{"id":585,"date":"2018-11-13T20:37:00","date_gmt":"2018-11-13T11:37:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=585"},"modified":"2022-05-26T20:35:12","modified_gmt":"2022-05-26T11:35:12","slug":"%e5%9b%ba%e5%bd%a2%e8%85%ab%e7%98%8d%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e6%b8%a9%e7%86%b1%e7%99%82%e6%b3%95%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ae","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e5%9b%ba%e5%bd%a2%e8%85%ab%e7%98%8d%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e6%b8%a9%e7%86%b1%e7%99%82%e6%b3%95%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ae\/","title":{"rendered":"\u56fa\u5f62\u816b\u760d\u306b\u5bfe\u3059\u308b\u6e29\u71b1\u7642\u6cd5\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u5275\u51fa"},"content":{"rendered":"\n

\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c24<\/p>\n\n\n\n

\u56fa\u5f62\u816b\u760d\u306b\u5bfe\u3059\u308b\u6e29\u71b1\u7642\u6cd5\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u5275\u51fa<\/p>\n\n\n\n

\uff5e\u30cf\u30a4\u30ea\u30b9\u30af\u60aa\u6027\u8edf\u90e8\u816b\u760d\u306b\u5bfe\u3059\u308b\u30cd\u30aa\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8<\/p>\n\n\n\n

\u5316\u5b66\u7642\u6cd5\u306b\u304a\u3051\u308b\u6e29\u71b1\u7642\u6cd5\u4f75\u7528\u306b\u95a2\u3059\u308b\u7121\u4f5c\u70ba\u81e8\u5e8a\u8a66\u9a13\uff5e<\/p>\n\n\n\n

 \u68ee\u7530\u3000\u52dd (\u4e5d\u5dde\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u6d88\u5316\u7ba1\u5916\u79d1)\u3000<\/p>\n\n\n\n

\u500b\u3005\u306e\u764c\u60a3\u8005\u306b\u5bfe\u3057\u6700\u826f\u306e\u6cbb\u7642\u3092\u9078\u629e\u3059\u308b\u969b\uff0cevidence-based medicine\uff08EBM\uff09\u3092\u8003\u616e\u3059\u308b\u3053\u3068\u306f\u91cd\u8981\u3067\u3042\u308b\uff0e\u4e00\u822c\u306b\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb\u306e\u9ad8\u3044\u7814\u7a76\u3068\u3057\u3066\uff0c\u7121\u4f5c\u70ba\u6bd4\u8f03\u8a66\u9a13(RCT: randomized controlled trial)\u3084RCT\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u304c\u3042\u3052\u3089\u308c\uff0c\u4e00\u6d41\u306e\u56fd\u969b\u8a8c\u306b\u53d6\u308a\u4e0a\u3052\u3089\u308c\u308b\u3053\u3068\u3082\u591a\u3044\uff0e<\/p>\n\n\n\n

\u3000\u6e29\u71b1\u7642\u6cd5\u304c\u6297\u764c\u5264\u30fb\u653e\u5c04\u7dda\u7642\u6cd5\u306e\u52b9\u679c\u5897\u5f37\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u306f\uff0c\u57fa\u790e\u5b9f\u9a13\uff0c\u81e8\u5e8a\u7d4c\u9a13\u304b\u3089\u3082\u5341\u5206\u306b\u8a8d\u8b58\u3055\u308c\u3066\u3044\u308b\uff0e\u3057\u304b\u3057\uff0c\u6e29\u71b1\u7642\u6cd5\u306e\u52b9\u679c\u306b\u95a2\u3059\u308b\u524d\u5411\u304d\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u306b\u95a2\u3059\u308b\u767a\u8868\u306f\u610f\u5916\u306b\u5c11\u306a\u3044\uff0e\u672c\u5e74\uff0cJAMA Oncology\u8a8c\u306b\uff0cESHO\uff08\u6b27\u5dde\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u5b66\u4f1a\uff09\u4e3b\u5c0e\u3067\u884c\u308f\u308c\u305f\u300c\u30cf\u30a4\u30ea\u30b9\u30af\u60aa\u6027\u8edf\u90e8\u816b\u760d\u306b\u5bfe\u3059\u308b\u30cd\u30aa\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u5316\u5b66\u7642\u6cd5\u306b\u304a\u3051\u308b\u6e29\u71b1\u7642\u6cd5\u4f75\u7528\u306b\u95a2\u3059\u308b\u7121\u4f5c\u70ba\u81e8\u5e8a\u8a66\u9a13(EORTC 62961-ESHO 95)\u300d\u306e\u9577\u671f\u6210\u7e3e\u304c\u63b2\u8f09\u3055\u308c1<\/sup>)<\/sup>\uff0c\u3055\u3089\u306b\uff0c\u91cd\u8981\u306a\u7d50\u679c\u3068\u3057\u3066\uff0cNature Reviews Clinical Oncology \u8a8c\u306b\u3066\u7d39\u4ecb\u3055\u308c\u305f2<\/sup>)<\/sup>\uff0e<\/p>\n\n\n\n

