\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c37<\/p>\n\n\n\n
\u304c\u3093\u306e\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u6cbb\u7642\u306b\u304a\u3051\u308b\u8d85\u97f3\u6ce2\u3068\u30de\u30a4\u30af\u30ed\u30d0\u30d6\u30eb\u306e\u4f75\u7528\u52b9\u679c\u306b\u3064\u3044\u3066<\/p>\n\n\n\n
\u9234\u6728\u3000\u4eae (\u5e1d\u4eac\u5927\u5b66)<\/p>\n\n\n\n
\u304c\u3093\u6cbb\u7642\u306b\u304a\u3051\u308b\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2 (HT) \u306f\uff0c\u69d8\u3005\u306a\u304c\u3093\u3067\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\uff0e\u307e\u305f\uff0cHT\u304c\u5316\u5b66\u7642\u6cd5\u3084\u653e\u5c04\u7dda\u7642\u6cd5\u306e\u611f\u53d7\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3082\uff0c\u57fa\u790e\u3084\u81e8\u5e8a\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0e\u305d\u306e\u305f\u3081\uff0cHT\u306b\u3088\u308b\u304c\u3093\u6cbb\u7642\u52b9\u679c\u3092\u5897\u5f37\u3059\u308b\u4f75\u7528\u7642\u6cd5\u306b\u3064\u3044\u3066\u3082\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u308b\uff0e<\/p>\n\n\n\n
\u8fd1\u5e74\uff0c\u8d85\u97f3\u6ce2\u3068\u30de\u30a4\u30af\u30ed\u30d0\u30d6\u30eb\u306e\u4f75\u7528\uff08USMB\uff09\u3092\u5229\u7528\u3057\u305f\u7d30\u80de\u5185\u3078\u306e\u85ac\u7269\u30fb\u907a\u4f1d\u5b50\u30c7\u30ea\u30d0\u30ea\u30fc\u6cd5\u3084\u8840\u7ba1\u900f\u904e\u6027\u4ea2\u9032\u306b\u3088\u308b\u80fd\u52d5\u7684\u85ac\u7269\u30c7\u30ea\u30d0\u30ea\u30fc\u6cd5\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\uff0e\u3053\u306e\u65b9\u6cd5\u306e\u539f\u7406\u306f\uff0c\u30de\u30a4\u30af\u30ed\u30d0\u30d6\u30eb\u3078\u306e\u8d85\u97f3\u6ce2\u7167\u5c04\u306b\u3088\u308a\uff0c\u30de\u30a4\u30af\u30ed\u30d0\u30d6\u30eb\u306e\u632f\u52d5\u3084\u5727\u58ca\u304c\u8a98\u5c0e\u3055\u308c\uff0c\u3053\u306e\u3068\u304d\u751f\u3058\u308b\u6a5f\u68b0\u7684\u4f5c\u7528\u304c\u8fd1\u96a3\u306e\u7d30\u80de\u819c\u306b\u4f5c\u7528\u3057\uff0c\u7d30\u80de\u819c\u306b\u4e00\u904e\u6027\u306e\u5c0f\u5b54\u304c\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u3067\u7d30\u80de\u5185\u306b\u85ac\u7269\u3084\u907a\u4f1d\u5b50\u3092\u5c0e\u5165\u3055\u308c\u308b\u3053\u3068\u306b\u3088\u308b\uff0e\u307e\u305f\uff0c\u3053\u306e\u30de\u30a4\u30af\u30ed\u30d0\u30d6\u30eb\u306e\u632f\u52d5\u3084\u5727\u58ca\u304c\u8840\u6d41\u4e2d\u3067\u8a98\u5c0e\u3055\u308c\u308b\u3068\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u4f5c\u7528\u3057\uff0c\u5185\u76ae\u7d30\u80de\u9593\u306e\u5bc6\u7740\u7d50\u5408\u304c\u4e00\u6642\u7684\u306b\u5f1b\u7de9\u3059\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0e\u5b9f\u969b\u306b\uff0c\u3053\u306e\u65b9\u6cd5\u3092\u8133\u5185\u306e\u8840\u7ba1\u306b\u9069\u7528\u3059\u308b\u3068\uff0c\u8840\u6db2-\u8133\u95a2\u9580\uff08BBB\uff09\u306e\u900f\u904e\u6027\u304c\u5897\u5927\u3059\u308b1-3)<\/sup>\uff0e\u307e\u305f\uff0cEl Kaffas\u3089\u306f\uff0c