{"id":587,"date":"2018-11-13T20:37:00","date_gmt":"2018-11-13T11:37:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=587"},"modified":"2022-05-26T20:35:37","modified_gmt":"2022-05-26T11:35:37","slug":"%e6%b6%b2-%e6%b6%b2%e7%9b%b8%e5%88%86%e9%9b%a2%e3%81%ab%e3%82%88%e3%82%8b%e7%b4%b0%e8%83%9e%e5%bf%9c%e7%ad%94%e3%81%ae%e6%96%b0%e5%b1%95%e9%96%8b","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e6%b6%b2-%e6%b6%b2%e7%9b%b8%e5%88%86%e9%9b%a2%e3%81%ab%e3%82%88%e3%82%8b%e7%b4%b0%e8%83%9e%e5%bf%9c%e7%ad%94%e3%81%ae%e6%96%b0%e5%b1%95%e9%96%8b\/","title":{"rendered":"\u6db2-\u6db2\u76f8\u5206\u96e2\u306b\u3088\u308b\u7d30\u80de\u5fdc\u7b54\u306e\u65b0\u5c55\u958b"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c23<\/p>\n\n\n\n<p>\u6db2-\u6db2\u76f8\u5206\u96e2\u306b\u3088\u308b\u7d30\u80de\u5fdc\u7b54\u306e\u65b0\u5c55\u958b<\/p>\n\n\n\n<p>&nbsp;\u5409\u6fa4\u3000\u62d3\u4e5f\uff08\u7acb\u547d\u9928\u5927\u5b66\uff09<\/p>\n\n\n\n<p>&nbsp;\u68ee\u3000\u82f1\u4e00\u6717\uff08\u5948\u826f\u770c\u7acb\u533b\u79d1\u5927\u5b66\uff09<\/p>\n\n\n\n<p>\u8fd1\u5e74\uff0c\u304c\u3093\u306e\u4e09\u5927\u6cbb\u7642\u6cd5\uff08\u5916\u79d1\u624b\u8853\u30fb\u653e\u5c04\u7dda\u7642\u6cd5\u30fb\u5316\u5b66\u7642\u6cd5\uff09\u304c\u753b\u671f\u7684\u306b\u767a\u5c55\u3092\u9042\u3052\u3066\u304d\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\uff0c\u4eca\u306a\u304a\uff0c\u304c\u3093\u306f\u65e5\u672c\u4eba\u306e\u6b7b\u56e0\u306e\u4e00\u4f4d\u3067\u3042\u308b\uff0e\u304c\u3093\u6cbb\u7642\u306b\u304a\u3044\u3066\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3084\u5316\u5b66\u7642\u6cd5\u306b\u3088\u3063\u3066DNA\u640d\u50b7\u3092\u751f\u3058\u3055\u305b\uff0c\u304c\u3093\u7d30\u80de\u3092\u7d30\u80de\u6b7b\u3078\u3068\u5c0e\u304f\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u308b\uff0e\u3057\u304b\u3057\u306a\u304c\u3089\uff0c\u304c\u3093\u7d30\u80de\u306fDNA\u640d\u50b7\u5fdc\u7b54\u3092\u542b\u3081\u305f\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u6a5f\u69cb\u304c\u6b63\u5e38\u7d30\u80de\u3088\u308a\u3082\u767a\u9054\u3057\u3066\u3044\u308b\u305f\u3081\uff0c\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u5236\u5fa1\u304c\u304c\u3093\u6cbb\u7642\u306b\u304a\u3044\u3066\u91cd\u8981\u3067\u3042\u308b\uff0e\u3068\u3053\u308d\u304c\uff0c\u304c\u3093\u306e\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u6a5f\u69cb\u306b\u306f\uff0c\u307e\u3060\u307e\u3060\u672a\u89e3\u660e\u306e\u73fe\u8c61\u304c\u591a\u304f\u6b8b\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>\u8fd1\u5e74\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u3092\u6301\u305f\u306a\u3044\u5929\u7136\u5909\u6027\u914d\u5217\u304c\u69d8\u3005\u306a\u75be\u60a3\u3068\u95a2\u9023\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u305f<sup>1)<\/sup>\uff0e\u5929\u7136\u5909\u6027\u914d\u5217\u3068\u306f\uff0c\u00e1\u30d8\u30ea\u30c3\u30af\u30b9\u3084\u00e2\u30b7\u30fc\u30c8\u7b49\u306e2\u6b21\u5143\u69cb\