\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c36<\/p>\n\n\n\n
\u524d\u7acb\u817a\u304c\u3093\u3092\u5bfe\u8c61\u306b\u3057\u305f\u91d1\u30ca\u30ce\u30b7\u30a7\u30eb\u3092\u7528\u3044\u305f\u5149\u6e29\u71b1\u30a2\u30d6\u30ec\u30fc\u30ec\u30fc\u30b7\u30e7\u30f3\u6cbb\u7642<\/strong><\/p>\n\n\n\n \u2015\u81e8\u5e8a\u5148\u884c\u7814\u7a76\u2015<\/strong><\/p>\n\n\n\n \u6cb3\u5408\u3000\u61b2\u5eb7\uff08\u540d\u53e4\u5c4b\u5e02\u7acb\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u3000\u814e\u30fb\u6ccc\u5c3f\u5668\u79d1\u5b66\u5206\u91ce\uff09<\/strong><\/p>\n\n\n\n \u4e16\u754c\u7684\u306b\u5149\u6e29\u71b1\u304c\u3093\u6cbb\u7642(Photothermal cancer therapy, PTT)\u304c\u6ce8\u76ee\u3092\u96c6\u3081,\u591a\u304f\u306e\u7814\u7a76\u5831\u544a\u304c\u3055\u308c\u3066\u3044\u308b\uff0e\u672c\u624b\u6cd5\u306f\u5468\u56f2\u7d44\u7e54\u306b\u306f\u5f71\u97ff\u306e\u306a\u3044\u6df1\u9054\u6027\u306e\u9ad8\u3044\u8fd1\u8d64\u5916\u7dda\uff08NIR\uff09\u3092\u7167\u5c04\u3059\u308b\u3068\u71b1\u3092\u767a\u751f\u3059\u308b\u91d1\u5c5e\u30ca\u30ce\u30b7\u30a7\u30eb\u3092\u7528\u3044\u3066\uff0c\u816b\u760d\u3092\u3088\u308a\u9078\u629e\u7684\u306b\uff0c\u304b\u3064\u52b9\u679c\u7684\u306b\u5149\u71b1\u5909\u63db\u3067\u816b\u760d\u7d44\u7e54\u306e\u307f\u3092\u30a2\u30d6\u30ec\u30fc\u30b7\u30e7\u30f3\u3067\u304d\u308b\u65b9\u6cd5\u3067\u3042\u308b\uff0e\u30ca\u30ce\u30b7\u30a7\u30eb\u306f\u7403\u5f62\u306e\u7d76\u7e01\u4f53\u306e\u82af\u3092\u8584\u3044\u91d1\u5c5e\u30b7\u30a7\u30eb\uff08\u6bbb\uff09\u3067\u8986\u3063\u305f\uff5e150 nm\u5f84\u306e\u7c92\u5b50\u3067\u3042\u308b\uff0eNIR\u5149\uff08820 nm\uff09\u7167\u5c04\u306b\u3088\u3063\u3066\u30ca\u30ce\u30b7\u30a7\u30eb\u8868\u9762\u306e\u4f1d\u5c0e\u6027\u91d1\u5c5e\u96fb\u5b50\u304c\u632f\u52d5\u3057\uff0c\u71b1\u3092\u767a\u751f\u3059\u308b\uff0e\u3044\u308f\u3086\u308b\u201c\u30ca\u30ce\u30d2\u30fc\u30c6\u30a3\u30f3\u30b0\u201d\u6cbb\u7642\u3067\u3042\u308b\uff0e\u3053\u308c\u3089\u306e\u539f\u7406\u306f16\u5e74\u524d\u306b\u5831\u544a\u3055\u308c\u3066\u304a\u308a1\uff09<\/sup>\uff0c\u305d\u306e\u5f8c\u3082\u57fa\u790e\u53ca\u3073\u524d\u81e8\u5e8a\u7814\u7a76\u306b\u3064\u3044\u3066\u306f\u591a\u304f\u306e\u5831\u544a\u304c\u3042\u308b\u304c\uff0c\u30d2\u30c8\u3067\u306e\u81e8\u5e8a\u5831\u544a\u4f8b\u306f\u5c11\u306a\u3044\uff0e\u3053\u3053\u3067\u7d39\u4ecb\u3059\u308b\u5185\u5bb9\u306f\u4f4e\u304a\u3088\u3073