{"id":568,"date":"2019-10-30T20:32:00","date_gmt":"2019-10-30T11:32:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=568"},"modified":"2022-05-26T20:32:22","modified_gmt":"2022-05-26T11:32:22","slug":"%e6%b8%a9%e7%86%b1%e6%8a%b5%e6%8a%97%e6%80%a7%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bstat3%e3%81%a8hsp105%e3%81%ae%e9%96%a2%e4%b8%8e%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e6%b8%a9%e7%86%b1%e6%8a%b5%e6%8a%97%e6%80%a7%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bstat3%e3%81%a8hsp105%e3%81%ae%e9%96%a2%e4%b8%8e%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6\/","title":{"rendered":"\u6e29\u71b1\u62b5\u6297\u6027\u306b\u304a\u3051\u308bStat3\u3068Hsp105\u306e\u95a2\u4e0e\u306b\u3064\u3044\u3066"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c31<\/p>\n\n\n\n<p>\u6e29\u71b1\u62b5\u6297\u6027\u306b\u304a\u3051\u308bStat3\u3068Hsp105\u306e\u95a2\u4e0e\u306b\u3064\u3044\u3066<\/p>\n\n\n\n<p>\u7530\u6e15\u3000\u572d\u7ae0 (\u5bcc\u5c71\u5927\u5b66)<\/p>\n\n\n\n<p>\u816b\u760d\u306e\u6e29\u71b1\u62b5\u6297\u6027\u306e\u7372\u5f97\u304c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2 (HT) \u306e\u554f\u984c\u70b9\u306e\u4e00\u3064\u3067\u3042\u308b\uff0e\u7d30\u80de\u306b\u4e88\u3081\u30de\u30a4\u30eb\u30c9HT (MHT) \u3092\u4e0e\u3048\u3066\u304a\u304f\u3068\uff0c\u305d\u306e\u5f8c\u306eHT\u306b\u5bfe\u3057\u3066\u4e00\u904e\u6027\u306b\u8010\u6027\u306b\u306a\u308b\u6e29\u71b1\u62b5\u6297\u6027\u306b\u306f\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea (HSPs)\uff0c\u7279\u306bHsp70 \u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u6f14\u3058\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b<sup>1)<\/sup>\uff0e\u3057\u304b\u3057\uff0c\u305d\u306e\u7372\u5f97\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5168\u8c8c\u306f\u307e\u3060\u5b8c\u5168\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\uff0e\u4ee5\u524d\u306b\uff0c<em>Hsp70<\/em>\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306b\u306f\u8ee2\u5199\u56e0\u5b50signal transducer and activator of transcription (Stat) 3\u306e\u7d50\u5408\u90e8\u4f4d\u304c\u3042\u308a\uff0cMHT\u306b\u3088\u308bHsp70\u767a\u73fe\u8a98\u5c0e\u306bStat3\u304c\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u305f<sup>2)<\/sup>\uff0e\u3053\u308c\u306b\u95a2\u3057\u3066\u672c\u5e74\uff0cMHT\u306b\u3088\u308b\u6e29\u71b1\u62b5\u6297\u6027\u306bStat3\u304c\u95a2\u4e0e\u3059\u308b\u3068\u3044\u3046\u8208\u5473\u6df1\u3044\u8ad6\u6587\u304c\u5831\u544a\u3055\u308c\u305f<sup>3)<\/sup>\uff0e<\/p>\n\n\n\n<p>\u30d2\u30c8\u5b50\u5bae\u9838\u304c\u3093\u7d30\u80deHeLa\u306b\u304a\u3044\u3066\uff0cMHT (43&nbsp;<sup>o<\/sup>C\uff0c1\u6642\u9593) \u8ca0\u8377\u306e\u5f8c\u306b37<sup>&nbsp;o<\/sup>C\u30675\u6642\u9593\u56de\u5fa9\u57f9\u990a\u3057\u305f\u969b\u306b\uff0cHT (45&nbsp;<sup>o<\/sup>C\uff0c1\u6642\u9593) \u306b\u5bfe\u3059\u308b\u660e\u3089\u304b\u306a\u6e29\u71b1\u62b5\u6297\u6027\u3092\u793a\u3057\u305f\uff0e\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u03b1\u306f\uff0cStat3\u3092\u30ea\u30f3\u9178\u5316\u3057\uff0c\u30ea\u30f3\u9178\u5316Stat3\u3092\u6838\u79fb\u884c\u3055\u305b\u308b\uff0e\u3053\u306e\u52b9\u679c\u3068\u540c\u69d8\u306b\uff0cMHT\u51e6\u7406\u7d30\u80de\u3067\u306f\uff0c\u30ea\u30f3\u9178\u5316Stat3\u306e\u9ad8\u767a\u73fe\u304c\u6838\u306b\u304a\u3044\u3066\u89b3\u5bdf\u3055\u308c\u305f\uff0eMHT\u306b\u3088\u308bStat3\u306e\u6d3b\u6027\u5316\u306f, Stat3\u306e\u30ea\u30f3\u9178\u5316\u306b\u95a2\u4e0e\u3059\u308bJAK (Janus kinase) \u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u5264AG490\u306b\u3088\u308a\u6291\u5236\u3055\u308c\u305f\uff0eHsp70\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u306b\u5bfe\u3059\u308b\u52b9\u679c\u3092\u691c\u8a0e\u3057\u305f\u3068\u3053\u308d\uff0cAG409\u306fMHT\u306b\u3088\u308bHsp70\u306e\u767a\u73fe\u8a98\u5c0e\u3092\u5b8c\u5168\u3067\u306f\u306a\u3044\u3082\u306e\u306e\uff0c\u7d0450\uff05\u7a0b\u5ea6\uff0c\u6709\u610f\u306b\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u5224\u3063\u305f\uff0e\u307e\u305f\uff0cHeLa\u7d30\u80de\u3078\u306e\u672c\u5316\u5408\u7269\u306e\u524d\u51e6\u7406\u306f\uff0cHT\u306b\u3088\u308b\u7d30\u80de\u969c\u5bb3\u306b\u5bfe\u3059\u308bMHT\u524d\u51e6\u7406\u306e\u52b9\u679c\u3092\u6709\u610f\u306b\u6e1b\u5f31\u3055\u305b\u305f\uff0e\u3053\u308c\u3068\u540c\u69d8\u306e\u6e1b\u5f31\u4f5c\u7528\u304cStat3\u306e\u963b\u5bb3\u5264Stattic\u3067\u3082\u89b3\u5bdf\u3055\u308c\u305f\uff0e\u4ee5\u4e0a\u3088\u308a\uff0cMHT\u306e\u6e29\u71b1\u62b5\u6297\u6027\u7372\u5f97\u306b\u304a\u3051\u308bStat3\u306e\u95a2\u4e0e\u304c\u793a\u5506\u3055\u308c\u305f\uff0e\u6b21\u306b\uff0cHSPs\u767a\u73fe\u306b\u5bfe\u3059\u308b\u3053\u308c\u3089\u306e\u963b\u5bb3\u5264\u306e\u52b9\u679c\u304c\u8abf\u3079\u3089\u308c\u305f\uff0eMHT\u51e6\u7406\u306b\u3088\u308b\u62b5\u6297\u6027\u7372\u5f97\u7d30\u80de\u306b\u304a\u3044\u3066\uff0cAG490\u306f\uff0cHsp27, Hsp70\u3068Hsp105\u306e\u767a\u73fe\u8a98\u5c0e\u3092\u6709\u610f\u306b\u963b\u5bb3\u3057\u305f\u304c\uff0cHsp60\u3068Hsp90\u306e\u767a\u73fe\u306b\u306f\u5f71\u97ff\u3092\u304a\u3088\u307c\u3055\u306a\u304b\u3063\u305f\uff0e\u4e00\u65b9\uff0cStattic\u306fHsp105\u306e\u767a\u73fe\u8a98\u5c0e\u306e\u307f\u3092\u963b\u5bb3\u3057\u305f\uff0e\u8457\u8005\u3089\u306f\u3053\u306e\u77db\u76fe\u3092\u8aac\u660e\u3057\u3066\u3044\u306a\u3044\u304c\uff0c\u3055\u3089\u306b\uff0c\u6e29\u71b1\u62b5\u6297\u6027\u306b\u304a\u3051\u308bHsp105\u306e\u5f79\u5272\u3092\u691c\u8a0e\u3057\u305f\uff0eHsp105\u306b\u5bfe\u3059\u308bsiRNA\uff08small interfering