{"id":600,"date":"2018-05-08T20:42:00","date_gmt":"2018-05-08T11:42:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=600"},"modified":"2022-05-26T20:39:15","modified_gmt":"2022-05-26T11:39:15","slug":"hsp70%e3%81%ae%e3%82%b3%e3%82%b7%e3%83%a3%e3%83%9a%e3%83%ad%e3%83%b3bag3%e3%81%a8%e3%81%8c%e3%82%93%e6%b8%a9%e7%86%b1%e7%99%82%e6%b3%95","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/hsp70%e3%81%ae%e3%82%b3%e3%82%b7%e3%83%a3%e3%83%9a%e3%83%ad%e3%83%b3bag3%e3%81%a8%e3%81%8c%e3%82%93%e6%b8%a9%e7%86%b1%e7%99%82%e6%b3%95\/","title":{"rendered":"Hsp70\u306e\u30b3\u30b7\u30e3\u30da\u30ed\u30f3BAG3\u3068\u304c\u3093\u6e29\u71b1\u7642\u6cd5"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c17<\/p>\n\n\n\n<p>Hsp70\u306e\u30b3\u30b7\u30e3\u30da\u30ed\u30f3BAG3\u3068\u304c\u3093\u6e29\u71b1\u7642\u6cd5<\/p>\n\n\n\n<p>\u7530\u6e15\u3000\u572d\u7ae0\uff0c\u67da\u6728\u3000\u9054\u4e5f (\u5bcc\u5c71\u5927\u5b66)<\/p>\n\n\n\n<p>BAG (BCL-2-associated athanogene) \u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u306eBAG3\u306f\uff0c\u9175\u6bcd\u30c4\u30fc\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6cd5\u306b\u3088\u308aHsc\/Hsp70 ATPase\u30c9\u30e1\u30a4\u30f3\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305f<sup>1)<\/sup>\uff0e\u4e88\u60f3\u901a\u308a\uff0c\u672c\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea (HSPs) \u306e\u4e3b\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8ceaHsp70\u306e\u30b3\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff0eBAG3\u306f\uff0c\u30d2\u30c8\u306e\u7d44\u7e54\u5168\u822c\u306b\u666e\u904d\u7684\u306b\u5206\u5e03\u3059\u308b\u304c\uff0c\u7279\u306b\u5fc3\u81d3\uff0c\u7b4b\u7d44\u7e54\u3084\u304c\u3093\u7d44\u7e54\u3067\u9ad8\u767a\u73fe\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u307e\u305f\uff0cBAG3\u306f\uff0c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\uff0c\u6e29\u71b1\uff0c\u91cd\u91d1\u5c5e\uff0c\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3084\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u963b\u5bb3\u7b49\uff0c\u7a2e\u3005\u306e\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u308b\uff0e<em>Bag3<\/em>\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306b\u306f\uff0c2\u304b\u6240\u306e\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30a8\u30ec\u30e1\u30f3\u30c8 (HSE) \u304c\u5b58\u5728\u3057\uff0c\u305d\u3053\u306b\u7d50\u5408\u3059\u308b\u71b1\u30b7\u30e7\u30c3\u30af\u8ee2\u5199\u56e0\u5b50HSF1\u304c<em>Bag3<\/em>\u306e\u4e3b\u8981\u306a\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308b\uff0eBAG3\u306f\uff0c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff0c\u7d30\u80de\u5206\u5316\uff0c\u7d30\u80de\u9aa8\u683c\u306e\u69cb\u7bc9\u3084\u30de\u30af\u30ed\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u7b49\u306e\u69d8\u3005\u306a\u7d30\u80de\u6a5f\u80fd\u306e\u5236\u5fa1\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u6570\u591a\u304f\u306e\u7814\u7a76\u304b\u3089\u660e\u3089\u304b\u3068\u306a\u3063\u305f\uff0e\u3055\u3089\u