{"id":564,"date":"2019-11-18T20:30:00","date_gmt":"2019-11-18T11:30:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=564"},"modified":"2022-05-26T20:27:32","modified_gmt":"2022-05-26T11:27:32","slug":"%e6%b8%a9%e7%86%b1%e6%b2%bb%e7%99%82%e3%81%af%e8%85%ab%e7%98%8d%e3%82%92hot-tumor%e5%8c%96%e3%81%99%e3%82%8b%e3%81%93%e3%81%a8%e3%81%a7%e5%85%8d%e7%96%ab%e3%83%81%e3%82%a7%e3%83%83%e3%82%af%e3%83%9d","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e6%b8%a9%e7%86%b1%e6%b2%bb%e7%99%82%e3%81%af%e8%85%ab%e7%98%8d%e3%82%92hot-tumor%e5%8c%96%e3%81%99%e3%82%8b%e3%81%93%e3%81%a8%e3%81%a7%e5%85%8d%e7%96%ab%e3%83%81%e3%82%a7%e3%83%83%e3%82%af%e3%83%9d\/","title":{"rendered":"\u6e29\u71b1\u6cbb\u7642\u306f\u816b\u760d\u3092Hot tumor\u5316\u3059\u308b\u3053\u3068\u3067\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u52b9\u679c\u3092\u5897\u5f37\u3059\u308b"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c33<\/p>\n\n\n\n<p>\u6e29\u71b1\u6cbb\u7642\u306f\u816b\u760d\u3092Hot tumor\u5316\u3059\u308b\u3053\u3068\u3067\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u52b9\u679c\u3092\u5897\u5f37\u3059\u308b<\/p>\n\n\n\n<p>\u6a2a\u5800\u6b66\u5f66\uff08\u7fa4\u99ac\u5927\u5b66\u672a\u6765\u5148\u7aef\u7814\u7a76\u6a5f\u69cb \u7d71\u5408\u816b\u760d\u5b66\u7814\u7a76\u90e8\u9580\uff09<\/p>\n\n\n\n<p>\u6d45\u5c3e\u9ad8\u884c\uff08\u7fa4\u99ac\u5927\u5b66\u672a\u6765\u5148\u7aef\u7814\u7a76\u6a5f\u69cb \u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u7d71\u5408\u89e3\u6790\u30bb\u30f3\u30bf\u30fc\uff09<\/p>\n\n\n\n<p>\u8fd1\u5e74\uff0c\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u304c\u624b\u8853\uff0c\u6297\u304c\u3093\u5264\uff0c\u653e\u5c04\u7dda\u3068\u4e26\u3076\u7b2c4\u306e\u6cbb\u7642\u30c4\u30fc\u30eb\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\uff0e\u7279\u306bT\u7d30\u80de\u4e0a\u3067\u767a\u73fe\u3059\u308bPD-1\u3084\u816b\u760d\u7d30\u80de\u306b\u767a\u73fe\u3059\u308bPD-1\u30ea\u30ac\u30f3\u30c9 (PD-L1\uff1a\u5225\u540dCD274, B7-H1)\u3092\u6a19\u7684\u3068\u3057\u305f\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u304c\u60aa\u6027\u9ed2\u8272\u816b\uff0c\u80ba\u304c\u3093\u306a\u3069\u3067\u8457\u52b9\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0e\u3057\u304b\u3057\uff0c\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u304c\u52b9\u679c\u3092\u793a\u3059\u75c7\u4f8b\u306f10\u301c20%\u524d\u5f8c\u3067\u3042\u308a\u904e\u534a\u6570\u306e\u75c7\u4f8b\u306b\u306f\u85ac\u52b9\u3092\u793a\u3055\u305a\uff0c\u305d\u306e\u8010\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3068\u5897\u611f\u5264\u306e\u958b\u767a\u304c\u5b9f\u81e8\u5e8a\u306b\u304a\u3044\u3066\u5207\u671b\u3055\u308c\u3066\u3044\u308b\uff0e\u73fe\u5728\u306e\u3068\u3053\u308d\uff0c\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306b\u62b5\u6297\u6027\u3092\u793a\u3059\u75c7\u4f8b\u306e\u7279\u5fb4\u3068\u3057\u3066\uff0c\u816b\u760d\u3078\u306e\u514d\u75ab\u7d30\u80de\u6d78\u6f64\u306b\u4e4f\u3057\u304f\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u73fe\u3057\u306a\u3044\u816b\u760d\uff0c\u3044\u308f\u3086\u308b\u708e\u75c7\u53cd\u5fdc\u306b\u4e4f\u3057\u3044Cold tumor\u3068\u547c\u3070\u308c\u308b\u75c5\u614b\u304c\u6319\u3052\u3089\u308c\u308b\uff0e\u3053\u306eCold tumor\u306e\u514d\u75ab\u7d30\u80de\u6d78\u6f64\u3084\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u3092\u5897\u9032\u3055\u305b\u308b\u6cbb\u7642\u30c4\u30fc\u30eb\u306fCold tumor\u3092Hot tumor\u306b\u8ee2\u63db\u3059\u308b\u3053\u3068\u3067\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u5897\u611f\u5264\u306b\u306a\u308a\u5f97\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\uff0c\u5b9f\u969b\u306bOncolytic virus\u306a\u3069\u306f\u305d\u306e\u5019\u88dc\u3068\u3057\u3066\u6709\u671b\u8996\u3055\u308c\u3066\u3044\u308b<sup>1, 