{"id":576,"date":"2019-05-17T20:34:00","date_gmt":"2019-05-17T11:34:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=576"},"modified":"2022-05-26T20:33:42","modified_gmt":"2022-05-26T11:33:42","slug":"%e8%82%9d%e7%b4%b0%e8%83%9e%e3%81%8c%e3%82%93%e3%81%ab%e3%81%8a%e3%81%84%e3%81%a6%e4%bf%9d%e8%ad%b7%e7%9a%84%e3%82%aa%e3%83%bc%e3%83%88%e3%83%95%e3%82%a1%e3%82%b8%e3%83%bc%e3%81%ae%e9%98%bb%e5%ae%b3","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e8%82%9d%e7%b4%b0%e8%83%9e%e3%81%8c%e3%82%93%e3%81%ab%e3%81%8a%e3%81%84%e3%81%a6%e4%bf%9d%e8%ad%b7%e7%9a%84%e3%82%aa%e3%83%bc%e3%83%88%e3%83%95%e3%82%a1%e3%82%b8%e3%83%bc%e3%81%ae%e9%98%bb%e5%ae%b3\/","title":{"rendered":"\u809d\u7d30\u80de\u304c\u3093\u306b\u304a\u3044\u3066\u4fdd\u8b77\u7684\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u963b\u5bb3\u306fATP-AMPK-mTOR\u3092\u4ecb\u3057\u3066\u6e29\u71b1\u8a98\u767a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u5897\u5f37\u3059\u308b"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c28<\/p>\n\n\n\n<p>\u809d\u7d30\u80de\u304c\u3093\u306b\u304a\u3044\u3066\u4fdd\u8b77\u7684\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u963b\u5bb3\u306fATP-AMPK-mTOR\u3092\u4ecb\u3057\u3066\u6e29\u71b1\u8a98\u767a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u5897\u5f37\u3059\u308b<\/p>\n\n\n\n<p>\u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u85ac\u5b66\u7814\u7a76\u90e8<strong>\uff09<\/strong><\/p>\n\n\n\n<p>RFA\uff08Radiofrequency Ablation\uff09<sup>*1<\/sup>\u306f\u6bd4\u8f03\u7684\u5c0f\u3055\u306a\u809d\u7d30\u80de\u304c\u3093\u306b\u5bfe\u3057\u3066\u6839\u6cbb\u304c\u671b\u3081\u308b\u6cbb\u7642\u6cd5\u3067\u3042\u308b\uff0e\u4e00\u65b9\uff0c\u4e0d\u5341\u5206\u306aRFA\u9818\u57df\u3067\u306f\uff0c\u4e0a\u76ae\u9593\u8449\u8ee2\u63db\u3084HIF-1\u03b1\/VEGFA\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u6b8b\u5b58\u304c\u3093\u7d30\u80de\u306b\u3088\u308b\u5c40\u6240\u518d\u767a\u3084\u518d\u5897\u6b96\u3092\u8a98\u767a\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u308b\uff0e\u672c\u8ad6\u6587\u3067\u306f\uff0c\u4e9c\u81f4\u6b7b\u7684\u6e29\u71b1\u51e6\u7406\u3067ATP-AMPK-mTOR\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u4ecb\u3057\u3066\uff0c\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f<sup>1<\/sup><sup>)<\/sup>\uff0e\u7528\u3044\u305f\u7d30\u80de\u306f\uff0c2\u7a2e\u985e\u306e\u30d2\u30c8\u809d\u7d30\u80de\u304c\u3093\uff0cSMMC7721(\u91ce\u751f\u578b<em>p53<\/em>)\u304a\u3088\u3073 Huh7(\u5909\u7570\u578b<em>p53<\/em>)\u3067\uff0cBALB\/c\u30cc\u30fc\u30c9\u30de\u30a6\u30b9\u3078\u306e\u79fb\u690d\u7cfb\u3067\u3082\u8abf\u3079\u305f\uff0e\u5b9f\u9a13\u306b\u5f53\u305f\u3063\u3066\u306fRFA\u6cbb\u7642\u3092\u6a21\u3057\u305f\u4e9c\u81f4\u6b7b\u7684\u6e29\u71b1\u51e6\u7406\uff0843\uff0c45\uff0c47<sup>o<\/sup>C\uff09\u306730\u5206\u3042\u308b\u3044\u306f1\u6642\u9593\u306e\u51e6\u7406\u3092\u3057\u305f\uff0e\u3053\u308c\u3089\u306e\u51e6\u7406\u306f\u6e29\u5ea6\u4f9d\u5b58\u6027\u306b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u8a98\u767a\u3057\u305f\uff0e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u30af\u30ed\u30ed\u30ad\u30f3<sup>*2<\/sup>\u3084\uff0c