306b\uff0c\u304c\u3093\uff0c\u30df\u30aa\u30d1\u30c1\u30fc\uff0c\u52a0\u9f62\u306b\u4f34\u3046\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7b49\uff0c\u591a\u69d8\u306a\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b<sup>2,3)<\/sup>\uff0e<\/p>\n\n\n\n<p>\u304c\u3093\u306b\u304a\u3051\u308bBAG3\u306e\u5f79\u5272\u3092\u7814\u7a76\u3057\u305f\u4f8b\u3092\u7d39\u4ecb\u3059\u308b\uff0e\u30d2\u30c8\u81b5\u7ba1\u817a\u304c\u3093\u306e\u7d30\u80de\u8cea\u306eBAG3\u306e\u9ad8\u767a\u73fe\u3068\u6b7b\u4ea1\u7387\u304c\u6b63\u306e\u76f8\u95a2\u3092\u793a\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u305f\uff0e\u307e\u305f\uff0c\u540c\u304c\u3093\u304b\u3089BAG3\u304c\u904a\u96e2\u3055\u308c\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u3067\u8a98\u5c0e\u3055\u308c\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8ceaIFITM2 (Interferon-induced transmembrane protein 2) \u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3068\u7d50\u5408\u3059\u308b\uff0e\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\uff0c\u6297BAG3\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u306f\uff0c\u30de\u30a6\u30b9\u306e\u79fb\u690d\u304c\u3093\u306e\u6210\u9577\u3092\u6291\u5236\u3057\u305f<sup>4)<\/sup>\uff0e\u81a0\u82bd\u816b\u306b\u304a\u3044\u3066BAG3\u304c\u9ad8\u767a\u73fe\u3057\uff0c\u3053\u308c\u304c\u5316\u5b66\u7642\u6cd5\u5264\u306b\u62b5\u6297\u6027\u3092\u793a\u3059\u304c\u3093\u5e79\u7d30\u80de\u306e\u7dad\u6301\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f<sup>5<\/sup><sup>\uff09<\/sup>\uff0e\u3053\u308c\u307e\u3067\u306b\uff0c\u69d8\u3005\u306a\u304c\u3093\u3067BAG3\u306e\u9ad8\u767a\u73fe\u3068\u305d\u306e\u7d30\u80de\u5897\u6b96\u4fc3\u9032\u3084\u7d30\u80de\u4fdd\u8b77\u4f5c\u7528\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u3044\u308b<sup>2)<\/sup>\uff0e<\/p>\n\n\n\n<p>\u4e0a\u8a18\u306e\u69d8\u306b\u7d30\u80de\u4fdd\u8b77\u4f5c\u7528\u3092\u6709\u3059\u308bBAG3\u306fHSF1\u306b\u3088\u308a\u8ee2\u5199\u304c\u6d3b\u6027\u5316\u3055\u308c\uff0c\u6e29\u71b1\u306b\u3088\u308a\u767a\u73fe\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3053\u3068\u304b\u3089\uff0c\u305d\u306e\u6a5f\u80fd\u963b\u5bb3\u306f\u6e29\u71b1\u306e\u52b9\u679c\u3092\u5897\u611f\u3059\u308b\u3068\u63a8\u5bdf\u3067\u304d\u308b\uff0e\u5b9f\u969b\uff0c\u30d2\u30c8\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u3084\u7db2\u819c\u82bd\u7d30\u80de\u816b\u306e\u304c\u3093\u7d30\u80de\u682a\u306b\u304a\u3044\u3066\uff0c\u6e29\u71b1\u306b\u3088\u308b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u8a98\u5c0e\u6642\u306bBAG3\u306b\u5bfe\u3059\u308bsiRNA (siBAG3) \u3092\u7528\u3044\u3066\u305d\u306e\u767a\u73fe\u8a98\u5c0e\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3059\u308b\u3068\uff0c\u4e88\u60f3\u901a\u308a\uff0c\u6e29\u71b1\u306e\u52b9\u679c\u304c\u5897\u5f37\u3055\u308c\u305f<sup>6,7)<\/sup>\uff0e\u8fd1\u5e74\uff0c\u304c\u3093\u7d30\u80de\u8fd1\u508d\u3067\u8fd1\u8d64\u5916\u7dda\u3068\u30ca\u30ce\u7c92\u5b50\u306b\u3088\u308b\u5149\u767a\u71b1\u52b9\u679c\u3092\u5229\u7528\u3059\u308b\u5149\u71b1 (\u6e29\u71b1) \u7642\u6cd5\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\uff0e\u91d1\u30ca\u30ce\u30ed\u30c3\u30c9\u306bsiBAG3\u3092\u7d50\u5408\u3055\u305b\uff0c\u3053\u308c\u3092\u7528\u3044\u305f\u5149\u71b1\u7642\u6cd5\u306b\u3088\u308a\uff0c\u30d2\u30c8\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u304c\u3093\u7d30\u80de\u306e\u6bba\u7d30\u80de\u52b9\u679c\u306e\u5897\u5f37\u304c\u793a\u3055\u308c\u305f\uff0e\u3055\u3089\u306b\uff0c\u30de\u30a6\u30b9\u306e\u79fb\u690d\u304c\u3093\u30e2\u30c7\u30eb\u306b\u5bfe\u3057\u3066\u3082\u3053\u306e\u7642\u6cd5\u306f\u9855\u8457\u306a\u816b\u760d\u6291\u5236\u4f5c\u7528\u3092\u793a\u3057\u305f<sup>8)<\/sup>\uff0e\u304c\u3093\u6e29\u71b1\u7642\u6cd5\u306b\u304a\u3044\u3066\uff0cBAG3\u306f\u6709\u7528\u306a\u6a19\u7684\u907a\u4f1d\u5b50\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e\u4eca\u5f8c\u306e\u3053\u306e\u52d5\u5411\u306b\u6ce8\u76ee\u3057\u305f\u3044\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Takayama S.,&nbsp;<em>et al<\/em>. An evolutionarily conserved family of Hsp70\/Hsc70 molecular chaperone regulators. J Biol Chem, 274: 781-6, 1999.<\/li><li>De Marco M.,&nbsp;<em>et al<\/em>. Role of BAG3 in cancer progression: A therapeutic opportunity. Semin Cell Dev Biol,&nbsp;<em>in press<\/em>.<\/li><li>St\u00fcrner E.,&nbsp;<em>et al<\/em>. The role of the multifunctional BAG3 protein in cellular protein quality control and in disease. Front Mol Neurosci, 10: 177, 2017.<\/li><li>Rosati A.,&nbsp;<em>et al<\/em>. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. Nature Commun, 6: 8695, 2015.<\/li><li>Im C.N.,&nbsp;<em>et al<\/em>. BIS-mediated STAT3 stabilization regulates glioblastoma stem cell-like phenotypes. Oncotarget, 7: 35056-70, 2016.<\/li><li>Yunoki T.,&nbsp;<em>et al<\/em>. The combination of silencing BAG3 and inhibition of the JNK pathway enhances hyperthermia sensitivity in human oral squamous cell carcinoma cells. Cancer Lett, 335: 52-7, 2013.<\/li><li>Yunoki T.,&nbsp;<em>et al<\/em>. BAG3 protects against hyperthermic stress by modulating NF-\u03baB and ERK activities in human retinoblastoma cells. Graefes Arch Clin Exp Ophthalmol, 253: 399-407, 2015.<\/li><li>Wang B.K.,&nbsp;<em>et al<\/em>. Gold-nanorods-siRNA nanoplex for improved photothermal therapy by gene silencing. Biomaterials, 78: 27-39, 2016.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c17 Hsp70\u306e\u30b3\u30b7\u30e3\u30da\u30ed\u30f3BAG3\u3068\u304c\u3093\u6e29\u71b1\u7642\u6cd5 \u7530\u6e15\u3000\u572d\u7ae0\uff0c\u67da\u6728\u3000\u9054\u4e5f (\u5bcc\u5c71\u5927\u5b66) BAG (BCL-2-associated athanogene) \u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-600","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=600"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/600\/revisions"}],"predecessor-version":[{"id":601,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/600\/revisions\/601"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}