{"id":593,"date":"2018-09-30T20:39:00","date_gmt":"2018-09-30T11:39:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=593"},"modified":"2022-05-26T20:37:40","modified_gmt":"2022-05-26T11:37:40","slug":"%e3%83%8a%e3%83%8e%e3%83%ad%e3%83%83%e3%83%89%e3%82%92%e7%94%a8%e3%81%84%e3%81%9f%e7%99%8c%e6%b2%bb%e7%99%82%e3%81%ae%e3%81%9f%e3%82%81%e3%81%ae%e5%85%89%e6%b8%a9%e7%86%b1%e6%b2%bb%e7%99%82%ef%bc%88ph","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e3%83%8a%e3%83%8e%e3%83%ad%e3%83%83%e3%83%89%e3%82%92%e7%94%a8%e3%81%84%e3%81%9f%e7%99%8c%e6%b2%bb%e7%99%82%e3%81%ae%e3%81%9f%e3%82%81%e3%81%ae%e5%85%89%e6%b8%a9%e7%86%b1%e6%b2%bb%e7%99%82%ef%bc%88ph\/","title":{"rendered":"\u30ca\u30ce\u30ed\u30c3\u30c9\u3092\u7528\u3044\u305f\u764c\u6cbb\u7642\u306e\u305f\u3081\u306e\u5149\u6e29\u71b1\u6cbb\u7642\uff08Photothermal therapy\uff09\u306b\u3064\u3044\u3066"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c20<\/p>\n\n\n\n<p>\u30ca\u30ce\u30ed\u30c3\u30c9\u3092\u7528\u3044\u305f\u764c\u6cbb\u7642\u306e\u305f\u3081\u306e\u5149\u6e29\u71b1\u6cbb\u7642\uff08Photothermal therapy\uff09\u306b\u3064\u3044\u3066<\/p>\n\n\n\n<p>\u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66 \u5927\u5b66\u9662\u533b\u5b66\u85ac\u5b66\u7814\u7a76\u90e8\uff09<\/p>\n\n\n\n<p>\u5149\u3092\u7528\u3044\u305f\u764c\u6cbb\u7642\u306b\u306f\u30ec\u30fc\u30b6\u5149\u7167\u5c04\u306b\u3088\u308b\u6e29\u71b1\u6cbb\u7642\uff08\u30ec\u30fc\u30b6\u30b5\u30fc\u30df\u30a2\uff09\u3084\u5149\u5897\u611f\u5264\u3092\u6295\u4e0e\u3057\uff0c\u6a19\u7684\u3068\u306a\u308b\u751f\u4f53\u7d44\u7e54\u306b\u30ec\u30fc\u30b6\u5149\u3092\u7167\u5c04\u3057\u3066\u5149\u5897\u611f\u5264\u304b\u3089\u4e00\u91cd\u9805\u9178\u7d20\u306a\u3069\u306e\u6d3b\u6027\u9178\u7d20\u3092\u751f\u3058\u3055\u305b\uff0c\u3053\u308c\u306b\u3088\u3063\u3066\u764c\u3092\u6cbb\u7642\u3059\u308b\u5149\u7dda\u529b\u5b66\u6cbb\u7642\uff08PDT\uff1bPhotodynamic therapy\uff09\u304c\u3042\u308b\u304c\uff0c\u524d\u8005\u3067\u306f\u816b\u760d\u9078\u629e\u6027\uff0c\u5f8c\u8005\u3067\u306f\u5149\u5316\u5b66\u53cd\u5fdc\u306b\u9178\u7d20\u3092\u5fc5\u8981\u3068\u3059\u308b\u70b9\uff0c\u7b49\u306e\u8ab2\u984c\u3082\u3042\u308b\uff0e<\/p>\n\n\n\n<p>\u73fe\u5728\uff0c\u3053\u306e\u5149\u533b\u5b66\u3068\u30ca\u30ce\u30b5\u30a4\u30a8\u30f3\u30b9\u3092\u878d\u5408\u3059\u308b\u6d41\u308c\u304c\u52a0\u901f\u3057\u3066\u3044\u308b\uff0ePubMed\u691c\u7d22\u3067\uff0c\u30ca\u30ce\u7c92\u5b50\u3092\u691c\u7d22\u3059\u308b\u306817\u4e07\u4ef6\uff0c\u30ca\u30ce\u30e1\u30c7\u30a3\u30b7\u30f3\u3092\u691c\u7d22\u3059\u308b\u30682\u4e07\u4ef6\u4ee5\u4e0a\u304c\u30d2\u30c3\u30c8\u3059\u308b\uff0e\u30ca\u30ce\u30b5\u30a4\u30ba\u7c92\u5b50\u306b\u306f\u2460\u6bd4\u8868\u9762\u7a4d\u304c\u5927\u304d\u304f\uff0c\u751f\u4f53\u5206\u5b50\u306e\u591a\u91cf\u7d50\u5408\u304c\u53ef\u80fd\uff0c\u2461\u9069\u5207\u306a\u8868\u9762\u52a0\u5de5\u3067\uff0c\u751f\u4f53\u5185\u5faa\u74b0\u6027\u304c\u5411\u4e0a\uff0c\u2462EPR(Enhanced