{"id":534,"date":"2020-06-29T20:23:00","date_gmt":"2020-06-29T11:23:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=534"},"modified":"2022-05-26T20:18:57","modified_gmt":"2022-05-26T11:18:57","slug":"%e6%b0%97%e7%ae%a1%e6%94%af%e3%82%b5%e3%83%bc%e3%83%a2%e3%83%97%e3%83%a9%e3%82%b9%e3%83%86%e3%82%a3%e3%81%af%e4%b8%8a%e7%9a%ae%e7%b4%b0%e8%83%9e%e7%94%b1%e6%9d%a5hsp60%e3%81%ae%e5%88%86%e6%b3%8c","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e6%b0%97%e7%ae%a1%e6%94%af%e3%82%b5%e3%83%bc%e3%83%a2%e3%83%97%e3%83%a9%e3%82%b9%e3%83%86%e3%82%a3%e3%81%af%e4%b8%8a%e7%9a%ae%e7%b4%b0%e8%83%9e%e7%94%b1%e6%9d%a5hsp60%e3%81%ae%e5%88%86%e6%b3%8c\/","title":{"rendered":"\u6c17\u7ba1\u652f\u30b5\u30fc\u30e2\u30d7\u30e9\u30b9\u30c6\u30a3\u306f\u4e0a\u76ae\u7d30\u80de\u7531\u6765HSP60\u306e\u5206\u6ccc\u3068\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30a2\u30eb\u30ae\u30cb\u30f3\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u6c17\u9053\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u6539\u5584\u3059\u308b"},"content":{"rendered":"\n

\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c48<\/p>\n\n\n\n

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\u5ca1\u6fa4\u6210\u7950, \u8fd1\u85e4\u3000\u9686*<\/p>\n\n\n\n

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\u96e3\u6cbb\u6027\u6c17\u7ba1\u652f\u5598\u606f\u3067\u306f\u5404\u7a2e\u6297\u4f53\u88fd\u5264\u306e\u958b\u767a\u304c\u3081\u3056\u307e\u3057\u3044\u304c\uff0c\u6297\u4f53\u88fd\u5264\u304c\u7121\u52b9\u306a\u307b\u3069\u306e\u96e3\u6cbb\u6027\u5598\u606f\u306e\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u6c17\u7ba1\u652f\u30b5\u30fc\u30e2\u30d7\u30e9\u30b9\u30c6\u30a3*1<\/sup>\uff08\u6c17\u7ba1\u652f\u71b1\u5f62\u6210\u8853\uff09(Bronchial thermoplasty\uff0c\u4ee5\u4e0bBT)\u304c\uff0c\u6c17\u9053\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0*2<\/sup>\u3092\u6539\u5584\u3059\u308b\u65b0\u3057\u3044\u7269\u7406\u7684\u6cbb\u7642\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b. \u3057\u304b\u3057\uff0c\u305d\u306e\u5206\u5b50\u6a5f\u5e8f\u306f\u5341\u5206\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044.\u6c17\u9053\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3068\u306f\u6c17\u7ba1\u652f\u5598\u606f\u306e\u96e3\u6cbb\u5316\u306e\u904e\u7a0b\u3067\u6c17\u7ba1\u652f\u58c1\u304c\u7dda\u7dad\u5316\u3092\u4f34\u3063\u305f\u539a\u3044\u5c64\u306b\u306a\u308b\u3053\u3068\u3067\u3042\u308b\uff0e\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u6c17\u7ba1\u652f\u5598\u606f\u60a3\u8005\u306e\u6c17\u7ba1\u652f\u5e73\u6ed1\u7b4b\u3067\u306f\u3001PRMT1(\u30bf\u30f3\u30d1\u30af\u8cea\u30a2\u30eb\u30ae\u30cb\u30f3\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc1)*3<\/sup>\u304c\u9ad8\u767a\u73fe\u3057\u3066\u304a\u308a\uff0c\u3053\u306ePRMT1\u306f\u80ba\u7dda\u7dad\u75c7\u3084\u6c17\u7ba1\u652f\u5598\u606f\u306e\u75c5\u7406\u904e\u7a0b\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

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\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

  1. Sun Q, et al<\/em>. Bronchial thermoplasty decreases airway remodelling by blocking epithelium-derived heat shock protein-60 secretion and protein arginine methyltransferase-1 in fibroblasts. Eur Respir J. 54(6):1900300, 2019.<\/li>
  2. Langton<\/a> D, et al<\/em>. Bronchial thermoplasty versus mepolizumab: Comparison of outcomes in a severe asthma clinic. Respirology. 2020 May 4. doi: 10.1111\/resp.13830. Online ahead of print.<\/li><\/ol>\n\n\n\n

