{"id":544,"date":"2020-05-01T20:26:00","date_gmt":"2020-05-01T11:26:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=544"},"modified":"2022-05-26T20:22:51","modified_gmt":"2022-05-26T11:22:51","slug":"%e5%b7%a8%e5%a4%a7%e3%81%aa%e5%88%87%e9%99%a4%e4%b8%8d%e8%83%bd%e4%bb%99%e9%aa%a8%e8%84%8a%e7%b4%a2%e8%85%ab%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e5%b7%a8%e5%a4%a7%e3%81%aa%e5%88%87%e9%99%a4%e4%b8%8d%e8%83%bd%e4%bb%99%e9%aa%a8%e8%84%8a%e7%b4%a2%e8%85%ab%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc\/","title":{"rendered":"\u5de8\u5927\u306a\u5207\u9664\u4e0d\u80fd\u4ed9\u9aa8\u810a\u7d22\u816b\u306b\u304a\u3051\u308b\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u540c\u6642\u4f75\u7528\u30b9\u30dd\u30c3\u30c8\u30b9\u30ad\u30e3\u30cb\u30f3\u30b0\u967d\u5b50\u7dda\u6cbb\u7642\u5f8c\u306e\u65e9\u671f\u306e\u81e8\u5e8a\u6210\u7e3e\u3068\u816b\u760d\u4f53\u7a4d\u5206\u6790"},"content":{"rendered":"\n

\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c43<\/p>\n\n\n\n

\u5de8\u5927\u306a\u5207\u9664\u4e0d\u80fd<\/strong>\u4ed9\u9aa8\u810a\u7d22\u816b<\/strong><\/em>\u306b\u304a\u3051\u308b\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u540c\u6642\u4f75\u7528\u30b9\u30dd\u30c3\u30c8\u30b9\u30ad\u30e3\u30cb\u30f3\u30b0\u967d\u5b50\u7dda\u6cbb\u7642\u5f8c\u306e\u65e9\u671f\u306e\u81e8\u5e8a\u6210\u7e3e\u3068\u816b\u760d\u4f53\u7a4d\u5206\u6790<\/strong><\/p>\n\n\n\n

\u8fd1\u85e4\u3000\u9686, \u6c34\u4e0a\u9054\u6cbb, \u9f4b\u85e4\u6df3\u4e00<\/p>\n\n\n\n

\uff08\u5bcc\u5c71\u5927\u5b66\u5b66\u8853\u7814\u7a76\u90e8\u533b\u5b66\u7cfb, \u653e\u5c04\u7dda\u8a3a\u65ad\u30fb\u6cbb\u7642\u5b66\u8b1b\u5ea7, \u653e\u5c04\u7dda\u816b\u760d\u5b66\u90e8\u9580\uff09<\/strong><\/p>\n\n\n\n

\u30cf\u30a4\u30d1\u30fc\u30b5\u30df\u30a2(HT)\u304c\u653e\u5c04\u7dda\u6cbb\u7642\u52b9\u679c\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u306f\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u6700\u8fd1\uff0c\u7dda\u91cf\u5206\u5e03\u306b\u512a\u308c\u305f\u967d\u5b50\u7dda\u6cbb\u7642\u306b\u3082HT\u3068\u306e\u4f75\u7528\u304c\u6709\u52b9\u306a\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f\u81e8\u5e8a\u5831\u544a\u304c\u3042\u308b1)<\/sup>.<\/p>\n\n\n\n

