\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c12<\/p>\n\n\n\n
\u71b1\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306b\u304a\u3051\u308bCell-nonautonomous \u5236\u5fa1\uff0c\u304a\u3088\u3073\u7d30\u80de\u9593\u30b7\u30e3\u30da\u30ed\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u3064\u3044\u3066<\/p>\n\n\n\n
\u5927\u585a\u5065\u4e09(\u4e2d\u90e8\u5927\u5b66\u5fdc\u7528\u751f\u7269\u5b66\u90e8)<\/p>\n\n\n\n
\u7d30\u80de\u304c\u71b1\u306a\u3069\u306e\u30b9\u30c8\u30ec\u30b9(\u4e00\u822c\u7684\u306b\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u6bd2\u6027\uff3b\u5909\u6027\uff3d\u3092\u5f15\u304d\u8d77\u3053\u3059\u30b9\u30c8\u30ec\u30b9)\u3092\u53d7\u3051\u308b\u3068\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u8ee2\u5199\u56e0\u5b50(HSF1)\u304c\u6d3b\u6027\u5316\u3055\u308c\u3066\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea(HSPs)\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u304c\u4fc3\u9032\u3055\u308c\u308b\uff0e\u305d\u306e\u7d50\u679c\u5408\u6210\u3055\u308c\u3066\u304d\u305fHSPs\u306f\uff0c\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u6a5f\u80fd\u3057\uff0c\u71b1\u3067\u5909\u6027\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u518d\u3073\u6298\u308a\u305f\u305f\u3093\u3067\u4fee\u5fa9\u3057\uff0c\u307e\u305f\uff0c\u4fee\u5fa9\u4e0d\u80fd\u306e\u5834\u5408\u306f\u5206\u89e3\u306e\u624b\u52a9\u3051\u3092\u3059\u308b\u306a\u3069\u3057\u3066\uff0c\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u305f\u7d30\u80de\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u6052\u5e38\u6027(protein homeostasis, proteostasis)\u3092\u7dad\u6301\u3057\uff0c\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u6b63\u5e38\u306b\u4fdd\u3064\u3088\u3046\u306b\u50cd\u3044\u3066 \u3044\u308b\uff0e\u3053\u306e\u4e00\u9023\u306e\u904e\u7a0b\u306f\u4e00\u500b\u306e\u7d30\u80de\u306e\u4e2d\u3067\u81ea\u5f8b\u7684\u306b\u8d77\u3053\u308b\u53cd\u5fdc\u3067\u3042\u308b\uff0e\u3053\u308c\u3092cell-autonomous(\u7d30\u80de\u81ea\u5f8b)\u5236\u5fa1\u3068\u3044\u3046\uff0e\u3053\u308c\u306f\u5358\u7d30\u80de\u751f\u7269\u3067\u3082\u591a\u7d30\u80de\u751f\u7269\u3067\u3082\u666e\u904d\u7684\u306b\u8d77\u3053\u308b\u904e\u7a0b\u3067\u3042\u308a\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u6bd2\u6027\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306e\u9632\u5fa1\u6a5f\u69cb\u3067\u3042\u308b\uff0e\u3057\u304b\u3057\u6700\u8fd1\uff0c\u71b1\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306b\u304a\u3051\u308bHSF1\u6d3b\u6027\u5316-HSPs\u5408\u6210\u3068\u3044\u3046\u904e\u7a0b\u304c\uff0c\u4ed6\u306e\u7d30\u80de\u304b\u3089\u306e\u30b7\u30b0\u30ca\u30eb\u3067\u3082\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u305f\uff0e \u6700\u521d\u306f\u7dda\u866b\u306b\u304a\u3044\u3066\u898b\u51fa\u3055\u308c\u305f\u6a5f\u69cb\u3067\u3042\u308b<\/p>\n\n\n\n