u9020\u3092\u53d6\u3089\u306a\u3044\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9818\u57df\u306e\u3053\u3068\u3092\u610f\u5473\u3057\uff0c\u305d\u306e\u30a2\u30df\u30ce\u9178\u306e\u7d44\u6210\u304b\u3089\uff0cLC\uff08\u4f4e\u8907\u96d1\u6027\uff1alow-complexity\uff09\u914d\u5217\uff08\u3082\u3057\u304f\u306fLC\u30c9\u30e1\u30a4\u30f3\uff09\u3068\u3082\u547c\u3070\u308c\u3066\u3044\u308b\uff0eLC\u30c9\u30e1\u30a4\u30f3\u3068\u306f\uff0c\u30a2\u30df\u30ce\u917820\u7a2e\u985e\u306e\u3046\u3061\uff0c\u308f\u305a\u304b\u6570\u7a2e\u985e\u3060\u3051\u3092\u4f7f\u3063\u3066\u69cb\u6210\u3055\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u914d\u5217\u3092\u6709\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u9818\u57df\u3067\u3042\u308a\uff0c\u305d\u306e\u69cb\u9020\u3084\u6a5f\u80fd\u306b\u95a2\u3057\u3066\u306f\u9577\u5e74\u8b0e\u306b\u5305\u307e\u308c\u3066\u3044\u305f\uff0e<\/p>\n\n\n\n<p>\u7d30\u80de\u306e\u4e2d\u306b\u306f\uff0c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3084\u5c0f\u80de\u4f53\u306e\u3088\u3046\u306b\uff0c\u819c\u306b\u3088\u3063\u3066\u5206\u753b\u3055\u308c\u308b\u30aa\u30eb\u30ac\u30cd\u30e9\u304c\u5b58\u5728\u3059\u308b\uff0e\u4e00\u65b9\u3067\uff0c\u819c\u3092\u6301\u305f\u306a\u3044\u30aa\u30eb\u30ac\u30cd\u30e9\u306f\uff08membrane-less organelle\uff09\uff0c\u6838\u5c0f\u4f53\u3084RNA\u9846\u7c92\u306a\u3069\u306e\u3088\u3046\u306a\u7d30\u80de\u5185\u306e\u7279\u5b9a\u306e\u90e8\u4f4d\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3066\u304a\u308a\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6301\u3064\u65b0\u305f\u306a\u6a5f\u80fd\u3068\u3057\u3066\u8fd1\u5e74\u7740\u76ee\u3055\u308c\u3066\u3044\u308b\uff0e\u305d\u3057\u3066\uff0c\u305d\u306e\u5f62\u6210\u306b\u306fLC\u914d\u5217\u3092\u6709\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u308bcross-\u00e2\u30dd\u30ea\u30de\u30fc\uff08\u00e2\u30b7\u30fc\u30c8\u69cb\u9020\u3092\u4ecb\u3057\u3066\u5f62\u6210\u3055\u308c\u305f\u30dd\u30ea\u30de\u30fc\uff09\u5f62\u6210\u3084\u6db2-\u6db2\u76f8\u5206\u96e2\uff08liquid-liquid phase separation\uff09\u3068\u3044\u3046\u73fe\u8c61\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u5f90\u3005\u306b\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u305f\uff0e<\/p>\n\n\n\n<p>\u67d3\u8272\u4f53\u8ee2\u5ea7\u306b\u3088\u308b\u8089\u816b\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308bFUS\uff08fused-in-sarcoma\uff09\u306f\uff0cRNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\uff0cN\u672b\u9818\u57df\u306bLC\u914d\u5217\u3092\u6709\u3059\u308b\uff0eFUS\u306f\uff0c\u771f\u6838\u7d30\u80de\u306eDNA\u4fee\u5fa9\u6a5f\u69cb\u306b\u304a\u3044\u3066\u6a5f\u80fd\u3057\u3066\u304a\u308a\uff0c\u3053\u306e\u6a5f\u69cb\u306e\u4e2d\u5fc3\u7684\u5236\u5fa1\u9175\u7d20\u3067\u3042\u308bDNA\u4f9d\u5b58\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30f3\u9178\u5316\u9175\u7d20\uff08DNA-PK\uff09\u306b\u3088\u3063\u3066\