{"id":554,"date":"2020-02-04T20:28:00","date_gmt":"2020-02-04T11:28:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=554"},"modified":"2022-05-26T20:24:31","modified_gmt":"2022-05-26T11:24:31","slug":"%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc%e3%83%9f%e3%82%a2%e3%81%8c%e3%82%93%e6%b2%bb%e7%99%82%e6%b3%95%e3%81%ae%e9%96%8b%e7%99%ba%e3%81%ab%e5%90%91%e3%81%91%e3%81%9f%e6%96%b0%e6%83%85","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc%e3%83%9f%e3%82%a2%e3%81%8c%e3%82%93%e6%b2%bb%e7%99%82%e6%b3%95%e3%81%ae%e9%96%8b%e7%99%ba%e3%81%ab%e5%90%91%e3%81%91%e3%81%9f%e6%96%b0%e6%83%85\/","title":{"rendered":"\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u304c\u3093\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u5411\u3051\u305f\u65b0\u60c5\u5831\u3000\u2015\u2015p53\u306f\u71b1\u5c04\u75c5\u767a\u75c7\u306e\u95be\u5024\u6e29\u5ea6\uff0840\u2103\uff09\u3067\u306f\u7d30\u80de\u81f4\u6b7b\u9632\u8b77\u56e0\u5b50\u3068\u3057\u3066\u50cd\u304f \u2015\u2015"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c38<\/p>\n\n\n\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u304c\u3093\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u5411\u3051\u305f\u65b0\u60c5\u5831\u3000\u2015\u2015p53\u306f\u71b1\u5c04\u75c5\u767a\u75c7\u306e\u95be\u5024\u6e29\u5ea6\uff0840\u2103\uff09\u3067\u306f\u7d30\u80de\u81f4\u6b7b\u9632\u8b77\u56e0\u5b50\u3068\u3057\u3066\u50cd\u304f \u2015\u2015<\/p>\n\n\n\n<p>\u9234\u6728\u6587\u7537\uff08\u5bcc\u5c71\u5927\u5b66\u5ba2\u54e1\u6559\u6388\uff0c\u5e83\u5cf6\u5927\u5b66\u540d\u8a89\u6559\u6388\uff09<\/p>\n\n\n\n<p>\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u7523\u7269p53\u306f\uff0c200\u7a2e\u985e\u4ee5\u4e0a\u306e\u6a5f\u80fd\u306e\u7570\u306a\u308b\u907a\u4f1d\u5b50\u3092\u767a\u73fe\u5236\u5fa1\u3057\u3066\u3044\u308b\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308b<sup>1<\/sup><sup>\uff09<\/sup>\uff0ep53\u306f\u6b63\u5e38\u7d30\u80de\u5185\u3067\u306f\u30e6\u30d3\u30ad\u30c1\u30f3\u4f9d\u5b58\u6027\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u30b7\u30b9\u30c6\u30e0 (proteasome system)\u3092\u4ecb\u3057\u3066\u901f\u3084\u304b\u306b\u5206\u89e3\u3055\u308c\u308b\u305f\u3081\u6975\u3081\u3066\u5c11\u306a\u3044\u91cf\u3057\u304b\u5b58\u5728\u3057\u306a\u3044\uff0e\u3057\u304b\u3057\uff0c\u7d30\u80de\u5185\u5916\u306e\u591a\u7a2e\u591a\u69d8\u306a\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u308b\u3068p53\u306f\u305d\u306e\u7a2e\u985e\u306b\u4f9d\u5b58\u3057\u3066\u7279\u5b9a\u306e\u90e8\u4f4d\u304c\u4fee\u98fe\u3055\u308c\uff0c\u5206\u89e3\u3055\u308c\u305a\u306b\u5b89\u5b9a\u5316\u3057\u305fp53\u304c\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u4fc3\u9032\u3057\uff0c\u7a2e\u3005\u306e\u7d30\u80de\u5fdc\u7b54 (cellular response)\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\uff0e\u305d\u306e\u7d50\u679c\uff0c\u7d30\u80de\u5468\u671f\u9032\u884c\u306e\u4e00\u6642\u7684\u306a\u505c\u6b62\uff0c\u7d30\u80de\u8001\u5316\u5f62\u8cea\u767a\u73fe\uff0c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306a\u3069\u304c\u8a98\u767a\u3055\u308c\u308b\u304c\uff0c\u3053\u308c\u3089\u306e\u7570\u5e38\u306f\u3044\u305a\u308c\u3082\u751f\u4f53\u5185\u306b\u304a\u3044\u3066\u306f\u5909\u7570\u7d30\u80de\u306e\u84c4\u7a4d\u306b\u3064\u306a\u304c\u308b\u306e\u3067p53\u306f\u304c\u3093\u767a\u75c7\u306b\u3082\u3064\u306a\u304c\u308b\u907a\u4f1d\u5b50\u4e0d\u5b89\u5b9a\u6027\u306e\u9632\u6b62\u3092\u3064\u304b\u3055\u3069\u308b\u30b2\u30ce\u30e0\u5b88\u8b77\u795e (the guardian of the genome)\u3068\u3057\u3066\u4f4d\u7f6e\u4ed8\u3051\u3089\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306f\u7a2e\u3005\u306e\u304c\u3093\u6cbb\u7642\u306b\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u308b\uff0e\u305d\u306e\u6839\u62e0\u306f\uff0c\u6bd4\u8f03\u7684\u304c\u3093\u7d30\u80de\u306f\u71b1\u306b\u5f31\u304f\uff0c\u60a3\u8005\u306b\u8ca0\u62c5\u3092\u304b\u3051\u308b\u3053\u3068\u306a\u304f\uff0c\u975e\u4fb5\u8972\u7684\u306b\u6cbb\u7642\u3067\u304d\u308b\u3068\u3053\u308d\u306b\u3042\u308b\uff0e\u5b9f\u969b\uff0c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u6cbb\u7642\u3067\u4f7f\u308f\u308c\u308b\uff0841.5\u2103\uff5e45.5\u2103\uff09\u306e\u71b1\u51e6\u7406\u306b\u3088\u308aDNA\u4e8c\u91cd\u9396\u5207\u65ad\uff08DNA double-strand breaks\uff09\u304c\u8a98\u767a\u3055\u308c\u304c\u3093\u7d30\u80de\u304c\u6b7b\u6ec5\u3059\u308b\u3068\u3068\u3082\u306b<sup>2<\/sup><sup>\uff09<\/sup>\uff0c\u305d\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u53d7\u3051\u3066p53\u304c\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u308b<sup>3<\/sup><sup>\uff09<\/sup>\uff0e\u3057\u304b\u3057\uff0c\u30d2\u30c8\u304c\u3093\u306e\u7d0450\uff05\u304c\u5909\u7570\u578b\u306ep53\u3092\u6709\u3057\uff0c\u305d\u308c\u4ee5\u5916\u3067\u3082p53\u304c\u95a2\u4e0e\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def (signal transduction pathway)\u3092\u62c5\u3046\u591a\u304f\u306e\u56e0\u5b50\u306b\u6a5f\u80fd\u55aa\u5931\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304b\u3089\uff0c\u71b1\u51e6\u7406\u5358\u72ec\u3067\u306e\u304c\u3093\u6cbb\u7642\u306b\u306f\u9650\u754c\u304c\u3042\u308b\u3082\u306e\u3068\u601d\u308f\u308c\u308b\uff0e\u4eca\u56de\u306f\uff0c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u3088\u308b\u304c\u3093\u6cbb\u7642\u6cd5\u306e\u6539\u5584\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\uff0c\u6700\u8fd1Cell Reports\u306b\u5831\u544a\u3055\u308c\u305f\u300c\u71b1\u5c04\u75c5\u767a\u75c7\u306e\u95be\u5024\u6e29\u5ea6(Heatstroke threshold temperature: HTT)\u3068\u3055\u308c\u308b40\u2103\u306e\u71b1\u51e6\u7406\u3067\u306f\u6b63\u5e38\u7d30\u80de\u3088\u308ap53\u5909\u7570\u7d30\u80de\u306e\u65b9\u304c\u6b7b\u6ec5\u3057\u3084\u3059\u304f\u306a\u308b\u300d\u3053\u3068\u3092\u8a3c\u660e\u3057\u305f\u8ad6\u6587<sup>4<\/sup><sup>\uff09<\/sup>\u3092\u7d39\u4ecb\u3059\u308b\uff0e<\/p>\n\n\n\n<p>\u307e\u305a\uff0c\u8457\u8005\u3089\u306f\uff0c\u91ce\u751f\u578b\u3068\u7a81\u7136\u5909\u7570\u578b\u306ep53\u3092\u6709\u3059\u308b\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u80ce\u5150\u3092\u7528\u3044\u306640\u2103 (HTT\u74b0\u5883)\u306845\u2103 (\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u74b0\u5883)\u3067\u98fc\u80b2\u3057\u305f\u3068\u304d\u306e\u751f\u5b58\u80fd\u3092\u6bd4\u8f03\u3057\u305f\uff0e\u305d\u306e\u7d50\u679c\uff0c45\u2103\u3067\u306f\u91ce\u751f\u578bp53\u80ce\u5150\u306e\u65b9\u304c\u5909\u7570\u578bp53\u80ce\u5150\u306b\u6bd4\u3079\u3066\u6b7b\u306b\u3084\u3059\u304f\u306a\u308b\u304c\uff0c40\u2103\u3067\u306f\u9006\u3068\u306a\u308ap53\u306f\u751f\u5b58\u80fd\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\uff0e\u30d2\u30c8\u57f9\u990a\u7d30\u80de\u3067\u306f40\u2103\u306845\u2103\u3067\u71b1\u51e6\u7406\u3055\u308c\uff0c45\u2103\u3067\u306f\u91ce\u751f\u578bp53\uff08p53<sup>+\/+<\/sup>\uff09\u7d30\u80de\u306e\u65b9\u304c\u5909\u7570\u578bp53\uff08p53<sup>-\/-<\/sup>\uff09\u7d30\u80de\u306b\u6bd4\u3079\u3066\u751f\u5b58\u80fd\u304c\u4f4e\u304f\u306a\u308b\u304c\uff0c40\u2103\u3067\u306f\u5168\u304f\u9006\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\uff0e\u524d\u8005\u306e\u7d50\u679c\u306f\uff0cATM-p53\u3092\u4ecb\u3057\u305fDNA\u640d\u50b7\u5fdc\u7b54 (DNA damage response: DDR)\u304c\u6d3b\u6027\u5316\u3055\u308c\u305f\u305f\u3081\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u8a98\u767a\u983b\u5ea6\u304c\u9ad8\u307e\u3063\u305f\u3053\u3068\u3067\u8aac\u660e\u3067\u304d\u308b\u304c\uff0c\u5f8c\u8005\u306b\u3064\u3044\u3066\u306f\u4e21\u7d30\u80de\u7a2e\u9593\u3067\u51e6\u7406\u5f8c\u306e\u7d30\u80de\u5468\u671f\u9032\u884c\u505c\u6b62\u3084\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304a\u3088\u3073\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u8a98\u767a\u983b\u5ea6\u306b\u5dee\u304c\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u304b\u3089\uff0c40\u2103\u51e6\u7406\u306b\u3088\u308b\u7d30\u80de\u81f4\u6b7b\u52b9\u679c\u306ep53\u4f9d\u5b58\u6027\u306f\u4ed6\u306e\u7d30\u80de\u5fdc\u7b54\u53cd\u5fdc\u306b\u8d77\u56e0\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\uff0e\u305d\u3053\u3067\u6b21\u306b\uff0c\u8457\u8005\u3089\u306f40\u2103\u4e0b\u3067\u3069\u306e\u69d8\u306a\u71b1\u30b7\u30e7\u30c3\u30af\u5fdc\u7b54 (heat shock response: HSR)\u53cd\u5fdc\u304c\u8a98\u767a\u3055\u308c\u308b\u304b\u306b\u3064\u3044\u3066\u8abf\u3079\u305f\uff0e<\/p>\n\n\n\n<p>\u7a81\u5982\u3068\u3057\u305f\u6e29\u5ea6\u4e0a\u6607\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\uff0c\u5e83\u7bc4\u306a\u751f\u7269\u7a2e\u306b\u308f\u305f\u3063\u3066\u6570\u591a\u304f\u306e\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea (heat shock proteins: HSPs)\u304c\u767a\u73fe\u3057\u3066\u3044\u308b<sup>5<\/sup><sup>\uff09<\/sup>\uff0e\u7279\u306b\u9ad8\u6b21\u69cb\u9020\u7570\u5e38\u3084\u51dd\u96c6\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7d50\u5408\u3057\uff0c\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc (autophagy)\u30b7\u30b9\u30c6\u30e0\u306b\u3088\u3063\u3066\u6392\u9664\u3059\u308b\u7d30\u80de\u5185\u6d44\u5316\u306b\u95a2\u308f\u308b\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3(molecular chaperon\uff0cHSP\u306e\u4e00\u7a2e)\u306f\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6052\u5e38\u6027 (homeostasis)\u7dad\u6301\u306b\u6b20\u304b\u305b\u306a\u3044\u3082\u306e\u3067\u3042\u308b\uff0e\u8457\u8005\u3089\u306f\u30d2\u30c8\u57f9\u990a\u7d30\u80de\u309240\u2103\u3067\u51e6\u7406\u306b\u3088\u3063\u3066<em>hsp<\/em>\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u62c5\u3046<em>hsf1<\/em>\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304cp53<sup>+\/+<\/sup>\u7d30\u80de\u3088\u308ap53<sup>-\/-<\/sup>\u7d30\u80de\u3067\u9ad8\u304f\u306a\u308b\u3053\u3068\uff0c\u3055\u3089\u306b<em>hsf1<\/em>\u907a\u4f1d\u5b50\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u3067\u3042\u308b<em>hsc70&nbsp;<\/em>(heat