{"id":562,"date":"2019-12-06T20:30:00","date_gmt":"2019-12-06T11:30:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=562"},"modified":"2022-05-26T20:28:25","modified_gmt":"2022-05-26T11:28:25","slug":"mr-hifu%e3%83%9e%e3%82%a4%e3%83%ab%e3%83%89%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc%e3%83%9f%e3%82%a2%e6%b2%bb%e7%99%82%e3%81%ae%e6%9c%80%e8%bf%91%e3%81%ae%e5%8b%95%e5%90%91%e2%80%95","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/mr-hifu%e3%83%9e%e3%82%a4%e3%83%ab%e3%83%89%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc%e3%83%9f%e3%82%a2%e6%b2%bb%e7%99%82%e3%81%ae%e6%9c%80%e8%bf%91%e3%81%ae%e5%8b%95%e5%90%91%e2%80%95\/","title":{"rendered":"MR-HIFU\u30de\u30a4\u30eb\u30c9\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u6cbb\u7642\u306e\u6700\u8fd1\u306e\u52d5\u5411\u2015\u6e29\u5ea6\u611f\u53d7\u6027\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u30ea\u30dd\u30bd\u30fc\u30e0\u306e\u4f75\u7528\u304a\u3088\u3073\u653e\u5c04\u7dda\u5897\u611f\u3078\u306e\u5229\u7528"},"content":{"rendered":"\n

\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c34<\/p>\n\n\n\n

MR-HIFU\u30de\u30a4\u30eb\u30c9\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u6cbb\u7642\u306e\u6700\u8fd1\u306e\u52d5\u5411\u2015\u6e29\u5ea6\u611f\u53d7\u6027\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u30ea\u30dd\u30bd\u30fc\u30e0\u306e\u4f75\u7528\u304a\u3088\u3073\u653e\u5c04\u7dda\u5897\u611f\u3078\u306e\u5229\u7528<\/p>\n\n\n\n

\u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u85ac\u5b66\u7814\u7a76\u90e8\uff09<\/p>\n\n\n\n

\u8fd1\u5e74\uff0cMR\u30ac\u30a4\u30c9\u4e0b\u306b\u96c6\u675f\u8d85\u97f3\u6ce2\u6cbb\u7642\u3092\u7528\u3044\u3066\u5c40\u6240\u7684\u306b\u60a3\u90e8\u3092\u713c\u707c\u3059\u308b\u6cbb\u7642\u6cd5\uff08\u4ee5\u4e0bMR-HIFU\uff09\u306f\u6cbb\u7642\u90e8\u4f4d\u306e\u753b\u50cf\u628a\u63e1\u3068\u3068\u3082\u306b\u6e29\u5ea6\u304c\u5b9f\u6e2c\u3067\u304d\u308b\u305f\u3081\u5c40\u6240\u52b9\u679c\u3092\u76ee\u6307\u3057\u305f\u975e\u89b3\u8840\u7684\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\uff0e\u6700\u8fd1\u3067\u306f\u7d4c\u982d\u84cb\u7684\u7167\u5c04\u304c\u53ef\u80fd\u306a\u88c5\u7f6e\u304c\u958b\u767a\u3055\u308c\uff0c\u8133\u3082\u6cbb\u7642\u5bfe\u8c61\u3068\u306a\u3063\u3066\u304d\u305f\uff0e\u3053\u306eMR-HIFU\u30b7\u30b9\u30c6\u30e0\u3092\u3042\u3048\u3066\u30de\u30a4\u30eb\u30c9\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2(MH)\u306b\u5229\u7528\u3059\u308b\u8a66\u307f\u304c\u591a\u304f\u306a\u3063\u3066\u304d\u305f\uff0e\u307e\u305f\uff0c\u85ac\u7269\u7642\u6cd5\u306f\u5fc5\u8981\u306a\u60a3\u90e8\u306b\u5fc5\u8981\u306a\u7528\u91cf\u3092\u5c4a\u3051\u308b\u3053\u3068\u304c\u9375\u3067\u3042\u308b\uff0e\u3053\u306e\u89b3\u70b9\u3067\uff0cMR-HIFU\u3092\u6b63\u78ba\u306a\u52a0\u6e29\u304c\u3067\u304d\u308bMH\u3068\u3057\u3066\u5229\u7528\u3057\uff0c\u753b\u50cf\u8a98\u5c0e\u4e0b\u306b\u85ac\u7269\u9001\u9054\u3092\u884c\u3063\u305f\u30e9\u30c3\u30c8\u6a2a\u7d0b\u7b4b\u8089\u816b\u6cbb\u7642\u306e\u5831\u544a1)<\/sup>\u3084\u30d2\u30c8\u3067\u3082\u6e29\u5ea6\u611f\u53d7\u6027\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u30ea\u30dd\u30bd\u30fc\u30e0(LTSL-DOX)\u3068\u4f75\u7528\u3059\u308b\u8a66\u307f\u306f\u809d\u81d3\u304c\u3093\u3092\u5bfe\u8c61\u306b\u81e8\u5e8a\u7b2c\uff11\u76f8\u8a66\u9a13\u3068\u3057\u3066\u5831\u544a\u3055\u308c\u3066\u3044\u308b2)<\/sup>\uff0e\u4e00\u65b9\uff0c\u6700\u9069\u306e\u52a0\u6e29\u6642\u9593\u3084\u6cbb\u7642\u53ef\u80fd\u6bd4\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u307e\u3060\u306a\u3044\uff0e\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u8ad6\u6587\u3067\u306fMR-HIFU\u306b\u3088\u308bMH\u3068LTSL-DOX\u3068\u306e\u4f75\u7528\u7642\u6cd5\u3067\uff0c\u52a0\u6e29\u6761\u4ef6\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u816b\u760d\u7d44\u7e54\u306eDOX\u6fc3\u5ea6\u3068\u6cbb\u7642\u53ef\u80fd\u6bd4\u306b\u5dee\u304c\u51fa\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a0e\u3057\u305f3)<\/sup>\uff0e<\/p>\n\n\n\n

