{"id":578,"date":"2019-05-14T20:35:00","date_gmt":"2019-05-14T11:35:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=578"},"modified":"2022-05-26T20:33:58","modified_gmt":"2022-05-26T11:33:58","slug":"modulated-electro-hyperthermia%e3%82%88%e3%82%8b%e3%83%aa%e3%83%9d%e3%82%bd%e3%83%bc%e3%83%a0%e6%80%a7%e6%8a%97%e3%81%8c%e3%82%93%e5%89%a4%e5%8f%96%e3%82%8a%e8%be%bc%e3%81%bf%e3%81%ae%e5%a2%97","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/modulated-electro-hyperthermia%e3%82%88%e3%82%8b%e3%83%aa%e3%83%9d%e3%82%bd%e3%83%bc%e3%83%a0%e6%80%a7%e6%8a%97%e3%81%8c%e3%82%93%e5%89%a4%e5%8f%96%e3%82%8a%e8%be%bc%e3%81%bf%e3%81%ae%e5%a2%97\/","title":{"rendered":"Modulated-electro hyperthermia\u3088\u308b\u30ea\u30dd\u30bd\u30fc\u30e0\u6027\u6297\u304c\u3093\u5264\u53d6\u308a\u8fbc\u307f\u306e\u5897\u5f37"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c27<\/p>\n\n\n\n<p>Modulated-electro hyperthermia\u3088\u308b\u30ea\u30dd\u30bd\u30fc\u30e0\u6027\u6297\u304c\u3093\u5264\u53d6\u308a\u8fbc\u307f\u306e\u5897\u5f37<\/p>\n\n\n\n<p>\u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u85ac\u5b66\u7814\u7a76\u90e8\uff09<\/p>\n\n\n\n<p>&nbsp;Modulated-electro hyperthermia (mEHT\u3068\u7565\uff0c\u901a\u79f0\u201d\u30aa\u30f3\u30b3\u30b5\u30fc\u30df\u30a2\u201d)\u306f\uff0c\u30d5\u30e9\u30af\u30bf\u30eb\u5909\u8abf\u3055\u308c\u305f13.56 MHz\u306eRF\u6ce2\u3092\u5229\u7528\u3059\u308b\u65b0\u898f\u6e29\u71b1\u7642\u6cd5\u3067\u3042\u308b\uff0e\u3053\u306e\u624b\u6cd5\u306f\uff0c\u52a0\u6e29\u3059\u308b\u3068\u3044\u3046\u70b9\u3067\u306f\u5f93\u6765\u306e\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u3068\u540c\u3058\u3067\u3042\u308b\u304c\uff0c\u816b\u760d\u3078\u306e\u9078\u629e\u6027\u306e\u9ad8\u3044\u52a0\u6e29\u304c\u7279\u5fb4\u3067\u3042\u308b\uff0e\u6b63\u5e38\u7d30\u80de\u3068\u7570\u306a\u308a\uff0c\u304c\u3093\u7d30\u80de\u304c\u7121\u79e9\u5e8f\uff0c\u72ec\u7acb\u306e\u7d44\u7e54\u3092\u5f62\u6210\u3059\u308b\u305f\u3081\u306b\u8d77\u304d\u308b\u5909\u8abf\u96fb\u6ce2\u306b\u5bfe\u3059\u308b\u5438\u53ce\u7387\u306e\u5897\u52a0\u3092\u5229\u7528\u3057\u3066\u3044\u308b\uff0e\u307e\u305f\uff0cmEHT\u306b\u304a\u3044\u3066\u306f\u6e29\u5ea6\u4e0a\u6607\u3060\u3051\u3067\u306f\u8aac\u660e\u3067\u304d\u306a\u3044\u751f\u7269\u52b9\u679c\u3082\u3042\u308a\uff0c\u6e29\u5ea6\u4e0a\u6607\u4ee5\u5916\u306e\u96fb\u78c1\u6ce2\u306e\u975e\u71b1\u7684\u4f5c\u7528\u3082\u91cd\u8981\u306a\u56e0\u5b50\u3068\u306a\u3063\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>\u201cLipodox\u00ae\u201d\u306f\uff0c\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3(Dox)\u3092\u542b\u6709\u3059\u308b\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u30ea\u30dd\u30bd\u30fc\u30e0<a