{"id":570,"date":"2019-10-17T20:32:00","date_gmt":"2019-10-17T11:32:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=570"},"modified":"2022-05-26T20:32:45","modified_gmt":"2022-05-26T11:32:45","slug":"in-vivo%e3%81%a7%e3%81%ae%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc%e3%83%9f%e3%82%a2%e3%81%a8%e6%94%be%e5%b0%84%e7%b7%9a%e4%bd%b5%e7%94%a8%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e8%85%ab","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/in-vivo%e3%81%a7%e3%81%ae%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc%e3%83%9f%e3%82%a2%e3%81%a8%e6%94%be%e5%b0%84%e7%b7%9a%e4%bd%b5%e7%94%a8%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e8%85%ab\/","title":{"rendered":"In vivo\u3067\u306e\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u3068\u653e\u5c04\u7dda\u4f75\u7528\u306b\u5bfe\u3059\u308b\u816b\u760d\u5fdc\u7b54\u306b\u304a\u3051\u308bHIF-1\u03b1\u306e\u5f79\u5272"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c30<\/p>\n\n\n\n<p><em>In vivo<\/em>\u3067\u306e\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u3068\u653e\u5c04\u7dda\u4f75\u7528\u306b\u5bfe\u3059\u308b\u816b\u760d\u5fdc\u7b54\u306b\u304a\u3051\u308bHIF-1\u03b1\u306e\u5f79\u5272<\/p>\n\n\n\n<p>\u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u85ac\u5b66\u7814\u7a76\u90e8<strong>\uff09<\/strong><\/p>\n\n\n\n<p>\u4eca\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u8cde\u306e\u5bfe\u8c61\u306f\u7d30\u80de\u306e\u4f4e\u9178\u7d20\u5fdc\u7b54\u306e\u4ed5\u7d44\u307f\u306e\u767a\u898b\u3067\u3042\u308a\uff0c\u201c\u9178\u7d20\u6fc3\u5ea6\u30bb\u30f3\u30b5\u30fcHIF-1\u201d\u306e\u767a\u898b\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u6790\u304c\u305d\u306e\u5185\u5bb9\u3067\u3042\u308b\uff0eHIF-\uff11\u306f\uff0c\u809d\u304c\u3093\u7d30\u80de\u682a Hep3B\u306b\u304a\u3044\u3066\u300c\u4f4e\u9178\u7d20\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u308b\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3\u8a98\u5c0e\u56e0\u5b50\u300d\u3068\u3057\u30661992\u5e74\u306b\u7c73\u30b8\u30e7\u30f3\u30ba\u30fb \u30db\u30d7\u30ad\u30f3\u30ba\u5927\u5b66\u306e\u30bb\u30e1\u30f3\u30b6\uff08Gregg L. Semenza\uff09\u6559\u6388\u306b\u3088\u3063\u3066\u767a\u898b\u3055\u308c\u305f\u5206\u5b50\u3067\u3042\u308b<sup>1)<\/sup>\uff0e\u5947\u3057\u304f\u3082\uff0c\u672c\u5e74\uff0c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u764c\u6cbb\u7642\u306e\u5148\u9054\u306b\u3088\u308b\u300c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\uff1a\u653e\u5c04\u7dda\u62b5\u6297\u6027\u4f4e\u9178\u7d20\u3092\u514b\u670d\u3059\u308b\u305f\u3081\u306e\u6700\u9069\u7642\u6cd5\u300d\u306e\u7dcf\u8aac\u304c\u5831\u544a\u3055\u308c\u305f<sup>2)<\/sup>\uff0e\u4f4e\u9178\u7d20\u306f\u7d30\u80de\u306e\u653e\u5c04\u7dda\u62b5\u6297\u6027\u56e0\u5b50\u3067\uff0c\u305d\u306e\u514b\u670d\u306b\u95a2\u3059\u308b\u975e\u5e38\u306b\u591a\u304f\u306e\u7814\u7a76\u5831\u544a\u304c\u3042\u308b\uff0e\u4e00\u65b9\uff0c\u3053\u306e\u7dcf\u8aac\u306b\u3082\u3042\u308b\u3088\u3046\u306b\u4f4e\u9178\u7d20\u306f\uff0c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u3068\u3063\u3066\u306f\u7d30\u80de\u306e\u6e29\u71b1\u611f\u53d7\u6027\u3092\u