    \u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n

    *1. \u6c17\u7ba1\u652f\u30b5\u30fc\u30e2\u30d7\u30e9\u30b9\u30c6\u30a3\uff08Bronchial thermoplasty, BT\uff09\uff1a\u6c17\u7ba1\u652f\u71b1\u5f62\u6210\u8853\u3068\u3044\u3046. 2015\u5e747\u6708\u306b\u65e5\u672c\u3067\u3082\u4fdd\u967a\u9069\u5fdc\u3068\u306a\u3063\u305f\u6c17\u7ba1\u652f\u5598\u606f\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u3067\u3042\u308b. \u96e3\u6cbb\u6027\u5598\u606f\u3067\u80a5\u539a\u3057\u305f\u6c17\u9053\u5e73\u6ed1\u7b4b\u306b\u5bfe\u3057\u3066\u5c40\u6240\u52a0\u71b1\u51e6\u7406\u3067\u6c17\u9053\u58c1\u5e73\u6ed1\u7b4b\u3092\u6e1b\u5c11\u3055\u305b\u308b. \u5185\u5f843\uff5e10\u3000mm\u306e\u6c17\u7ba1\u652f\u3092\u5bfe\u8c61\u306b, \u6c17\u7ba1\u652f\u93e1\u4e0b\u306b\u5c02\u7528\u306e\u30ab\u30c6\u30fc\u30c6\u30eb\u3092\u633f\u5165\u3057, \u76ee\u7684\u3068\u3059\u308b\u6c17\u7ba1\u652f\u3067\u30d0\u30b9\u30b1\u30c3\u30c8\u3092\u958b\u304d, \u9ad8\u5468\u6ce2\u96fb\u6d41\u306b\u3088\u308a65\u2103\u306710\u79d2\u9593\u901a\u96fb\u3059\u308b. \u6cbb\u7642\u88c5\u7f6e\u3068\u3057\u3066Alair\u2122\u6c17\u7ba1\u652f\u30b5\u30fc\u30e2\u30d7\u30e9\u30b9\u30c6\u30a3\uff08BT\uff09\u30b7\u30b9\u30c6\u30e0\u304c\u3042\u308b. \u8a73\u7d30\u306b\u3064\u3044\u3066\u306f\u56fd\u7acb\u56fd\u969b\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u75c5\u9662\u306e\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\uff08http:\/\/www.hosp.ncgm.go.jp\/s003\/010\/110\/index.html<\/a>\uff09\u3092\u53c2\u7167\u3055\u308c\u305f\u3044.<\/p>\n\n\n\n