\u3053\u3053\u3067\u306f\u30a6\u30b5\u30ae\u306e\u809d\u81d3\u306b\u79fb\u690d\u3057\u305fVx2\u816b\u760d\u3092\u5bfe\u8c61\u306bLTSL-DOX\u3068\u3057\u3066\u201cThermoDoxR\u201d\u3092\u7528\u3044\u3066\u5c40\u6240\u53ca\u3073\u5168\u8eab\u306b\u304a\u3051\u308bDOX\u306e\u5206\u5e03\u309242\u2103\uff0c10\u5206\u53ca\u307340\u5206\u306e\u52a0\u6e29\u6642\u9593\u3067\u6bd4\u8f03\u3057\u305f\uff0e\u6642\u9593\u7684\uff0c\u7a7a\u9593\u7684\u306b\u5236\u5fa1\u3055\u308c\u305fMH\u3092\u5b9f\u65bd\u3059\u308b\u305f\u3081\u306bMR-HIFU (\u5468\u6ce2\u65701.2 MHz, \u51fa\u529b40-60 \uff37)\u3092\u7528\u3044\u305f\uff0eLTSL-DOX\u6295\u4e0e\u306f\u52a0\u6e29\u958b\u59cb5\u5206\u3067\u884c\u308f\u308c\u305f\uff0e\u816b\u760d\uff0c\u5fc3\u81d3\uff0c\u7b4b\u8089\uff0c\u809d\u81d3\uff0c\u814e\u81d3\uff0c\u813e\u81d3\u304a\u3088\u3073\u80ba\u306e\u7d44\u7e54\u4e2dDOX\u6fc3\u5ea6\u3092\u8abf\u3079\u305f\u304c\uff0c\u816b\u760d\u306e\u307f10\u5206\u304a\u3088\u307340\u5206\u306e\u6bd4\u8f03\u3067\u52a0\u6e29\u306b\u4f34\u3046\u6fc3\u5ea6\u5897\u52a0(\u7d042.4\u500d)\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0e\u307e\u305f\uff0c\u975e\u52a0\u6e29\u816b\u760d\u306b\u6bd4\u3079\u305f\u816b\u760d\u7d44\u7e54\u4e2d\u306e\u85ac\u5264\u6fc3\u5ea6\u306f10\u5206\u30672.7\u500d\uff0c40\u5206\u30675.8\u500d\u5897\u52a0\u3057\u305f\uff0e\u5fc3\u81d3\u3092\u5bfe\u7167\u81d3\u5668\u3068\u3057\u3066\u52a0\u6e29\u816b\u760d\u3078\u306e\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u53d6\u308a\u8fbc\u307f\u306e\u6bd4\u3067\u8a55\u4fa1\u3055\u308c\u305f\u6cbb\u7642\u53ef\u80fd\u6bd4Therapeutic ratio\u306f10\u5206\u52a0\u6e29\u30671.9 + 1.3\uff0c40\u5206\u52a0\u6e29\u30674.4 + 1.8\u3067\u3042\u308a\uff0c40\u5206\u52a0\u6e29\u304c\u512a\u308c\u3066\u3044\u305f\uff0eMR-HIFU\u306f\u524d\u81e8\u5e8a\u7814\u7a76\u3068\u3057\u3066\u7528\u3044\u305f\u30a6\u30b5\u30aeVx2\u816b\u760d\u30e2\u30c7\u30eb\u3067\u306e\u6e29\u5ea6\u30e2\u30cb\u30bf\u30fc\u3068\u5236\u5fa1\u306b\u3088\u308b\u6b63\u78ba\u306aMH\u6cbb\u7642\u304c\u53ef\u80fd\u3067\uff0c\u30ea\u30dd\u30bd\u30fc\u30e0\u7531\u6765\u306e\u9ad8\u6fc3\u5ea6\u306eDOX\u3092\u6a19\u7684\u60a3\u90e8\u306b\u63d0\u4f9b\u3059\u308b\u52b9\u7387\u7684\u624b\u6cd5\u3067\u3042\u308b\uff0e<\/p>\n\n\n\n

