{"id":602,"date":"2018-04-17T20:42:00","date_gmt":"2018-04-17T11:42:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=602"},"modified":"2022-05-26T20:39:45","modified_gmt":"2022-05-26T11:39:45","slug":"%e7%86%b1%e3%82%b7%e3%83%a7%e3%83%83%e3%82%af%e8%bb%a2%e5%86%99%e5%9b%a0%e5%ad%90hsf1%e3%81%ae%e6%96%b0%e3%81%9f%e3%81%aa%e6%a9%9f%e8%83%bd%e2%88%92ku%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e7%86%b1%e3%82%b7%e3%83%a7%e3%83%83%e3%82%af%e8%bb%a2%e5%86%99%e5%9b%a0%e5%ad%90hsf1%e3%81%ae%e6%96%b0%e3%81%9f%e3%81%aa%e6%a9%9f%e8%83%bd%e2%88%92ku%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa\/","title":{"rendered":"\u71b1\u30b7\u30e7\u30c3\u30af\u8ee2\u5199\u56e0\u5b50HSF1\u306e\u65b0\u305f\u306a\u6a5f\u80fd\u2212Ku\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3057\u3066DNA\u4fee\u5fa9\u3092\u963b\u5bb3\u3059\u308b\u2212"},"content":{"rendered":"\n

\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c16<\/p>\n\n\n\n

\u71b1\u30b7\u30e7\u30c3\u30af\u8ee2\u5199\u56e0\u5b50HSF1\u306e\u65b0\u305f\u306a\u6a5f\u80fd\u2212Ku\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3057\u3066DNA\u4fee\u5fa9\u3092\u963b\u5bb3\u3059\u308b\u2212<\/p>\n\n\n\n

\u5927\u585a\u5065\u4e09\uff08\u4e2d\u90e8\u5927\u5b66\u5fdc\u7528\u751f\u7269\u5b66\u90e8\uff09<\/p>\n\n\n\n

\u3000\u71b1\u30b7\u30e7\u30c3\u30af\u306a\u3069\u306e\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u65b0\u305f\u306b\u5408\u6210\u3055\u308c\u308b\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea\uff08heat shock proteins, HSPs\uff09\u306e\u767a\u73fe\u306f\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u8ee2\u5199\u56e0\u5b501\uff08heat shock factor 1, HSF1\uff09\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\uff0e\u5408\u6210\u3055\u308c\u3066\u304d\u305fHSPs\u306f\uff0c\u30b9\u30c8\u30ec\u30b9\u3067\u7d30\u80de\u5185\u306b\u751f\u3058\u305f\u7570\u5e38\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u84c4\u7a4d\u3057\u306a\u3044\u3088\u3046\u306b\u54c1\u8cea\u7ba1\u7406\uff08\u4fee\u5fa9\u3084\u5206\u89e3\uff09\u3092\u304a\u3053\u306a\u3044\uff0c\u7d30\u80de\u306e\u6b63\u5e38\u6a5f\u80fd\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\uff0e\u3057\u305f\u304c\u3063\u3066\uff0c\u3053\u306eHSF1-HSPs \u30b7\u30b9\u30c6\u30e0\u306f\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306e\u9632\u5fa1\u6a5f\u69cb\u306e\u4e00\u3064\u3067\u3042\u308b\uff0e\u3068\u3053\u308d\u304c\uff0c\u304c\u3093\u7d30\u80de\u3067\u306f\uff0cHSF1\u306fHSPs\u3060\u3051\u3067\u306f\u306a\u304f\uff0c\u7d30\u80de\u306e\u751f\u5b58\u3092\u4fc3\u9032\u3059\u308b\u3088\u3046\u306a\u6570\u591a\u304f\u306e\u907a\u4f1d\u5b50\u3092\u8ee2\u5199\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u3053\u308c\u306f\u300c\u304c\u3093\u7d30\u80de\u304cHSF1\u306e\u6a5f\u80fd\u3092\u3046\u307e\u304f\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\uff0c\u30b9\u30c8\u30ec\u30b9\u306e\u591a\u3044\u5bbf\u4e3b\u306e\u74b0\u5883\u3067\u3082\u751f\u304d\u5ef6\u3073\u308b\u3088\u3046\u306b\u9069\u5fdc\u3057\u3066\u3044\u308b\u300d\u3068\u306e\u8003\u3048\u65b9\u3092\u652f\u6301\u3059\u308b1)<\/sup>\uff0e<\/p>\n\n\n\n

\u3000\u6700\u8fd1\uff0cHSF1\u306e\u8ee2\u5199\u56e0\u5b50\u3068\u3057\u3066\u306e\u6a5f\u80fd\u3068\u306f\u7121\u95a2\u4fc2\u306b\uff0cHSF1\u30bf\u30f3\u30d1\u30af\u8cea\u304cKu\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067DNA\u4fee\u5fa9\u3092\u963b\u5bb3\u3057\uff0c\u653e\u5c04\u7dda\u7167\u5c04\u5f8c\u306e\u30b2\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\u3092\u5897\u52a0\u3055\u305b\uff0c\u304c\u3093\u306e\u767a\u751f\u3092\u4fc3\u9032\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u8ad6\u6587\u304c\u5831\u544a\u3055\u308c\u305f\uff12<\/sup>)<\/sup>\uff0e<\/p>\n\n\n\n

