{"id":598,"date":"2018-05-09T20:41:00","date_gmt":"2018-05-09T11:41:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=598"},"modified":"2022-05-27T15:38:51","modified_gmt":"2022-05-27T06:38:51","slug":"%e7%a3%81%e6%80%a7%e3%83%8a%e3%83%8e%e7%b2%92%e5%ad%90%e3%81%ab%e3%82%88%e3%82%8b%e7%b4%b0%e8%83%9e%e5%86%85%e5%b1%80%e6%89%80%e5%8a%a0%e6%b8%a9%e3%81%a8%e5%90%88%e6%88%90%e7%94%9f%e7%89%a9%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e7%a3%81%e6%80%a7%e3%83%8a%e3%83%8e%e7%b2%92%e5%ad%90%e3%81%ab%e3%82%88%e3%82%8b%e7%b4%b0%e8%83%9e%e5%86%85%e5%b1%80%e6%89%80%e5%8a%a0%e6%b8%a9%e3%81%a8%e5%90%88%e6%88%90%e7%94%9f%e7%89%a9%e5%ad%a6\/","title":{"rendered":"\u78c1\u6027\u30ca\u30ce\u7c92\u5b50\u306b\u3088\u308b\u7d30\u80de\u5185\u5c40\u6240\u52a0\u6e29\u3068\u5408\u6210\u751f\u7269\u5b66\u5206\u91ce\u3078\u306e\u5fdc\u7528"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c18<\/p>\n\n\n\n<p>\u78c1\u6027\u30ca\u30ce\u7c92\u5b50\u306b\u3088\u308b\u7d30\u80de\u5185\u5c40\u6240\u52a0\u6e29\u3068\u5408\u6210\u751f\u7269\u5b66\u5206\u91ce\u3078\u306e\u5fdc\u7528<\/p>\n\n\n\n<p>\u4e95\u85e4\u3000\u5f70\uff08\u4e5d\u5dde\u5927\u5b66 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\u751f\u4f53\u7269\u8cea\u306b\u307b\u3068\u3093\u3069\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u3044\uff0c2) \u6bd4\u8f03\u7684\u6df1\u90e8\u307e\u3067\u5230\u9054\u3059\u308b\uff0c\u3068\u3044\u3063\u305f\u5229\u70b9\u304c\u3042\u308b\u3053\u3068\u304b\u3089\u6709\u529b\u306a\u9078\u629e\u80a2\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\uff0eHuang\u3089\u306f\u78c1\u6027\u30ca\u30ce\u7c92\u5b50\u3092\u7d30\u80de\u306b\u5c0e\u5165\u3057\u3066\u4ea4\u6d41\u78c1\u5834\u7167\u5c04\u3059\u308b\u3053\u3068\u3067\uff0c\u78c1\u6027\u30ca\u30ce\u7c92\u5b50\u3092\u7d30\u80de\u5185\u5c40\u6240\u3067\u767a\u71b1\u3055\u305b\uff0c\u6e29\u5ea6\u30bb\u30f3\u30b5\u30fc\u3067\u3042\u308b\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u578b\u819c\u30bf\u30f3\u30d1\u30af\u8ceaTRPV1\u3092\u958b\u304f\u3053\u3068\u3067\u795e\u7d4c\u7d30\u80de\u306e\u6d3b\u52d5\u96fb\u4f4d\u3092\u60f9\u8d77\u3055\u305b\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u305f<sup>2)<\/sup>\uff0e\u3055\u3089\u306b\uff0cStanley\u3089\u306f\uff0c\u7d30\u80de\u5185\u3067\u78c1\u6027\u30ca\u30ce\u7c92\u5b50\u3092\u5f62\u6210\u3059\u308b\u6027\u8cea\u3092\u3082\u3064\u9244\u8caf\u8535\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u30d5\u30a7\u30ea\u30c1\u30f3\u306e\u907a\u4f1d\u5b50\u3068<em>TRPV1<\/em>\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u7d30\u80de\u306b\u5c0e\u5165\u3057\uff0c\u78c1\u5834\u7167\u5c04\u306b\u3088\u3063\u3066TRPV1\u3092\u4ecb\u3057\u3066\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u3092\u6d41\u5165\u3055\u305b\uff0c\u5171\u5c0e\u5165\u3057\u305f\u4eba\u5de5\u907a\u4f1d\u5b50\u56de\u8def\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u907a\u4f1d\u5b50\u3092\u767a\u73fe\u3055\u305b\u308b\u4ed5\u7d44\u307f\u3092\u69cb\u7bc9\u3057\u305f<sup>3)<\/sup>\uff0e\u4e00\u65b9\uff0c\u6211\u3005\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\uff0c\u6e29\u71b1\u8a98\u5c0e\u578b\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3068\u3057\u3066\u30d2\u30c8HSP70B\u2019\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u5229\u7528\u3057\uff0c\u30c6\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u767a\u73fe\u5236\u5fa1\u7cfb\u306eTet-Off\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u878d\u5408\u3059\u308b\u3053\u3068\u3067\u4eba\u5de5\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u958b\u767a\u3057\uff0c\u4ea4\u6d41\u78c1\u5834\u7167\u5c04\u306b\u3088\u308b\u78c1\u6027\u30ca\u30ce\u7c92\u5b50\u306e\u767a\u73fe\u3092\u5f15\u304d\u91d1\u3068\u3057\u305f\u6cbb\u7642\u907a\u4f1d\u5b50\u306e\u8a98\u5c0e\u9ad8\u767a\u73fe\u30b7\u30b9\u30c6\u30e0\u3092\u69cb\u7bc9\u3057\u305f<sup>4-5)<\/sup>\uff0e\u3053\u306e\u6e29\u71b