4e0a\u3052\u308b\u5fae\u5c0f\u74b0\u5883\u56e0\u5b50\u3067\u3042\u308b\uff0e\u305d\u306e\u305f\u3081\u304b\uff0c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u3088\u308bHIF-1\u03b1\u8a98\u5c0e\u306b\u95a2\u3059\u308b\u5831\u544a\u306f\u6563\u898b\u3055\u308c\u308b\u3082\u306e\u306e\u81e8\u5e8a\u7684\u7acb\u5834\u306b\u5373\u3057\u305f\u5831\u544a\u306f\u5c11\u306a\u3044\uff0e<\/p>\n\n\n\n<p>\u653e\u5c04\u7dda\u5fdc\u7b54\u306b\u304a\u3044\u3066\uff0cHIF-1\u03b1\u306f\u816b\u760d\u306e\u8840\u7ba1\u65b0\u751f\u3084\u518d\u767a\u306b\u91cd\u8981\u306a\u50cd\u304d\u3092\u62c5\u3063\u3066\u3044\u308b\u306e\u3067\uff0c\u3053\u306e\u5206\u5b50\u306e\u5f79\u5272\u3092\u63a2\u308a\uff0c\u5236\u5fa1\u6cd5\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u306f\u304c\u3093\u6cbb\u7642\u6210\u7e3e\u306e\u5411\u4e0a\u306b\u8ca2\u732e\u3059\u308b\uff0e\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u5831\u544a<sup>3)<\/sup>\u3067\u306f\uff0c\u2460\u9ad8\u7dda\u91cf\u653e\u5c04\u7dda\u306f\u8840\u7ba1\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3057\uff0c\u8840\u6d41\u3092\u4f4e\u4e0b\u3055\u305b\uff0c\u816b\u760d\u306e\u4f4e\u9178\u7d20\u72b6\u6cc1\u3092\u4ea2\u9032\u3059\u308b\uff0c\u2461\u3053\u308c\u306b\u3088\u308b\u4f4e\u9178\u7d20\u306fHIF-1\u03b1\u3084\u305d\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u3067\u3042\u308bVEGF\u3092\u6d3b\u6027\u5316\u3057\uff0c\u8840\u7ba1\u65b0\u751f\u3084\u518d\u767a\u3092\u4fc3\u9032\u3059\u308b\uff0c\u2462\u3053\u308c\u306b\u5bfe\u3057\u3066\uff0c\u30de\u30a4\u30eb\u30c9\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306f\u816b\u760d\u306e\u9178\u7d20\u5316\u3092\u8a98\u5c0e\u3057\uff0c\u653e\u5c04\u7dda\u8a98\u767aHIF-1\u03b1\u304a\u3088\u3073\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u8a98\u5c0e\u3092\u963b\u5bb3\u3059\u308b\uff0c\u3068\u306e\u4eee\u8aac\u3092\u7acb\u3066\uff0c\u3053\u308c\u3092\u691c\u8a3c\u3057\u305f\uff0e<\/p>\n\n\n\n<p>\u816b\u760d\u30e2\u30c7\u30eb\u3068\u3057\u3066\uff0cC3H\u30de\u30a6\u30b9\u306e\u76ae\u4e0b\u306b\u690d\u3048\u305fFSaII\u7e4a\u7dad\u8089\u816b\u3092\u7528\u3044\uff0c<sup>60<\/sup>Co\u306e\u03b3\u7dda\u304a\u3088\u3073\u201d\u30aa\u30f3\u30b3\u30b5\u30fc\u30df\u30a2\u201c\u306b\u3088\u308b41<sup>o<\/sup>C(\u816b\u760d\u4e2d\u5fc3\u90e8)30\u5206\u51e6\u7406\u3092\uff0c\u5358\u72ec\u304a\u3088\u3073\u4f75\u7528\u3067\u884c\u306a\u3063\u305f\uff0e\u816b\u760d\u5185\u306e\u8840\u6db2\u9084\u6d41\u306fHoechst33342\uff0c\u4f4e\u9178\u7d20\u306f\u30d4\u30e2\u30cb\u30c0\u30be\u30fc\u30eb\u306b\u3088\u308b\u514d\u75ab\u86cd\u5149\u753b\u50cf\u306e\u89b3\u5bdf\u3068\u5b9a\u91cf\u5316\u3067\u8a55\u4fa1\u3057\u305f\uff0eHIF-1\u03b1\uff0cCA9\u304a\u3088\u3073VGEF\u306b\u3064\u3044\u3066\u306f\u514d\u75ab\u7d44\u7e54\u5b66\u7684\u306b\u8abf\u3079\uff0c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306fTUNNEL\u67d3\u8272\u3067\uff0c\u816b\u760d\u5897\u6b96\u306f\u816b\u760d\u5f84\u6e2c\u5b9a\u3067\u8a55\u4fa1\u3057\u305f\uff0e<\/p>\n\n\n\n<p>\u653e\u5c04\u7dda\u309215 