\u4e2d\u30ea\u30b9\u30af\u3068\u8a3a\u65ad\u3055\u308c\u305f16\u4f8b\u306e\u30d2\u30c8\u524d\u7acb\u817a\u304c\u3093\u3092\u5bfe\u8c61\u306b\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u691c\u8a0e\u3057\u305f\u91d1\u2015\u30b7\u30ea\u30ab\u30ca\u30ce\u30b7\u30a7\u30eb(AuroShells)\u3092\u7528\u3044\u305f\u5149\u6e29\u71b1\u7642\u6cd5\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u7814\u7a76\u306e\u5831\u544a\u3067\u3042\u308b2)<\/sup>\uff0e<\/p>\n\n\n\n \u672c\u7814\u7a76\u3067\u306f58-79\u6b73\u307e\u3067\u306e\u524d\u7acb\u817a\u764c\u60a3\u8005\u3067\u81e8\u5e8a\u75c5\u671fT2a\u4ee5\u4e0b\uff08\u8ee2\u79fb\u304c\u306a\u304f\u524d\u7acb\u817a\u306e\u5de6\u53f3\u3069\u3061\u3089\u304b\u7247\u65b9\u307f\u306e\u9650\u5c40\u6027\uff09\uff0cGleason score (\u30b0\u30ea\u30bd\u30f3\u30b9\u30b3\u30a2)4+3=7\u4ee5\u4e0b\uff08\u3044\u308f\u3086\u308b\u60aa\u6027\u5ea6\u304c\u4f4e\u301c\u4e2d\uff09\u306e16\u4f8b\u3092\u5bfe\u8c61\u306bPTT\u3092\u5b9f\u65bd\u3057\u305f\uff0e16\u540d\u306fmultiparametric MRI (mpMRI)\u3068\u30a8\u30b3\u30fc\u3092\u878d\u5408\u3055\u305b\u305f\u751f\u691c(mpMRI-US\u878d\u5408\u751f\u691c)\u306b\uff0c12\u30ab\u6240\u7cfb\u7d71\u7684\u751f\u691c\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u4e0a\u3067\uff0c\u524d\u7acb\u817a\u764c\u306f1\u30ab\u6240\u306e\u307f\u3067\u3042\u308b\u3068\u8a3a\u65ad\u3057\u305f\u60a3\u8005\u3067\u3042\u308b\uff0e\u6cbb\u7642\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u306fAuroShells (7.5 mg\/kg)\u3092\u6ce8\u5c04\u5f8c\uff0c\u7fcc\u65e5\u306b\u5168\u8eab\u9ebb\u9154\u4e0b\uff0c\u7815\u77f3\u4f4d\u3067\u4f1a\u9670\u90e8\u304b\u3089mpMRI-US\u306e\u30b7\u30b9\u30c6\u30e0\u3067\uff0cNIR\u7167\u5c04\u7528\u306e\u30d7\u30ed\u30fc\u30d6\u3092\u764c\u90e8\u4f4d\u306b\u523a\u5165\u30573\u5206\u9593NIR\u3092\u7167\u5c04\u3059\u308b\uff0e1\uff0c3\uff0c6\uff0c12\u30f6\u6708\u5f8c\u306b\u524d\u7acb\u817a\u764c\u816b\u760d\u30de\u30fc\u30ab\u30fcPSA\uff0c\u304a\u3088\u3073\u6392\u5c3f\u75c7\u72b6\uff0cQOL\u610f\u8b58\uff0c\u6027\u751f\u6d3b\u306e\u6d3b\u52d5\u6027\u3092\u6570\u5024\u5316\u3059\u308b\u30a2\u30f3\u30b1\u30fc\u30c8\uff08\u305d\u308c\u305e\u308cIPSS, QOL Index, SHIM\uff09\u3092\u8a55\u4fa1\u3057\u305f\uff0e\u3055\u3089\u306b3\u304a\u3088\u307312\u30f6\u6708\u3067\u306fmpMRI\u3068mpMRI-US\u751f\u691c\uff0b12\u30ab\u6240\u7cfb\u7d71\u751f\u691c\u3092\u5b9f\u65bd\u3057\u305f. PSA\u306f\u6cbb\u7642\u524d6.7ng\/ml\u3067\u3042\u3063\u305f\u304c\u6cbb\u76423\u30f6\u6708\u5f8c\u306f3.9ng\/ml\u306b\u4f4e\u4e0b\u3057\u305f\uff0eCTCAE \u30b0\u30ec\u30fc\u30c93\u4ee5\u4e0a\u306e\u6709\u5bb3\u4e8b\u8c61\u3082\u8a8d\u3081\u306a\u304b\u3063\u305f\uff0eIPSS, QOL Index, SHIM\u3082\u6cbb\u7642\u524d\u5f8c\u306b\u6709\u610f\u306a\u5dee\u306f\u8a8d\u3081\u306a\u304b\u3063\u305f\uff0e16\u4f8b\u4e2dNIR\u7167\u5c04\u304c\u3067\u304d\u305f\u306e\u306f15\u4f8b\uff0c\u751f\u691c\u306b\u3088\u308b\u6cbb\u7642\u90e8\u4f4d\u306e\u7d44\u7e54\u8a55\u4fa1\u3067\u306f3\u30f6\u6708\u5f8c\u306b9\u4f8b\uff089\/15\uff1a60.0\uff05\uff09\u306f\u58ca\u6b7b\u7d44\u7e54\u3068\u306a\u308a\u524d\u7acb\u817a\u764c\u306f\u8a8d\u3081\u306a\u304b\u3063\u305f\u304c\uff0c12\u30f6\u6708\u5f8c\u3067\u306f13\u4f8b\uff0813\/15\uff1a86.6\uff05\uff09\u304c\u58ca\u6b7b\u7d44\u7e54\u3067\u524d\u7acb\u817a\u764c\u306f\u8a8d\u3081\u306a\u304b\u3063\u305f.\u7d50\u679c\u306f\u672c\u6cd5\u306e\u4f4e\u304a\u3088\u3073\u4e2d\u30ea\u30b9\u30af\u7fa4\u306b\u304a\u3044\u3066\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u793a\u3057\u305f\u3082\u306e\u3068\u8a00\u3048\u308b\uff0e<\/p>\n\n\n\n \u524d\u7acb\u817a\u764c\u6cbb\u7642\u3082QOL\u306e\u5411\u4e0a\u3092\u3081\u3056\u3057,\u764c\u90e8\u5206\u306e\u307f\u3092\u6cbb\u7642\u3059\u308bFocal therapy\u304c\u81e8\u5e8a\u3067\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\uff0e\u3053\u3053\u3067\u7528\u3044\u305f\u30ca\u30ce\u7c92\u5b50\u306f\u6bd4\u8f03\u7684\u9078\u629e\u7684\u306b\u816b\u760d\u90e8\u306b\u53d6\u308a\u8fbc\u307e\u308c\uff0cNIR\u5149\u7167\u5c04\u90e8\u306e\u307f\u3067\u306e\u767a\u71b1\u3092\u5229\u7528\u3059\u308b\u9078\u629e\u6027\u306e\u9ad8\u3044\u6cbb\u7642\u6cd5\u3067\u3042\u308b\uff0e\u4eca\u5f8c\u3082\u6cbb\u7642\u7528\u30ca\u30ce\u7c92\u5b50\u958b\u767a\u3082\u767a\u5c55\u3059\u308b\u3068\u601d\u308f\u308c\uff0c\u764c\u306e\u30ca\u30ce\u6cbb\u7642\u7814\u7a76\u304c\u3055\u3089\u306b\u9032\u3080\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n \u53c2\u8003\u6587\u732e<\/strong><\/p>\n\n\n\n 1) Hirsch LR, et al<\/em>. Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci USA, 100: 13549\u201354, 2003.<\/p>\n\n\n\n 2) Rastinehad AR, et al.<\/em> Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study. Proc Natl Acad Sci USA, 116: 18590-6, 2019.<\/p>\n\n\n\n \u7528\u8a9e\u89e3\u8aac<\/strong><\/p>\n\n\n\n \u5149\u6e29\u71b1\u6cbb\u7642\uff1a<\/strong>Photothermal therapy<\/strong> (PTT)\u3068\u79f0\u3059\u308b.