1\u8a98\u5c0e\u578b\u907a\u4f1d\u5b50\u767a\u73fe\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u3066\uff0cA549\u30d2\u30c8\u80ba\u80de\u57fa\u5e95\u4e0a\u76ae\u817a\u764c\u7d30\u80de\u3092\u76ae\u4e0b\u63a5\u7a2e\u3057\u305f\u62c5\u764c\u30cc\u30fc\u30c9\u30de\u30a6\u30b9\u306b\u5bfe\u3059\u308b\u78c1\u6027\u30ca\u30ce\u7c92\u5b50\u306b\u3088\u308b\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u3068<em>TNF-\u03b1<\/em>\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u4f75\u7528\u3092\u884c\u3063\u305f\u3068\u3053\u308d\uff0c30\u65e5\u9593\u306b\u308f\u305f\u3063\u3066\u5f37\u304f\u816b\u760d\u5897\u6b96\u3092\u6291\u5236\u3059\u308b\u6cbb\u7642\u52b9\u679c\u304c\u307f\u3089\u308c\u305f<sup>6)<\/sup>\uff0e\u3053\u308c\u3089\u306e\u6280\u8853\u306f\u78c1\u6027\u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3068\u5408\u6210\u751f\u7269\u5b66\u306e\u878d\u5408\u3068\u8a00\u3048\u3088\u3046\uff0e\u5408\u6210\u751f\u7269\u5b66\u3092\u99c6\u4f7f\u3057\u3066\uff0c\u9060\u9694\u3067\u306e\u4ea4\u6d41\u78c1\u5834\u7167\u5c04\u3092\u5f15\u304d\u91d1\u306b\u6cbb\u7642\u907a\u4f1d\u5b50\u304c\u8a98\u5c0e\u767a\u73fe\u3055\u308c\u308b\u6280\u8853\u3068\u3057\u3066\uff0c\u3055\u3089\u306a\u308b\u767a\u5c55\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u4f8b\u306b\u793a\u3055\u308c\u308b\u3088\u3046\u306b\uff0c\u78c1\u6027\u30ca\u30ce\u7c92\u5b50\u306b\u3088\u308b\u7d30\u80de\u5185\u5c40\u6240\u52a0\u6e29\u6280\u8853\u306f\uff0c\u7d30\u80de\u306e\u71b1\u5fdc\u7b54\u306e\u751f\u7406\u5b66\u7684\u7814\u7a76\u306e\u307f\u306a\u3089\u305a\uff0c\u5408\u6210\u751f\u7269\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308b\u7d30\u80de\u6a5f\u80fd\u5236\u5fa1\u3084\u907a\u4f1d\u5b50\u6cbb\u7642\u306b\u6709\u7528\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\uff0e<\/p>\n\n\n\n<p>TRPV1\uff1atransient receptor potential cation channel subfamily V member 1<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Ito A.,&nbsp;<em>et al<\/em>. Intracellular hyperthermia using magnetic nanoparticles: A novel method for hyperthermia clinical applications. Thermal Med, 24: 113-129, 2008.<\/li><li>Huang H.,&nbsp;<em>et al<\/em>. Remote control of ion channels and neurons through magnetic-field heating of nanoparticles. Nat Nanotechnol, 5: 602-606, 2010.<\/li><li>StanleyA.,<em>&nbsp;et al<\/em>., Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles. Nat Med, 21: 92-98, 2015.<\/li><li>Ito A.,&nbsp;<em>et al.<\/em>&nbsp;Heat-inducible transgene expression with transcriptional amplification mediated by a transactivator. Int J Hyperthermia, 28: 788-798, 2012.<\/li><li>Yamaguchi M.,<em>&nbsp;et al.<\/em>&nbsp;Heat-inducible transgene expression system incorporating a positive feedback loop of transcriptional amplification for hyperthermia-induced gene therapy. J Biosci Bioeng, 114: 460-465, 2012.<\/li><li>Yamaguchi M.,&nbsp;<em>et al.&nbsp;<\/em>Heat-inducible gene expression system by applying alternating magnetic field to magnetic nanoparticles. ACS Synth Biol, 3: 273-279, 2014.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c18 \u78c1\u6027\u30ca\u30ce\u7c92\u5b50\u306b\u3088\u308b\u7d30\u80de\u5185\u5c40\u6240\u52a0\u6e29\u3068\u5408\u6210\u751f\u7269\u5b66\u5206\u91ce\u3078\u306e\u5fdc\u7528 \u4e95\u85e4\u3000\u5f70\uff08\u4e5d\u5dde\u5927\u5b66 \u5927\u5b66\u9662\u5de5\u5b66\u7814\u7a76\u9662 \u5316\u5b66\u5de5\u5b66\u90e8\u9580\uff09 \u30de\u30b0\u30cd\u30bf\u30a4\u30c8\uff08Fe3O4\uff09\u3042\u308b\u3044\u306f\u30de\u30b0\u30d8\u30de\u30a4\u30c8\uff08Fe2O3\uff09\u304b\u3089\u306a\u308b [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-598","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=598"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/598\/revisions"}],"predecessor-version":[{"id":599,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/598\/revisions\/599"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}