{"id":528,"date":"2020-08-27T20:21:00","date_gmt":"2020-08-27T11:21:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=528"},"modified":"2022-05-26T20:16:16","modified_gmt":"2022-05-26T11:16:16","slug":"%e6%b8%a9%e7%86%b1%e7%99%82%e6%b3%95%e3%81%ab%e3%82%88%e3%82%8b%e5%85%8d%e7%96%ab%e3%83%81%e3%82%a7%e3%83%83%e3%82%af%e3%83%9d%e3%82%a4%e3%83%b3%e3%83%88%e9%98%bb%e5%ae%b3%e5%89%a4%e3%81%ae%e5%8a%b9","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e6%b8%a9%e7%86%b1%e7%99%82%e6%b3%95%e3%81%ab%e3%82%88%e3%82%8b%e5%85%8d%e7%96%ab%e3%83%81%e3%82%a7%e3%83%83%e3%82%af%e3%83%9d%e3%82%a4%e3%83%b3%e3%83%88%e9%98%bb%e5%ae%b3%e5%89%a4%e3%81%ae%e5%8a%b9\/","title":{"rendered":"\u6e29\u71b1\u7642\u6cd5\u306b\u3088\u308b\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u52b9\u679c\u5897\u5f37"},"content":{"rendered":"\n<p>\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.117\u3010\u5b66\u8853\u5831\u544a51\u3011<\/p>\n\n\n\n<p>\u6700\u8fd1\u306e\u8a71\u984c51\uff082020\/08\/27\u914d\u4fe1\uff09<\/p>\n\n\n\n<p>\u6e29\u71b1\u7642\u6cd5\u306b\u3088\u308b\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u52b9\u679c\u5897\u5f37<\/p>\n\n\n\n<p>\u68ee\u7530\u3000\u52dd\uff08\u56fd\u7acb\u75c5\u9662\u6a5f\u69cb\u4e5d\u5dde\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u3000\u6d88\u5316\u7ba1\u5916\u79d1\uff09<\/p>\n\n\n\n<p>\u3000\u60aa\u6027\u816b\u760d\u306e\u6cbb\u7642\u3068\u3057\u3066\u624b\u8853\uff0c\u6297\u304c\u3093\u5264\uff0c\u653e\u5c04\u7dda\u7642\u6cd5\u306f\u98db\u8e8d\u7684\u306a\u9032\u6b69\u3092\u9042\u3052\u3066\u304d\u305f\u304c\uff0c\u7b2c\u56db\u306e\u6cbb\u7642\u3068\u3044\u308f\u308c\u3066\u304d\u305f\u514d\u75ab\u7642\u6cd5\u306f\u306a\u304b\u306a\u304b\u65e5\u306e\u76ee\u3092\u898b\u306a\u304b\u3063\u305f\uff0e\u3057\u304b\u3057\uff0c\u8fd1\u5e74\uff0c\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264<sup>*<\/sup>\uff08Immune checkpoint inhibitor, ICI\uff09\u304c\u958b\u767a\u3055\u308c\uff0c\u69d8\u3005\u306a\u304c\u3093\u816b\u3078\u306e\u81e8\u5e8a\u5fdc\u7528\u304c\u306a\u3055\u308c\uff0c\u811a\u5149\u3092\u6d74\u3073\u3066\u3044\u308b\uff0e\u5f93\u6765\u306e\u514d\u75ab\u7642\u6cd5\u304c\u514d\u75ab\u8ce6\u6d3b\u578b\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\uff0c\u672c\u6cbb\u7642\u306f\u514d\u75ab\u306e\u30d6\u30ec\u30fc\u30ad\u3092\u89e3\u9664\u3059\u308b\u3068\u3044\u3046\u9006\u8ee2\u306e\u767a\u60f3\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>\u3000\u4e00\u65b9\uff0c\u6e29\u71b1\u306f\u304c\u3093\u7d30\u80de\u7279\u7570\u7684\u306b\u6bba\u7d30\u80de\u52b9\u679