{"id":532,"date":"2020-07-15T20:22:00","date_gmt":"2020-07-15T11:22:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=532"},"modified":"2022-05-26T20:18:35","modified_gmt":"2022-05-26T11:18:35","slug":"%e5%88%86%e5%ad%90%e3%82%b7%e3%83%a3%e3%83%9a%e3%83%ad%e3%83%b3%e7%a0%94%e7%a9%b6%e3%81%af%e6%96%b0%e3%81%9f%e3%81%aa%e3%82%8b%e3%82%b9%e3%83%86%e3%83%bc%e3%82%b8%e3%81%b8","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e5%88%86%e5%ad%90%e3%82%b7%e3%83%a3%e3%83%9a%e3%83%ad%e3%83%b3%e7%a0%94%e7%a9%b6%e3%81%af%e6%96%b0%e3%81%9f%e3%81%aa%e3%82%8b%e3%82%b9%e3%83%86%e3%83%bc%e3%82%b8%e3%81%b8\/","title":{"rendered":"\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u7814\u7a76\u306f\u65b0\u305f\u306a\u308b\u30b9\u30c6\u30fc\u30b8\u3078"},"content":{"rendered":"\n

\u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.114\u3010\u5b66\u8853\u5831\u544a49\u3011<\/p>\n\n\n\n

\u6700\u8fd1\u306e\u8a71\u984c49<\/p>\n\n\n\n

\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u7814\u7a76\u306f\u65b0\u305f\u306a\u308b\u30b9\u30c6\u30fc\u30b8\u3078<\/p>\n\n\n\n

\u9f4b\u5c3e \u667a\u82f1\uff08\u5317\u6d77\u9053\u5927\u5b66\uff09<\/p>\n\n\n\n

\u68ee \u82f1\u4e00\u6717\uff08\u5948\u826f\u770c\u7acb\u533b\u79d1\u5927\u5b66\uff09<\/p>\n\n\n\n

\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306f\uff0c\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6a5f\u80fd\u3059\u308b\u6700\u7d42\u7523\u7269\u3068\u3057\u3066\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u3068\u7ffb\u8a33\u3059\u308b\u30d7\u30ed\u30bb\u30b9\u306e\u6700\u7d42\u6bb5\u968e\u3067\u3042\u308b\uff0e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\uff0c\u6298\u308a\u305f\u305f\u307f\u3084\u305d\u306e\u5f8c\u306e\u6a5f\u80fd\u767a\u73fe\u306b\u81f3\u308b\u307e\u3067\uff0c\u7ffb\u8a33\u5f8c\u4fee\u98fe\u3084\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u306a\u3069\u306b\u3088\u3063\u3066\u53b3\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\uff0e\u7d30\u80de\u304c\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3059\u308b\u969b\uff0cheat shock protein\uff08HSP\uff09\u3068\u547c\u3070\u308c\u308b\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u306b\u3088\u3063\u3066\u5909\u6027\u304b\u3089\u5b88\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\uff0c\u8fd1\u5e74\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u306e\u6982\u5ff5\u304c\u5927\u304d\u304f\u5909\u308f\u308d\u3046\u3068\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

