{"id":606,"date":"2017-10-18T20:43:00","date_gmt":"2017-10-18T11:43:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=606"},"modified":"2022-05-26T20:40:49","modified_gmt":"2022-05-26T11:40:49","slug":"phase-separation%e3%82%92%e9%80%9a%e3%81%98%e3%81%9f%ef%bc%8c%e7%86%b1%e3%82%b7%e3%83%a7%e3%83%83%e3%82%af%e6%99%82%e3%81%ae%e3%82%b9%e3%83%88%e3%83%ac%e3%82%b9%e9%a1%86%e7%b2%92%e5%bd%a2%e6%88%90","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/phase-separation%e3%82%92%e9%80%9a%e3%81%98%e3%81%9f%ef%bc%8c%e7%86%b1%e3%82%b7%e3%83%a7%e3%83%83%e3%82%af%e6%99%82%e3%81%ae%e3%82%b9%e3%83%88%e3%83%ac%e3%82%b9%e9%a1%86%e7%b2%92%e5%bd%a2%e6%88%90\/","title":{"rendered":"Phase separation\u3092\u901a\u3058\u305f\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u6642\u306e\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5f62\u6210"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c14<\/p>\n\n\n\n<p>Phase separation\u3092\u901a\u3058\u305f\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u6642\u306e\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5f62\u6210<\/p>\n\n\n\n<p>\u79cb\u5149 \u4fe1\u4f73\uff08\u6771\u4eac\u5927\u5b66\u30a2\u30a4\u30bd\u30c8\u30fc\u30d7\u7dcf\u5408\u30bb\u30f3\u30bf\u30fc\uff09<\/p>\n\n\n\n<p>\u306f\u3058\u3081\u306b<\/p>\n\n\n\n<p>\u71b1\uff0c\u653e\u5c04\u7dda\uff0c\u6d78\u900f\u5727\uff0c\u6804\u990a\u72b6\u614b\uff0c\u9178\u7d20\u6fc3\u5ea6\uff0c\u5316\u5b66\u7269\u8cea\u306a\u3069\u306e\u5916\u7684\u30b9\u30c8\u30ec\u30b9\u306b\u7d30\u80de\u304c\u66dd\u3055\u308c\u305f\u5834\u5408\uff0c\u305d\u308c\u305e\u308c\u306e\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u9069\u5207\u306b\u5fdc\u7b54\u3059\u308b\u6a5f\u69cb\u3092\u7d30\u80de\u306f\u6709\u3059\u308b\uff0e\u3053\u306e\u3088\u3046\u306a\u5fdc\u7b54\u6a5f\u69cb\u306e\u4e2d\u306b\uff0c\u7d30\u80de\u5185\u69cb\u9020\u4f53\uff08\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\uff09\u306e\u5f62\u6210\u304c\u77e5\u3089\u308c\u3066\u3044\u308b<sup>1<\/sup><sup>\uff09<\/sup>\uff0e\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306f0.1\u304b\u30894 \u03bcm\u7a0b\u5ea6\u306e\u69cb\u9020\u4f53\u3067\u3042\u308a\uff0c\u71b1\u523a\u6fc0\u3057\u305f\u30c8\u30de\u30c8\u7d30\u80de\u3067\u6700\u521d\u306b\u767a\u898b\u3055\u308c\u305f\uff0e\u305d\u306e\u5f8c\u306e\u7814\u7a76\u304b\u3089\uff0c\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306e\u5f62\u6210\u304c\u7d30\u80de\u306e\u71b1\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u6301\u3064\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u3066\u3044\u308b\uff0e\u6700\u8fd1\uff0c\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306e\u5f62\u6210\u6a5f\u69cb\u3068\u3057\u3066phase separation (phase transition\u3068\u3082\u547c\u3076)\u3068\u3044\u3046\u73fe\u8c61\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\uff0ephase separation\u3068\u306f\uff0c\u6eb6\u6db2\u306e\u76f8\u8ee2\u79fb\u73fe\u8c61\u306e\u4e00\u3064\u3067\uff0c\u5747\u4e00\u306a\u6eb6\u6db2\u304c\u6e29\u5ea6\u3084\u5727\u529b\u306e\u5909\u5316\u306b\u3088\u3063\u3066\u76f8\u6eb6\u6027\u304c\u5909\u5316\u3057\uff0c\u305d\u306e\u7d50\u679c\uff0c\u5747\u4e00\u306a\u6eb6\u6db2\u3067\u3042\u308b\u4e00\u76f8\u72b6\u614b\u304b\u3089\u4e8c\u76f8\u72b6\u614b\uff08\u76f8\u5206\u96e2\uff09\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u3092\u3044\u3046\uff0e\u76f8\u5206\u96e2\u3092\u8d77\u3053\u3059\u6df7\u5408\u6db2\u4f53\u