\u3000\u3053\u308c\u3092\u8aac\u660e\u3059\u308b\u305f\u3081\u306b\uff0cDNA\u4e8c\u672c\u9396\u5207\u65ad(double strand break, DSB)\u306e\u4fee\u5fa9\u306b\u3064\u3044\u3066\u7c21\u6f54\u306b\u8ff0\u3079\u308b\uff0eDNA\u306bDSB\u304c\u751f\u3058\u305f\u3068\u304d\u306b\u305d\u306e\u5207\u65ad\u672b\u7aef\u3092\u518d\u7d50\u5408\u3059\u308b\u6a5f\u69cb\u3068\u3057\u3066\uff0c\u76f8\u540c\u7d44\u63db\u3048\uff08homologous recombination, HR\uff09\u3068\u975e\u76f8\u540c\u672b\u7aef\u7d50\u5408\uff08non-homologous end joining, NHEJ\uff09\u306e\u4e8c\u3064\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u7d30\u80de\u306e\u6e1b\u6570\u5206\u88c2\u306a\u3069\u306e\u751f\u7406\u5b66\u7684\u904e\u7a0b\u3067\u306f\u4e3b\u306bHR\u304c\u306f\u305f\u3089\u304d\uff0c\u653e\u5c04\u7dda\u306a\u3069\u306e\u5916\u7684\u306a\u4f5c\u7528\u3067DSB\u304c\u751f\u3058\u305f\u3068\u304d\u306b\u306f\u4e3b\u306bNHEJ\u306b\u3088\u3063\u3066\u4fee\u5fa9\u3055\u308c\u308b\uff0eNHEJ\u3067\u306f\uff0c\u307e\u305a\u751f\u3058\u305f\u4e8c\u3064\u306e\u5207\u65ad\u672b\u7aef\u306b\u305d\u308c\u305e\u308cKu\u30bf\u30f3\u30d1\u30af\u8cea\uff08Ku70\u3068Ku86\u306e\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\uff09\u304c\u7d50\u5408\u3059\u308b\uff0e\u3053\u306eKu\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u306fDSB\u3092\u611f\u77e5\u3059\u308b\u30bb\u30f3\u30b5\u30fc\u3067\u3042\u308b\uff0e\u3053\u308c\u3089\u4e8c\u3064\u306e\u4e8c\u91cf\u4f53\u540c\u58eb\u304c\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u5207\u65ad\u672b\u7aef\u304c\u96e2\u308c\u306a\u3044\u3088\u3046\u306b\u3064\u306a\u304e\u6b62\u3081\u3066\u3044\u308b\uff0e\u305d\u3053\u306b\uff0c\u4fee\u5fa9\u306b\u5fc5\u8981\u306a\u3055\u307e\u3056\u307e\u306a\u30bf\u30f3\u30d1\u30af\u8cea\uff0c\u4f8b\u3048\u3070DNA\u4f9d\u5b58\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff08DNA-PKCS<\/sub>\uff0cCS<\/sub>\u306fcatalytic subunit\u306e\u7565\uff09\uff0cArtemis\uff08\u30a8\u30ad\u30bd\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u3068\u30a8\u30f3\u30c9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u306e\u4e8c\u3064\u306e\u6d3b\u6027\u3092\u3082\u3064\uff09\uff0cXRCC4\uff0cDNA\u30ea\u30ac\u30fc\u30bcIV\u306a\u3069\u304c\u96c6\u307e\u308a\uff0cDNA\u306e\u4e8c\u672c\u9396\u672b\u7aef\u3092\u518d\u7d50\u5408\u3055\u305b\u308b3<\/sup>\uff09<\/sup>\uff0e<\/p>\n\n\n\n