\u3000\u7d30\u80de\u306f\u6838\u3084\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3084\u5c0f\u80de\u4f53\u306a\u3069\uff0c\u819c\u306b\u3088\u3063\u3066\u56f2\u307e\u308c\u305f\u69cb\u9020\u7269\u3067\u3042\u308b\u30aa\u30eb\u30ac\u30cd\u30e9\uff08\u7d30\u80de\u5185\u5c0f\u5668\u5b98\uff09\u306b\u3088\u3063\u3066\u69d8\u3005\u306a\u6a5f\u80fd\u3092\u533a\u753b\u5316\u3057\u3066\u3044\u308b\uff0e2010\u5e74\u4ee3\u306b\u5165\u3063\u3066\u304b\u3089\uff0c\u6838\u5c0f\u4f53\u3084RNA\u9846\u7c92\u306a\u3069\u3068\u3044\u3063\u305f\u819c\u306b\u56f2\u307e\u308c\u3066\u3044\u306a\u3044\u30aa\u30eb\u30ac\u30cd\u30e9\uff08\u975e\u819c\u30aa\u30eb\u30ac\u30cd\u30e9\uff09\u306e\u6a5f\u80fd\u3084\u69cb\u9020\u306b\u3064\u3044\u3066\u306e\u77e5\u898b\u304c\u6025\u901f\u306b\u6df1\u307e\u3063\u305f\uff0e\u975e\u819c\u30aa\u30eb\u30ac\u30cd\u30e9\u306f\uff0c\u751f\u4f53\u5206\u5b50\uff08\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u6838\u9178\u306a\u3069\uff09\u304c\u6db2-\u6db2\u76f8\u5206\u96e2\uff08liquid-liquid phase separation\uff1aLLPS\uff09\u3057\u3066\u5f62\u6210\u3055\u308c\u3066\u304a\u308a\uff0c\u975e\u5e38\u306b\u52d5\u7684\u306a\u69cb\u9020\u7269\u3067\u3042\u308b\uff0e\u3053\u306e\u3088\u3046\u306b\u76f8\u5206\u96e2\u3057\u3066\u5f62\u6210\u3055\u308c\u305f\u7d30\u80de\u5185\u306e\u69cb\u9020\u4f53\u3092\u751f\u7269\u5b66\u7684\u76f8\u5206\u96e2\u3068\u547c\u3073\uff0c\u3053\u306e\u5236\u5fa1\u3068\u7834\u7dbb\u3068\u75be\u60a3\u3068\u306e\u5bc6\u63a5\u306a\u95a2\u4fc2\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u308b1)<\/sup>\uff0e<\/p>\n\n\n\n

\u3000\u751f\u7269\u5b66\u7684\u76f8\u5206\u96e2\u306f\uff0c\u751f\u4f53\u5206\u5b50\u306e\u6bd4\u8f03\u7684\u7de9\u3044\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u6210\u7acb\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u591a\u304f\uff0c\u305d\u308c\u3086\u3048\u7ffb\u8a33\u5f8c\u4fee\u98fe\u3084\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u306b\u3088\u308b\u5fae\u8abf\u6574\u306b\u3088\u3063\u3066\u7cbe\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\uff0e\u6e29\u71b1\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\uff0c\u4e00\u822c\u7684\u306a\u6838\u8f38\u9001\u53d7\u5bb9\u4f53\u306f\u6838\u5916\uff08\u7d30\u80de\u8cea\uff09\u3078\u3068\u79fb\u52d5\u3057\u3066\u3057\u307e\u3044\uff0c\u6838\u2013\u7d30\u80de\u8cea\u9593\u8f38\u9001\u304c\u963b\u5bb3\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\uff0cHSP\u306e\u69d8\u306a\u30b9\u30c8\u30ec\u30b9\u6642\u306b\u5fc5\u8981\u306a\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u7fa4\u306fHIKESHI\u3068\u547c\u3070\u308c\u308b\u6838\u8f38\u9001\u53d7\u5bb9\u4f53\u306b\u3088\u3063\u3066\u6838\u5185\u8f38\u9001\u3055\u308c\u308b2)<\/sup>\uff0e\u307e\u305f\uff0c\u6838\u8f38\u9001\u53d7\u5bb9\u4f53\u81ea\u4f53\u304c\uff0c\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u3067\uff0c\u751f\u7269\u5b66\u7684\u76f8\u5206\u96e2\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b3,4)<\/sup>\uff0e<\/p>\n\n\n\n