\u5207\u9664\u4e0d\u80fd\u4ed9\u9aa8\u810a\u7d22\u816b\u60a3\u8005<\/em>5<\/em>\u540d<\/em>(57<\/em>\uff5e<\/em>72<\/em>\u6b73\u3001\u7537\u6027<\/em>)<\/em>\u306b<\/em>70 Gy(RBE)(1<\/em>\u56de<\/em>2.5 Gy(RBE) x 28<\/em>\u5206\u5272\u3001\u9031<\/em>5<\/em>\u56de\uff0c<\/em>5.5<\/em>\u9031<\/em>)<\/em>\uff0c<\/em>Paul Scherrer Institute<\/em>\u306e<\/em>\u967d\u5b50\u7dda\u6cbb\u7642\u30bb\u30f3\u30bf\u30fc\u306e\u30da\u30f3\u30b7\u30eb\u30d3\u30fc\u30e0<\/em>\u30b9\u30ad\u30e3\u30cb\u30f3\u30b0\u5f37\u5ea6\u5909\u8abf\u967d\u5b50\u7dda\u6cbb\u7642\u88c5\u7f6e\u3067\u967d\u5b50\u7dda\u3092\u7167\u5c04\u3057\u305f<\/em>\uff0eHT\u6cbb\u7642\u306f\u6bce\u9031\u884c\u308f\u308c\uff0c<\/em>Sigma-HyperPlan<\/em>\u306b\u3088\u308b\u6cbb\u7642\u8a08\u753b\u306b\u57fa\u3065\u304d\uff0c<\/em>BSD 2000<\/em>\u306b\u3088\u308a\uff0c<\/em>100 MHz RF<\/em>\u6ce2\u52a0\u6e29\u306b\u3088\u308b<\/em>HT\u6cbb\u7642\u3092\u5b9f\u65bd\u3057\u305f\uff0e\u52a0\u6e29\u6642\u9593\u306f47\uff5e92\u5206\uff0c<\/em>\u5e73\u5747\u306eHT\u6cbb\u7642\u304a\u3088\u3073\u967d\u5b50\u7dda\u6cbb\u7642\u306e\u9593\u9694\u306f123\u5206\uff0892\uff5e172\uff09\u3067\u3042\u3063\u305f\uff0e\u816b\u760d\u4f53\u7a4d\u4e2d\u592e\u5024735 cc(369\uff5e42), \u8ffd\u8de1\u671f\u9593\u306e\u4e2d\u592e\u502418\u304b\u6708\uff089\uff5e26\uff09\u3067\u3042\u3063\u305f\uff0eMRI\u753b\u50cf\u4e0a\u660e\u3089\u304b\u306a\u816b\u760d\u306e\u7e2e\u5c0f\u3092\u8a8d\u3081\uff0c<\/em>\u7e2e\u5c0f\u7387\u306e\u4e2d\u592e\u502446\uff05(9\uff5e72)\u3067\u3042\u3063\u305f\uff0eRECIST guideline (version 1.1)\u306b\u3088\u308b\u52b9\u679c\u5224\u5b9a\u306fPR3\u4f8b\u3001SD\u304c2\u4f8b\u3067\u3042\u3063\u305f\uff0e\u6709\u5bb3\u4e8b\u8c61\u306fCTCAE_v4\u3067\u8a55\u4fa1\u3055\u308c\u305f\uff0e\u5168\u4f8b\u3067\u6025\u6027\u306e\u30b0\u30ec\u30fc\u30c92-3\u306e\u5c40\u6240\u75bc\u75db\u3092\u8a8d\u3081\u305f\uff0e1\u4f8b\u3067\u306f\u6669\u671f\u30b0\u30ec\u30fc\u30c93\u306e\u8178\u9aa8\u9aa8\u6298\u3092\u8a8d\u3081\u305f\uff0e\u53d7\u5bb9\u53ef\u80fd\u306a\u6709\u5bb3\u4e8b\u8c61\u3067\u3042\u308a\uff0c<\/em>\u4f75\u7528\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f1)<\/sup>\uff0e<\/p>\n\n\n\n