2)<\/sup>\uff0e<\/p>\n\n\n\n<p>\u6e29\u71b1\u6cbb\u7642\u306f\u304c\u3093\u7d30\u80de\u306b\u76f4\u63a5\u7684\u306b\u4f5c\u7528\u3057\uff0c\u6297\u816b\u760d\u52b9\u679c\u3092\u8a98\u5c0e\u3059\u308b\u3060\u3051\u3067\u306a\u304f\uff0c\u816b\u760d\u514d\u75ab\u3092\u6d3b\u6027\u5316 (\u8840\u6d41\u5897\u52a0\u306b\u3088\u308b\u514d\u75ab\u7d30\u80de\u6d78\u6f64\u2191\uff0c\u304c\u3093\u7279\u7570\u7684\u6297\u539f\u63d0\u793a\u2191\u306a\u3069)\u3059\u308b\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u4eca\u56de\u7d39\u4ecb\u3059\u308bLiu\u3089\u306e\u7814\u7a76\u3067\u306f\uff0cFVIO-mediated mild hyperthermia\u304c\u30de\u30a6\u30b9\u306e\u4e73\u304c\u3093\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066PD-L1\u3092\u6a19\u7684\u3068\u3057\u305f\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u611f\u53d7\u6027\u3092\u6709\u610f\u306b\u4ea2\u9032\u3055\u305b\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u308b<sup>3)<\/sup>\uff0e\u7279\u306b\uff0c\u6e29\u71b1\u3068PD-L1\u963b\u5bb3\u7642\u6cd5\u306e\u4f75\u7528\u306b\u3088\u308a\u816b\u760d\u5897\u6b96\u304c\u307b\u307c\u5b8c\u5168\u306b\u5236\u5fa1\u3067\u304d\uff0c\u3055\u3089\u306b\uff0c\u80ba\u8ee2\u79fb\u3082\u6709\u610f\u306b\u6291\u5236\u3055\u308c\u308b\u70b9\u306f\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\uff0e\u307e\u305f\uff0c\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e\u306e\u305f\u3081\u306b\u6e29\u71b1\u4ecb\u5165\u5f8c\u306e\u816b\u760d\u5c40\u6240\u306e\u514d\u75ab\u7d30\u80de\u6d78\u6f64\u3092\u8a55\u4fa1\u3057\u305f\u7d50\u679c\uff0c\u6e29\u71b1\u306b\u3088\u308a\u6709\u610f\u306b\u816b\u760d\u5185\u306bCD8\u967d\u6027T\u7d30\u80de\u304c\u6d78\u6f64\u3057\uff0c\u816b\u760d\u514d\u75ab\u3092\u6291\u5236\u3059\u308b\u9aa8\u9ac4\u7531\u6765\u514d\u75ab\u6291\u5236\u7d30\u80de\uff08myeloid-derived suppressor cell: MDSC\uff09\u306e\u6d78\u6f64\u306f\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u305f\uff0e\u3055\u3089\u306b\uff0c\u6e29\u71b1\u3068PD-L1\u963b\u5bb3\u7642\u6cd5\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3088\u308a\u6709\u610f\u306aT\u7d30\u80de\u6d78\u6f64\u4ea2\u9032\u3068MDSC\u6d78\u6f64\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u305f\uff0e<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u77e5\u898b\u304b\u3089\uff0c\u6e29\u71b1\u6cbb\u7642\u306f\u5c40\u6240\u306e\u816b\u760d\u514d\u75ab\u53cd\u5fdc\u3092\u4ea2\u9032\u3055\u305b (Cold tumor\u2192Hot tumor)\uff0c\u3055\u3089\u306b\u306f\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u5897\u611f\u6cbb\u7642\u30c4\u30fc\u30eb\u3068\u306a\u308a\u5f97\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\uff0e\u4eca\u5f8c\uff0c\u6e29\u71b1\u6cbb\u7642\u306b\u3088\u308a\u6cbb\u7642\u6a19\u7684\u816b\u760d\u3092\u6587\u5b57\u901a\u308aHot tumor\u306b\u8ee2\u63db\u3059\u308b\u6cbb\u7642\u6226\u7565\u3068\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u4f75\u7528\u306e\u610f\u7fa9\u3092\u3055\u3089\u306b\u691c\u8a0e\u3057\u3066\u3044\u304f\u5fc5\u8981\u304c\u3042\u308b\u3060\u308d\u3046\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ribas A,&nbsp;<em>et al.<\/em>&nbsp;Oncolytic virotherapy promotes intratumoral T cell infiltration and improves anti-PD-1 immunotherapy. Cell 170: 1109-1119, 2017. 2017.<\/li><li>Haanen JBAG. Converting cold into hot tumors by combining immunotherapies.<\/li><\/ul>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Cell 170: 1055-1056, 2017.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Liu X,<em>&nbsp;et al.<\/em>&nbsp;Ferrimagnetic vortex nanoring-mediated mild magnetic hyperthermia imparts potent immunological effect for treating cancer metastasis. ACS Nano. 13: 8811-8825, 2019.