c\u3092\u793a\u3059\u306e\u307f\u3067\u306a\u304f\uff0c\u751f\u4f53\u5185\u3067\u306f\u816b\u760d\u514d\u75ab\u3092\u6d3b\u6027\u5316\u3059\u308b\uff0e\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\uff0c\u7d44\u7e54\u8840\u6d41\u5897\u52a0\u306b\u3088\u308b\u514d\u75ab\u62c5\u5f53\u7d30\u80de\u306e\u904a\u8d70\uff0cHSP\uff0c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff0c\u6d3b\u6027\u9178\u7d20\u306e\u653e\u51fa\uff0c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u3088\u308b\u514d\u75ab\u7cfb\u3078\u306e\u523a\u6fc0\uff0c\u304c\u3093\u7279\u7570\u6297\u539f\u306e\u63d0\u793a\u306a\u3069\u591a\u304f\u304c\u6319\u3052\u3089\u308c\u308b<sup>1)<\/sup>\uff0e<\/p>\n\n\n\n<p>\u3000ICI\u306f\u6642\u306b\u5287\u7684\u306a\u52b9\u679c\u3092\u793a\u3057\uff0c\u96e3\u6cbb\u6027\u306e\u304c\u3093\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u3068\u3057\u3066\u7279\u306b\u6709\u671b\u3067\u3042\u308b\u304c\uff0c\u594f\u52b9\u7387\u306e\u95a2\u3057\u3066\u306f\u4e00\u822c\u306b20\uff5e30%\u7a0b\u5ea6\u3067\u3042\u308b\uff0e\u6e29\u71b1\u306f\u653e\u5c04\u7dda\u3084\u6297\u304c\u3093\u5264\u306e\u52b9\u679c\u3092\u5897\u5f37\u3059\u308b\u306e\u307f\u306a\u3089\u305a\u514d\u75ab\u3092\u8ce6\u6d3b\u3059\u308b\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\uff0cICI\u6295\u4e0e\u6642\u306b\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u6297\u816b\u760d\u52b9\u679c\u304c\u5897\u5f37\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u308b<sup>2)<\/sup>\uff0e\u672c\u300c\u6700\u8fd1\u306e\u8a71\u984c33\u300d\u3067\u30822019\u5e7411\u6708\u306b\u6a2a\u5800\u3089\u304c\u300c\u6e29\u71b1\u6cbb\u7642\u306f\u816b\u760d\u3092Hot tumor\u5316\u3059\u308b\u3053\u3068\u3067\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u52b9\u679c\u3092\u5897\u5f37\u3059\u308b\u300d\u306e\u30bf\u30a4\u30c8\u30eb\u3067\u6e29\u71b1\u306eICI\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u5897\u52a0\u3092\u793a\u3059\u52d5\u7269\u5b9f\u9a13\u3092\u7d39\u4ecb\u3057\u305f\uff0e\u3053\u308c\u306fPD-L1\u306a\u3069\u306e\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u306b\u4e4f\u3057\u3044\u305f\u3081\u306bICI\u306b\u52b9\u304d\u306b\u304f\u3044Cold tumor\u306b\u6e29\u71b1\u3092\u52a0\u3048\u308b\u3053\u3068\u3067\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u3092\u4fc3\u3059\u3053\u3068\u306b\u3088\u308aHot tumor\u306b\u8ee2\u63db\u3055\u305bICI\u306e\u52b9\u679c\u5897\u5f37\u3092\u56f3\u308b\u3068\u3044\u3046\u7406\u8ad6\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\uff0e\u4eca\u56de\uff0c\u540c\u69d8\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u57fa\u3065\u3044\u3066\uff0c\u5149\u6e29\u71b1\u7642\u6cd5<sup>*<\/sup>\uff08PTT: Photothermal therapy\uff09\u306e\u4f75\u7528\u306b\u3088\u308aICI(\u6297PD-L1\u6297\u4f53)\u306e\u52b9\u679c\u5897\u5f37\u3092\u793a\u3057\u305f\u52d5\u7269\u5b9f\u9a13\u304cNature Communications\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u305f<sup>3)<\/sup>\u306e\u3067\u7d39\u4ecb\u3059\u308b\uff0e<\/p>\n\n\n\n<p>\u3000\u672c\u5b9f\u9a13\u3067\u306f\uff0c\u5149\u5897\u611f\u5264\u3068\u6297PD-L1\u6297\u4f53\u3092\u8102\u8cea\u306b\u6df7\u5408\u3055\u305b\u30b2\u30eb\u5316\u3057\u305f\u8907\u5408\u4f53\u3092\u4f5c\u88fd\u3057\u305f\uff0e\u3053\u306e\u8907\u5408\u4f53\u306f\u7279\u5b9a\u306e\u6ce2\u9577\u306e\u5149\u3092\u7167\u5c04\u3059\u308b\u3068\u71b1\u3092\u767a\u3059\u308b\u3053\u3068\u3067\uff0c39.5\u2103\u306b\u306a\u308b\u3068\u6eb6\u89e3\u3059\u308b\u3088\u3046\u306b\u8abf\u6574\u3057\u305f\uff0e\u305d\u3053\u3067\uff0c\u30de\u30a6\u30b9\u306e\u79fb\u690d\u816b\u760d\u5185\u306b\u8907\u5408\u4f53\u3092\u6ce8\u5165\u3057\uff0c\u5149\u3092\u7167\u5c04\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u5c40\u6240\u306e\u30de\u30a4\u30eb\u30c9\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\uff0845\u2103\u4ee5\u4e0b\uff09\u3068\u85ac\u5264\u306e\u653e\u51fa\u304c\u540c\u6642\u306b\u884c\u308f\u308c\u308b\u3068\u3044\u3046\u539f\u7406\u3067\u3042\u308b\uff0e\u8907\u5408\u4f53\u5c40\u6ce8\uff0b\u5149\u7167\u5c04\u7fa4\u3067\u306f\u5404\u5bfe\u7167\u7fa4\uff08PBS\uff0c\u6297PD-L1\u6297\u4f53\u306a\u3057\uff0c\u5149\u7167\u5c04\u306a\u3057\uff0c\u8102\u8cea\u306a\u3057\uff09\u3092\u6bd4\u8f03\u3057\u305f\u3068\u3053\u308d\uff0c\u539f\u767a\u5de3\u306e\u307f\u306a\u3089\u305a\u80ba\u8ee2\u79fb\u5de3\u306e\u5897\u6b96\u3082\u6291\u5236\u3055\u308c\u305f\uff0e\u514d\u75ab\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u3092\u307f\u308b\u3068\u672c\u6cbb\u7642\u306b\u3088\u308a\uff0c\u30ea\u30f3\u30d1\u7bc0\u3067\u306e\u6a39\u72b6\u7d30\u80de\u306e\u6210\u719f\u5316\u3068\u3068\u3082\u306b\uff0c\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de (CTL) \u306e\u6d78\u6f64\u3068\u5236\u5fa1\u6027T\u7d30\u80de\uff08Treg\uff09\u306e\u6291\u5236\u304c\u539f\u767a\uff0c\u8ee2\u79fb\u5de3\u3068\u3082\u306b\u8a8d\u3081\u3089\u308c\uff0c\u514d\u75ab\u7cfb\u304c\u8ce6\u6d3b\u5316\u3057\u3066\u3044\u305f\uff0e\u3055\u3089\u306b\uff0c\u6cbb\u7642\u306b\u3088\u308b\u8ee2\u79fb\u6291\u5236\u52b9\u679c\u306f\u9577\u671f\u9593\u8a8d\u3081\u3089\u308c\uff0c\u514d\u75ab\u304c\u8a18\u61b6\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff0e<\/p>\n\n\n\n<p>\u3000\u672c\u5b9f\u9a13\u306f\uff0c\u5149\u6e29\u71b1\u306b\u3088\u308b\u5c40\u6240\u30de\u30a4\u30eb\u30c9\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u3088\u308a\u514d\u75ab\u72b6\u614b\u304cCold