Beclin 1\u3068Atg5\u3092siRNA\u3067\u963b\u5bb3\u3059\u308b\u3068\u6e29\u71b147<sup>o<\/sup>C\u8a98\u767a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092<em>in vitro&nbsp;<\/em>\u3067\u3082<em>in vivo<\/em>\u3067\u3082\u5897\u5f37\u3057\u305f\uff0e\u307e\u305f\uff0c\u3053\u308c\u3089\u306e\u51e6\u7406\u306f\u304c\u3093\u7d30\u80de\u5897\u6b96\u3092\u963b\u5bb3\u3057\uff0c\u79fb\u690d\u816b\u760d\u306e\u5897\u6b96\u3092\u9855\u8457\u306b\u6291\u5236\u3057\u305f\uff0e\u6e29\u71b1\u8a98\u767a\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\uff0c\u7d30\u80de\u5185ATP\u306e\u4f4e\u4e0b\u304c\uff0cAMP\/ATP\u6bd4\u306e\u5897\u52a0\u3092\u5f15\u304d\u8d77\u3053\u3057\uff0c\u3053\u308c\u306fThr172\u306e\u30ea\u30f3\u9178\u5316\u3092\u4ecb\u3057\u3066\uff0cAMPK\u03b1\u3092\u6d3b\u6027\u5316\u3059\u308b\uff0e\u305d\u306e\u7d50\u679c\uff0c\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u6291\u5236\u3059\u308bmTOR\u3092\u963b\u5bb3\u3059\u308b\uff0e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306f\u6e29\u71b1\u8a98\u767a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u5bfe\u3057\u3066\u4fdd\u8b77\u7684\u306b\u4f5c\u7528\u3059\u308b\u306e\u3067\uff0c\u30af\u30ed\u30ed\u30ad\u30f3\u306b\u3088\u308b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u963b\u5bb3\u306f\u6e29\u71b1\u8a98\u767a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u5897\u5f37\u3059\u308b\uff0e\u3053\u306e\u7d4c\u8def\u306e\u4ecb\u5728\u306fAMPK<sup>*3<\/sup>\u306e\u6d3b\u6027\u5316\u56e0\u5b50AICAR<sup>*4<\/sup>\u304a\u3088\u3073AMPK\u963b\u5bb3\u5264\u3067\u3042\u308bCompound C\u306e\u6dfb\u52a0\u5b9f\u9a13\u3067\u78ba\u8a8d\u3055\u308c\u305f\uff0e<\/p>\n\n\n\n<p>\u6700\u8fd1\uff0cRAF\u2192 MEK\u2192ERK\u306e\u963b\u5bb3\u306b\u3088\u308a\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u4fdd\u8b77\u7684\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306f\uff0cRAS\u8a98\u5c0e\u6027\u304c\u3093\u306b\u5bfe\u3059\u308b\u4e00\u3064\u306e\u6cbb\u7642\u6226\u7565\u3067\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u305f<sup>2)<\/sup>\uff0e\u3053\u306e\u8ad6\u6587\u306f\uff0c\u96e3\u6cbb\u304c\u3093\u3067\u3042\u308b\u81b5\u81d3\u304c\u3093\u306b\u5bfe\u3057\u3066\u7d30\u80de\u30ec\u30d9\u30eb\u304a\u3088\u3073\u62c5\u304c\u3093\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3067\uff0c\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6<sup>*5<\/sup>+\u30af\u30ed\u30ed\u30ad\u30f3\u51e6\u7406\u3067\u5897\u6b96\u6291\u5236\u52b9\u679c\u3092