permeation and retention\uff09\u52b9\u679c\u306b\u3088\u308b\u816b\u760d\u96c6\u7a4d\u6027\u306e\u5411\u4e0a\uff0c\u7b49\u306e\u7279\u5fb4\u304c\u3042\u308b<sup>1)<\/sup>\uff0e\u30ca\u30ce\u30e1\u30c7\u30a3\u30b7\u30f3\u306e\u4e00\u89d2\u3092\u306a\u3059\u5149\u6e29\u71b1\u6cbb\u7642(PTT\uff1bPhotothermal therapy)\u306f\u30ca\u30ce\u7c92\u5b50\u5229\u7528\u3067\u958b\u59cb\u3055\u308c\u305f\u304c\uff0c\u6700\u8fd1\u306f\u8fd1\u8d64\u5916\u7dda\u9818\u57df\u306e\u5438\u53ce\u306b\u512a\u308c\u308b\u3053\u3068\u304b\u3089\uff0c\u9577\u6ce2\u9577\u30ec\u30fc\u30b6\u3092\u7528\u3044\u305f PTT\u3068\u3057\u3066\u7403\u72b6\u30ca\u30ce\u7c92\u5b50\u3088\u308a\u3082\u30ca\u30ce\u30ed\u30c3\u30c9\u306e\u5229\u7528\u304c\u6ce8\u76ee\u3092\u6d74\u3073\u3066\u3044\u308b\uff0e\u30ca\u30ce\u30ed\u30c3\u30c9\u3067\u306f\u30a2\u30b9\u30da\u30af\u30c8\u6bd4(\u7e26\u6a2a\u6bd4)\u3092\u4e0a\u3052\u308b\u3068\u5438\u53ce\u6ce2\u9577\u304c\u3055\u3089\u306b\u9577\u6ce2\u9577\u5074\u306b\u30b7\u30d5\u30c8\u3057\u3066\u5149\u306e\u6df1\u9054\u6027\u304c\u5411\u4e0a\u3057\uff0c\u307e\u305f\uff0c\u8868\u9762\u3092\u764c\u306b\u7279\u7570\u7684\u306a\u6297\u4f53\u3067\u52a0\u5de5\u3059\u308b\u3053\u3068\u306b\u3088\u308a\uff0c\u764c\u7d44\u7e54\u3078\u306e\u9078\u629e\u6027\u3092\u3088\u308a\u9ad8\u3081\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\uff0c\u30ca\u30ce\u30ed\u30c3\u30c9\u306e\u5149\u767a\u71b1\u52b9\u679c\u3092\u5229\u7528\u3057\u305f\u304c\u3093\u6cbb\u7642\u306e\u5229\u70b9\u306f\u591a\u3044\uff0e<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u306b\uff0c\u6700\u8fd1\u306e\u7814\u7a76\u4f8b\u3092\u793a\u3059\uff0e\u30e1\u30e9\u30ce\u30fc\u30de\u7d30\u80de\u306b\u5bfe\u3059\u308b\u89aa\u548c\u6027\u3092\u5897\u3059\u305f\u3081\u306b\u8449\u9178\u4fee\u98fe\u3057\u305f\u91d1\u30ca\u30ce\u30ed\u30c3\u30c9\uff08GNRs-FA\uff09\u3092\u5408\u6210\u3057\uff0c\u7d30\u80de\u6c34\u6e96\u3067PTT\u3092\u5b9f\u65bd\u3057\u305f\uff0e\u30de\u30a6\u30b9\u30e1\u30e9\u30ce\u30fc\u30deB16-BL6\u7d30\u80de\u3092GNRs-FA\u306724\u6642\u9593\u51e6\u7406\u3057\u305f\u5f8c\uff0c808 nm\u306e\u8fd1\u8d64\u5916\u30ec\u30fc\u30b6\u3092\u7570\u306a\u308b\u5f37\u5ea6(0.96 W, 1.28 W, 1.59 W)\u3067\uff0c15\u5206\u9593\u7167\u5c04\u3057\u305f\uff0e\u8fd1\u8d64\u5916\u653e\u5c04\u6e29\u5ea6\u8a08\u306e\u6e2c\u5b9a\u3067\u306f\uff0c\u5230\u9054\u6e29\u5ea6\u306e\u6700\u9ad8\u5024\u306f\uff0c\u305d\u308c\u305e\u308c43<sup>&nbsp;o<\/sup>C, 