\u4eca\u5e74\u306b\u306a\u3063\u3066\uff0c\u96c6\u675f\u8d85\u97f3\u6ce2\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u3088\u308bHigh grade\u30b0\u30ea\u30aa\u30fc\u30de\u653e\u5c04\u7dda\u7642\u6cd5\u306e\u5897\u5f37\u306b\u95a2\u3059\u308b\u7dcf\u8aac4)<\/sup>\u304a\u3088\u3073\u653e\u5c04\u7dda\u5897\u611f\u306e\u305f\u3081\u306e\u8d85\u97f3\u6ce2\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u6280\u8853\u306b\u95a2\u3059\u308b\u7dcf\u8aac5)<\/sup>\u304c\u767a\u8868\u3055\u308c\uff0c\u6e29\u5ea6\u30e2\u30cb\u30bf\u30fc\u3067\u304d\u308b\u201c\u6b63\u78ba\u306a\u201d\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u6cbb\u7642\uff08MR-HIFU, MRg-FUS\uff09\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u4f75\u7528\u306b\u95a2\u3057\u3066\u4eca\u5f8c\u306e\u52d5\u5411\u306b\u8208\u5473\u304c\u6301\u305f\u308c\u308b\uff0e<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e\uff1a<\/p>\n\n\n\n

1)  Hijnen N, et al<\/em>. Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound. Proc Natl Acad Sci U S A. 114: E4802-11, 2017.<\/p>\n\n\n\n

2)  Lyon PC et al<\/em>. Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): A single-centre, open-label, phase 1 trial. Lancet Oncol. 19:1027-39, 2018.<\/p>\n\n\n\n

3)  Bing C et al.<\/em> Longer heating duration increases localized doxorubicin deposition and therapeutic index in Vx2 tumors using MR-HIFU mild hyperthermia and thermosensitive liposomal doxorubicin. <\/strong>Int J Hyperthermia 36: 196-203, 2019.<\/p>\n\n\n\n

4)  Schneider CS et al<\/em>. Radiosensitization of high-grade gliomas through induced hyperthermia: Review of clinical experience and the potential role of MR-guided focused ultrasound. Radiother Oncol. S0167-8140(19)33010-5, 2019.<\/p>\n\n\n\n

5) Zhu L et al. <\/em>Ultrasound hyperthermia technology for radiosensitization. Ultrasound Med Biol 45: 1025-43, 2019.<\/p>\n\n\n\n