\u3000\u540c\u30b0\u30eb\u30fc\u30d7\u306f\u6700\u521d\u306e\u6e29\u71b1\u967d\u5b50\u7dda\u6cbb\u7642\u30922\u4f8b\u306e\u5207\u9664\u4e0d\u80fd\u306a\u4e0b\u80a2\u8edf\u90e8\u7d44\u7e54\u8089\u816b(\u30b0\u30ec\u30fc\u30c92\u7c98\u6db2\u6027\u7e4a\u7dad\u8089\u816b\uff0c<\/em>\u30b0\u30ec\u30fc\u30c93\u672a\u5206\u5316\u591a\u578b\u8089\u816b)\u306b\u5b9f\u65bd\u3057\u305f\uff0e1<\/em>\u56de<\/em>2.0 Gy (RBE)<\/em>\u3067<\/em>7<\/em>\u9031\u9593\uff0c\u8a08<\/em>70-72 Gy(RBE)<\/em>\u7167\u5c04\u3057\uff0c\u9031<\/em>1<\/em>\u56de\u967d\u5b50\u7dda\u6cbb\u7642\u5f8c\u306b<\/em>HT\u6cbb\u7642\u3092\u5b9f\u65bd\u3057\u305f<\/em>\uff0e\u660e\u3089\u304b\u306a\u65e9\u671f\uff0c\u6669\u671f\u306e\u6709\u5bb3\u4e8b\u8c61\u306f\u306a\u304b\u3063\u305f<\/em>\uff0e\u307e\u305f\uff0c<\/em>MRI<\/em>\u753b\u50cf\u4e0a\u306e<\/em>\u52b9\u679c\u5224\u5b9a\u306fCR\u3067\u3042\u3063\u305f\uff0e\u60a3\u8005\u306f\u8ffd\u8de1\u671f\u95935\u304a\u3088\u307314\u304b\u6708\u306e\u9593\uff0c<\/em>\u5c4b\u5185\u5916\u306e\u6d3b\u52d5\u304c\u53ef\u80fd\u3067\u3042\u3063\u305f2<\/sup>\uff09<\/sup>\uff0e<\/p>\n\n\n\n

\u3000\u672c\u90a6\u3067\u3082\u7b51\u6ce2\u5927\u5b66\u3067\u60aa\u6027\u7dda\u7dad\u6027\u7d44\u7e54\u7403\u816b(MFH)\u306b\u5bfe\u3057\u3066\u6e29\u71b1\u967d\u5b50\u7dda\u6cbb\u7642\u304c\u884c\u308f\u308c\u305f\uff0e60\u6b73\uff0c<\/em>\u7537\u6027\uff0c<\/em>\u5de6\u5927\u817f\u90e8\u306e6\u00d74 cm\u306eMFH\u306b, 18\u5206\u5272, \u8a0872 Gy (RBE)<\/em>\u306e\u967d\u5b50\u7dda\u30687\u56de\u306eHT\u6cbb\u7642\u304cThermotron-RF8\u3067\u884c\u308f\u308c\u305f\uff0eHT\u6cbb\u7642\u306f\u967d\u5b50\u7dda\u6cbb\u7642\u76f4\u5f8c\u306b\u5b9f\u65bd\u3055\u308c\uff0c<\/em>RF\u51fa\u529b900 W\uff0c\u52a0\u6e29\u6642\u9593\u306f60\u5206\u3067\u3042\u3063\u305f\uff0e7\u5e74\u9593\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\uff0c<\/em>\u91cd\u7be4\u306a\u65e9\u671f\u53ca\u3073\u6669\u671f\u6709\u5bb3\u4e8b\u8c61\u306f\u306a\u304f\uff0c<\/em>\u9577\u671f\u306b\u308f\u305f\u308b\u5c40\u6240\u5236\u5fa1\u304c\u53ef\u80fd\u3067\u3042\u3063\u305f3<\/sup>\uff09<\/sup>\uff0e<\/p>\n\n\n\n