USMB\u306b\u3088\u308b\u816b\u760d\u5185\u8840\u7ba1\u306e\u50b7\u5bb3\u304c\u653e\u5c04\u7dda\u7642\u6cd5\u306e\u52b9\u679c\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u308b4)<\/sup>\uff0e\u3057\u304b\u3057\uff0c\u3053\u308c\u307e\u3067\u306e\u691c\u8a0e\u3067\u306f\uff0cHT\u3068USMB\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u7814\u7a76\u306f\u884c\u308f\u308c\u3066\u3044\u306a\u3044\uff0e\u4eca\u56de\u7d39\u4ecb\u3059\u308bSharma\u3089\u306e\u5831\u544a\u306f\uff0c\u30d2\u30c8\u524d\u7acb\u817a\u304c\u3093\u79fb\u690d\u30de\u30a6\u30b9\u306b\u5bfe\u3057\u3066\uff0cHT\u3068USMB\u4f75\u7528\u306b\u3088\u308b\u304c\u3093\u6cbb\u7642\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u305f\u5185\u5bb9\u3067\u3042\u308b5)<\/sup>\uff0e<\/p>\n\n\n\n \u3000\u30d2\u30c8\u524d\u7acb\u817a\u304c\u3093\u7d30\u80de\uff08PC3\uff09\u3092SCID\u30de\u30a6\u30b9\u306e\u76ae\u4e0b\u306b\u79fb\u690d\u3057\uff0c3-4\u9031\u9593\u5f8c\u306b\u816b\u760d\u5f84\u304c 8-10 mm \u7a0b\u5ea6\u3068\u306a\u3063\u305f\u3068\u3053\u308d\u3067\uff0cDefinity\uff08\u30de\u30a4\u30af\u30ed\u30d0\u30d6\u30eb\uff09\u3092\u9759\u8108\u5185\u304b\u3089\u6295\u4e0e\u3057\uff0c\u5404\u7a2e\u5f37\u5ea6 (0-740 kPa) \u306e\u8d85\u97f3\u6ce2 (500 kHz) \u3092\u304c\u3093\u7d44\u7e54\u306b\u7167\u5c04\u3057\u305f\uff0e\u305d\u306e\u5f8c\uff0c\u30de\u30a6\u30b9\u309243\u2103\u306e\u6e29\u6d74\u306b\u3066HT (0-50 \u5206\u9593) \u3092\u884c\u3063\u305f\uff0e\u6cbb\u764224\u6642\u9593\u5f8c\u306b\u304c\u3093\u7d44\u7e54\u306eTUNEL\u67d3\u8272\u884c\u3063\u305f\u3068\u3053\u308d\uff0cUSMB\u306e\u307f\u3084HT 40\u5206\u9593\u306e\u307f\u306b\u304a\u3044\u3066TUNEL\u67d3\u8272\u967d\u6027\u7d30\u80de\u306e\u5897\u52a0\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff0e\u4e00\u65b9\uff0cHT 50\u5206\u9593\u306e\u307f\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\uff0cTUNEL\u67d3\u8272\u967d\u6027\u7d30\u80de\u306e\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0e\u3055\u3089\u306b\uff0c246 kPa \u3084570 kPa \u306e\u8d85\u97f3\u6ce2\u5f37\u5ea6\u306b\u304a\u3051\u308bUSMB\u3068HT (40\u307e\u305f\u306f50\u5206\u9593)\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\uff0c\u9855\u8457\u306bTUNEL\u67d3\u8272\u967d\u6027\u7d30\u80de\u306e\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0e\u3053\u306e\u3088\u3046\u306b\uff0cUSMB\u3068HT\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\uff0c\u304c\u3093\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u8a98\u5c0e\u52b9\u7387\u3092\u9ad8\u3081\u3089\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\uff0e\u306a\u304a\uff0c\u8d85\u97f3\u6ce2\u5f37\u5ea6\u3092740 kPa\u307e\u3067\u9ad8\u304f\u3057\u3066\u3082570 kPa \u3068\u540c\u7b49\u306e\u52b9\u679c\u3067\u3042\u3063\u305f\uff0e\u305d\u306e\u305f\u3081\uff0c\u4ee5\u964d\u306e\u691c\u8a0e\u3067\u306f\uff0c570 kPa \u306e\u8d85\u97f3\u6ce2\u7167\u5c04\u5f37\u5ea6\u3067\u306e\u691c\u8a0e\u3092\u884c\u3063\u305f\uff0e<\/p>\n\n\n\n USMB\u3067\u306f\uff0c\u30de\u30a4\u30af\u30ed\u30d0\u30d6\u30eb\u306e\u632f\u52d5\u3084\u5727\u58ca\u304c\u8840\u7ba1\u5185\u3067\u8a98\u5c0e\u3055\u308c\u308b\u305f\u3081\uff0c\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u304c\u6700\u3082\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u308b\uff0e\u305d\u3053\u3067\u6b21\u306e\u691c\u8a0e\u3067\u306f\uff0cUSMB (0-570 kPa) \u3068HT (0-40 \u5206\u9593) \u3067\u51e6\u7406\u3057\u305f\u304c\u3093\u7d44\u7e54\u309224\u6642\u9593\u5f8c\u306b\u53d6\u308a\u51fa\u3057\uff0c\u304c\u3093\u7d44\u7e54\u306e\u5207\u7247\u3092CD31\u6297\u4f53\u3067\u514d\u75ab\u67d3\u8272\u3057\u8840\u7ba1\u5bc6\u5ea6\u306e\u89b3\u5bdf\u3092\u884c\u3063\u305f\uff0e\u305d\u306e\u7d50\u679c\uff0cUSMB\u5358\u72ec\u6cbb\u7642\u3067\u306f\u304c\u3093\u7d44\u7e54\u5185\u306e\u8840\u7ba1\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff0e\u307e\u305f\uff0cHT \u5358\u72ec\u6cbb\u7642\u3067\u306f\uff0c50\u5206\u9593\u306e\u6cbb\u7642\u3067\u8840\u7ba1\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0e\u4e00\u65b9\uff0cUSMB\u3068HT\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u306f\uff0cUSMB\uff08246 kPa\uff09\u3068HT 40\u5206\u9593\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u8840\u7ba1\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\uff0cUSMB\uff08570 kPa\uff09\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u306fHT 10\u5206\u9593\u306b\u304a\u3044\u3066\u3082\u8840\u7ba1\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u305f\uff0e\u3053\u306e\u3088\u3046\u306b\uff0cUSMB\u3068HT\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\uff0c\u52b9\u7387\u3088\u304f\u304c\u3093\u7d44\u7e54\u5185\u306e\u8840\u7ba1\u5bc6\u5ea6\u306e\u6e1b\u5c11\u3092\u8a98\u5c0e\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff0e\u305d\u3053\u3067\uff0cUSMB\u5358\u72ec\uff0cHT\u5358\u72ec\u307e\u305f\u306f\u3053\u308c\u3089\u306e\u7d44\u307f\u5408\u308f\u305b\u30671\u56de\u6cbb\u7642\u3092\u884c\u3063\u305f\u3068\u304d\u306e\u6cbb\u7642\u52b9\u679c\u3092\u691c\u8a0e\u3057\u305f\uff0e\u305d\u306e\u7d50\u679c\uff0cUSMB\u3084HT\u306e\u5358\u72ec\u6cbb\u7642\u3067\u306f\uff0c\u6cbb\u7642\u52b9\u679c\u304c\u307b\u3068\u3093\u3069\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff0e\u4e00\u65b9\uff0c\u7d44\u307f\u5408\u308f\u305b\u3067\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u9855\u8457\u306a\u6cbb\u7642\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0e<\/p>\n\n\n\n \u3000\u6b21\u306b\uff0c\u90312\u56de\u306e\u6cbb\u7642\u30924\u9031\u9593\u7e70\u308a\u8fd4\u3057\u3066\uff0c\u6cbb\u7642\u52b9\u679c\u3092\u691c\u8a0e\u3057\u305f\uff0e\u305d\u306e\u7d50\u679c\uff0cUSMB\u5358\u72ec\u3067\u306f\u82e5\u5e72\u306e\u816b\u760d\u5897\u6b96\u6291\u5236\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0e\u4e00\u65b9\uff0cHT\u5358\u72ec\u3084USMB\u3068HT\u306e\u7d44\u307f\u5408\u308f\u305b\u6cbb\u7642\u3067\u306f\uff0c2\u9031\u76ee\u4ee5\u964d\u306e\u816b\u760d\u4f53\u7a4d\u304c\u5897\u52a0\u3057\u306a\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\uff0e\u3053\u308c\u3089\u306e\u7fa4\u306b\u304a\u3044\u3066\uff0c\u816b\u760d\u4f53\u7a4d\u306e\u6291\u5236\u52b9\u679c\u306f\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\uff0e\u816b\u760d\u5185\u306e\u72b6\u614b\u3092\u89b3\u5bdf\u3059\u308b\u305f\u3081\uff0cMasson\u2019s trichrome \u67d3\u8272\uff08fibrosis\u306e\u78ba\u8a8d\uff09\u304a\u3088\u3073Ki-67\u306e\u514d\u75ab\u67d3\u8272\uff08\u5897\u6b96\u7d30\u80de\u306e\u78ba\u8a8d\uff09\u3092\u884c\u3063\u305f\uff0e\u305d\u306e\u7d50\u679c\uff0c\u7121\u51e6\u7f6e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3084USMB\u5358\u72ec\u6cbb\u7642\u7fa4\u3068\u6bd4\u3079\u3066\uff0cHT\u5358\u72ec\u3068USMB\u3068HT\u306e\u7d44\u307f\u5408\u308f\u305b\u6cbb\u7642\u7fa4\u3067\u306f\uff0cfibrosis\u30a8\u30ea\u30a2\u306e\u5897\u5927\u3068\u5897\u6b96\u7d30\u80de\u306e\u6e1b\u5c11\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0e\u3053\u306e\u7d50\u679c\u3092\u8a73\u7d30\u306b\u691c\u8a0e\u3057\u305f\u3068\u3053\u308d\uff0cUSMB\u3068HT\u306e\u7d44\u307f\u5408\u308f\u305b\u6cbb\u7642\u7fa4\u3067\u306fHT\u5358\u72ec\u6cbb\u7642\u7fa4\u3088\u308a\uff0cKi-67\u967d\u6027\uff08\u5897\u6b96\uff09\u7d30\u80de\u304c\u9855\u8457\u306b\u5c11\u306a\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\uff0e<\/p>\n\n\n\n \u4ee5\u4e0a\u3088\u308a\uff0cUSMB\u3068HT\u306e\u4f75\u7528\u6cbb\u7642\u306f\uff0cHT\u5358\u72ec\u6cbb\u7642\u3088\u308a\u52b9\u679c\u306e\u9ad8\u3044\u304c\u3093\u6cbb\u7642\u6cd5\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\uff0e\u3053\u306e\u3088\u3046\u306b\uff0cUSMB\u3068HT\u306e\u7d44\u307f\u5408\u308f\u305b\u306f\uff0c\u3088\u308a\u52b9\u679c\u7684\u306a\u304c\u3093\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u304a\u3051\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306b\u306a\u308b\u3082\u306e\u3068\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n \u53c2\u8003\u6587\u732e<\/p>\n\n\n\n 1) McDannold N., et al.<\/em> Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index. Ultrasound Med Biol, 34: 834-840, 2008.<\/p>\n\n\n\n 2) Weber-Adrian D., et al.<\/em> Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer’s disease. Theranostics, 9: 8127-8137, 2019.<\/p>\n\n\n\n 3) McMahon D., et al<\/em>. Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability. Expert Opin Drug Deliv, 16: 129-142, 2019.<\/p>\n\n\n\n 4) El Kaffas A., et al<\/em>. Tumour vascular shutdown and cell death following ultrasound-microbubble enhanced radiation therapy. Theranostics, 8: 314-327, 2018<\/p>\n\n\n\n 5) Sharma D., et al<\/em>. Ultrasound microbubble potentiated enhancement of hyperthermia-effect in tumors. PLOS ONE, 14(12): e0226475, 2019.<\/p>\n","protected":false},"excerpt":{"rendered":" \u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c37 \u304c\u3093\u306e\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u6cbb\u7642\u306b\u304a\u3051\u308b\u8d85\u97f3\u6ce2\u3068\u30de\u30a4\u30af\u30ed\u30d0\u30d6\u30eb\u306e\u4f75\u7528\u52b9\u679c\u306b\u3064\u3044\u3066 \u9234\u6728\u3000\u4eae (\u5e1d\u4eac\u5927\u5b66) \u304c\u3093\u6cbb\u7642\u306b\u304a\u3051\u308b\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2 (HT) \u306f\uff0c\u69d8\u3005\u306a\u304c\u3093\u3067\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-556","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=556"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/556\/revisions"}],"predecessor-version":[{"id":557,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/556\/revisions\/557"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}