{"id":566,"date":"2019-11-11T20:31:00","date_gmt":"2019-11-11T11:31:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=566"},"modified":"2022-05-26T20:31:00","modified_gmt":"2022-05-26T11:31:00","slug":"%e6%b8%a9%e7%86%b1%e8%b2%a0%e8%8d%b7%e8%85%ab%e7%98%8d%e7%b4%b0%e8%83%9e%e7%94%b1%e6%9d%a5%e3%81%ae%e3%82%a8%e3%82%af%e3%82%bd%e3%82%bd%e3%83%bc%e3%83%a0%e3%81%afil-6%e3%82%92%e4%bb%8b%e3%81%97","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e6%b8%a9%e7%86%b1%e8%b2%a0%e8%8d%b7%e8%85%ab%e7%98%8d%e7%b4%b0%e8%83%9e%e7%94%b1%e6%9d%a5%e3%81%ae%e3%82%a8%e3%82%af%e3%82%bd%e3%82%bd%e3%83%bc%e3%83%a0%e3%81%afil-6%e3%82%92%e4%bb%8b%e3%81%97\/","title":{"rendered":"\u6e29\u71b1\u8ca0\u8377\u816b\u760d\u7d30\u80de\u7531\u6765\u306e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306fIL-6\u3092\u4ecb\u3057\u3066\u5236\u5fa1\u6027\uff34\u7d30\u80de\u304b\u3089Th17\u7d30\u80de\u3078\u306e\u5909\u63db\u306b\u3088\u308a\u816b\u760d\u5897\u6b96\u3092\u963b\u5bb3\u3059\u308b"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c32<\/p>\n\n\n\n<p>\u6e29\u71b1\u8ca0\u8377\u816b\u760d\u7d30\u80de\u7531\u6765\u306e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306fIL-6\u3092\u4ecb\u3057\u3066\u5236\u5fa1\u6027\uff34\u7d30\u80de\u304b\u3089Th17\u7d30\u80de\u3078\u306e\u5909\u63db\u306b\u3088\u308a\u816b\u760d\u5897\u6b96\u3092\u963b\u5bb3\u3059\u308b<\/p>\n\n\n\n<p>\u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u85ac\u5b66\u7814\u7a76\u90e8<strong>\uff09<\/strong><\/p>\n\n\n\n<p>\u8fd1\u5e74\uff0c\u7d30\u80de\u5916\u5c0f\u80de(Extracellular vesicle)\u306e\u4e00\u3064\u3067\u3042\u308b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\uff0c\u4f53\u5185\u3092\u5faa\u74b0\u3057\uff0c\u7d30\u80de\u9593\u60c5\u5831\u4f1d\u9054\u3092\u62c5\u3044\uff0c\u305d\u3057\u3066\uff0c\u591a\u304f\u306e\u75be\u60a3\u3068\u306e\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\uff0c\u4eca\u975e\u5e38\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\uff0e\u764c\u6cbb\u7642\u3068\u306e\u95a2\u9023\u3067\uff0c\u816b\u760d\u7d30\u80de\u7531\u6765\u306e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0(TEXs: Exosomes derived from tumor cells)\u306b\u95a2\u3059\u308b\u5831\u544a\u306f\u591a\u3044\u304c\uff0c\u6e29\u71b1\u8ca0\u8377\u306b\u3088\u308b\u816b\u760d\u7d30\u80de\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0(HS-TEXs: Exosomes derived from&nbsp;Heat-Stressed&nbsp;tumor