\u3053\u308c\u3089\u3092\u6bd4\u8f03\u3057\u3066\u307f\u308b\u3068\uff0c\u5f8c\u534a2\u8ad6\u6587\u306e\u7167\u5c04\u7dda\u91cf\u306f2 Gy (RBE)<\/em>\/\u56de\u3067\u3042\u308b\u306e\u306b\u5bfe\u3057\u3066\uff0c\u4e3b\u8ad6\u6587\u306f2.5 Gy (RBE)<\/em>\/\u56de\u3067\u3042\u308a\uff0c<\/em>\u7dcf\u7dda\u91cf70 Gy(RBE)\u306f\u99ac\u5c3e\u306e\u8010\u5bb9\u7dda\u91cf\u3092\u8d85\u3048\u308b\u305f\u3081\uff0c\u9577\u671f\u306e\u5b89\u5168\u6027\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3068\u601d\u308f\u308c\u308b\uff0e\u901a\u5e38\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u62b5\u6297\u6027\u3067\u3042\u308b\u810a\u7d22\u816b\u306b\u5bfe\u3057\uff0c\u6cbb\u7642\u5f37\u5ea6\u3092\u9ad8\u3081\u305f\u967d\u5b50\u7dda\u6cbb\u7642\u3068HT\u306e\u4f75\u7528\u306f\u6709\u671b\u306a\u53ef\u80fd\u6027\u304c\u3042\u308b\u304c\uff0c\u4eca\u5f8c\uff0c\u6669\u671f\u795e\u7d4c\u969c\u5bb3\u306a\u3069\u306e\u8a55\u4fa1\u306b\u3064\u3044\u3066\u306f\u7559\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\uff0e<\/p>\n\n\n\n

\u5c1a\uff0c<\/em>\u30a4\u30f3\u30d3\u30c8\u30ed\u306e\u5b9f\u9a13\u7cfb\u3067\u306fCHO (Chinese hamster ovary)\u7d30\u80de\u306e\u91ce\u751f\u682a\u304a\u3088\u3073DNA\u4fee\u5fa9\u6b20\u640d\u682a\u3092\u7528\u3044\u3066, \u967d\u5b50\u7dda\u7167\u5c04\u5f8c\uff0c<\/em>HT(42.5\u2103\uff0c<\/em>1<\/em>\u6642\u9593)\u51e6\u7406\u3057\uff0c<\/em>\u30b3\u30ed\u30cb\u30fc\u5f62\u6210\u6cd5\u3067\u751f\u5b58\u7387\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\uff0c<\/em>\u91ce\u751f\u682a\u304a\u3088\u3073NHEJ\u4fee\u5fa9\u6b20\u640d\u682a\u3067\u306f\u660e\u3089\u304b\u306aHT\u306b\u3088\u308b\u653e\u5c04\u7dda\u5897\u611f\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u305f\u304c\uff0c<\/em>HR\u4fee\u5fa9\u6b20\u640d\u682a\u3067\u306f\u5897\u611f\u52b9\u679c\u306f\u306a\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff14\uff09<\/sup>\uff0e<\/p>\n\n\n\n

\u4ee5\u4e0a\uff0c<\/em>\u96e3\u6cbb\u764c\u306e\u6cbb\u7642\u306b\u969b\u3057\uff0c\u6bba\u7d30\u80de\u52b9\u679c\u306fX\u7dda\u3068\u307b\u307c\u540c\u7b49\u3068\u3055\u308c\u308b\u967d\u5b50\u7dda\u306b\u5bfe\u3057\u3066\u3082\uff0c<\/em>HT\u4f75\u7528\u306b\u3088\u308b\u6cbb\u7642\u52b9\u679c\u306e\u5411\u4e0a\u306e\u53ef\u80fd\u6027\u3082\u3042\u308a\uff0c<\/em>\u8ab2\u984c\u89e3\u6c7a\u3092\u542b\u3081\uff0c<\/em>\u4eca\u5f8c\u306e\u3055\u3089\u306a\u308b\u9032\u5c55\u304c\u671b\u307e\u308c\u308b\uff0e<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

1)  Tran S, et al<\/em>. Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas. Brit J Radiol, 93:20180883, 2020.<\/p>\n\n\n\n

2)  Datta NR, et al<\/em>. Proton irradiation with hypertehrmia in unresectable soft tissue sarcoma. Int J Partcle Ther, 3: 327-36, 2016.<\/p>\n\n\n\n

3)  Iizumi T, et al<\/em>. Large malignant fibrous histiocytoma treated with hypofractionated proton beam therapy and local hyperthermia. Int J Partcle Ther,<\/a> 6: 35-41, 2019.<\/p>\n\n\n\n

4)  Maeda J, et al<\/em>. Hypertehrmia-induced radiosensitization in CHO wild-type, NHEJ repair mutant and HR reair mutant following proton and carbon-ion exposure. Oncol Lett, 10: 2828-34, 2015.<\/p>\n\n\n\n