Gy\u7167\u5c04\u3059\u308b\u3068\uff0c\u816b\u760d\u306e\u8840\u6d41\u4f4e\u4e0b\uff0c\u4f4e\u9178\u7d20\u72b6\u614b\u306e\u4ea2\u9032\uff0cHIF-1\u03b1\uff0cCA-9\u3084VGEF\u767a\u73fe\u3092\u8a98\u5c0e\u3057\u305f\uff0e\u4e00\u65b9\uff0c41<sup>o<\/sup>C\uff0c30\u5206\u51e6\u7406\u3092\u4f75\u7528\u3059\u308b\u3068\uff0c\u8840\u6d41\u306e\u5897\u52a0\uff0c\u816b\u760d\u306e\u9178\u7d20\u5316\uff0c\u653e\u5c04\u7dda\u8a98\u767aHIF-1\u03b1\uff0cCA-9\u304a\u3088\u3073VGEF\u767a\u73fe\u306e\u6291\u5236\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\uff0e\u3055\u3089\u306b\uff0c\u816b\u760d\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u5897\u5f37\u3057\uff0c\u816b\u760d\u5897\u6b96\u306e\u9045\u5ef6\u3092\u62db\u3044\u305f\uff0e\u816b\u760d\u5897\u6b96\u9045\u5ef6\u52b9\u679c\u306f\u653e\u5c04\u7dda\u7167\u5c04\u524d\u306b\u6e29\u71b1\u51e6\u7406\u3092\u884c\u3063\u305f\u5834\u5408\u306e\u65b9\u304c\u9ad8\u304b\u3063\u305f\uff0e\u3053\u308c\u3089\u306e\u7d50\u679c\u306f41<sup>o<\/sup>C\uff0c30\u5206\u51e6\u7406\u304c\u653e\u5c04\u7dda\u306b\u3088\u308b\u6297\u816b\u760d\u52b9\u679c\u306e\u5897\u5f37\u3092\u793a\u3059\u3082\u306e\u3067\u3042\u308b\u304c\uff0c\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u653e\u5c04\u7dda\u306b\u3088\u308bHIF-1\u03b1\u767a\u73fe\u8a98\u5c0e\u306e\u963b\u5bb3\u52b9\u679c\u304c\u95a2\u308f\u308b\u3053\u3068\u3092\u793a\u3057\u305f\uff0e\u4eca\u5f8c\uff0c\u6e29\u71b1\u306b\u3088\u308bHIF-1\u03b1\u767a\u73fe\u8abf\u7bc0\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u3055\u3089\u306b\u9032\u3080\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p>1)&nbsp; Semenza GL, Wang GL: A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol, 12: 5447-5454, 1992.<\/p>\n\n\n\n<p>2)&nbsp; Elming PB&nbsp;<em>et al.<\/em>&nbsp;Hyperthermia: The optimal treatment to overcome radiation resistant hypoxia. Cancers (Basel), 11(1) pii: E60. 2019. doi: 10.3390\/cancers11010060. Review.<\/p>\n\n\n\n<p>3)&nbsp; Kim W,<em>&nbsp;et al.<\/em>&nbsp;Role of HIF-1\u03b1 in response of tumors to a combination of hyperthermia and radiation&nbsp;<em>in vivo<\/em>. Int J Hyperthermia, 34: 276-283, 2018.<\/p>\n\n\n\n<p>\u7528\u8a9e\u89e3\u8aac<\/p>\n\n\n\n<p>HIF\uff1aHIF\uff08Hypoxia-inducible factor; \u4f4e\u9178\u7d20\u8a98\u5c0e\u56e0\u5b50\uff09\u306f\uff0c\u7d30\u80de\u5185\u304c\u4f4e\u9178\u7d20\u72b6\u614b\u306b\u9665\u3063\u305f\u969b\u306b\u6d3b\u6027\u5316\u3055\u308c\u308b\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308a\uff0cHIF-1\u306f HIF-1\u03b1 \u3068 HIF-1\u03b2 \u306e\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u3067\u3042\u308b\uff0e\u3053\u306e\u8ee2\u5199\u56e0\u5b50\u306f\u4f4e\u9178\u7d20\u72b6\u614b\u3078\u9806\u5fdc\u3059\u308b\u305f\u3081\uff0cVEGF\uff0cEPO\uff08\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3\uff09\uff0c\u30b0\u30eb\u30b3\u30fc\u30b9\u30fb\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff0c\u5404\u7a2e\u7cd6\u5206\u89e3\u9175\u7d20\u306a\u3069\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8ee2\u5199\u3092\u4fc3\u9032\u3059\u308b\uff0eHIF\u306f\u7d30\u80de\u5185\u306e\u9178\u7d20\u6fc3\u5ea6\u304c\u6b63\u5e38\u6642\u306f\u91cf\u3068\u6d3b\u6027\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u304c\uff0c\u4f4e\u9178\u7d20\u72b6\u614b\u3067\u767a\u73fe\u304a\u3088\u3073\u6d3b\u6027\u304c\u4e0a\u6607\u3059\u308b\uff0e\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30fb\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u306e\u95a2\u9023\u3067\u306fHIF-1\u03b1 \u306f\u7d30\u80de\u8cea\u5185\u306b\u304a\u3044\u3066\uff0cHsp90 \u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u5b89\u5b9a\u6027\u304c\u5897\u3059\uff0e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u3068\u3057\u3066HIF-2\u03b1, HIF-3\u03b1,\u7b49\u304c\u3042\u308b\uff0e<\/p>\n\n\n\n<p>\u30cf\u30a4\u30dd\u30ad\u30b7\u30a2\u3068HIF\u306b\u95a2\u3059\u308b\u89e3\u8aac<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.novusbio.com\/support\/hypoxia-and-hif-faqs\n<\/div><\/figure>\n\n\n\n<p>VGEF\uff1aVEGF\uff08Vascular endothelial growth factor; \u8840\u7ba1\u5185\u76ae\u7d30\u80de\u5897\u6b96\u56e0\u5b50\uff09\u306f\u4e0b\u5782\u4f53foliculo-stellate\uff08\u661f\u72b6\u6ffe\u80de\uff09\u7d30\u80de\u306e\u57f9\u990a\u6db2\u3088\u308a\u5358\u96e2\u3055\u308c\u305f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u7279\u7570\u7684\u306b\u4f5c\u7528\u3059\u308b\u5897\u6b96\u56e0\u5b50\u3067\u3042\u308b\uff0e\u80ce\u751f\u671f\u306b\u304a\u3051\u308b&nbsp;<em>de novo<\/em>&nbsp;\u306a\u8840\u7ba1\u5f62\u6210\uff08Vasculogenesis; \u8108\u7ba1\u5f62\u6210\uff09\u3084\uff0c\u65e2\u5b58\u306e\u8840\u7ba1\u304b\u3089\u306e\u5206\u5c90\u4f38\u9577\u306b\u3088\u308b\u65b0\u305f\u306a\u8840\u7ba1\u306e\u5f62\u6210\uff08Angiogenesis; \u8840\u7ba1\u65b0\u751f\uff09\u306b\u304a\u3044\u3066\uff0c\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\uff0eVEGF-A\uff0cVEGF-B\uff0cVEGF-C\uff0cVEGF-D\uff0cVEGF-E\uff0cPlGF\uff08\u80ce\u76e4\u5897\u6b96\u56e0\u5b50 placental growth factor\uff09-1\uff0cPlGF-2\u306e7\u3064\u304c\u3042\u308a\uff0c\u300cVEGF\u30d5\u30a1\u30df\u30ea\u30fc\u300d\u3092\u69cb\u6210\u3059\u308b\uff0e<\/p>\n\n\n\n<p>CA-9: Carbonic anhydrase 9\uff1a\u70ad\u9178\u8131\u6c34\u9175\u7d209\u306e\u3053\u3068\uff0e\u7d30\u80de\u5897\u6b96\u304a\u3088\u3073\u5f62\u8cea\u8ee2\u63db\u306e\u5236\u5fa1\u306b\u95a2\u4e0e\u3057\uff0c\u307e\u305f\uff0c\u5b50\u5bae\u9838\u90e8\u816b\u760d\u7279\u7570\u7684\u306a\u65b0\u898f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c30 In vivo\u3067\u306e\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u3068\u653e\u5c04\u7dda\u4f75\u7528\u306b\u5bfe\u3059\u308b\u816b\u760d\u5fdc\u7b54\u306b\u304a\u3051\u308bHIF-1\u03b1\u306e\u5f79\u5272 \u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u85ac\u5b66\u7814\u7a76\u90e8\uff09 \u4eca\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u8cde\u306e\u5bfe\u8c61\u306f\u7d30\u80de\u306e\u4f4e\u9178\u7d20\u5fdc\u7b54\u306e\u4ed5\u7d44\u307f [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-570","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/570","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=570"}],"version-history":[{"count":3,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/570\/revisions"}],"predecessor-version":[{"id":627,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/570\/revisions\/627"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=570"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=570"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}