\u5149\u5897\u611f\u5264\u3092\u7528\u3044\u7279\u5b9a\u306e\u5438\u53ce\u6ce2\u9577\u306e\u30ec\u30fc\u30b6\u5149\u3092\u7167\u5c04\u3059\u308b\u764c\u6cbb\u7642\u306fPhotodynamic therapy<\/strong> (PDT,\u5149\u7dda\u529b\u5b66\u7684\u6cbb\u7642)\u3068\u79f0\u3055\u308c\u81e8\u5e8a\u5fdc\u7528\u3055\u308c\u3066\u3044\u308b\u304c\u5149\u5316\u5b66\u53cd\u5fdc\u3092\u5229\u7528\u3059\u308b\u969b\u306b\u9178\u7d20\u304c\u5fc5\u8981\u3067\u3042\u308b\uff0e\u5373\u3061\u764c\u306e\u4f4e\u9178\u7d20\u9818\u57df\u306b\u5bfe\u3057\u3066\u52b9\u679c\u306f\u4f4e\u304f\u306a\u308b.\u307e\u305f,\u5149\u5897\u611f\u5264\u306e\u5149\u6bd2\u6027\u306b\u3088\u308b\u526f\u4f5c\u7528\u3082\u8ab2\u984c\u3067\u3042\u308b\uff0e\u4e00\u65b9,PTT\u3067\u306f\u5897\u611f\u5264\u306e\u91d1\u5c5e\u30b3\u30fc\u30c8\u3057\u305f\u30ca\u30ce\u7c92\u5b50\u306b\u8fd1\u8d64\u5916\u7dda\u3092\u7167\u5c04\u3057\u305d\u306e\u767a\u71b1\u3092\u5229\u7528\u3059\u308b\u305f\u3081,\u4f4e\u9178\u7d20\u6027\u816b\u760d\u3082\u6cbb\u7642\u53ef\u80fd\u3067\u3042\u308b\uff0e<\/p>\n\n\n\n mpMRI<\/strong>:multiparametric MRI<\/strong>.\u30de\u30eb\u30c1\u30d1\u30e9\u30e1\u30c8\u30ea\u30c3\u30afMRI\u3068\u306f\uff0c\u5f93\u6765\u304b\u3089\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u5f62\u614b\u753b\u50cf\u3068\u3057\u3066\u306eT2\u5f37\u8abf\u50cf\u306b\uff0c2\u7a2e\u985e\u4ee5\u4e0a\u306e\u6a5f\u80fd\u753b\u50cf\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u8a3a\u65ad\u6cd5\u3067\u3042\u308b\uff0e\u4ee3\u8868\u7684\u306a\u6a5f\u80fd\u753b\u50cf\u306b\u306f\uff0c\u9020\u5f71\u5264\u3092\u7528\u3044\u3066\u75c5\u5de3\u306e\u704c\u6d41\u3092\u8a55\u4fa1\u3059\u308b\u9020\u5f71\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u3068\uff0c\u6c34\u306e\u62e1\u6563\u73fe\u8c61\u3092\u753b\u50cf\u5316\u3059\u308b\u62e1\u6563\u5f37\u8abf\u50cf\u304c\u3042\u308b\uff0e\u672c\u6cd5\u306e\u6709\u7528\u6027\u306f\uff0c\u816b\u760d\u691c\u51fa\u30fb\u5c40\u5728\u8a3a\u65ad\uff0c\u60aa\u6027\u5ea6\u306e\u8a55\u4fa1\u306b\u52a0\u3048\uff0c\u75c5\u671f\u8a3a\u65ad\uff0c\u6cbb\u7642\u52b9\u679c\u5224\u5b9a\uff0c\u518d\u767a\u8a3a\u65ad\u3084\u4e88\u5f8c\u4e88\u6e2c\u3068\u591a\u5c90\u306b\u308f\u305f\u308a\uff0c\u5f97\u3089\u308c\u308b\u8a3a\u65ad\u60c5\u5831\u306f\u524d\u7acb\u817a\u764c\u306e\u9069\u5207\u306a\u6cbb\u7642\u6cd5\u306e\u6c7a\u5b9a\u306b\u304a\u3044\u3066\u304d\u308f\u3081\u3066\u91cd\u8981\u3068\u306a\u3063\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n \u30b0\u30ea\u30bd\u30f3\u30b9\u30b3\u30a2\uff1a<\/strong>\u524d\u7acb\u817a\u91dd\u751f\u691c\u3067\u63a1\u53d6\u3057\u305f\u7d44\u7e54\u3092\u9855\u5fae\u93e1\u3067\u691c\u67fb\u3057\uff0c\u764c\u306e\u60aa\u6027\u5ea6\u3092\u5224\u65ad\u3059\u308b\u8a55\u4fa1\u6307\u6a19\uff0e\u512a\u52e2\u75c5\u5909\uff08\u3082\u3063\u3068\u3082\u591a\u3044\u75c5\u5909\uff09\u3068\u968f\u4f34\u75c5\u5909(2\u756a\u76ee\u306b\u591a\u3044\u75c5\u5909)\u3092\u5224\u5b9a\u3057\uff0c\u305d\u306e\u6570\u5024\u306e\u5408\u8a08\u30672\uff5e10\u306e9\u6bb5\u968e\u306b\u5206\u985e\u3059\u308b\uff0e\u30b0\u30ea\u30bd\u30f3\u30b9\u30b3\u30a2\u304c\u9ad8\u3044\u307b\u3069\uff0c\u764c\u306e\u60aa\u6027\u5ea6\u306f\u9ad8\u3044\uff0e<\/p>\n\n\n\n \u30b0\u30ea\u30bd\u30f3\u30b9\u30b3\u30a2\u30008\u4ee5\u4e0a\uff1a<\/strong>\u60aa\u6027\u5ea6\u306e\u9ad8\u3044\u4f4e\u5206\u5316\u578b\u524d\u7acb\u817a\u304c\u3093<\/p>\n\n\n\n \u30b0\u30ea\u30bd\u30f3\u30b9\u30b3\u30a2\u30007\uff1a<\/strong>\u4e2d\u7b49\u5ea6\u306e\u60aa\u6027\u5ea6\u306e\u524d\u7acb\u817a\u304c\u3093<\/p>\n\n\n\n \u30b0\u30ea\u30bd\u30f3\u30b9\u30b3\u30a2\u30006\u4ee5\u4e0b\uff1a<\/strong>\u6bd4\u8f03\u7684\u9032\u884c\u306e\u9045\u3044\u9ad8\u5206\u5316\u578b\u524d\u7acb\u817a\u304c\u3093 SHIM score: Sexual Health Inventory for Men score<\/strong><\/p>\n\n\n\n CTCAE: Common Terminology Criteria for Adverse Events<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":" \u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c36 \u524d\u7acb\u817a\u304c\u3093\u3092\u5bfe\u8c61\u306b\u3057\u305f\u91d1\u30ca\u30ce\u30b7\u30a7\u30eb\u3092\u7528\u3044\u305f\u5149\u6e29\u71b1\u30a2\u30d6\u30ec\u30fc\u30ec\u30fc\u30b7\u30e7\u30f3\u6cbb\u7642 \u2015\u81e8\u5e8a\u5148\u884c\u7814\u7a76\u2015 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[…]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-558","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=558"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/558\/revisions"}],"predecessor-version":[{"id":559,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/558\/revisions\/559"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=558"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
IPSS: International Prostate Symptom Score<\/strong><\/p>\n\n\n\n