306e\u591a\u304f\u306f\uff0c\u9ad8\u6e29\u3067\u6df7\u3056\u308a\u5408\u3044\uff0c\u6e29\u5ea6\u306e\u4f4e\u4e0b\u306b\u4f34\u3063\u30662\u76f8\u306b\u5206\u96e2\u3059\u308b\uff0e\u3057\u304b\u3057\u306a\u304c\u3089\uff0c\u7d30\u80de\u306e\u4e2d\u3067\u306f\uff0c\u6e29\u5ea6\u4e0a\u6607\u306b\u4f34\u3063\u30662\u76f8\u5206\u96e2\u304c\u8d77\u304d\u3066\u9846\u7c92\u72b6\u306e\u69cb\u9020\u4f53\u304c\u5f62\u6210\u3055\u308c\u308b\u70b9\u304c\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\uff0e\u307e\u305f\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306f\u4e00\u6b21\u69cb\u9020\u304b\u3089\u56db\u6b21\u69cb\u9020\u307e\u3067\u306e\u6bb5\u968e\u7684\u69cb\u9020\u3092\u69cb\u7bc9\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\uff0cphase separation\u3092\u901a\u3058\u305f\u9846\u7c92\u5f62\u6210\u306f\u4e94\u6b21\u69cb\u9020\u3068\u3082\u547c\u3070\u308c\u3066\u304a\u308a\uff0c\u305d\u306e\u69cb\u7bc9\u539f\u7406\u3084\u751f\u7406\u7684\u5f79\u5272\u306e\u89e3\u660e\u304c\u30db\u30c3\u30c8\u306a\u7814\u7a76\u9818\u57df\u3068\u306a\u3063\u3066\u3044\u308b<sup>2, 3<\/sup><sup>\uff09<\/sup>\uff0e\u3055\u3089\u306b\uff0cphase separation\u306f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u539f\u56e0\u3068\u8003\u3048\u3089\u308c\u308b\u7d30\u80de\u5185\u4e0d\u6eb6\u6027\u51dd\u96c6\u4f53\u306e\u5f62\u6210\u306b\u304a\u3044\u3066\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304b\u3089\uff0c\u81e8\u5e8a\u306e\u89b3\u70b9\u304b\u3089\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b<sup>4<\/sup><sup>\uff09<\/sup>\uff0e\u672c\u7a3f\u3067\u306f\uff0c\u307e\u305a\uff0c\u6700\u8fd1\u6ce8\u76ee\u3055\u308c\u308bphase separation\u306b\u3064\u3044\u3066\u6982\u8aac\u3059\u308b\uff0e\u6b21\u306b\uff0c\u71b1\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u308b\u7d30\u80de\u8cea\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5f62\u6210\u306bpolyA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u91cd\u8981\u306a\u50cd\u304d\u3092\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u305f\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\uff0c\u71b1\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306b\u304a\u3051\u308bphase separation\u306e\u610f\u7fa9\u306b\u3064\u3044\u3066\u7d39\u4ecb\u3059\u308b\uff0e<\/p>\n\n\n\n<p>Phase separation\u306b\u3088\u308b\u7d30\u80de\u5185\u9846\u7c92\u5f62\u6210<\/p>\n\n\n\n<p>\u7d30\u80de\u5185\u306b\u306f\uff0c\u819c\u69cb\u9020\u3092\u6301\u3064\u30aa\u30eb\u30ac\u30cd\u30e9\u306e\u4ed6\u306b\uff0c\u819c\u69cb\u9020\u3092\u6301\u305f\u306a\u3044\u69cb\u9020\u4f53\uff08\u9846\u7c92\u3068\u3082\u547c\u3070\u308c\u308b\uff09\u3068\u3057\u3066\uff0c\u7d30\u80de\u8cea\u306eP-body\u3084germ granule\uff0c\u6838\u5185\u306b\u6838\u5c0f\u4f53\u3084\u30ab\u30cf\u30fc\u30eb\u4f53\u306a\u3069\u304c\u5b58\u5728\u3059\u308b\uff0e\u3055\u3089\u306b\uff0c\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3084\u8ee2\u5199\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u9818\u57df\u3067\u3082\u9846\u7c92\u69cb\u9020\u304c\u5f62\u6210\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\uff0c\u751f\u547d\u73fe\u8c61\u306e\u30c0\u30a4\u30ca\u30df\u30ba\u30e0\u3068\u9846\u7c92\u5f62\u6210\u306f\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\uff0e\u3053\u308c\u3089\u306e\u9846\u7c92\u306f\uff0c\u6eb6\u6db2\u4e2d\u3067\u7279\u5b9a\u306e\u5206\u5b50\u7fa4\uff08RNA\u3084\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u304c\u96c6\u5408\u3057\u3066\u5f62\u6210\u3055\u308c\uff08\u76f8\u5206\u96e2\uff0c\u3059\u306a\u308f\u3061phase