    *<\/sup>2. \u6c17\u9053(\u6c17\u7ba1\u652f)\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\uff1a\u50b7\u5bb3\u3092\u53d7\u3051\u305f\u6c17\u9053\u7d44\u7e54\u306b\u7a2e\u3005\u306e\u4fee\u5fa9\u6a5f\u8ee2\u304c\u50cd\u3044\u305f\u7d50\u679c\uff0c\u6b63\u5e38\u304b\u3089\u9038\u8131\u3057\u305f\u75c5\u7684\u306a\u69cb\u9020\u5909\u5316\u3092\u751f\u3058\uff0c\u6a5f\u80fd\u4f4e\u4e0b\u3092\u3082\u305f\u3089\u3059\u3053\u3068\uff0e\u7279\u306b\u975e\u53ef\u9006\u7684\u306a\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306f\uff0c\u6c17\u7ba1\u652f\u5598\u606f\u306e\u96e3\u6cbb\u5316\u306e\u91cd\u8981\u306a\u8981\u56e0\u3068\u8003\u3048\u3089\u308c\u308b. \u3053\u308c\u306f\u5358\u7d14\u306b\u8a33\u3059\u3068\u300e\u6c17\u7ba1\u652f\u306e\u518d\u69cb\u7bc9\u300f\u3067\u3042\u308b. \u8fd1\u5e74, \u91cd\u75c7\u5316\u3057\u305f\u96e3\u6cbb\u6027\u5598\u606f\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u3064\u3068\u3057\u3066, \u75c5\u7406\u5b66\u7684\u306a\u7406\u89e3\u304c\u6df1\u307e\u308a, \u6c17\u7ba1\u652f\u58c1\u304c\u7dda\u7dad\u5316\u3092\u4f34\u3063\u305f\u539a\u3044\u5c64\u306b\u306a\u308b\u3053\u3068\u3092\u610f\u5473\u3057, \u6162\u6027\u7684\u306a\u6c17\u9053\u72ed\u7a84\u3092\u3082\u305f\u3089\u3059. \u3053\u306e\u72ed\u7a84\u306f, \u5358\u7d14\u306a\u6c17\u9053\u306e\u53ce\u7e2e\uff08\u6c17\u7ba1\u652f\u3092\u53d6\u308a\u5dfb\u304f\u7b4b\u8089\u306e\u53ce\u7e2e\uff09\u3084\u6d6e\u816b\u3068\u9055\u3063\u3066, \u5341\u5206\u306b\u56de\u5fa9\u3057\u306a\u3044. \u6c17\u7ba1\u652f\u5598\u606f\u306f\uff0c\u6c17\u9053\u306e\u6162\u6027\u708e\u75c7\u6027\u75be\u60a3\u3067\u3042\u308a, \u305d\u306e\u6162\u6027\u708e\u75c7\u306b\u3088\u3063\u3066\u6c17\u9053\u904e\u654f\u6027\u304c\u4e0a\u6607\u3057, \u6c17\u9053\u306e\u7b4b\u8089\u53ce\u7e2e\u30fb\u6d6e\u816b\u30fb\u7c98\u6db2\u904e\u5206\u6ccc\u3068\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306b\u3088\u3063\u3066\u6c17\u9053\u72ed\u7a84\uff08\u6c17\u6d41\u9589\u585e\uff09\u3092\u3082\u305f\u3089\u3057, \u606f\u5207\u308c\u30fb\u5598\u9cf4\u30fb\u54b3\u306a\u3069\u306e\u767a\u4f5c\u75c7\u72b6\u3092\u8d77\u3053\u3059\u3068\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n

    *<\/sup>3. \u30bf\u30f3\u30d1\u30af\u8cea\u30a2\u30eb\u30ae\u30cb\u30f3\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff08Protein Arginine Methyltransferase\uff1aPRMT\uff09\uff1aPRMT1\u306f\u4e3b\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u30a2\u30eb\u30ae\u30cb\u30f3\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u306e\u4e00\u3064\u3067\u3042\u308b.1996\u5e74\u306bGary \u3089\u306b\u3088\u308a\u540c\u5b9a\u3055\u308c\u305f. in vitro<\/em>\u3068in vivo<\/em>\u3067, \u30d2\u30b9\u30c8\u30f3H4\u306e3\u756a\u76ee\u306e\u30a2\u30eb\u30ae\u30cb\u30f3\uff08Arg3\uff09\u3092\u7279\u7570\u7684\u306b\u30e1\u30c1\u30eb\u5316\u3059\u308b. \u3053\u308c\u306b\u3088\u308a, \u6838\u5185\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\u306b\u3088\u308b\u8ee2\u5199\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b. \u76f8\u540c\u7d44\u63db\u3048\u4fee\u5fa9\u3068\u975e\u76f8\u540c\u672b\u7aef\u7d50\u5408\u4fee\u5fa9\u53cd\u5fdc\u306e\u4e21\u65b9\u306b\u95a2\u4e0e\u3059\u308bDNA \u4fee\u5fa9\u9175\u7d20\u3067\u3042\u308bMRE11\u304cPRMT\uff11\u306b\u3088\u308a\u30e1\u30c1\u30eb\u5316\u3055\u308c\u308b\u7b49, DNA\u4fee\u5fa9\u6d3b\u6027\u306b\u304a\u3044\u3066\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\uff0e\u5598\u606f\u60a3\u8005\u306e\u6c17\u9053\u5e73\u6ed1\u7b4b\u7d30\u80de\u3067\u306f\u9ad8\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