\u3000Kang\u3089\u306e\u8ad6\u65873)<\/sup>\u3067\u306f\uff0c\u7d30\u80de\u306b5\u307e\u305f\u306f10 Gy\u306e\u03b3\u7dda\u7167\u5c04\u5f8c\uff0c4N\u4ee5\u4e0a\uff08\u7570\u6570\u6027\uff09\u306e\u7d30\u80de\u306e\u5272\u5408\u304a\u3088\u3073\u30b3\u30e1\u30c3\u30c8\u30a2\u30c3\u30bb\u30a4\u306b\u3088\u308bDNA\u640d\u50b7\u306e\u7a0b\u5ea6\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\uff0cHSF1\u3092siRNA\u6cd5\u306b\u3088\u308a\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3057\u305f\u7d30\u80de\u3067\u306f\u5bfe\u7167\u306e\u7d30\u80de\u306b\u6bd4\u3079\u3066\uff0c\u7570\u6570\u6027\u306e\u7d30\u80de\u306e\u5272\u5408\u304c\u6e1b\u5c11\u3057\uff0cDNA\u640d\u50b7\u3082\u5c11\u306a\u304b\u3063\u305f\uff0e\u307e\u305f\uff0cHSF1\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u7d30\u80de\uff08HSF1-\/-<\/sup>\uff09\u3067\u306f\u6b63\u5e38\u7d30\u80de\uff08HSF1+\/+<\/sup>\uff09\u306b\u6bd4\u3079\u3066\uff0c\u3084\u306f\u308a\uff0c\u03b3\u7dda\u7167\u5c04\u5f8c\u306e\u7570\u6570\u6027\u306e\u7d30\u80de\u306e\u5272\u5408\u304c\u4f4e\u4e0b\u3057DNA\u640d\u50b7\u3082\u5c11\u306a\u304b\u3063\u305f\uff0e\u3064\u307e\u308a\uff0cHSF1\u306f\u653e\u5c04\u7dda\u7167\u5c04\u306b\u3088\u308bDNA\u640d\u50b7\u306e\u4fee\u5fa9\u3092\u963b\u5bb3\u3057\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308b\uff0e\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u8457\u8005\u3089\u306f\uff0cHSF1\u304c\u76f4\u63a5Ku70\u3068Ku86\u306b\u7d50\u5408\u3057Ku70-Ku86\u306e\u4e8c\u91cf\u4f53\u5f62\u6210\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\uff0e\u3055\u3089\u306b\uff0cHSF1\u306b\u3088\u308bDNA\u4fee\u5fa9\u963b\u5bb3\u52b9\u679c\u306f\uff0cHSF1\u306e\u30ea\u30f3\u9178\u5316\u3084\u8ee2\u5199\u56e0\u5b50\u6d3b\u6027\u3068\u306f\u7121\u95a2\u4fc2\u3067\u3042\u308a\uff0cHSF1\u30bf\u30f3\u30d1\u30af\u8cea\u72ec\u81ea\u306e\u6027\u8cea\u306b\u3088\u308b\u3068\u3044\u3046\uff0e\u30e9\u30c3\u30c8\u306e\u4e73\u304c\u3093\uff08\u767a\u304c\u3093\u5264\u3067\u767a\u75c7\uff09\u306b\u304a\u3044\u3066HSF1\u304c\u9ad8\u767a\u73fe\u3057\u3066\u3044\u308b\u816b\u760d\u7d44\u7e54\u3067\u306f\uff0cKu70-Ku86\u306e\u4e8c\u91cf\u4f53\u5f62\u6210\u304c\u963b\u5bb3\u3055\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u7d50\u679c\u3082\u5f97\u3089\u308c\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n

\u3000HSF1\u304c\u3055\u307e\u3056\u307e\u306a\u304c\u3093\u7d30\u80de\u3067\u9ad8\u767a\u73fe\u3057\u3066\u3044\u308b\u306e\u3067\uff0cHSF1\u306f\u8ee2\u5199\u56e0\u5b50\u3068\u3057\u3066\u304c\u3093\u7d30\u80de\u306e\u751f\u5b58\u306b\u5fc5\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u8a98\u5c0e\u3057\u3066\u7d30\u80de\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u305f\uff0e\u3057\u304b\u3057\uff0c\u4eca\u56de\u306e\u5831\u544a\u306f\uff0cHSF1\u30bf\u30f3\u30d1\u30af\u8cea\u81ea\u8eab\u304cKu\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066DNA\u4fee\u5fa9\u3092\u963b\u5bb3\u3057\uff0c\u653e\u5c04\u7dda\u7167\u5c04\u5f8c\u306e\u30b2\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\u3092\u5897\u52a0\u3055\u305b\uff0c\u304c\u3093\u306e\u767a\u751f\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\uff0e\u6b63\u5e38\u7d30\u80de\u3067\u306f\uff0cHSF1\u306fHsp90\u3084Hsp70\u306a\u3069\u306e\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u4f1a\u5408\u3057\u3066\u3044\u3066\u4e0d\u6d3b\u6027\u306a\u72b6\u614b\u306b\u4fdd\u305f\u308c\u3066\u3044\u308b\u306e\u3067\uff0cDNA\u4fee\u5fa9\u963b\u5bb3\u306f\u3057\u306a\u3044\u3068\u601d\u308f\u308c\u308b\uff0e\u3057\u304b\u3057\uff0cHSF1\u304c\u7570\u5e38\u306b\u9ad8\u767a\u73fe\u3059\u308b\u3088\u3046\u306b\u306a\u308b\u3068\uff0c\u3053\u306e\u3088\u3046\u306a\u300c\u60aa\u3055\u300d\u3092\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\uff0e<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

1) Anckar J., et al<\/em>. Regulation of HSF1 function in the heat stress response: Implication in aging and disease. Annu Rev Biochem, 80: 1089-1115, 2011.<\/p>\n\n\n\n

2) Kang G.Y., et al<\/em>. Heat shock factor 1, an inhibitor of non-homologous end joining repair. Oncotarget, 6: 29712-29724, 2015.<\/p>\n\n\n\n

3) Downs J.A., et al<\/em>. A means to a DNA end: The many roles of Ku. Nat Rev Mol Cell Biol, 5: 367-378, 2004.<\/p>\n","protected":false},"excerpt":{"rendered":"

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