\u78ba\u8a8d\u3057\u305f\u5f8c\uff0c\u81e8\u5e8a\u7684\u306b\u5316\u5b66\u7642\u6cd5\u306b\u4e0d\u5fdc\u7b54\u60a3\u8005\u306b\u5bfe\u3057\u3066\u3082\u6cbb\u7642\u52b9\u679c\u3092\u793a\u3057\u305f\u753b\u671f\u7684\u5185\u5bb9\u3067\u3042\u308b\uff0e<\/p>\n\n\n\n<p>\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u4e2d\u5fc3\u3068\u3059\u308b\u7d30\u80de\u6b7b\u306e\u69d8\u5f0f\u3082\u73fe\u5728\uff0c12\u7a2e\u985e\u306b\u5206\u985e\u3055\u308c\u3066\u3044\u308b<sup>3)<\/sup>\uff0e\u3053\u308c\u3089\u7d30\u80de\u6b7b\u306f\u5171\u901a\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3082\u3042\u308a\uff0c\u72ec\u7acb\u3057\u305f\u3082\u306e\u3067\u306f\u306a\u304f\uff0c\u76f8\u4e92\u95a2\u4fc2\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3082\u4fdd\u8b77\u7684\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc(protective autophagy)\u3068\u5b9a\u7fa9\u3055\u308c\u308b\u69d8\u5f0f\u3082\u3042\u308a\uff0c\u6700\u8fd1\uff0c\u3053\u306eProtective autophagy\u3068\u304c\u3093\u6cbb\u7642\u304c\u95a2\u4fc2\u3059\u308b\u8ad6\u6587\u304c\u5897\u52a0\u3057\uff0cPubMed\u691c\u7d22\u3067\u306f300\u7bc7\u3092\u8d85\u3048\uff0c\u6e29\u71b1\u6cbb\u7642\u306e\u89b3\u70b9\u304b\u3089\u3082\u6ce8\u76ee\u3059\u3079\u304d\u7d30\u80de\u6b7b\u306e\u69d8\u5f0f\u3067\u3042\u308b\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e\uff1a<\/p>\n\n\n\n<p>\u30001\uff09Jiang J,<em>&nbsp;et al.<\/em>&nbsp;Targeting autophagy enhances heat stress-induced apoptosis via the ATP-AMPK-mTOR axis for hepatocellular carcinoma. Int J Hyperthermia 36: 499-510, 2019.<\/p>\n\n\n\n<p>\u30002\uff09Kinsey CG,&nbsp;<em>et al<\/em>. Protective autophagy elicited by RAF\u2192MEK\u2192ERK inhibition suggests a treatment strategy for RAS-driven cancers. Nat Med 25: 620-7, 2019.<\/p>\n\n\n\n<p>\u65e5\u672c\u8a9e\u306f<a href=\"http:\/\/aasj.jp\/news\/watch\/9823\">http:\/\/aasj.jp\/news\/watch\/9823<\/a>\u3092\u53c2\u7167<\/p>\n\n\n\n<p>\u30003\uff09Galluzzi L,&nbsp;<em>et al<\/em>. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ 25: 486-541, 2018.<\/p>\n\n\n\n<p>\u7528\u8a9e\u8aac\u660e<\/p>\n\n\n\n<p><sup>*1<\/sup>RFA: Radiofrequency Ablation\uff0e\u30e9\u30b8\u30aa\u6ce2\u713c\u707c\u7642\u6cd5\u306e\u3053\u3068\uff0eRFA\u306f\u816b\u760d\u7d30\u80de\u306b\u71b1\u3092\u52a0\u3048\u308b\u6cbb\u7642\u3067\u3042\u308b\u304c\u6545\u306b\uff0c\u4e0d\u5b8c\u5168\u306a\u713c\u707c\u3067\u306f\u816b\u760d\u306e\u60aa\u6027\u5ea6\u304c\u6025\u6fc0\u306b\u5897\u3059\u3053\u3068\u3082\u3042\u308aRFA\u6cbb\u7642\u65bd\u884c\u3059\u308b\u969b\u306b\u306f\u809d\u304c\u3093\u7d30\u80de\u3092\u6b8b\u3059\u3053\u3068\u306a\u304f\u713c\u707c\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\uff0e<\/p>\n\n\n\n<p><sup>*2<\/sup>\u30af\u30ed\u30ed\u30ad\u30f3\uff1aChloroquine\u306f\u6297\u30de\u30e9\u30ea\u30a2\u5264\u306e\u3072\u3068\u3064\uff0e\u30af\u30ed\u30ed\u30ad\u30f3\u304a\u3088\u3073\u30d2\u30c9\u30ed\u30ad\u30b7\u30af\u30ed\u30ed\u30ad\u30f3\u306f\u30ea\u30bd\u30bd\u30fc\u30e0\u306e\u5206\u89e3\u80fd\u3092\u963b\u5bb3\u3057\uff0c\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u963b\u5bb3\u3059\u308b\uff0e<\/p>\n\n\n\n<p><sup>*3<\/sup>AMPK\uff08AMP-activated