href=\"https:\/\/ja.wikipedia.org\/wiki\/%E6%8A%97%E7%82%8E%E7%97%87%E8%96%AC\">\u6297\u304c\u3093\u5264<\/a>\u3067\u3042\u308b\uff0e\u672c\u85ac\u5264\u3068mEHT\u3042\u308b\u3044\u306f\u5bfe\u7167\u3068\u306a\u308b\u6e29\u71b1\u51e6\u7406(HT)\u3092\u4f75\u7528\u3057\u3066\uff0c\u57f9\u990a\u7d30\u80de\u304a\u3088\u3073\u30de\u30a6\u30b9\u79fb\u690d\u816b\u760d\u30e2\u30c7\u30eb\u3067\u305d\u306e\u52b9\u679c\u306e\u6bd4\u8f03\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u305f<sup>1)<\/sup>\uff0e\u7d30\u80de\u3068\u3057\u3066\uff0c\u30d2\u30c8\u809d\u304c\u3093\u7531\u6765HepG2, \u540c\u80ba\u304c\u3093\u7531\u6765A549, \u540c\u30b0\u30ea\u30aa\u30fc\u30de\u7531\u6765U87MG, \u30de\u30a6\u30b9\u7d50\u8178\u304c\u3093\u7531\u6765CT26\u3092\u4f7f\u7528\u3057\u305f\uff0eLipodox\u3092HT\u3042\u308b\u3044\u306fmEHT\u3068\u4f75\u7528\u3057\uff08\u4e21\u8005\u3068\u3082\u6e29\u5ea6\u6761\u4ef6\u306f42<sup>o<\/sup>C, 30\u5206\uff09\uff0c\u30c8\u30ea\u30d1\u30f3\u9752\u67d3\u8272\u3067Viability\u306e\u4f4e\u4e0b\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\uff0c\u5168\u7d30\u80de\u3067\u5358\u72ec\u306emEHT\u306b\u3088\u308b\u6709\u610f\u306aViability\u4f4e\u4e0b\u3092\u793a\u3059\u3068\u3068\u3082\u306b\uff0cLipodox\u4f75\u7528\u3067\u3055\u3089\u306a\u308b\u6e1b\u5c11\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\uff0emEHT \u4f75\u7528\u306b\u3088\u308bLipodox\u306e\u53d6\u308a\u8fbc\u307f\u306b\u3064\u3044\u3066Dox\u86cd\u5149\u3092\u6307\u6a19\u306b\u8abf\u3079\u305f\u3068\u3053\u308d\uff0cHepG2\uff1eA549\uff1eU87MG\uff1eCT26\u306e\u7d30\u80de\u9806\u3067\u3042\u3063\u305f\uff0eHepG2\u7d30\u80de\u306b\u304a\u3051\u308bLipodox\u306e\u53d6\u308a\u8fbc\u307f\u306b\u3064\u3044\u3066\uff0cNaN<sub>3&nbsp;<\/sub>(ATPase\u963b\u5bb3\u5264)\uff0cChlorpromazine (\u30af\u30e9\u30b9\u30ea\u30f3\u4ecb\u5728\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u963b\u5bb3\u5264)\uff0cWortmannin (\u30de\u30af\u30ed\u30d4\u30ce\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u963b\u5bb3\u5264)\uff0cFilipin (\u30ab\u30d9\u30aa\u30e9\u4ecb\u5728\u7d4c\u8def\u963b\u5bb3\u5264)\u3092\u7528\u3044\u305f\u3068\u3053\u308d\uff0cFilipin\u4ee5\u5916\u3067\u53d6\u308a\u8fbc\u307f\u6291\u5236\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0eWortmannin\u306f\uff0c\u307e\u305f\uff0cmEHT+Lipodox\u306b\u3088\u308bViability\u4f4e\u4e0b\u3092\u9855\u8457\u306b\u6291\u5236\u3057\u305f\uff0eCT26\u3092\u7528\u3044\u305f\u30de\u30a6\u30b9\u79fb\u690d\u816b\u760d\u7cfb\u3067\u3082\uff0cmEHT+Lipodox\u7fa4\u3067\u660e\u3089\u304b\u306a\u816b\u760d\u5897\u6b96\u6291\u5236\u304c\u8a8d\u3081\u3089\u308c\u308b\u3068\u3068\u3082\u306b\uff0cHT+Lipodox\u7fa4\u306b\u6bd4\u3079\u3066\u816b\u760d\u5185\u53d6\u308a\u8fbc\u307f\u3082\u7d042\u500d\u306b\u5897\u52a0\u3057\u305f\uff0e\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\uff0cmEHT\u306f\uff0c\u30a8\u30cd\u30eb\u30ae\u30fc\u4f9d\u5b58\u6027\u30de\u30af\u30ed\u30d4\u30ce\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9<sup>*1<\/sup>\u3092\u4ecb\u3057\u3066Lipodox\u306e\u816b\u760d\u5185\u53d6\u308a\u8fbc\u307f\u3092\u5897\u3084\u3057\uff0c\u6cbb\u7642\u52b9\u679c\u306b\u5bc4\u4e0e\u3059\u308b\u3068\uff0c\u8457\u8005\u3089\u306f\u7d50\u8ad6\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>mEHT\u306f\uff0c\u901a\u5e38\u306eHT\u306b\u6bd4\u3079\u308b\u3068\u816b\u760d\u7d30\u80de\u819c\uff0c\u7279\u306b\u8102\u8cea\u30e9