\u3000\u30cf\u30a4\u30ea\u30b9\u30af\u60aa\u6027\u8edf\u90e8\u816b\u760d\u306b\u5bfe\u3057\u3066\u306f\u5c40\u6240\u7642\u6cd5\u3084\u5168\u8eab\u5316\u5b66\u7642\u6cd5\u304c\u884c\u308f\u308c\u308b\u304c\uff0c\u6cbb\u7642\u5f8c\u306e\u518d\u767a\u7387\u306f\u9ad8\u3044\uff0e\u672c\u8a66\u9a13\u306f\uff0c\u9060\u9694\u8ee2\u79fb\u9670\u6027\uff0c\u7b4b\u819c\u307e\u3067\u9054\u3059\u308b5 cm\u4ee5\u4e0a\uff0cFNCLCC\u30b0\u30ec\u30fc\u30c92\uff0c3\u306e\u60aa\u6027\u8edf\u90e8\u816b\u760d\u3092\u5bfe\u8c61\u3068\u3057\uff0c\u7121\u4f5c\u70ba\u306b\u30cd\u30aa\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u5316\u5b66\u7642\u6cd5\uff08\u5316\u7642\u7fa4\uff09\u3068\u5316\u5b66\u6e29\u71b1\u7642\u6cd5(\u6e29\u71b1\u4f75\u7528\u7fa4)\u306b1:1\u3067\u5272\u308a\u4ed8\u3051\u305f\uff0e\u5c40\u6240\u7642\u6cd5\uff08\u624b\u8853\u00b1\u7167\u5c04\uff09\u306e\u524d\u5f8c\u306b\u5316\u7642\u7fa4\u3067\u306f\u5168\u8eab\u5316\u5b66\u7642\u6cd5(doxorubicin, ifosfamide, etoposide)\uff0c\u6e29\u71b1\u4f75\u7528\u7fa4\u3067\u306fifosfamide\u6295\u4e0e\u306b\u5c40\u6240\u6e29\u71b1\u7642\u6cd5\uff0842\u2103\uff0c60\u5206\uff09\u3092\u52a0\u3048\u305f\uff0e341\u4f8b\u306e\u3046\u3061329(\u5316\u7642:167\uff0c\u6e29\u71b1\u4f75\u7528:162)\u4f8b\u304c\u9069\u683c\u4f8b\u3067\u3042\u3063\u305f\uff0e\u89b3\u5bdf\u671f\u9593\u4e2d\u592e\u5024\u304c11.3\u5e74\u3068\u9577\u671f\u306b\u30d5\u30a9\u30ed\u30fc\u3055\u308c\u3066\u3044\u308b\uff0e\u4e00\u6b21\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308b\u5c40\u6240\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306f\u4e2d\u592e\u5024\u3067\u5316\u7642\u7fa429.2\u30f6\u6708\u306b\u5bfe\u3057\uff0c\u6e29\u71b1\u4f75\u7528\u7fa4\u3067\u306f67.3\u30f6\u6708\u3067\uff0c\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u3067\u307f\u308b\u30680.65\u3068\u6e29\u71b1\u4f75\u7528\u7fa4\u3067\u6709\u610f\u306b\u826f\u597d\u306a\u6210\u7e3e\u3067\u3042\u3063\u305f\uff0e\u5168\u751f\u5b58\u7387\u3067\u307f\u3066\u3082\u5316\u7642\uff0c\u6e29\u71b1\u4f75\u7528\u7fa4\u3067\u306f\u5404\u30055\u5e74\u751f\u5b5851.3%, 62.7%\uff0c10\u5e74\u751f\u5b58 42.7%, 52.6%\u3068\u6e29\u71b1\u4f75\u7528\u7fa4\u304c\u6709\u610f\u306b\u826f\u597d\u3067\u3042\u3063\u305f\uff08HR:0.73\uff09\uff0e\u3055\u3089\u306b\uff0c\u5e74\u9f62\uff0c\u816b\u760d\u5360\u62e0\u90e8\u4f4d\uff0c\u816b\u760d\u5f84\uff0c\u5207\u9664\u5ea6\uff0c\u30b0\u30ec\u30fc\u30c9\uff0c\u7d44\u7e54\u578b\u306a\u3069\u5168\u3066\u306e\u30b5\u30d6\u30af\u30e9\u30b9\u89e3\u6790\u306b\u304a\u3044\u3066\uff0c\u6e29\u71b1\u4f75\u7528\u7fa4\u306f\u5316\u7642\u7fa4\u306b\u5bfe\u3057\u4e88\u5f8c\u826f\u597d\u3067\u3042\u3063\u305f\uff0e<\/p>\n\n\n\n