1)\uff0e\u7dda\u866b\u3067\u306f\u6e29\u5ea6\u611f\u53d7\u6027\u30cb\u30e5\u30fc\u30ed\u30f3(AFDs)\u304c\u74b0\u5883\u306e\u6e29\u5ea6\u5909\u5316\u3092\u611f\u77e5\u3057\uff0c\u305d\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u4ecb\u5728\u30cb\u30e5\u30fc\u30ed\u30f3(AIY)\u306b\u4f1d\u3048\uff0cAIY\u304c\u6e29\u5ea6\u4f9d\u5b58\u7684\u306a\u7dda\u866b\u306e\u884c\u52d5(\u4e0d\u9069\u5207\u306a\u6e29\u5ea6\u304b\u3089\u306f\u9003\u907f\u3057\uff0c\u6700\u9069\u306a\u6e29\u5ea6\u57df\u3078\u306e\u79fb\u52d5)\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3068\u3044\u3046\uff0e\u305d\u3053\u3067\u6e29\u5ea6\u611f\u53d7\u6027\u30cb\u30e5\u30fc\u30ed\u30f3(AFDs)\uff0c\u307e\u305f\u306fAIY\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u6a5f\u80fd\u3092\u6291\u5236\u3059\u308b\u7279\u7570\u7684\u306a\u5909\u7570\u4f53\u3067\u306f\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u306b\u3088\u308b\u5404\u7d44\u7e54\u3067\u306eHsp70\u306e\u767a\u73fe\u304c\u963b\u5bb3\u3055\u308c\u308b\u3068\u3044\u3046\uff0e\u3053\u306e\u3053\u3068\u306f\uff0c\u5404\u7d44\u7e54\u3067\u306e\u71b1\u30b7\u30e7\u30c3\u30af\u5fdc\u7b54\u304c\u6e29\u5ea6\u611f\u53d7\u6027\u30cb\u30e5\u30fc\u30ed\u30f3\u4f9d\u5b58\u7684\u3067\u3042\u308a\uff0ccell-nonautonomous\u5236\u5fa1\u3067\u3042\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u3066\u3044\u308b\uff0e \u3053\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u3088\u308b\u6a19\u7684\u7d30\u80de\u3067\u306e\u71b1\u30b7\u30e7\u30c3\u30af\u5fdc\u7b54\u304c\uff0c\u5b9f\u306f\u30cb\u30e5\u30fc\u30ed\u30f3\u304b\u3089\u653e\u51fa\u3055\u308c\u308b\u30bb\u30ed\u30c8\u30cb\u30f3\u306b\u3088\u308b\u3053\u3068\u304c\u7dda\u866b\u306b\u304a\u3044\u3066\u8a3c\u660e\u3055\u308c\u305f<\/p>\n\n\n\n
2)\uff0e\u3053\u3053\u3067\u306f\uff0c\u7dda\u866b\u306e\u6e29\u5ea6\u611f\u53d7\u6027\u30cb\u30e5\u30fc\u30ed\u30f3(AFDs)\u306b\uff0c\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u5149\u611f\u53d7\u6027\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb(channelrhodopsin)\u907a\u4f1d\u5b50\u3092\u7279\u7570\u7684\u306b\u767a\u73fe\u3057\uff0c\u9752\u3044\u5149\u3092\u7167\u5c04\u3059\u308b\u3053\u3068\u3067AFD\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u307f\