tumor\u3092Hot tumor\u306b\u5909\u5316\u3055\u305bICI\u306e\u52b9\u679c\u3092\u5897\u5f37\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\uff0c\u52a0\u6e29\u3057\u305f\u539f\u767a\u5de3\u306e\u307f\u306a\u3089\u305a\u8ee2\u79fb\u5de3\u306b\u3082\u52b9\u679c\u3092\u793a\u3057\u305f\u70b9\uff0c\u3055\u3089\u306b\u306f\u8102\u8cea\u3092\u7528\u3044\u3066\u4f5c\u88fd\u3057\u305f\u8907\u5408\u4f53\u306b\u5149\u3092\u52a0\u3048\u308b\u3053\u3068\u306b\u3088\u308a\u52a0\u6e29\u3068\u85ac\u5264\u306e\u653e\u51fa\u304c\u540c\u6642\u306b\u53ef\u80fd\u3068\u306a\u3063\u305f\u70b9\u3067\u3082\uff0c\u6975\u3081\u3066\u91cd\u8981\u3067\u30a8\u30ec\u30ac\u30f3\u30c8\u306a\u5b9f\u9a13\u3068\u3044\u3048\u308b\uff0e\u3000<\/p>\n\n\n\n<p>\u3000\u4eca\u5f8c\uff0c ICI\u3068\u6e29\u71b1\u306e\u4f75\u7528\u306b\u95a2\u3057\u3066\u3055\u3089\u306a\u308b\u69d8\u3005\u306a\u57fa\u790e\u5b9f\u9a13\u3092\u91cd\u306d\uff0c\u4f75\u7528\u52b9\u679c\uff0c\u4f5c\u7528\u6a5f\u5e8f\u3042\u308b\u3044\u306f\u6bd2\u6027\u3092\u691c\u8a0e\u3057\u305f\u3046\u3048\u3067\uff0cICI\u306e\u52b9\u679c\u5897\u5f37\u3068\u3057\u3066\u306e\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306e\u81e8\u5e8a\u5fdc\u7528\u304c\u958b\u59cb\u3055\u308c\uff0c\u81e8\u5e8a\u8a66\u9a13\u3092\u901a\u3057\u3066\u672c\u4f75\u7528\u7642\u6cd5\u304c\u5e83\u304f\u4e16\u306e\u4e2d\u306b\u8a8d\u3081\u3089\u308c\u308b\u65e5\u304c\u6765\u308b\u3053\u3068\u3092\u9858\u3063\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p>1\uff09Hurwitz MD. Hyperthermia and immunotherapy: Clinical opportunities. Int J Hyperthermia, 36(S1):4-9, 2019.<\/p>\n\n\n\n<p>2\uff09Bull JMC. A review of immune therapy in cancer and a question: Can thermal therapy increase tumor response? Int J Hyperthermia, 34(6):840-52, 2018.<\/p>\n\n\n\n<p>3\uff09Huang L, et al. Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy. Nat Commun, 10:4871, 2019. doi:10.1038\/s41467-019-12771-9.<\/p>\n\n\n\n<p>\u7528\u8a9e\u89e3\u8aac\uff1a<\/p>\n\n\n\n<p><sup>*<\/sup>\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\uff1a\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\uff08Immune checkpoint\uff09\u3068\u306f\u6297\u539f\u306b\u5bfe\u3057\u514d\u75ab\u7cfb\u304c\u4e0d\u5fdc\u7b54 (Anergy) 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