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b<sup>2)<\/sup>\uff0eFUS\u306eLC\u30c9\u30e1\u30a4\u30f3\u304cDNA-PK\u306b\u3088\u3063\u3066\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u3068\uff0c\u30dd\u30ea\u30de\u30fc\u5f62\u6210\u304c\u963b\u5bb3\u3055\u308c\u308b<sup>3)<\/sup>\uff0e\u307e\u305f\uff0cFUS\u306eLC\u30c9\u30e1\u30a4\u30f3\u304c\u76f8\u5206\u96e2\u3057\u3066\u3067\u304d\u305f\u6db2\u6ef4\u5185\u90e8\u306b\u3082\uff0c\u30dd\u30ea\u30de\u30fc\u69cb\u9020\u304c\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u518d\u78ba\u8a8d\u3055\u308c\uff0c\u305d\u306e\u30dd\u30ea\u30de\u30fc\u69cb\u9020\u304c\u30ea\u30f3\u9178\u5316\u306b\u3088\u308a\u5d29\u58ca\u3059\u308b\u3053\u3068\u3067\uff0c\u6db2\u6ef4\u304c\u878d\u89e3\u3055\u308c\u308b\u6a5f\u69cb\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f<sup>4)<\/sup>\uff0e<\/p>\n\n\n\n<p>\u7d30\u80de\u304c\u6e29\u71b1\u306a\u3069\u306e\u30b9\u30c8\u30ec\u30b9\u74b0\u5883\u306b\u3055\u3089\u3055\u308c\u308b\u3068\uff0c\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u3068\u547c\u3070\u308c\u308bRNA\u306b\u5bcc\u3093\u3060\u819c\u3092\u6301\u305f\u306a\u3044\u30aa\u30eb\u30ac\u30cd\u30e9\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\uff0c\u3053\u306e\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306e\u5f62\u6210\u306b\u306f\uff0cFUS\u306a\u3069\u306eLC\u30c9\u30e1\u30a4\u30f3\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\uff0e\u307e\u305f\uff0c\u6838\u5185\u8f38\u9001\u53d7\u5bb9\u4f53\u306eImportin\u304c\u30b7\u30e3\u30da\u30ed\u30f3\u69d8\u306b\u50cd\u304f\u3053\u3068\u3067\uff0cFUS\u306e\u6db2-\u6db2\u76f8\u5206\u96e2\u304c\u963b\u5bb3\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f<sup>5)<\/sup>\uff0e\u3053\u306e\u767a\u898b\u306b\u3088\u308a\uff0cLC\u30c9\u30e1\u30a4\u30f3\u306b\u3088\u308b\u6db2-\u6db2\u76f8\u5206\u96e2\u3068\u3044\u3046\u73fe\u8c61\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u306f\uff0c\u4e00\u65b9\u5411\u6027\u306e\u6a5f\u5e8f\u306e\u89e3\u660e\u3060\u3051\u3067\u306f\u4e0d\u5341\u5206\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff0e<\/p>\n\n\n\n<p>\u53e4\u304f\u304b\u3089\uff0cDNA\u4fee\u5fa9\u56e0\u5b50\u306e\u7d30\u80de\u5185\u3067\u306e\u6319\u52d5\u306f\uff0c\u8907\u96d1\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u4f8b\u3048\u3070\uff0cBRCA2\u306a\u3069\u306eDNA\u4fee\u5fa9\u306b\u95a2\u308f\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6e29\u71b1\u51e6\u7406\u306b\u3088\u308a\u6e1b\u5c11\u3057\u305f\u308a\uff0cDNA\u640d\u50b7\u8a8d\u8b58\u56e0\u5b50\uff0853BP1\u3084SMC1\uff09\u306e\u30d5\u30a9\u30fc\u30ab\u30b9\u5f62\u6210\u304c\uff0c\u6e29\u71b1\u51e6\u7406\u306b\u3088\u308a\u963b\u5bb3\u3092\u53d7\u3051\u305f\u308a\uff0cDNA\u4fee\u5fa9\u56e0\u5b50\u306eMre11\u304c\u6e29\u71b1\u51e6\u7406\u5f8c\u306b\u7d30\u80de\u6838\u304b\u3089\u7d30\u80de\u8cea\u3078\u3068\u79fb\u52d5\u3057\u305f\u308a\u3059\u308b\u3068\u3055\u308c\u3066\u304d\u305f\uff0e\u3057\u