\u6e29\u71b1\u306a\u3069\u306e\u7d30\u80de\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u7d30\u80de\u5fdc\u7b54\u3068\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u306e\u95a2\u4fc2\u6027\u3082\uff0c\u5f90\u3005\u306b\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u308b\uff0e\u30b9\u30c8\u30ec\u30b9\u4e0b\u306e\u6838\u5c0f\u4f53\u306b\u304a\u3044\u3066\u306fnucleophosmin\uff08NPM1\uff09*\u3068HSP70\u304c\u5354\u540c\u3057\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u51dd\u96c6\u3059\u308b\u3053\u3068\u304b\u3089\u5b88\u3063\u3066\u3044\u308b5)<\/sup>\uff0e\u307e\u305f\uff0cHSP27\u306f\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u7b54\u3057\uff0cRNA\u3092\u591a\u304f\u542b\u3080\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306b\u5c40\u5728\u3059\u308b\uff0e\u305d\u306e\u969b\uff0c\u540c\u3058\u3088\u3046\u306b\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306b\u5c40\u5728\u3057\u3066\u3044\u308bfused-in-sarcoma (FUS)*\u3068low-complexity (LC)\u30c9\u30e1\u30a4\u30f3*\u3092\u4ecb\u3057\u3066\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\uff0cFUS\u306eLLPS\u2015\u3053\u306e\u5834\u5408\u306f\u7d30\u80de\u8cea\u3067\u306e\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5f62\u6210\u2015\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f6)<\/sup>\uff0e\u3053\u306e\u7814\u7a76\u3067\u306f\uff0c\u5206\u5b50\u52d5\u614b\u306e\u8a55\u4fa1\u306bnuclear magnetic resonance\uff08NMR\uff09\u3068\u547c\u3070\u308c\u308b\u624b\u6cd5\u304c\u6d3b\u304b\u3055\u308c\u3066\u3044\u308b\uff0e\u3055\u3089\u306b\uff0cHSP\u7b49\u306e\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308bheat shock factor 1\uff08HSF1\uff09\u3082\uff0c\u76f8\u5206\u96e2\u3057\u3066\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b7)<\/sup>\uff0eHSF1\u306f\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u7b54\u3057\u7d30\u80de\u6838\u306e\u4e2d\u306b\u5c0f\u3055\u306a\u30d5\u30a9\u30fc\u30ab\u30b9\uff08foci\uff09\u3092\u5f62\u6210\u3059\u308b\u304c\uff0c\u7d30\u80de\u3078\u306e\u30b9\u30c8\u30ec\u30b9\u306e\u8ca0\u8377\u304c\u5927\u304d\u304f\u306a\u308b\u3068HSF1\u306e\u30d5\u30a9\u30fc\u30ab\u30b9\u3082\u5927\u304d\u304f\u5b89\u5b9a\u5316\u3057\u305f\uff0e\u3053\u306e\u3088\u3046\u306b\uff0c\u5f93\u6765\u306e\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u306e\u76f8\u5206\u96e2\u5236\u5fa1\u306b\u304a\u3051\u308b\u6a5f\u80fd\u306b\u3064\u3044\u3066\u3082\uff0c\u5f90\u3005\u306b\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u308b\uff0e\u4eca\u5f8c\uff0c\u751f\u7269\u5b66\u7684\u76f8\u5206\u96e2\u306b\u95a2\u9023\u3059\u308b\u5206\u91ce\u306b\u304a\u3044\u3066\uff0cHSP\u3084\u6838\u8f38\u9001\u53d7\u5bb9\u4f53\u3092\u542b\u3081\u305f\u3088\u308a\u5e83\u7fa9\u306e\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u9032\u3080\u3053\u3068\u3067\uff0c\u7d30\u80de\u306e\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306b\u5bfe\u3059\u308b\u7406\u89e3\u304c\u6df1\u307e\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

  1. \u68ee \u82f1\u4e00\u6717\uff08\u7de8\uff09\uff0e\u76f8\u5206\u96e2\u751f\u7269\u5b66\uff1a\u76f8\u5206\u96e2\u30e1\u30ac\u30cd\u306e\u30b9\u30b9\u30e1\uff08\u7279\u96c6\uff09\uff0e\u751f\u7269\u5de5\u5b66\u4f1a\u8a8c, 98: 228-54, 2020.<\/li>
  2. Kose S, et al<\/em>. Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage. Cell, 149: 578-89, 2012.<\/li>
  3. Yoshizawa T, et al<\/em>. Nuclear import receptor inhibits phase separation of FUS through binding to multiple sites. Cell, 173: 693-705, 2018.<\/li>
  4. Springhower CE, et al. <\/em>Karyopherins and condensates. Curr Opin Cell Biol, 64: 112-23, 2020.<\/li>
  5. Frottin F, et al<\/em>. The nucleolus functions as a phase-separated protein quality control compartment. Science, 365: 342-7, 2019.<\/li>
  6. Liu Z, et al<\/em>. Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation. Nat Struct Mol Biol, 27: 363-72, 2020.<\/li>
  7. Gaglia G, et al<\/em>. HSF1 phase transition mediates stress adaptation and cell fate decisions. Nat Cell Biol, 22: 151-8, 2020.<\/li><\/ol>\n\n\n\n