    *4. CCAAT\/\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u4ee5\u4e0bC\/EBP\uff09\uff1aCCAAT\/\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u4ee5\u4e0bC\/EBP\uff09\u30d5\u30a1\u30df\u30ea\u30fc\u306f, C\u672b\u7aef\u306b\u5869\u57fa\u6027\u30ed\u30a4\u30b7\u30f3\u30b8\u30c3\u30d1\u30fc\u3092\u6301\u3061, \u30d8\u30c6\u30ed\u30c0\u30a4\u30de\u30fc\u3042\u308b\u3044\u306f\u30db\u30e2\u30c0\u30a4\u30de\u30fc\u3092\u5f62\u6210\u3057\u3066DNA\u306b\u7d50\u5408\u3057, \u69d8\u3005\u306a\u7d30\u80de\u306b\u304a\u3044\u3066\u708e\u75c7\u30fb\u5897\u6b96\u30fb\u4ee3\u8b1d\u30fb\u5206\u5316\u30fb\u7d30\u80de\u5897\u6b96\u306a\u3069\u306b\u5354\u8abf\u7684\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u8ee2\u5199\u56e0\u5b50\u7fa4\u3067\u3042\u308b. C\/EBP\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u306fC\/EBP\u03b1, \u03b2, \u03b3, \u03b4, \u03b5, \u03b6\u306e6\u7a2e\u985e\u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u304c\u3042\u308a, \u305d\u306e\u5185C\/EBP\u03b1, \u03b2, \u03b4, \u03b5\u306e4\u7a2e\u985e\u304c\u8ee2\u5199\u6d3b\u6027\u5316\u30c9\u30e1\u30a4\u30f3\u3092\u6709\u3059\u308b\uff0e<\/p>\n\n\n\n

    *5. miR-19a\uff1amiR-17-92\u30af\u30e9\u30b9\u30bf\u30fc\uff08miR-17\uff0cmiR-18a\uff0cmiR-20a\uff0cmiR-19b-1\uff0cmiR-92a-1\uff09\u306e\u4e00\u3064\uff0e6\u3064\u306emiRNA\u306f\uff0c\u7d041kb\u306e\u30b2\u30ce\u30e0\u9818\u57df\u306b\u8fd1\u63a5\u3057\u3066\u9023\u7d9a\u3059\u308b\u5f62\u3067\u914d\u7f6e\u3055\u308c\u3066\u304a\u308a\uff0c\u3053\u308c\u3089\u306emiRNA\u306e\u524d\u99c6\u4f53\u3092\u542b\u3080\u4e00\u3064\u306e\u30db\u30b9\u30c8RNA\uff08miRNA\u4e00\u6b21\u8ee2\u5199\u7523\u7269\uff09\u304b\u3089\u7523\u751f\u3055\u308c\u308b\uff0e\u3053\u306e\u3088\u3046\u306b\u8fd1\u63a5\u3057\u3066\u5b58\u5728\u3057\uff0c\u4e00\u3064\u306e\u30db\u30b9\u30c8RNA\u304b\u3089\u7523\u751f\u3055\u308c\u308bmiRNA\u7fa4\u306fmiRNA\u30af\u30e9\u30b9\u30bf\u30fc\u3068\u547c\u79f0\u3059\u308b\uff0e<\/p>\n\n\n\n

    *<\/sup>6. ERK1\/2(extracellular signal-regulated kinase-1\/2)<\/p>\n\n\n\n

    ERK\u306f\u7d30\u80de\u5916\u304b\u3089\u306e\u523a\u6fc0\u3092\u6838\u306b\u4f1d\u9054\u3059\u308bMAP\u30ad\u30ca\u30fc\u30bc\u30fb\u30b5\u30d6\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u3064\u3067\u3042\u308a\uff0cERK1\u3068ERK2\u3068\u3044\u3046\u9ad8\u3044\u76f8\u540c\u914d\u5217\u3092\u6301\u3064\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u304c\u5b58\u5728\u3059\u308b\uff0eERK2\u306f\u7d30\u80de\u8cea\uff0c\u6838\u306b\u304a\u3044\u3066\u69d8\u3005\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u57fa\u8cea\u3068\u3057\u3066\u30ea\u30f3\u9178\u5316\u3059\u308b\u4e8b\u3067\uff0c\u7d30\u80de\u5468\u671f\u5236\u5fa1\u304b\u3089\u8133\u306e\u9ad8\u6b21\u6a5f\u80fd\u307e\u3067\u69d8\u3005\u306a\u7d30\u80de\u6a5f\u80fd\u306b\u5e83\u7bc4\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