\u7528\u8a9e\u89e3\u8aac<\/strong>\uff1a<\/p>\n\n\n\n

\u4ed9\u9aa8\u810a\u7d22\u816b<\/strong><\/em> (sacral chordomas)<\/strong>\uff1a<\/strong><\/p>\n\n\n\n

\u4ed9\u9aa8\u810a\u7d22\u816b\u3068\u306f\u4ed9\u9aa8\u306b\u767a\u751f\u3059\u308b\u60aa\u6027\u816b\u760d\u3067\u3042\u308b\uff0e\u3086\u3063\u304f\u308a\u5897\u6b96\u3057\uff0c\u9060\u9694\u8ee2\u79fb\u3082\u65e9\u671f\u306b\u306f\u8d77\u3053\u3055\u306a\u3044\uff0e\u5207\u9664\u304c\u7b2c\u4e00\u9078\u629e\u3067\u3042\u308b\u304c\uff0c\u8a3a\u65ad\u3055\u308c\u305f\u6642\u70b9\u3067\u816b\u760d\u304c\u5de8\u5927\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u591a\u304f\u6cbb\u7642\u304c\u56f0\u96e3\u306a\u3053\u3068\u3082\u591a\u3044\uff0e\u307e\u305f\uff0c\u816b\u760d\u5207\u9664\u306b\u3088\u308a\u4ed9\u9aa8\u795e\u7d4c\u3092\u5207\u65ad\u3059\u308b\u305f\u3081\uff0c\u6392\u5c3f\u6392\u4fbf\u6a5f\u80fd\u3084\u6b69\u884c\u306b\u969c\u5bb3\u3092\u304d\u305f\u3059\u3053\u3068\u3082\u3042\u308b\uff0e<\/p>\n\n\n\n

\u60aa\u6027\u7dda\u7dad\u6027\u7d44\u7e54\u7403\u816b<\/strong>\uff08<\/strong>malignant fibrous histiocytoma; MFH<\/strong>\uff09<\/strong>\uff1a<\/strong><\/p>\n\n\n\n

\u60aa\u6027\u7dda\u7dad\u6027\u7d44\u7e54\u7403\u816b\u306f\u8089\u816b\u306e\u4e00\u7a2e\u3067\u3042\u308a\uff0c\u8edf\u90e8\u7d44\u7e54\u3068\u9aa8\u304b\u3089\u767a\u751f\u3059\u308b\u8d77\u6e90\u4e0d\u660e\u306e\u60aa\u6027\u816b\u760d\u3067\u3042\u308b\uff0eMFH\u306f4\u3064\u306e\u4e9c\u578b(\u82b1\u7b75\u72b6\u2010\u591a\u5f62\u578b, \u7c98\u6db2\u578b, \u5de8\u7d30\u80de\u578b \u708e\u75c7\u578b)\u306b\u5206\u985e\u3055\u308c\u308b\u3088\u3046\u306a\u5e45\u5e83\u3044\u7d44\u7e54\u50cf\u3092\u5448\u3059\u308b\uff0e\u672a\u5206\u5316\u591a\u5f62\u8089\u816b\u3068\u3082\u79f0\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n

\u99ac\u5c3e\uff1a<\/strong><\/p>\n\n\n\n

\u3000\u99ac\u5c3e\uff08cauda equina\uff09\u306f\u3001\u810a\u9ac4\u5f8c\u4f4d\u306e\u810a\u9ac4\u795e\u7d4c\u3068\u7d42\u7cf8\u304c\u3068\u3082\u306b\u4e26\u3076\u90e8\u4f4d\u3067\u3042\u308b\u3002\u810a\u9ac4\u5f8c\u4f4d\u306e\u4ed9\u9aa8\u795e\u7d4c\u3001\u5c3e\u9aa8\u795e\u7d4c\u306f\u690e\u9593\u5b54\u3092\u51fa\u308b\u307e\u3067\u3001\u307b\u3068\u3093\u3069\u810a\u9ac4\u7d42\u7cf8\u306b\u4f75\u884c\u3057\u3066\u8d70\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u305d\u306e\u5f62\u304c\u99ac\u306e\u5c3e\u306b\u4f3c\u305f\u5f62\u614b\u3092\u793a\u3059\u305f\u3081\u3001\u99ac\u5c3e\uff08\u3070\u3073\uff09\u3068\u547c\u3070\u308c\u308b\u3002<\/p>\n\n\n\n