separation\uff09\uff0c\u9846\u7c92\u306e\u4e2d\u3067\u306f\u7279\u7570\u7684\u306a\u751f\u5316\u5b66\u53cd\u5fdc\u304c\u9032\u884c\u3057\u3066\u3044\u308b\uff0e\u91cd\u8981\u306a\u70b9\u306f\uff0c\u9846\u7c92\u5185\u3067\u306f\u6eb6\u8cea\u3067\u3042\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u62e1\u6563\u79fb\u52d5\u3067\u304d\u308b\u305f\u3081\uff0c\u9846\u7c92\u5185\u306f\u6db2\u76f8\u306e\u751f\u5316\u5b66\u53cd\u5fdc\u304c\u9032\u884c\u3057\u3066\u3044\u308b\u3053\u3068\u3067\u3042\u308b\uff0e\u307e\u305f\uff0cphase separation\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u308b\u9846\u7c92\u4e2d\u3067\u306f\u5c64\u69cb\u9020\u304c\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308b\uff0e\u3055\u3089\u306b\uff0c\u9846\u7c92\u306f\u53ef\u9006\u7684\u306b\u5206\u6563\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u308b\uff0e\u3053\u308c\u3089\u306e\u70b9\u304c\uff0c\u305f\u3060\u306e\u51dd\u96c6\u4f53\u3068phase separation\u3092\u901a\u3058\u3066\u5f62\u6210\u3055\u308c\u308b\u7d30\u80de\u5185\u9846\u7c92\u3068\u306e\u9055\u3044\u3067\u3042\u308b\uff0e<\/p>\n\n\n\n<p>Phase separation\u306b\u95a2\u4e0e\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u6570\u591a\u304f\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\uff0c\u305d\u308c\u3089\u306e\u591a\u304f\u306b\u5171\u901a\u3057\u305f\u6027\u8cea\u3068\u3057\u3066\uff0c\u5929\u7136\u5909\u6210\u72b6\u614b\u306e\u9818\u57df\uff08Low-complexity region\uff09\u3092\u542b\u3080\u3053\u3068\u304c\u77e5\u3089\u308c\u308b\uff0e\u3053\u306e\u5929\u7136\u5909\u6210\u9818\u57df\u3092\u4ecb\u3057\u3066\u8907\u6570\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u540c\u58eb\uff08\u7570\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u540c\u58eb\uff0c\u3042\u308b\u3044\u306f\u540c\u3058\u30bf\u30f3\u30d1\u30af\u8cea\u540c\u58eb\uff09\u304c\u7d50\u5408\u30fb\u91cd\u5408\u3057\u3066\u884c\u304f\u3053\u3068\u3067\uff0cphase separation\u304c\u8d77\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\uff0e\u5316\u5b66\u7684\u73fe\u8c61\u3068\u3057\u3066\uff0cphase separation\u306f\u6e29\u5ea6\u306b\u5f37\u304f\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\uff0c\u5b9f\u969b\u306b\uff0c\u71b1\u51e6\u7406\u306b\u3088\u3063\u3066\u7d30\u80de\u5185\u3067\u5f62\u6210\u3055\u308c\u308b\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5f62\u6210\u3067\u3082phase separation\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\uff0e<\/p>\n\n\n\n<p>\u71b1\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5f62\u6210\u3068phase separation<\/p>\n\n\n\n<p>\u3000mRNA\u306f\uff0c\u305d\u306e3\u2019\u672b\u7aef\u306b\u30dd\u30eaA\u5c3e\u90e8\u3092\u6709\u3059\u308b\u304c\uff0c\u3053\u306e\u30dd\u30eaA\u306b\u7279\u7570\u7684\u306a\u7d50\u5408\u89aa\u548c\u6027\u3092\u6709\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u30dd\u30eaA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08polyA binding