RNA\uff09\u3092\u7528\u3044\u305f\u6a5f\u80fd\u963b\u5bb3\u5b9f\u9a13\u306b\u3088\u308a\uff0cMHT\u306b\u3088\u308b\u6e29\u71b1\u62b5\u6297\u6027\u306bHsp105\u304c\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff0e\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\uff0c\u8457\u8005\u3089\u306f\u6e29\u71b1\u62b5\u6297\u6027\u306bStat3\u306e\u6d3b\u6027\u5316\u306b\u7d9a\u304fHsp105\u306e\u767a\u73fe\u8a98\u5c0e\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u7d50\u8ad6\u3057\u3066\u3044\u308b<sup>3)<\/sup>\uff0e<\/p>\n\n\n\n<p>Stat\u8ee2\u5199\u56e0\u5b50\u7fa4\u306f\uff0c\u69d8\u3005\u306a\u7d30\u80de\u6a5f\u80fd\u3092\u8abf\u7bc0\u3059\u308b\u975e\u5e38\u306b\u91cd\u8981\u306a\u5206\u5b50\u7fa4\u3067\u3042\u308b\uff0e\u71b1\u30b7\u30e7\u30c3\u30af\u8ee2\u5199\u56e0\u5b50HSF1\u304c\uff0cStat1\u3068\u8ee2\u5199\u8907\u5408\u4f53\u3092\u5f62\u6210\u5f8c\u306bHsp27\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3057\uff0c\u6e29\u71b1\u62b5\u6297\u6027\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308b<sup>4)<\/sup>\uff0e\u307e\u305f\uff0cStat1\uff0cStat3\u3068HSF1\u306e\u8ee2\u5199\u8907\u5408\u4f53\u304c\uff0cHsp90\u306e\u767a\u73fe\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b<sup>5<\/sup><sup>\uff09<\/sup>\uff0e\u6e29\u71b1\u62b5\u6297\u6027\u306b\u304a\u3051\u308b\uff0cStat\uff0cHSF1\u3084HSPs\u306e\u5404\u3005\u306e\u5206\u5b50\u3084\u5206\u5b50\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u8a73\u7d30\u304c\u89e3\u660e\u3055\u308c\uff0c\u81e8\u5e8a\u3078\u5fdc\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e\uff1a<\/p>\n\n\n\n<p>1) Lindquist S. The heat-shock response. Annu Rev Biochem. 55: 1151-91, 1986.<\/p>\n\n\n\n<p>2) Yamagishi N.,&nbsp;<em>et al<\/em>. Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3. FEBS J. 276: 5870-80, 2009.<\/p>\n\n\n\n<p>3) Matozaki M.,&nbsp;<em>et al<\/em>. Involvement of Stat3 phosphorylation in mild heat shock-induced thermotolerance. Exp Cell Res. 377: 67-74, 2019.<\/p>\n\n\n\n<p>4) Yokota S.,&nbsp;<em>et al<\/em>. Suppression of thermotolerance in mumps virus-infected cells is caused by lack of HSP27 induction contributed by STAT-1. J Biol Chem. 278: 41654-60, 2003.<\/p>\n\n\n\n<p>5) Chen X.S.,&nbsp;<em>et al<\/em>. Diverse effects of Stat1 on the regulation of hsp90alpha gene under heat shock. J Cell Biochem. 102:1059-66, 2007.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c31 \u6e29\u71b1\u62b5\u6297\u6027\u306b\u304a\u3051\u308bStat3\u3068Hsp105\u306e\u95a2\u4e0e\u306b\u3064\u3044\u3066 \u7530\u6e15\u3000\u572d\u7ae0 (\u5bcc\u5c71\u5927\u5b66) \u816b\u760d\u306e\u6e29\u71b1\u62b5\u6297\u6027\u306e\u7372\u5f97\u304c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2 (HT) \u306e\u554f\u984c\u70b9\u306e\u4e00\u3064\u3067\u3042\u308b\uff0e\u7d30\u80de\u306b\u4e88\u3081\u30de\u30a4\u30eb\u30c9HT [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-568","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=568"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/568\/revisions"}],"predecessor-version":[{"id":569,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/568\/revisions\/569"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}