46<sup>&nbsp;o<\/sup>C,\u304a\u3088\u307349<sup>&nbsp;o<\/sup>C\u3067\u3042\u3063\u305f\uff0e\u4e00\u65b9\uff0cGNRs-FA\u3092\u542b\u307e\u306a\u3044\u5bfe\u7167\u306ePBS\u6eb6\u6db2\u3067\u306f\u6e29\u5ea6\u4e0a\u6607\u306f\u306a\u304b\u3063\u305f\uff0e\u7d30\u80de\u6b7b\u3092\u691c\u8a0e\u3057\u3068\u3053\u308d\uff0c43<sup>&nbsp;o<\/sup>C\u3067\u306f\u751f\u5b58\u7d30\u80de\u304c50\uff05\u4ee5\u4e0a\u3067\uff0c\u7d30\u80de\u6b7b\u3067\u3042\u308b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff0c\u30cd\u30af\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\uff0c\u304a\u3088\u3073\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u306e\u5272\u5408\u304c10%,18%\u304a\u3088\u307318%\u3067\u3042\u3063\u305f\uff0e49<sup>&nbsp;o<\/sup>C\u3067\u306f\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u306e\u5272\u5408\u304c50\uff05\u4ee5\u4e0a\u3068\u306a\u308b\u304c\uff0c\u4e2d\u7b49\u5ea6\u306e46<sup>&nbsp;o<\/sup>C\u3067\u306f\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff0c\u30cd\u30af\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u5272\u5408\u304c\u9ad8\u304f\u306a\u308a\u5f8c\u8005\u3067\uff0c\u6700\u5927\u306e35\uff05\u3092\u793a\u3057\u305f\uff0e\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u6e29\u5ea6\u4f9d\u5b58\u6027\u306b\u7d30\u80de\u6b7b\u306e\u69d8\u5f0f\u304c\u5909\u308f\u308a\uff0cPTT\u3067\u306f\u30cd\u30af\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u304c\u305d\u306e\u4e2d\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f<sup>2)<\/sup>\uff0e\u3055\u3089\u306b\uff0c\u6700\u8fd1\uff0c\u653e\u5c04\u7dda\u304a\u3088\u3073MRI\u8a3a\u65ad\u306b\u5229\u7528\u3067\u304d\uff0c\u307e\u305f\uff0c\u6cbb\u7642\u306b\u3082\u5229\u7528\u3067\u304d\u308bGd\u30b7\u30a7\u30eb\u3067\u52a0\u5de5\u3055\u308c\u305f\u91d1\u30ca\u30ce\u30ed\u30c3\u30c9\u304c\u958b\u767a\u3055\u308c\u305f\uff0e\u30e9\u30c3\u30c8\u7d50\u8178\u764c\u306e\u809d\u8ee2\u79fb\u30e2\u30c7\u30eb\u3067\uff0c\u3053\u308c\u3092\u7528\u3044\u305f\u8a3a\u65ad\u3068\u4f53\u5916\u304b\u3089\u30ab\u30c6\u30fc\u30c6\u30eb\u3092\u7528\u3044\u305f\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30ca\u30ebPTT \u6cbb\u7642\u5b9f\u9a13\u306e\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u305f<sup>3)<\/sup>\uff0e\u30ca\u30ce\u30ed\u30c3\u30c9\u306f\u5f62\u72b6\u3084\u8868\u9762\u52a0\u5de5\u306e\u5de5\u592b\u306b\u3088\u308a\uff0c\u591a\u304f\u306e\u5fdc\u7528\u304c\u53ef\u80fd\u3067\uff0c\u3053\u308c\u306b\u8fd1\u8d64\u5916\u30ec\u30fc\u30b6\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u764c\u6cbb\u7642\u306e\u305f\u3081\u306e\u5149\u6e29\u71b1\u6cbb\u7642\u306f\u3055\u3089\u306a\u308b\u767a\u5c55\u304c\u671f\u5f85\u3067\u304d\u308b\uff0e<\/p>\n\n\