protein; PABP\uff09\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0ePABP\u306f\u9175\u6bcd\u304b\u3089\u30d2\u30c8\u306b\u81f3\u308b\u307e\u3067\u4fdd\u5b58\u3055\u308c\u3066\u304a\u308a\uff0c\u30dd\u30eaA\u5c3e\u90e8\u3078\u306e\u7d50\u5408\u3092\u901a\u3058\u3066\u7ffb\u8a33\u3084RNA\u5206\u89e3\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\uff0e\u6700\u8fd1\uff0cRiback\u3089\u306f\uff0c\u9175\u6bcd\u306b\u304a\u3051\u308b\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5f62\u6210\u306b\u304a\u3044\u3066PABP\u306e\u91cd\u8981\u6027\u3092\u5831\u544a\u3057\u305f<sup>5<\/sup><sup>\uff09<\/sup>\uff0e\u3059\u306a\u308f\u3061\uff0c\u751f\u7406\u7684\u306a\u7bc4\u56f2\u3067\u306e\u9ad8\u6e29\u51e6\u7406\u3084pH\u5909\u5316\u306b\u3088\u3063\u3066\u9175\u6bcd\u306e\u7d30\u80de\u8cea\u3067\u306f\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u304c\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u304c\u4ee5\u524d\u304b\u3089\u77e5\u3089\u308c\u3066\u3044\u305f\u304c\uff0c\u3053\u306e\u73fe\u8c61\u306bPABP\u304c\u6df1\u304f\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\uff0e\u975e\u30b9\u30c8\u30ec\u30b9\u8ca0\u8377\u6642\u3067\u306f\uff0c\u30dd\u30eaA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u306fmRNA\u306e\u30dd\u30eaA\u5c3e\u90e8\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u304c\uff0c\u30b9\u30c8\u30ec\u30b9\u306e\u8ca0\u8377\u306b\u3088\u3063\u3066\uff0cPABP\u304cmRNA\u304b\u3089\u904a\u96e2\u3057\uff0c\u81ea\u5df1\u96c6\u5408\u3057\u3066\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u3092\u5f62\u6210\u3059\u308b\uff0e\u3053\u306e\u81ea\u5df1\u96c6\u5408\u3067\u306f\uff0cPABP\u306e\u5929\u7136\u5909\u6210\u9818\u57df\u3092\u4ecb\u3057\u305f\u81ea\u5df1\u96c6\u5408\u306b\u3088\u308b\u30cf\u30a4\u30c9\u30ed\u30b2\u30eb\u5f62\u6210\u304c\u91cd\u8981\u306a\u6a5f\u69cb\u3068\u306a\u3063\u3066\u3044\u308b\uff0e\u3055\u3089\u306b\uff0cPABP\u306e\u5929\u7136\u5909\u6210\u9818\u57df\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u305d\u306e\u3082\u306e\u306e\u9032\u5316\u7684\u4fdd\u5b58\u6027\u306f\u4f4e\u3044\u304c\uff0c\u8102\u80aa\u65cf\u30a2\u30df\u30ce\u9178\u306e\u542b\u6709\u5ea6\u304c\u9ad8\u3044\u3068\u3044\u3046\u6027\u8cea\u306f\u9032\u5316\u7684\u306b\u4fdd\u5b58\u3055\u308c\u3066\u304a\u308a\uff0c\u5929\u7136\u5909\u6210\u9818\u57df\u4e2d\u306e\u8102\u80aa\u65cf\u30a2\u30df\u30ce\u9178\u3092\u4ed6\u306e\u30a2\u30df\u30ce\u9178\u306b\u5909\u7570\u3055\u305b\u308b\u3068PABP\u304c\u51dd\u96c6\u3057\u306a\u304f\u306a\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\uff0e\u672c\u8ad6\u6587\u3067\u5831\u544a\u3055\u308c\u305f\u6570\u3042\u308b\u767a\u898b\u306e\u306a\u304b\u3067\u3082\uff0c\u7279\u306b\u8208\u5473\u6df1\u3044\u70b9\u306f\uff0c\u5f93\u6765\u77e5\u3089\u308c\u3066\u3044\u305f\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5f62\u6210\u3067\u306f\uff0cRNA\u304c\u9846\u7c92\u5f62\u6210\u306e\u30b3\u30a2\u3068\u306a\u308b\u4f8b\u304c\u591a\u304b\u3063\u305f\u306e\u306b\u5bfe\u3057\uff0c\u4eca\u56de\uff0cPABP\u306fmRNA\u304b\u3089\u904a\u96e2\u3057\u3066\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u305f\u70b9\u3067\u3042\u308b\uff0e\u3053\u306e\u3088\u3046\u306a\u3057\u304f\u307f\u306e\u751f\u7406\u7684\u610f\u7fa9\u306e\u89e3\u660e\u306f\u3053\u308c\u304b\u3089\u3067\u3042\u308b\u304c\uff0c\u4e00\u6642\u7684\u306b\u7ffb\u8a33\u304c\u5168\u822c\u7684\u306b\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u71b1\u30b7\u30e7\u30c3\u30af\u306b\u5bfe\u3057\u3066\u751f\u304d\u6b8b\u308b\u305f\u3081\u306b\u91cd\u8981\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u6642\u306e\u7ffb\u8a33\u3092\u30b0\u30ed\u30fc\u30d0\u30eb\u306b\u6291\u5236\u3059\u308b\u3057\u304f\u307f\u3068\u3057\u3066PABP\u306e\u904a\u96e2\u