\u3000\u672c\u8a66\u9a13\u306f\uff0c\u53b3\u5bc6\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u305f\u524d\u5411\u304d\u8a66\u9a13\u306e\u7d50\u679c\u3068\u3057\u3066\uff0c\u6e29\u71b1\u7642\u6cd5\u306e\u5316\u5b66\u7642\u6cd5\u3078\u306e\u4e0a\u4e57\u305b\u52b9\u679c\u3092\uff0c\u9577\u671f\u751f\u5b58\u3067\u793a\u3057\u305f\u6975\u3081\u3066\u91cd\u8981\u306a\u5831\u544a\u3067\u3042\u308b\uff0e\u3055\u3089\u306b\uff0c\u81e8\u5e8a\u8a66\u9a13\u3067\u7d50\u679c\u3092\u51fa\u3059\u3053\u3068\u304c\u56f0\u96e3\u306a\u7a00\u306a\u816b\u760d\u3067\uff0c\u6e29\u71b1\u7642\u6cd5\u306e\u6709\u52b9\u6027\u3092\u793a\u3057\u3066\u3044\u308b\u70b9\u3067\u3082\u610f\u7fa9\u6df1\u3044\uff0e\u3053\u306e\u7d50\u679c\u306f\uff0c\u60aa\u6027\u8edf\u90e8\u816b\u760d\u306b\u3068\u3069\u307e\u3089\u305a\uff0c\u4ed6\u306e\u56fa\u5f62\u816b\u760d\u306b\u5bfe\u3057\u3066\u3082\u6e29\u71b1\u7642\u6cd5\u306e\u81e8\u5e8a\u52b9\u679c\u3092\u671f\u5f85\u3055\u305b\u308b\u7d50\u679c\u3068\u3044\u3048\u308b\uff0e\u8ad6\u6587\u4e2d\u3067\u306f\uff0c\u6b27\u5dde\u3067\u884c\u308f\u308c\u3066\u3044\u308b\u81b5\u764c\u306b\u5bfe\u3059\u308b\u7b2c\u2162\u76f8\u7121\u4f5c\u70ba\u8a66\u9a13\uff08NCT01077427\uff09\u3092\u7d39\u4ecb\u3057\u3066\u3044\u308b\uff0e\u4eca\u5f8c\uff0c\u6e29\u71b1\u7642\u6cd5\u304c\u5404\u3005\u306e\u56fa\u5f62\u816b\u760d\u3067\u6a19\u6e96\u7642\u6cd5\u3068\u8a8d\u3081\u3089\u308c\u78ba\u7acb\u3057\u3066\u3044\u304f\u305f\u3081\u306b\u306f\uff0c\u69d8\u3005\u306a\u969c\u58c1\u306f\u3042\u308b\u3082\u306e\u306e\uff0c\u672c\u7814\u7a76\u306e\u3088\u3046\u306b\u8cea\u306e\u9ad8\u3044\u591a\u65bd\u8a2d\u5171\u540c\u306e\u524d\u5411\u304d\u8a66\u9a13\u3092\u4f01\u753b\u3057\uff0c\u7d50\u679c\u3092\u5f97\u308b\u3053\u3068\u304c\u671b\u307e\u308c\u308b\uff0e<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

  1. Issels RD, et al<\/em>. Effect of neoadjuvant chemotherapy plus regional hyperthermia on long-term outcomes among patients with localized high-risk soft tissue sarcoma: The EORTC 62961-ESHO 95 randomized clinical trial. JAMA Oncol 4:483-92, 2018.<\/li>
  2. Killock D. Sarcoma: Local hyperthermia improves survival. Nat Rev Clin Oncol 15:266, 2018.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c24 \u56fa\u5f62\u816b\u760d\u306b\u5bfe\u3059\u308b\u6e29\u71b1\u7642\u6cd5\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u5275\u51fa \uff5e\u30cf\u30a4\u30ea\u30b9\u30af\u60aa\u6027\u8edf\u90e8\u816b\u760d\u306b\u5bfe\u3059\u308b\u30cd\u30aa\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8 \u5316\u5b66\u7642\u6cd5\u306b\u304a\u3051\u308b\u6e29\u71b1\u7642\u6cd5\u4f75\u7528\u306b\u95a2\u3059\u308b\u7121\u4f5c\u70ba\u81e8\u5e8a\u8a66\u9a13\uff5e  \u68ee\u7530\u3000\u52dd (\u4e5d […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-585","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/585","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=585"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/585\/revisions"}],"predecessor-version":[{"id":586,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/585\/revisions\/586"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=585"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=585"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=585"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}