DNA<\/strong>\u4fee\u5fa9<\/strong>(DNA repair)<\/strong>\uff1a<\/strong><\/p>\n\n\n\n

\u76f8\u540c\u7d44\u63db\u3048(homologous recombination: HR)\u304a\u3088\u3073\u975e\u76f8\u540c\u672b\u7aef\u7d50\u5408(non-homologous end joining\uff1aNHEJ)\u304c\u3042\u308b\uff0eHR\u3067\u306f\u5207\u65ad\u90e8\u306e\u4fee\u5fa9\u306e\u969b\u306b\u7528\u3044\u308b\u92f3\u578b\u3068\u3057\u3066\u540c\u4e00\u3082\u3057\u304f\u306f\uff0c<\/em>\u3088\u304f\u4f3c\u305f\u914d\u5217\u3092\u3082\u3064\u30b2\u30ce\u30e0\u3092\u5229\u7528\u3059\u308b\uff0eNHEJ\u3067\u306f\u59c9\u59b9\u67d3\u8272\u5206\u4f53\u3092\u5fc5\u8981\u3068\u305b\u305a\uff0c\u3059\u3079\u3066\u306e\u7d30\u80de\u5468\u671f\u5185\u306b\u304a\u3044\u3066\u6a5f\u80fd\u3057\uff0c\u76f8\u540c\u6027\u3068\u306f\u7121\u95a2\u4fc2\u306b\u5207\u65ad\u3055\u308c\u305f\u672b\u7aef\u540c\u58eb\u3092\u76f4\u63a5\u9023\u7d50\u3059\u308b\u305f\u3081\uff0cDNA\u672b\u7aef\u306e\u63a5\u5408\u90e8\u306b\u304a\u3044\u3066\u5909\u7570\u304c\u8d77\u3053\u308a\u3084\u3059\u3044\uff0e\u3053\u3053\u3067\u7d39\u4ecb\u3057\u305f\u8ad6\u6587\uff14\uff09<\/sup>\u3067\u306f\uff0c<\/em>CHO (Chinese hamster ovary)-51D1, RAD51D\u6b20\u640d\u682a\u3084CHO-V3, DNA-PKcs\u6b20\u640d\u682a\u3092\u7528\u3044\u3066\u3044\u308b\u304c\uff0c\u524d\u8005\u304cHR\uff0c\u5f8c\u8005\u304cNHEJ\u3092\u6b20\u304f\uff0e<\/p>\n\n\n\n

RECIST: Response Evaluation Criteria In Solid Tumours<\/p>\n\n\n\n

CTCAE: Common Terminology Criteria for Adverse Events<\/p>\n","protected":false},"excerpt":{"rendered":"

\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c43 \u5de8\u5927\u306a\u5207\u9664\u4e0d\u80fd\u4ed9\u9aa8\u810a\u7d22\u816b\u306b\u304a\u3051\u308b\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u540c\u6642\u4f75\u7528\u30b9\u30dd\u30c3\u30c8\u30b9\u30ad\u30e3\u30cb\u30f3\u30b0\u967d\u5b50\u7dda\u6cbb\u7642\u5f8c\u306e\u65e9\u671f\u306e\u81e8\u5e8a\u6210\u7e3e\u3068\u816b\u760d\u4f53\u7a4d\u5206\u6790 \u8fd1\u85e4\u3000\u9686, \u6c34\u4e0a\u9054\u6cbb, \u9f4b\u85e4\u6df3\u4e00 \uff08\u5bcc\u5c71\u5927\u5b66\u5b66\u8853\u7814\u7a76\u90e8\u533b\u5b66\u7cfb […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-544","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/544","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=544"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/544\/revisions"}],"predecessor-version":[{"id":545,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/544\/revisions\/545"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=544"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=544"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}