shock-cognate protein of 70 KDa)\u306e\u767a\u73fe\u3082\u540c\u69d8\u306b\u9ad8\u307e\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\uff0e\u3053\u306e\u7d50\u679c\u306f\uff0cHSC70\u306f\u30b7\u30e3\u30da\u30ed\u30f3\u4ecb\u5728\u6027\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc (chaperon-mediated autophagy: CMA)\u306e\u521d\u671f\u6bb5\u968e\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089<sup>6<\/sup><sup>\uff09<\/sup>\uff0cp53<sup>-\/-<\/sup>\u7d30\u80de\u3067\u306f40\u2103\u3067\u904e\u5270\u306aHSR\u304c\u8a98\u767a\u3055\u308c\uff0c\u7d30\u80de\u5185\u306b\u84c4\u7a4d\u3057\u305fHSC70\u304c\u7570\u5e38\u30ec\u30d9\u30eb\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u3092\u5f15\u304d\u8d77\u3053\u3057\uff0c\u7d30\u80de\u6b7b\u306b\u81f3\u3089\u305b\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>\u8208\u5473\u3042\u308b\u306e\u306f\uff0c<em>hsf1<\/em>\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306bp53\u304c\u7d50\u5408\u3057\u3066HSC70\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3084\uff0c40\u2103\u51e6\u7406\u3067p53\u306e37\u756a\u76ee\u30bb\u30ea\u30f3 (S37)\u304c\u30ea\u30f3\u9178\u5316\u3059\u308b\u3053\u3068\uff0c\u3055\u3089\u306bS37\u304c\u30ea\u30f3\u9178\u5316\u3055\u308c\u3066\u3044\u306a\u3044p53\u3067\u306f<em>hsf1<\/em>\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306b\u7d50\u5408\u3057\u3066hsf1\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\uff0c\u8457\u8005\u3089\u304c\u5831\u544a\u3057\u3066\u3044\u308b\u3053\u3068\u3067\u3042\u308b\uff0e\u307e\u305f\uff0c40\u2103\u4e0b\u3067\u306fHSP90\u304c\u84c4\u7a4d\u3057p53\u3068\u7d50\u5408\u3057\u3066\u305d\u306e\u6a5f\u80fd\u3092\u4fdd\u5168\u3059\u308b\u3053\u3068\u3084\uff0cHSP90\u3092\u6db8\u6e07\u72b6\u614b\u306b\u3059\u308b\u3068p53\u306e\u7d30\u80de\u5185\u84c4\u7a4d\u91cf\u304c\u4f4e\u4e0b\u3057\u3066\u7d30\u80de\u306e\u751f\u5b58\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3082\u898b\u3064\u3051\u3066\u3044\u308b\uff0e\u3053\u308c\u3089\u306e\u7814\u7a76\u7d50\u679c\u306f\uff0c\u7d30\u80de\u306e\u751f\u5b58\u80fd\u6e2c\u5b9a\u3092\u7cbe\u5ea6\u306b\u96e3\u70b9\u306e\u3042\u308bMTT\u6cd5 (\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u8131\u6c34\u7d20\u9175\u7d20\u306b\u3088\u308b\u30db\u30eb\u30de\u30b6\u30f3\u751f\u6210\u91cf\u3092\u6307\u6a19)\u306e\u307f\u3067\u884c\u3063\u3066\u3044\u308b\u70b9\u306b\u4e0d\u5b89\u306f\u3042\u308b\u304c\uff0c\u7a2e\u3005\u306e\u5206\u5b50\u751f\u7269\u5b66\u7684\u624b\u6cd5\u3092\u99c6\u4f7f\u3057\u3066\u2460p53\u304c40\u2103\u3067\u306e\u904e\u5270\u53cd\u5fdc\u7684\u306aHSR\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u7d30\u80de\u6b7b\u3092\u9632\u6b62\u3057\u3066\u3044\u308b\u3053\u3068\u3084\uff0c\u246140\u2103\u4e0b\u3067\u306f\u904e\u5270\u306aHSC70\u3092\u4ecb\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u306b\u3088\u308b\u7d30\u80de\u6b7b\u304c\u751f\u3058\u308b\u3053\u3068\uff0c\u2462p53\u306f40\u2103\u3067\u308237\u756a\u76ee\u30bb\u30ea\u30f3\u304c\u30ea\u30f3\u9178\u5316\u3055\u308c\u305aHSP90\u3068\u7d50\u5408\u3057\u3066\u5b89\u5b9a\u7684\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>\u52a0\u3048\u