3068\u81ea\u5df1\u96c6\u5408\u304c\u7d30\u80de\u5185\u3067\u8d77\u3053\u308b\u3068\u3044\u3046\u89e3\u91c8\u304c\u63d0\u6848\u3055\u308c\u3066\u3044\u308b\uff0e\u307e\u305f\uff0c\u3053\u306e\u3088\u3046\u306a\u3057\u304f\u307f\u3092\u69cb\u7bc9\u3059\u308b\u4e0a\u3067\uff0cPABP\u304c\u751f\u7406\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u30bb\u30f3\u30b5\u30fc\u3067\u3042\u308b\u3068\u7b46\u8005\u3089\u306f\u4e3b\u5f35\u3057\u3066\u3044\u308b\uff0e<\/p>\n\n\n\n<p>\u3000\u71b1\u30b7\u30e7\u30c3\u30af\u5fdc\u7b54\u3067\u306f\uff0c\u8ee2\u5199\u56e0\u5b50HSF1\u304b\u3089\u30b7\u30e3\u30da\u30ed\u30f3\u304c\u30ea\u30ea\u30fc\u30b9\u3055\u308c\uff0c\u305d\u306e\u5f8c\u306eHSF1\u306e\u81ea\u5df1\u96c6\u5408\uff08\u4e09\u91cf\u4f53\u5f62\u6210\uff09\u3068\u6838\u5185\u79fb\u884c\u304c\u71b1\u30b7\u30e7\u30c3\u30af\u907a\u4f1d\u5b50\u3092\u8ee2\u5199\u6d3b\u6027\u5316\u3057\uff0c\u7d30\u80de\u5185\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u884c\u304f\u30e2\u30c7\u30eb\u304c\u5e83\u304f\u53d7\u3051\u5165\u308c\u3089\u308c\u3066\u3044\u308b\uff0e\u4eca\u56de\u306eRiback\u3089\u306e\u5831\u544a\u306b\u3088\u3063\u3066\uff0cHSF1\u4ee5\u5916\u306b\u3082\u30b9\u30c8\u30ec\u30b9\u30bb\u30f3\u30b5\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u5206\u5b50\u3084\u5206\u5b50\u6a5f\u69cb\u304c\u5b58\u5728\u3057\uff0c\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u69d8\u3005\u306a\u6bb5\u968e\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067\u9069\u5207\u306a\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3092\u884c\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u518d\u8a8d\u8b58\u3055\u308c\u305f\uff0e<\/p>\n\n\n\n<p>\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Mahboubi H, Stochaj U. Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease. Biochim Biophys Acta, 1863: 884-895, 2017.<\/li><li>Mitrea DM, Kriwacki RW. Phase separation in biology; functional organization of a higher order. Cell Commun Signal, 14: 1, 2016.<\/li><li>Protter DS, Parker R. Principles and properties of stress granules. Trends Cell Biol, 26: 668-679, 2016.<\/li><li>Taylor JP,&nbsp;<em>et al<\/em>. Decoding ALS: from genes to mechanism. Nature, 539: 197-206, 2016.<\/li><li>Riback JA,&nbsp;<em>et al<\/em>. Stress-triggered phase separation is an adaptive, evolutionarily tuned response. Cell, 168: 1028-1040, 2017.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c14 Phase separation\u3092\u901a\u3058\u305f\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u6642\u306e\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5f62\u6210 \u79cb\u5149 \u4fe1\u4f73\uff08\u6771\u4eac\u5927\u5b66\u30a2\u30a4\u30bd\u30c8\u30fc\u30d7\u7dcf\u5408\u30bb\u30f3\u30bf\u30fc\uff09 \u306f\u3058\u3081\u306b \u71b1\uff0c\u653e\u5c04\u7dda\uff0c\u6d78\u900f\u5727\uff0c\u6804\u990a\u72b6\u614b\uff0c\u9178\u7d20\u6fc3\u5ea6\uff0c\u5316\u5b66\u7269\u8cea [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-606","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/606","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=606"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/606\/revisions"}],"predecessor-version":[{"id":607,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/606\/revisions\/607"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=606"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=606"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}