\u7528\u8a9e\u89e3\u8aac\uff1a<\/p>\n\n\n\n

MR-HIFU\uff1aMagnetic Resonance\u2013High-intensity focused ultrasound\u306e\u3053\u3068\uff0eMR \u30ac\u30a4\u30c9\u4e0b\u96c6\u675f\u8d85\u97f3\u6ce2\uff08MRI\u2013guided focused ultrasound\uff1aMRgFUS\u3084MRgHIFU\uff09\u3068\u79f0\u3059\u308b\u5834\u5408\u3082\u3042\u308b\uff09\uff1aMRI\u3067\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306b\u6cbb\u7642\u90e8\u4f4d\u3068\u6e29\u5ea6\u3092\u30e2\u30cb\u30bf\u30fc\u3057\u306a\u304c\u3089\uff0c\u8d85\u97f3\u6ce2\u3092\u96c6\u675f\u3055\u305b\u3066\uff0c\u7d44\u7e54\u3092\u71b1\u51dd\u56fa\u3042\u308b\u3044\u306f\u52a0\u6e29\u3059\u308b\u88c5\u7f6e\u3067\u3042\u308b\uff0e\u672c\u90a6\u3067\u306f\u4eca\u5e74\u304b\u3089\uff0c\u7d4c\u982d\u84cb\u7684\u7167\u5c04\u304c\u53ef\u80fd\u306a\u88c5\u7f6e\u3067\u306e\u85ac\u5264\u62b5\u6297\u6027\u672c\u614b\u6027\u632f\u6226\uff08essential tremor\uff09\u306e\u6cbb\u7642\u306b\u4fdd\u967a\u9069\u7528\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0e\u672c\u88c5\u7f6e\u3067\u306f\u975e\u89b3\u8840\u7684\u8133\u624b\u8853\u304c\u53ef\u80fd\u3067\uff0c\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u6cbb\u7642\u5fdc\u7528\u3082\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\uff0e\u96c6\u675f\u8d85\u97f3\u6ce2\u306f\u524d\u7acb\u817a\u80a5\u5927\uff0c\u540c\u764c\uff0c\u5b50\u5bae\u7b4b\u816b\u306e\u713c\u707c\u7642\u6cd5\u3084\u4e73\u764c\u6cbb\u7642\u306b\u3082\u5229\u7528\u3055\u308c\u3066\u304d\u305f\u304c\uff0c\u9aa8\u8ee2\u79fb\u306b\u4f34\u3046\u6cbb\u7642\u62b5\u6297\u6027\u306e\u75db\u307f\u306b\u5bfe\u3059\u308b\u4f7f\u7528\u3082\u691c\u8a0e\u3055\u308c\u3066\u304a\u308a\u5229\u7528\u306f\u5e83\u304c\u308a\u3092\u307f\u305b\u3066\u3044\u308b\uff0eMRI\u3068\u4e00\u4f53\u5316\u3057\u305f\u6cbb\u7642\u88c5\u7f6e\u3068\u3057\u3066\u306fSonalleve \uff08MR-HIFU\uff09\uff0cProfound Medical Co. Canada\u304a\u3088\u3073Exablate\uff08MRg-FUS\uff09\uff0cINSIGHTEC Ltd. Israel\u304c\u3042\u308b\uff0eExablate Neuro\u306f\u7d4c\u982d\u84cb\u7684\u7167\u5c04\u7528\u306eINSIGHTEC\u306e\u88fd\u54c1\u3067\u3042\u308b\uff0e<\/p>\n\n\n\n

LTSL-DOX\uff1a\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u3092\u5185\u90e8\u306b\u542b\u3080Lysolipid thermally sensitive liposomes.  ThermoDoxR\u306fCelsion Corp. NJ, USA\u306e\u88fd\u54c1\u3067\u3042\u308b\uff0e<\/p>\n\n\n\n

High grade \u30b0\u30ea\u30aa\u30fc\u30de\uff1aWHO\u8133\u816b\u760d\u5206\u985e\u7b2c\uff14\u7248\uff08WHO2007\uff09\u3067\u306f\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u661f\u7d30\u80de\u7cfb\uff0c\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\uff0c\u4e0a\u8863\u7cfb\u306b\u5927\u5225\u3055\u308c\u308b\uff0e\u4f8b\u5916\u7684\u306b\u826f\u6027\u816b\u760d\u3067\u3042\u308b\u9650\u5c40\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u306fWHO grade I\u306b\uff0c\u305d\u306e\u4ed6\u306e\u6d78\u6f64\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u306f\uff0c\u4f4e\u60aa\u6027\u7fa4\u306b\u3064\u3044\u3066\u306fgrade II\uff0c\u60aa\u6027\u7fa4\u306b\u3064\u3044\u3066\u306fgrade III\u306b\u5206\u985e\u3055\u308c\u308b\uff0e\u6700\u60aa\u6027\u5ea6\u306egrade IV\u306f\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306b\u306e\u307f\u304c\u8a2d\u5b9a\u3055\u308c\u3066\u3044\u308b\uff08\u81a0\u82bd\u816b\uff0cglioblastoma\uff09\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"

\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c34 MR-HIFU\u30de\u30a4\u30eb\u30c9\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u6cbb\u7642\u306e\u6700\u8fd1\u306e\u52d5\u5411\u2015\u6e29\u5ea6\u611f\u53d7\u6027\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u30ea\u30dd\u30bd\u30fc\u30e0\u306e\u4f75\u7528\u304a\u3088\u3073\u653e\u5c04\u7dda\u5897\u611f\u3078\u306e\u5229\u7528 \u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u85ac\u5b66\u7814\u7a76\u90e8\uff09 \u8fd1\u5e74\uff0cMR\u30ac\u30a4\u30c9 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-562","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=562"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/562\/revisions"}],"predecessor-version":[{"id":563,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/562\/revisions\/563"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=562"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}