<\/li><\/ul>\n\n\n\n<p>\u7528\u8a9e\u89e3\u8aac\uff1a<\/p>\n\n\n\n<p>\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\uff1a\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u514d\u75ab\u7d30\u80de\u306b\u3088\u308a\u81ea\u5df1\u306e\u7d44\u7e54\u304c\u653b\u6483\u3055\u308c\u306a\u3044\u3088\u3046\u306b\uff0c\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u6a5f\u80fd\u3057\u3066\u3044\u308b\u304c\uff0c\u304c\u3093\u7d30\u80de\u306f\u3053\u306e\u6a5f\u80fd\u3092\u5229\u7528\u3057\u3066\u751f\u4f53\u5185\u3067\u751f\u5b58\uff0c\u5897\u6b96\u3057\u3066\u3044\u308b\uff0e\u3053\u306e\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642\u85ac\u306f\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u3068\u547c\u3070\u308c\uff0c\u3055\u307e\u3056\u307e\u306a\u764c\u816b\u3067\u9855\u8457\u306a\u6cbb\u7642\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0e\u3053\u306e\u300c\u514d\u75ab\u6291\u5236\u306e\u963b\u5bb3\u306b\u3088\u308b\u304c\u3093\u6cbb\u7642\u6cd5\u306e\u767a\u898b\u300d\u306b\u3088\u308a\u4eac\u90fd\u5927\u5b66\u306e\u672c\u5eb6\u4f51\u6559\u6388\u306f\u30ce\u30fc\u30d9\u30eb\u533b\u5b66\u751f\u7406\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>Cold tumor\/Hot tumor\uff1aPD-L1\u306a\u3069\u306e\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u306b\u4e4f\u3057\u304f\uff0cT\u7d30\u80de\u306a\u3069\u306e\u514d\u75ab\u7d30\u80de\u6d78\u6f64\u306e\u5c11\u306a\u3044\u816b\u760d\u306f\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u611f\u53d7\u6027\u306b\u4e4f\u3057\u304fCold tumor\uff0c\u9006\u306b\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u767a\u73fe\u3057\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\u306e\u9ad8\u5ea6\u306a\u6d78\u6f64\u3092\u8a8d\u3081\u308b\u816b\u760d\u306f\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u52b9\u679c\u304c\u9ad8\u304fHot tumor\u3068\u547c\u3070\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>Oncolytic virus\uff1a\u816b\u760d\u6eb6\u89e3\u6027\u30a6\u30a4\u30eb\u30b9\u306f\u304c\u3093\u7d30\u80de\u306b\u611f\u67d3\u3057\u3066\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u30a6\u30a4\u30eb\u30b9\u306e\u7dcf\u79f0\u3067\u3042\u308a\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\uff0c\u30ec\u30aa\u30a6\u30a4\u30eb\u30b9\uff0c\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\uff0c\u73fe\u5728\u306f\u3088\u308a\u816b\u760d\u9078\u629e\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u306e\u6539\u826f\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u308b\uff0e\u53c2\u8003\u6587\u732e1)\u3067Ribas\u3089\u304c\u7528\u3044\u305fTalimogene laherparepvec\uff08T-VEC\uff0c\u5546\u54c1\u540dImlygic\uff09\u306f\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u816b\u760d\u6eb6\u89e3\u6027\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9\u3067\u3042\u308a\u30e1\u30e9\u30ce\u30fc\u30de\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u85ac\u3068\u3057\u3066\uff0c\u3059\u3067\u306bFDA\u306b\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>FVIO: ferrimagnetic vortex-domain iron oxide nanoring (FVIO)\u306f\u78c1\u6c17\u30ca\u30ce\u30d1\u30fc\u30c6\u30a3\u30af\u30eb\u3092\u5229\u7528\u3057\uff0c\u6e29\u71b1\u3092\u8a98\u5c0e\u3059\u308b\u624b\u6cd5\u306e\u4e00\u7a2e\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c33 \u6e29\u71b1\u6cbb\u7642\u306f\u816b\u760d\u3092Hot tumor\u5316\u3059\u308b\u3053\u3068\u3067\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u52b9\u679c\u3092\u5897\u5f37\u3059\u308b \u6a2a\u5800\u6b66\u5f66\uff08\u7fa4\u99ac\u5927\u5b66\u672a\u6765\u5148\u7aef\u7814\u7a76\u6a5f\u69cb \u7d71\u5408\u816b\u760d\u5b66\u7814\u7a76\u90e8\u9580\uff09 \u6d45\u5c3e\u9ad8\u884c\uff08\u7fa4\u99ac\u5927\u5b66\u672a\u6765\u5148\u7aef\u7814\u7a76\u6a5f 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