\u30d5\u30c8\u306b\u71b1\u640d\u50b7\u3092\u96c6\u7a4d\u3057\u3084\u3059\u304f\uff0c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u308b\uff0e\u5375\u5de3\u304c\u3093\u3084\u5b50\u5bae\u9838\u304c\u3093\u7d30\u80de\u3092\u7528\u3044\u305f\u5b9f\u9a13\u3067\uff0cmEHT\u304a\u3088\u3073\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u963b\u5bb3\u5264\u3067\u3042\u308b3-Methyladenine\u306e\u4f75\u7528\u306b\u3088\u3063\u3066\uff0c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u5897\u52a0\u3059\u308b\u3068\u306e\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<sup>2)<\/sup>\uff0emEHT\u306b\u3064\u3044\u3066\u306f\u81e8\u5e8a\u5229\u7528\u304c\u5148\u884c\u3057\uff0c\u305d\u306e\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u4e0d\u660e\u306a\u70b9\u3082\u3042\u3063\u305f\u304c\uff0c\u7d30\u80de\u819c\u8f38\u9001\u3078\u306e\u5f71\u97ff\u3082\u660e\u3089\u304b\u3068\u306a\u308a\uff0c\u4eca\u5f8c\u306e\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u671b\u307e\u308c\u308b\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tsang YW,&nbsp;<em>et al<\/em>. Modulated electro-hyperthermia-enhanced liposomal drug uptake by cancer cells. Int J Nanomed.14: 1269-79, 2019.<\/li><li>Yang W,<em>&nbsp;et al.<\/em>&nbsp;Combined treatment with modulated electro-hyperthermia and an autophagy inhibitor effectively inhibit ovarian and cervical cancer growth. Int J Hyperthermia 36: 9-20, 2019.<\/li><\/ul>\n\n\n\n<p><sup>*1<\/sup>\u30de\u30af\u30ed\u30d4\u30ce\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\uff1a\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306e\u4e00\u7a2e\uff0e\u7d30\u80de\u5916\u306e\u6db2\u4f53\u3068\u305d\u3053\u306b\u542b\u307e\u308c\u308b\u7269\u8cea\u3092\uff0c\u30de\u30af\u30ed\u30d4\u30ce\u30bd\u30fc\u30e0\u3068\u547c\u3070\u308c\u308b\u5927\u578b\u3067\u4e0d\u5747\u4e00\u306a\u5c0f\u80de\u306b\u3088\u3063\u3066\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u3080\u73fe\u8c61\uff0e\u7279\u5b9a\u306e\u304c\u3093\u7d30\u80de\u306b\u304a\u3044\u3066\uff0c\u7d30\u80de\u5916\u306e\u6804\u990a\u5206\u3092\u52b9\u679c\u7684\u306b\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u3080\u305f\u3081\u306b\uff0c\u30de\u30af\u30ed\u30d4\u30ce\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u304c\u4fc3\u9032\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308b\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c27 Modulated-electro hyperthermia\u3088\u308b\u30ea\u30dd\u30bd\u30fc\u30e0\u6027\u6297\u304c\u3093\u5264\u53d6\u308a\u8fbc\u307f\u306e\u5897\u5f37 \u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u85ac\u5b66\u7814\u7a76\u90e8\uff09 &nbsp;Modulated-ele [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-578","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=578"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/578\/revisions"}],"predecessor-version":[{"id":579,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/578\/revisions\/579"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=578"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}