cells)\u306e\u5206\u6ccc\u3084\u305d\u306e\u50cd\u304d\u306b\u3064\u3044\u3066\u306e\u5831\u544a\u306f, \u5fc5\u305a\u3057\u3082\u591a\u304f\u306a\u3044\uff0e<\/p>\n\n\n\n<p>HS-TEXs\u306f\u591a\u304f\u306eHSP70\u3092\u542b\u307f\uff0c\u514d\u75ab\u539f\u6027\u304c\u9ad8\u304f\uff0c\u52b9\u7387\u3088\u304f\u816b\u760d\u7279\u7570\u7684\u50b7\u5bb3\u6027T\u7d30\u80de\u5fdc\u7b54\u3092\u62c5\u3046\u3053\u3068<sup>1)<\/sup>\uff0c\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\u306e\u4e00\u7a2e\u3067\u3042\u308bTh1\u7d30\u80de\u3092\u8a98\u5c0e\u3057\uff0c\u6297\u816b\u760d\u52b9\u679c\u3092\u793a\u3059\u3053\u3068<sup>2)<\/sup>\u7b49\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>HS-TEXs\u306e\u5f37\u529b\u306a\u6297\u816b\u760d\u514d\u75ab\u5fdc\u7b54\u306f\u3053\u308c\u306b\u542b\u307e\u308c\u308b\u591a\u91cf\u306eHSP70\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308a\uff0cHSP70\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308bIL-6\u306fIL-17\u767a\u73fe\u3092\u4fc3\u9032\u3057\uff0c\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\uff0cHS-TEXs\u304c\u5236\u5fa1\u6027T\u7d30\u80de(Tregs)\u304b\u3089Th17\u7d30\u80de\u3078\u306e\u5909\u63db\u306b\u3088\u308a\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u304b\u5426\u304b\u306f\u4e0d\u660e\u3067\u3042\u308a\uff0c\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u7814\u7a76\u306f\u3053\u306e\u3053\u3068\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u884c\u306a\u308f\u308c\u305f<sup>3)<\/sup>\uff0e<em>In vitro<\/em>\u5b9f\u9a13\u3067\u306f\uff0c\u30de\u30a6\u30b9\u7d50\u8178\u764cMC38\u3092\u4f7f\u7528\u3057\u305f\uff0eTEXs\u3068HS-TEXs(\u52a0\u6e29\u6761\u4ef6\u306f42\u2103\uff0c1 h)\u3092\u6bd4\u8f03\u3057\u305f\u3068\u3053\u308d\uff0c\u5f8c\u8005\u306e\u65b9\u304cHSP70\u304a\u3088\u3073HSC70\u306e\u91cf\u306f\u591a\u304f\uff0cAlix (apoptosis-linked gene 2-interacting protein X)\u306f\u5c11\u306a\u304b\u3063\u305f\uff0eHS-TEXs\u306f\u9aa8\u9ac4\u306e\u6a39\u72b6\u7d30\u80de\u304b\u3089\u306eIL-6\u5206\u6ccc\u3092\u3088\u308a\u5f37\u304f\u523a\u6fc0\u3057\u305f\uff0e\u307e\u305f\uff0c\u6a39\u72b6\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u305fIL-6\u306f\u816b\u760d\u7d30\u80de\u7531\u6765\u306eTGF-\u03b21\u306e\u8a98\u5c0e\u306b\u3088\u308bTregs (Foxp3<sup>+<\/sup>\u7d30\u80de\u3092\u6307\u6a19\u306b)\u306e\u5206\u5316\u3092\u963b\u5bb3\u3057\uff0cTh17\u7d30\u80de(IL-17<sup>+<\/sup>\u7d30\u80de\u3092\u6307\u6a19\u306b)\u306e\u5206\u5316\u3092\u4fc3\u9032\u3057\u305f\uff0e\u3057\u304b\u3057\uff0cIL-6<sup>-\/-<\/sup>\u30de\u30a6\u30b9\u304b\u3089\u5f97\u3089\u308c\u305f\u6a39\u72b6\u7d30\u80de\u3092\u7528\u3044\u305f\u5834\u5408\u306f\uff0cHS-TEXs \u306b\u3088\u308bTh17\u7d30\u80de\u306e\u5206\u5316\u4fc3\u9032\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f\uff0e<em>In vivo<\/em>\u5b9f\u9a13\u3067\u306f\uff0cTEXs \u3068\u6bd4\u8f03\u3057\u3066HS-TEXs\u306fMC38\u62c5\u764c\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3067\u5f37\u529b\u306a\u816b\u760d\u5897\u6b96\u9045\u5ef6\u52b9\u679c\u3068\uff0c\u52b9\u679c\u7684\u306aTregs\u304b\u3089Th17\u7d30\u80de\u3078\u306e\u5909\u63db\u52b9\u679c\u3092\u793a\u3057\u305f\uff0e\u3057\u304b\u3057IL-6<sup>-\/-<\/sup>\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u62c5\u764c\u30e2\u30c7\u30eb\u3067\u306f\u3001\u3084\u306f\u308a\u4e0a\u8a18\u306e\u52b9\u679c\u306f\u6d88\u5931\u3057\u305f\uff0e\u3057\u305f\u304c\u3063\u3066\uff0cHS-TEXs \u306b\u3088\u308b\u6297\u816b\u760d\u52b9\u679c\u306fIL-6\u4f9d\u5b58\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff0e\u307e\u305fIL-17\u4e2d\u548c\u6297\u4f53\u3067\u51e6\u7406\u3059\u308b\u3068TEXs\u306e\u6297\u816b\u760d\u52b9\u679c\u306f\u6d88\u5931\u3057\u305f\u304c\uff0cHS-TEXs\u306e\u6297\u816b\u760d\u52b9\u679c\u306e\u6d88\u5931\u306f\u90e8\u5206\u7684\u3067\u3042\u3063\u305f\uff0e<\/p>\n\n\n\n<p>\u3055\u3089\u306b\uff0c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u6cbb\u7642(\u88c5\u7f6e\u306fNRL-002\u578b\u3067\uff0c30.32\u304a\u3088\u307340.68\u2009MHz \u306e\u6ce2\u9577\u3092\u5229\u7528\u3059\u308bRF\u52a0\u6e29\u88c5\u7f6e\uff0cJilin Maida Co., Jilin, China\u3092\u4f7f\u7528\uff0c\u76f4\u8178\u6e29\u5ea6\u306739<sup>o<\/sup>C\uff0c60\u5206\u52a0\u6e29)\u3092\u53d7\u3051\u305f\u7d50\u76f4\u8178\u764c\u60a3\u800512\u4f8b(40-60\u6b73)\u3067\u306f\u8840\u6e05\u4e2d\u306eIL-6 \u304a\u3088\u3073IL-17\u306e\u30ec\u30d9\u30eb\u304c\u4e0a\u6607\u3057\uff0c\u307e\u305f\uff0c\u6cbb\u7642\u5f8c\u306e\u5358\u96e2\u3055\u308c\u305f\u672b\u68a2\u8840\u5358\u6838\u7d30\u80de\u5206\u753b\u306eCD4<sup>+<\/sup>T\u7d30\u80de\u3042\u305f\u308a\u306eTh17\u7d30\u80de\u306e\u5897\u52a0\u3068Tregs\u306e\u6e1b\u5c11\u304c\u5224\u660e\u3057\u305f\uff0e<\/p>\n\n\n\n<p>\u4ee5\u4e0a\u3088\u308a\uff0c\u672c\u7814\u7a76\u6210\u679c\u306fHS-TEXs\u306f\u514d\u75ab\u6291\u5236\u6027Tregs\u304b\u3089IL-6\u3092\u4ecb\u3057\u3066Th17\u7d30\u80de\u306b\u5909\u63db\u3059\u308b\u9ad8\u3044\u80fd\u529b\u3092\u6709\u3057\u3066\u304a\u308a\uff0c\u81e8\u5e8a\u7684\u306b\u3082\u6297\u816b\u760d\u52b9\u679c\u306b\u8ca2\u732e\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f\uff0e\u81e8\u5e8a\u4f8b\u3067HS-TEXs\u304c\u76f4\u63a5\u95a2\u4fc2\u3059\u308b\u304b\u5426\u304b\u306f\u4eca\u5f8c\u306e\u691c\u8a0e\u306b\u59d4\u306d\u3089\u308c\u308b\u304c\uff0c\u4eca\u5f8c\u3068\u3082\u6e29\u71b1\u523a\u6fc0\u306b\u7279\u7570\u7684\u306aTEXs\u7814\u7a76\u304c\u3055\u3089\u306b\u9032\u3080\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p>1)&nbsp; Dai S&nbsp;<em>et al<\/em>. More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells. Clin Cancer Res, 11:7554-7563, 2005.\uff08\u71b1\u8ca0\u8377\u306f43<sup>o<\/sup>C, 1\u6642\u9593\uff09\uff0e<\/p>\n\n\n\n<p>2)&nbsp; Cho JA&nbsp;<em>et al.<\/em>&nbsp;MHC independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models. Cancer Lett, 275:256-265, 2009.<\/p>\n\n\n\n<p>3)&nbsp; Guo D&nbsp;<em>et al.