3066\u8457\u8005\u3089\u306f\uff0cp53<sup>+\/+<\/sup>\u7d30\u80de\u3068p53<sup>-\/-<\/sup>\u7d30\u80de\u3092\u79fb\u690d\u305740\u2103\u4e0b\u3067\u306e\u816b\u760d\u5897\u6b96\u52d5\u614b\u3092\u8abf\u3079\u305f\u7d50\u679c\uff0cp53<sup>+\/+<\/sup>\u306b\u6bd4\u3079\u3066p53<sup>-\/-<\/sup>\u7d30\u80de\u816b\u760d\u306e\u65b9\u304c\uff0c\u5897\u6b96\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u305f\uff0e\u3053\u306e\u8ad6\u6587\u3067\u793a\u3055\u308c\u305f\u7d50\u679c\u306f\uff0c\u5b8c\u5168\u306b\u816b\u760d\u5897\u6b96\u3092\u6b62\u3081\u308b\u7a0b\u3067\u306f\u306a\u3044\u3082\u306e\u306e\uff0cHTT (40\u2103)\u6e29\u5ea6\u306e\u71b1\u51e6\u7406\u304c\u6b63\u5e38\u7d44\u7e54\u306b\u969c\u5bb3\u3092\u4e0e\u3048\u308b\u3053\u3068\u306a\u304fp53\u6b20\u640d\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u6291\u5236 (\u304c\u3093\u6cbb\u7642)\u306b\u4f7f\u3048\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3082\u306e\u3067\u3042\u308a\uff0c\u4eca\u5f8c\u306f\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u304c\u3093\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u5411\u3051\u305f\u81e8\u5e8a\u5fdc\u7528\u7814\u7a76\u3078\u3068\u767a\u5c55\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p>1) &nbsp; Levine AJ.,&nbsp;<em>et al<\/em>. The P53 pathway: what questions remain to be explored. Cell Death Differ, 13: 1027-36, 2006.<\/p>\n\n\n\n<p>2) &nbsp; Takahashi A.,<em>&nbsp;et al<\/em>. Evidence for the involvement of double-strand breaks in heat-induced cell killing. Cancer Res, 64: 8839-45, 2004.<\/p>\n\n\n\n<p>3) &nbsp; Miyakoda M.,&nbsp;<em>et al<\/em>. Activation of ATM and phosphorylation of p53 by heat shock. Oncogene, 21: 1090-96, 2002.<\/p>\n\n\n\n<p>4)&nbsp; Gong L.,&nbsp;<em>et al<\/em>. p53 protects cells from death at the heatstroke threshold temperature. Cell Rep, 29: 3693-707, 2019.<\/p>\n\n\n\n<p>5) &nbsp; Garbuz DG., Regulation of heat shock gene expression in response to stress. Mol Biol, 51: 352-67, 2017.<\/p>\n\n\n\n<p>6)&nbsp; &nbsp;Cuervo AM, Wong E, Chaperone-mediated autophagy: roles in disease and aging. Cell Res, 24: 92-104, 2014.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c38 \u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u304c\u3093\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u5411\u3051\u305f\u65b0\u60c5\u5831\u3000\u2015\u2015p53\u306f\u71b1\u5c04\u75c5\u767a\u75c7\u306e\u95be\u5024\u6e29\u5ea6\uff0840\u2103\uff09\u3067\u306f\u7d30\u80de\u81f4\u6b7b\u9632\u8b77\u56e0\u5b50\u3068\u3057\u3066\u50cd\u304f \u2015\u2015 \u9234\u6728\u6587\u7537\uff08\u5bcc\u5c71\u5927\u5b66\u5ba2\u54e1\u6559\u6388\uff0c\u5e83\u5cf6\u5927\u5b66\u540d\u8a89\u6559\u6388\uff09 \u304c\u3093 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-554","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/554","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=554"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/554\/revisions"}],"predecessor-version":[{"id":555,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/554\/revisions\/555"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=554"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=554"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=554"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}