    \u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n

    *nucleophosmin\uff08NPM1\uff09\uff1a\u7d30\u80de\u6838\u306e\u4e2d\u306b\u3042\u308b\u6838\u5c0f\u4f53\u3068\u547c\u3070\u308c\u308b\u975e\u819c\u30aa\u30eb\u30ac\u30cd\u30e9\u306e\u69cb\u6210\u56e0\u5b50\uff0e\u30ea\u30dc\u30bd\u30fc\u30e0\u751f\u5408\u6210\u3084\u30bb\u30f3\u30c8\u30ed\u30bd\u30fc\u30e0\u8907\u88fd\u3092\u542b\u3081\u305f\u591a\u69d8\u306a\u751f\u547d\u6a5f\u80fd\u306e\u5834\u3092\u62c5\u3063\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

    *fused-in-sarcoma\uff08FUS\uff09\uff1a\u8089\u816b\u306b\u304a\u3051\u308b\u67d3\u8272\u4f53\u8ee2\u5ea7\u306b\u3088\u3063\u3066\u767a\u898b\u3055\u308c\u305fRNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff0e\u8ee2\u5199\u3084\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\uff0cRNA\u8f38\u9001\u3084DNA\u4fee\u5fa9\u306a\u3069\uff0c\u69d8\u3005\u306a\u6838\u9178\u5236\u5fa1\u306b\u95a2\u308f\u308b\u6a5f\u80fd\u3092\u62c5\u3063\u3066\u3044\u308b\uff0e\u5909\u7570\u306b\u3088\u308b\u6a5f\u80fd\u7570\u5e38\u3068\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u3084\u524d\u982d\u5074\u982d\u578b\u8a8d\u77e5\u75c7\uff08FTD\uff09\u7b49\u306e\u795e\u7d4c\u96e3\u75c5\u3068\u306e\u95a2\u9023\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u308b\uff0e\u307e\u305f\u8fd1\u5e74\uff0c\u751f\u7269\u5b66\u7684\u76f8\u5206\u96e2\u306e\u30e2\u30c7\u30eb\u5206\u5b50\u3068\u3057\u3066\u7814\u7a76\u304c\u76db\u3093\u306b\u304a\u3053\u306a\u308f\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

    *low-complexity\uff08LC\uff09\u30c9\u30e1\u30a4\u30f3\uff1a20\u7a2e\u985e\u306e\u30a2\u30df\u30ce\u9178\u306e\u4e2d\u304b\u3089\u9650\u3089\u308c\u305f\u6570\u500b\u306e\u30a2\u30df\u30ce\u9178\u306e\u307f\u3092\u7528\u3044\u3066\u5f62\u6210\u3055\u308c\u308b\u9818\u57df\u3092\u6307\u3057\uff0c\u4f4e\u8907\u96d1\u6027\u914d\u5217\u3068\u8a33\u3055\u308c\u308b\uff0e\u4e00\u822c\u7684\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e2\u6b21\u69cb\u9020\u3092\u53d6\u3089\u306a\u3044\u3053\u3068\u304b\u3089\uff0c\u5929\u7136\u5909\u6027\u914d\u5217\u3068\u3082\u547c\u3070\u308c\u308b\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u4e00\u793e\uff09\u65e5\u672c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\u30cb\u30e5\u30fc\u30b9No.114\u3010\u5b66\u8853\u5831\u544a49\u3011 \u6700\u8fd1\u306e\u8a71\u984c49 \u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u7814\u7a76\u306f\u65b0\u305f\u306a\u308b\u30b9\u30c6\u30fc\u30b8\u3078 \u9f4b\u5c3e \u667a\u82f1\uff08\u5317\u6d77\u9053\u5927\u5b66\uff09 \u68ee \u82f1\u4e00\u6717\uff08\u5948\u826f\u770c\u7acb\u533b\u79d1\u5927\u5b66\uff09 \u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306f\uff0c\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6a5f\u80fd\u3059\u308b […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-532","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/532","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=532"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/532\/revisions"}],"predecessor-version":[{"id":533,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/532\/revisions\/533"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=532"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=532"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=532"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}