protein kinase\uff0cAMP\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff09\uff1a\u7d30\u80de\u5185\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u72b6\u614b\u3092\u76e3\u8996\u3057\uff0c\u305d\u306e\u72b6\u614b\u306b\u5fdc\u3058\u3066\u7cd6\u30fb\u8102\u8cea\u4ee3\u8b1d\u306a\u3069\u3092\u8abf\u7bc0\u3059\u308b\u30bb\u30ea\u30f3\u30fb\u30b9\u30ec\u30aa\u30cb\u30f3\u30ad\u30ca\u30fc\u30bc\u3067\u300c\u4ee3\u8b1d\u30de\u30b9\u30bf\u30fc\u30b9\u30a4\u30c3\u30c1\u300d\u3068\u3088\u3070\u308c\u3066\u3044\u308b.<\/p>\n\n\n\n<p><sup>*4<\/sup>AICAR\uff1a5-aminoimidazole-4-carboxamide ribonucleotide\uff08\u548c\u540d\uff0c\u30a2\u30ab\u30c7\u30b7\u30f3\uff09\uff0eAMPK\u306e\u30a2\u30af\u30c1\u30d9\u30fc\u30bf\u30fc\u3067\u3042\u308a\uff0c\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\u306e\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p><sup>*5<\/sup>\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\uff1aTrametinib\uff0eMEK\u963b\u5bb3\u52b9\u679c\u306b\u3088\u308a\uff0c\u7d30\u80de\u306e\u5897\u6b96\u306b\u5bc4\u4e0e\u3059\u308bMAPK\/ERK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u963b\u5bb3\u3057\u3066\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u5206\u5b50\u6a19\u7684\u85ac\u306b\u5206\u985e\u3055\u308c\u308b\u6297\u304c\u3093\u5264\uff0e\u5546\u54c1\u540d\u30e1\u30ad\u30cb\u30b9\u30c8\uff0cBRAF\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6709\u3059\u308b\u5207\u9664\u4e0d\u80fd\u306a\u9032\u884c\u307e\u305f\u306f\u518d\u767a\u306e\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\uff0cBRAF\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6709\u3059\u308b\u60aa\u6027\u9ed2\u8272\u816b\u304c\u5bfe\u8c61\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c28 \u809d\u7d30\u80de\u304c\u3093\u306b\u304a\u3044\u3066\u4fdd\u8b77\u7684\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u963b\u5bb3\u306fATP-AMPK-mTOR\u3092\u4ecb\u3057\u3066\u6e29\u71b1\u8a98\u767a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u5897\u5f37\u3059\u308b \u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u85ac\u5b66\u7814\u7a76\u90e8\uff09 RFA\uff08Radiofreq [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-576","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=576"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/576\/revisions"}],"predecessor-version":[{"id":577,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/576\/revisions\/577"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}