n\n<p>\u88dc\u8db3\u8aac\u660e<\/p>\n\n\n\n<p>\u30ca\u30ce\u30ed\u30c3\u30c9\uff1a\u30ca\u30ce\u30d1\u30fc\u30c6\u30a3\u30af\u30eb\uff08\u30ca\u30ce\u7c92\u5b50\uff09\u306b\u306f\u7403\u72b6\u3068\u30ed\u30c3\u30c9\uff08\u68d2\uff09\u72b6\u306e\u5fae\u7c92\u5b50\u304c\u3042\u308a\uff0c\u30ed\u30c3\u30c9\uff08\u68d2\uff09\u72b6\u306e\u30ca\u30ce\u7c92\u5b50\u306e\u3053\u3068\u3092\u300c\u30ca\u30ce\u30ed\u30c3\u30c9(Nanorod)\u300d\u3068\u3044\u3046\uff0e\u4e2d\u3067\u3082\u91d1\u30ca\u30ce\u30ed\u30c3\u30c9\u306f\u53ef\u8996\uff5e\u8fd1\u8d64\u5916\u9818\u57df\u306b\u77ed\u8ef8\u65b9\u5411\u304a\u3088\u3073\u9577\u8ef8\u65b9\u5411\u306e<a href=\"http:\/\/www.jsms.jp\/word\/contents\/surfaceplasmonabsorption.html\">\u8868\u9762\u30d7\u30e9\u30ba\u30e2\u30f3\u5171\u9cf4<\/a>&nbsp;(Surface Plasmon Resonance)\u306b\u7531\u6765\u3059\u308b\u4e8c\u672c\u306e\u5438\u53ce\u5e2f\u3092\u793a\u3057\uff0c\u30ed\u30c3\u30c9\u306e\u5f62\u72b6\u306b\u3088\u3063\u3066\u4e8c\u3064\u306e\u5438\u53ce\u30d4\u30fc\u30af\u3092\u5236\u5fa1\u3067\u304d\u308b\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Elahi N.,&nbsp;<em>et al.&nbsp;<\/em>Recent biomedical applications of gold nanoparticles: A review. Talanta, 184: 537-556, 2018.<\/li><li>Zhang Y.,&nbsp;<em>et al<\/em>. Temperature-dependent cell death patterns induced by functionalized gold nanoparticle photothermal therapy in melanoma cells. Sci Rep, 8: 8720, 2018.<\/li><li>Parchur A.K.,&nbsp;<em>et al<\/em>. Vasculature interventional radiology-guided photothermal therapy of colorectal cancer liver metastasis with theranostic gold nanorods. ACS Nano, 2018. DOI:10.1021\/acsnano.8b01424.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c20 \u30ca\u30ce\u30ed\u30c3\u30c9\u3092\u7528\u3044\u305f\u764c\u6cbb\u7642\u306e\u305f\u3081\u306e\u5149\u6e29\u71b1\u6cbb\u7642\uff08Photothermal therapy\uff09\u306b\u3064\u3044\u3066 \u8fd1\u85e4\u3000\u9686\uff08\u5bcc\u5c71\u5927\u5b66 \u5927\u5b66\u9662\u533b\u5b66\u85ac\u5b66\u7814\u7a76\u90e8\uff09 \u5149\u3092\u7528\u3044\u305f\u764c\u6cbb\u7642\u306b\u306f\u30ec\u30fc\u30b6\u5149\u7167\u5c04\u306b\u3088\u308b\u6e29 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-593","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/593","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=593"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/593\/revisions"}],"predecessor-version":[{"id":594,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/593\/revisions\/594"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=593"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=593"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=593"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}