    *7. PGC1\u03b1 (peroxisome proliferator-activated receptor-\u03b3 coactivator-1\u03b1): Peroxisome proliferator-activated receptor-\u03b3\uff08PPAR-\u03b3\uff09\u30b3\u30a2\u30af\u30c1\u30d9\u30fc\u30bf-1\u03b1\uff08PGC-1\u03b1\uff09\u306f\uff0c\u7279\u306bNRF-1\u3068TFAM\u306a\u3069\u8ee2\u5199\u5236\u5fa1\u56e0\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\uff0ePGC-1\u03b1\u306f\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u5f37\u529b\u306a\u8abf\u7bc0\u88c5\u7f6e\u3067\u3042\u308a\uff0c\u9069\u5fdc\u6027\u71b1\u7523\u751f\uff0c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30d0\u30a4\u30aa\u30b8\u30a7\u30cd\u30b7\u30b9\uff0c\u30d6\u30c9\u30a6\u7cd6\u3068\u8102\u80aa\u9178\u4ee3\u8b1d\u3092\u542b\u3080\u591a\u7a2e\u591a\u69d8\u306a\u751f\u4f53\u5fdc\u7b54\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\uff0e\u901a\u5e38\u306f\uff0c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u8c4a\u5bcc\u306a\u6d3b\u52d5\u6027\u9178\u5316\u4ee3\u8b1d\u7d44\u7e54\uff08\u4f8b\u3048\u3070\u5fc3\u81d3\u3068\u9aa8\u683c\u7b4b\u306a\u3069\uff09\u3067\u9ad8\u5ea6\u306b\u767a\u73fe\u3059\u308b\uff0e<\/p>\n\n\n\n

    *<\/sup>8. \u71b1\u30b7\u30e7\u30c3\u30af\u86cb\u767d\u8cea60\uff08HSP60\uff09\uff1a\u5225\u540d\u306fHSPD1\u3067, \u30b7\u30e3\u30da\u30ed\u30cb\u30f3\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u30e1\u30f3\u30d0\u30fc\u3067\u3042\u308a,\u751f\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u7d30\u80de\u751f\u5b58\u3092\u4fc3\u9032\u3059\u308b\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b. HSP60\u306f, \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u304a\u3051\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u6298\u308a\u305f\u305f\u307f\u3084\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\u9396\u306e\u7d44\u307f\u7acb\u3066\u7b49, \u591a\u304f\u306e\u7d30\u80de\u6a5f\u80fd\u3068\u306e\u95a2\u9023\u304c\u793a\u3055\u308c\u3066\u3044\u308b. \u8fd1\u5e74\uff0cHSP60\u306f, \u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3084\u764c\u7d30\u80de\u5897\u6b96\u963b\u5bb3\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b. \u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u306e\u4e2d\u3067\u3082, \u7279\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u305f\u305f\u307f\u306b\u91cd\u8981\u3067\u3042\u308b\u5206\u5b50\u304c\u30b7\u30e3\u30da\u30ed\u30cb\u30f3\u3067\u3042\u308b. \u30b7\u30e3\u30da\u30ed\u30cb\u30f3\u306f\u305d\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u3084\u69cb\u9020\u7684\u7279\u6027\u3092\u57fa\u306b\u5927\u304d\u304f\u4e8c\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u2160\u304a\u3088\u3073\u30b0\u30eb\u30fc\u30d7\u2161\u306b\u5206\u3051\u3089\u308c\u308b. \u30b0\u30eb\u30fc\u30d7\u2160\u30b7\u30e3\u30da\u30ed\u30cb\u30f3\u306b\u306f\u539f\u6838\u751f\u7269\u306eGroEL \u3084\u771f\u6838\u751f\u7269\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2HSP60, \u30b0\u30eb\u30fc\u30d7\u2161\u30b7\u30e3\u30da\u30ed\u30cb\u30f3\u306b\u306f\u771f\u6838\u751f\u7269\u306e\u7d30\u80de\u8cea\u30b7\u30e3\u30da\u30ed\u30cb\u30f3CCT \u3084\u53e4\u7d30\u83cc\u30b0\u30eb\u30fc\u30d7\u2161\u30b7\u30e3\u30da\u30ed\u30cb\u30f3\u306a\u3069\u304c\u5b58\u5728\u3059\u308b.<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c48 \u6c17\u7ba1\u652f\u30b5\u30fc\u30e2\u30d7\u30e9\u30b9\u30c6\u30a3\u306f\u4e0a\u76ae\u7d30\u80de\u7531\u6765HSP60\u306e\u5206\u6ccc\u3068\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30a2\u30eb\u30ae\u30cb\u30f3\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u6c17\u9053\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u6539\u5584\u3059\u308b \u5ca1\u6fa4\u6210\u7950, \u8fd1\u85e4\u3000\u9686* […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-534","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=534"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/534\/revisions"}],"predecessor-version":[{"id":535,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/534\/revisions\/535"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=534"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}