304b\u3057\uff0c\u6e29\u71b1\u51e6\u7406\u5f8c\u3057\u3070\u3089\u304f\u3059\u308b\u3068\uff0c\u518d\u3073\u6838\u5185\u306b\u623b\u308a\uff0cDNA\u640d\u50b7\u90e8\u4f4d\u306b\u96c6\u7a4d\u3059\u308b<sup>6)<\/sup>\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u306a\u3063\u305f\uff0e\u3055\u3089\u306b\uff0c\u7269\u8cea\u306e\u8f38\u9001\u306b\u95a2\u9023\u3059\u308bImportin\u304cFUS\u306e\u76f8\u5206\u96e2\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b<sup>5)<\/sup>\u3068\u3044\u3046\u3053\u3068\u304b\u3089\uff0c\u6db2-\u6db2\u76f8\u5206\u96e2\u3068\u7269\u8cea\u8f38\u9001\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u306f\uff0c\u3053\u308c\u307e\u3067\u8003\u3048\u3089\u308c\u3066\u3044\u305f\u3088\u308a\u3082\u8907\u96d1\u3067\u3042\u308b\u3053\u3068\u304c\u60f3\u50cf\u3055\u308c\uff0c\u304c\u3093\u7d30\u80de\u306e\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u6a5f\u69cb\u306e\u7406\u89e3\u306b\u306f\uff0c\u3053\u308c\u3089\u306e\u8907\u5408\u7684\u306a\u7406\u89e3\u304c\u6b20\u304b\u305b\u306a\u3044\uff0e\u6db2-\u6db2\u76f8\u5206\u96e2\u306e\u9818\u57df\u306b\u304a\u3044\u3066\uff0c\u4eca\u5f8c\u306e\u7814\u7a76\u306e\u5c55\u958b\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Taylor JP,&nbsp;<em>et al<\/em>. Decoding ALS: from genes to mechanism. Nature 539:197-206, 2016.<\/li><li>Deng Q,&nbsp;<em>et al<\/em>. FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage. J Neurosci 34:7802-13, 2014.<\/li><li>Kato M,&nbsp;<em>et al<\/em>. Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell 149:753-67, 2012.<\/li><li>Murray DT,&nbsp;<em>et al<\/em>. Structure of FUS protein fibrils and its relevance to self-assembly and phase separation of low-complexity domains. Cell 171:615-27, 2017.<\/li><li>Yoshizawa T,&nbsp;<em>et al<\/em>. Nuclear import receptor inhibits phase separation of FUS through binding to multiple sites. Cell 173:693-705, 2018.<\/li><li>Takahashi A,&nbsp;<em>et al<\/em>. The foci of DNA double strand break-recognition proteins localize with gamma H2AX after heat treatment. J Radiat Res 51:91-5, 2010.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c23 \u6db2-\u6db2\u76f8\u5206\u96e2\u306b\u3088\u308b\u7d30\u80de\u5fdc\u7b54\u306e\u65b0\u5c55\u958b &nbsp;\u5409\u6fa4\u3000\u62d3\u4e5f\uff08\u7acb\u547d\u9928\u5927\u5b66\uff09 &nbsp;\u68ee\u3000\u82f1\u4e00\u6717\uff08\u5948\u826f\u770c\u7acb\u533b\u79d1\u5927\u5b66\uff09 \u8fd1\u5e74\uff0c\u304c\u3093\u306e\u4e09\u5927\u6cbb\u7642\u6cd5\uff08\u5916\u79d1\u624b\u8853\u30fb\u653e\u5c04\u7dda\u7642\u6cd5\u30fb\u5316\u5b66\u7642\u6cd5\uff09\u304c\u753b\u671f [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-587","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=587"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/587\/revisions"}],"predecessor-version":[{"id":588,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/587\/revisions\/588"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}