syndrome\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3067\u3042\u308a\uff0c\u7d0450-kDa\u306e\u30bb\u30ea\u30f3\/\u30b9\u30ec\u30aa\u30cb\u30f3\u30ad\u30ca\u30fc\u30bc\u3067\u3042\u308b\uff0e\u80ba\u304c\u3093\u3084\u5b50\u5bae\u9838\u304c\u3093\u306a\u3069\u3067\u3057\u3070\u3057\u3070\u5909\u7570\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u816b\u760d\u6291\u5236\u56e0\u5b50\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\uff0eLKB1\u306fAMPK\u3092\u542b\u3080\u5341\u6570\u500b\u306e\u4e0b\u6d41\u306e\u30ad\u30ca\u30fc\u30bc\u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\u3053\u3068\u3067\uff0c\u7d30\u80de\u306e\u6975\u6027\uff0c\u4ee3\u8b1d\uff0c\u5206\u5316\uff0c\u5897\u6b96\u306a\u3069\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>*<strong>PP2A<\/strong><strong>\uff08protein phosphatase 2A\uff09<\/strong>\uff1a\u30bf\u30f3\u30d1\u30af\u8cea\u8131\u30ea\u30f3\u9178\u5316\u9175\u7d20\uff0e\u30d8\u30c6\u30ed\u4e09\u91cf\u4f53\u3067\u30bb\u30ea\u30f3\u3084\u30b9\u30ec\u30aa\u30cb\u30f3\u306b\u7d50\u5408\u3057\u305f\u30ea\u30f3\u9178\u57fa\u3092\u5916\u3059\uff0e\u5e83\u3044\u57fa\u8cea\u7279\u7570\u6027\u3092\u3082\u3064\u304c\uff0c\u816b\u760d\u4fc3\u9032\u6027\u306e\u30b7\u30b0\u30ca\u30eb\u56e0\u5b50\u3067\u3042\u308bRAF\uff0cMEK\uff0cAKT\u306a\u3069\u3082\u8131\u30ea\u30f3\u9178\u5316\u3057\u3066\u4e0d\u6d3b\u6027\u5316\u3059\u308b\u306e\u3067\u816b\u760d\u6291\u5236\u56e0\u5b50\u3068\u3057\u3066\u306e\u6a5f\u80fd\u3082\u3042\u308b\uff0e<\/p>\n\n\n\n<p>*<strong>SREBP1<\/strong><strong>\uff08sterol regulatory element binding protein 1\uff09<\/strong>\uff1a\u8102\u8cea\u4ee3\u8b1d\u306e\u4e2d\u5fc3\u7684\u8ee2\u5199\u56e0\u5b50\uff0e<em>ACC1<\/em>\uff08acetyl CoA carboxylase\uff09\uff0c<em>FASN<\/em>\uff08fatty acid synthase\uff09\uff0c<em>LDLR<\/em>\uff08low-density lipoprotein receptor\uff09\uff0c<em>HMGCR<\/em>\uff083-hydroxy-3methylglutaryl CoA reductase\uff09\u306a\u3069\u3092\u542b\u3080\u7d0430\u306e\u907a\u4f1d\u5b50\u3092\u8ee2\u5199\u8a98\u5c0e\u3057\uff0c\u8102\u8cea\u5408\u6210\u3084\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.123\u3010\u5b66\u8853\u5831\u544a52\u3011 \u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c52\uff082020\/10\/16\u914d\u4fe1\uff09 HSF1\u306fAMPK\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u30e1\u30e9\u30ce\u30fc\u30de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b \u5927\u585a\u5065\u4e09\uff08\u4e2d\u90e8\u5927\u5b66 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-522","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/522","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=522"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/522\/revisions"}],"predecessor-version":[{"id":523,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/522\/revisions\/523"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=522"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=522"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=522"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}