<\/em>&nbsp;Exosomes from heat-stressed tumour cells inhibit tumour growth by converting regulatory T cells to Th17 cells<em>&nbsp;via<\/em>&nbsp;IL-6. Immunology, 154: 132-143, 2018.<\/p>\n\n\n\n<p>\u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n<p>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0(Exosome)\uff1a\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u76f4\u5f8450\uff5e150 nm\u306e\u9846\u7c92\u72b6\u306e\u5c0f\u80de\uff0e\u8868\u9762\u306f\u7d30\u80de\u819c\u7531\u6765\u306e\u8102\u8cea\u3084\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u69cb\u6210\u3055\u308c\uff0c\u5185\u90e8\u306f\u6838\u9178(mRNA, microRNA, DNA)\u306e\u4ed6\uff0c\u591a\u80de\u4f53\u5f62\u6210\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea(Alix\u306a\u3069)\u3084\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea(HSP70, HSP90)\u306a\u3069\u3092\u542b\u3080\uff0e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u8840\u6db2\u4e2d\u3092\u5faa\u74b0\u3057\u3066\u304a\u308a\u7d30\u80de\u9593\u60c5\u5831\u4f1d\u9054\u3092\u62c5\u3063\u3066\u3044\u308b\uff0e\u304c\u3093\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u591a\u304f\u306e\u75be\u60a3\u3068\u306e\u95a2\u9023\u306e\u5831\u544a\u3082\u3042\u308b\uff0e\u307e\u305f\uff0c\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u75c5\u6c17\u306e\u8a3a\u65ad\u3084\u6cbb\u7642\u306b\u5229\u7528\u3059\u308b\u691c\u8a0e\u3082\u591a\u304f\uff0cPubMed\u3067Exosome\u3092\u691c\u7d22\u3059\u308b\u3068\u30d2\u30c3\u30c8\u6570\u306f1\u4e07\u4ef6\u4ee5\u4e0a\u3067\u3042\u308b\uff0e<\/p>\n\n\n\n<p>\u5236\u5fa1\u6027T\u7d30\u80de\uff1aTreg\u3068\u79f0\u3059\u308b\uff0e\u4eca\u5e74\u5ea6\u306e\u6587\u5316\u52f2\u7ae0\u306e\u53d7\u7ae0\u8005\u3067\u3042\u308b\u5742\u53e3\u5fd7\u6587\u5927\u962a\u5927\u5b66\u7279\u4efb\u6559\u6388\u304c\u767a\u898b\u3057\u305f\u514d\u75ab\u5fdc\u7b54\u306e\u6291\u5236\u7684\u5236\u5fa1(\u514d\u75ab\u5bdb\u5bb9)\u3092\u53f8\u308bT\u7d30\u80de\u306e\u4e00\u7a2e\uff0e \u514d\u75ab\u5fdc\u7b54\u6a5f\u69cb\u306e\u904e\u5270\u306a\u514d\u75ab\u5fdc\u7b54\u3092\u6291\u5236\u3059\u308b\u305f\u3081\u306e\u30d6\u30ec\u30fc\u30ad(\u8ca0\u306e\u5236\u5fa1\u6a5f\u69cb)\u3084\uff0c\u514d\u75ab\u306e\u6052\u5e38\u6027\u7dad\u6301\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\uff0e\u304c\u3093\u7d30\u80de\u306f\u3053\u306e\u5236\u5fa1\u6027T\u7d30\u80de\u3092\u5229\u7528\u3057\u3066\uff0c\u514d\u75ab\u7cfb\u304b\u3089\u306e\u653b\u6483\u3092\u56de\u907f\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>Th17\u7d30\u80de\uff1a\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de(Th\u7d30\u80de)\u306e\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u4e00\u3064\u3067\u3042\u308a\uff0c\u8fd1\u5e74\u65b0\u305f\u306b\u767a\u898b\u3055\u308c\u305f\u3082\u306e\u3067\u3042\u308b\uff0e \u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308b\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3(IL)-17\u3092\u7523\u751f\u3059\u308b\u80fd\u529b\u3092\u6709\u3059\u308b\u3053\u3068\u304b\u3089\u3053\u306e\u540d\u304c\u3042\u308b\uff0e<\/p>\n\n\n\n<p>IL-6\uff1aT\u7d30\u80de\u3084\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u7b49\u306e\u7d30\u80de\u306b\u3088\u308a\u7523\u751f\u3055\u308c\u308b\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308a\uff0c\u6db2\u6027\u514d\u75ab\u3092\u5236\u5fa1\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4e00\u3064\u3067\u3042\u308b\uff0eIL-6\u53d7\u5bb9\u4f53\u306f\u5206\u5b50\u91cf130 kDa\u306e\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bgp130(CD130)\u3068\u4f1a\u5408\u3057\u3066\u7d30\u80de\u5185\u306b\u60c5\u5831\u3092\u4f1d\u3048\u308b\uff0eIL-6\u306f1986\u5e74\u306b\u76f8\u88dc\u7684DNA(cDNA)\u304c\u5927\u962a\u5927\u5b66\u306e\u5e73\u91ce (\u73fe\u3001\u91cf\u5b50\u79d1\u5b66\u6280\u8853\u7814\u7a76\u958b\u767a\u6a5f\u69cb(QST)\u7406\u4e8b\u9577) \u3089\u306b\u3088\u308a\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3055\u308c\uff0c\u4ee5\u964dIL-6\u306f\u975e\u5e38\u591a\u304f\u306e\u751f\u7406\u73fe\u8c61\u3084\u708e\u75c7\uff65\u514d\u75ab\u75be\u60a3\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\uff0e<\/p>\n\n\n\n<p>NRL-002\u578b\u52a0\u6e29\u88c5\u7f6e\u4ed6\u306e\u60c5\u5831\u306f\u4ee5\u4e0b\u306eHP\u3092\u53c2\u7167\uff1a<\/p>\n\n\n\n<p><a href=\"http:\/\/www.jlmaida.com\/index.php?c=Product&amp;a=product_list&amp;pro_cat_id=2\">http:\/\/www.jlmaida.com\/index.php?c=Product&amp;a=product_list&amp;pro_cat_id=2<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c32 \u6e29\u71b1\u8ca0\u8377\u816b\u760d\u7d30\u80de\u7531\u6765\u306e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306fIL-6\u3092\u4ecb\u3057\u3066\u5236\u5fa1\u6027\uff34\u7d30\u80de\u304b\u3089Th17\u7d30\u80de\u3078\u306e\u5909\u63db\u306b\u3088\u308a\u816b\u760d\u5897\u6b96\u3092\u963b\u5bb3\u3059\u308b \u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u85ac\u5b66\u7814\u7a76\u90e8\uff09 \u8fd1\u5e74\uff0c\u7d30\u80de\u5916\u5c0f\u80de(Ext [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-566","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/566","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=566"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/566\/revisions"}],"predecessor-version":[{"id":567,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/566\/revisions\/567"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=566"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=566"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=566"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}