u3092\u6d3b\u6027\u5316(\u6d3b\u52d5\u96fb\u4f4d\u3092\u767a\u751f)\u3055\u305b\u308b\u3068\u3044\u3046\uff0c\u5149\u907a\u4f1d\u5b66(optogenetics)\u306e\u624b\u6cd5\u3092\u7528\u3044\u3066\u3044\u308b\uff0e\u305d\u3053\u3067\uff0cAFD\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u5149\u3092\u5f53\u3066\u308b\u3068\uff0c\u6e29\u5ea6\u4e0a\u6607\u304c\u306a\u304f\u3066\u3082\u751f\u6b96\u817a\u7d44\u7e54\u306b\u304a\u3044\u3066HSF1\u306e\u6d3b\u6027\u5316(HSF1\u9846\u7c92\u306e\u5f62\u6210)\u304c\u898b\u3089\u308c\u308b\uff0e\u3053\u306e\u3068\u304d\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u62ee\u6297\u5264(gramine)\u3092\u52a0\u3048\u3066\u304a\u304f\u3068HSF1\u306e\u6d3b\u6027\u5316\u304c\u6291\u5236\u3055\u308c\u308b\uff0e\u307e\u305f\uff0c\u30bb\u30ed\u30c8\u30cb\u30f3\u306b\u3088\u308bHSF1\u306e\u6d3b\u6027\u5316\u306f\u6a19\u7684\u7d30\u80de\u306b\u3042\u308b\u30bb\u30ed\u30c8\u30cb\u30f3\u53d7\u5bb9\u4f53\u3092\u4ecb\u3059\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u3044\u308b\uff0e \u6b21\u306e\u4f8b\u3082\u7dda\u866b\u3067\u306e\u7814\u7a76\u3067\u3042\u308b<\/p>\n\n\n\n
3)\uff0e\u305d\u306e\u5831\u544a\u306b\u3088\u308b\u3068\uff0c\u7b4b\u8089\u7d44\u7e54\u306b\u304a\u3044\u3066\u5909\u7570\u30df\u30aa\u30b7\u30f3\u3092\u767a\u73fe\u3055\u305b\u308b\u3068\u7b4b\u8089\u7dda\u7dad\u304c\u4e71\u308c\uff0c\u7dda\u866b\u500b\u4f53\u306e\u904b\u52d5\u80fd\u3082\u969c\u5bb3\u3055\u308c\u308b\uff0e\u305d\u3057\u3066\u5909\u7570\u30df\u30aa\u30b7\u30f3(\u7570\u5e38\u306a\u30bf\u30f3\u30d1\u30af\u8cea)\u306e\u84c4\u7a4d\u306b\u3088\u3063\u3066\u71b1\u30b7\u30e7\u30c3\u30af\u5fdc\u7b54\u304c\u8a98\u5c0e\u3055\u308cHsp90\u304c\u9ad8\u767a\u73fe\u3059\u308b\uff0e\u4e0d\u601d\u8b70\u306a\u3053\u3068\u306b\uff0c\u3053\u306e\u500b\u4f53\u3067\u306fHsp90\u306f\u7b4b\u8089\u7d44\u7e54\u3060\u3051\u3067\u306a\u304f\u5c0f\u8178\u3084\u4ed6\u306e\u7d44\u7e54\u3067\u3082\u9ad8\u767a\u73fe\u3059\u308b\u3068\u3044\u3046\uff0e\u3053\u308c\u306f\u7b4b\u8089\u7d44\u7e54\u3067\u306e\u71b1\u30b7\u30e7\u30c3\u30af\u5fdc\u7b54\u306e\u30b7\u30b0\u30ca\u30eb\u304c\uff0c\u4ed6\u306e\u7d44\u7e54(\u5c0f\u8178\u306a\u3069)\u306b\u4f1d\u3048\u3089\u308c\u308b\u3053\u3068\u306b\u306a\u308b\uff0e\u307e\u305f\uff0c\u7b4b\u8089\u7d44\u7e54\u306b\u304a\u3044\u3066\u5909\u7570\u30df\u30aa\u30b7\u30f3\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\u500b\u4f53\u3067\uff0c\u305d\u306e\u7b4b\u8089\u7d44\u7e54\u306b\u3055\u3089\u306bHsp90\u907a\u4f1d\u5b50\u3092\u5c0e\u5165\u3057\u3066\u9ad8\u767a\u73fe\u3055\u305b\u308b\u3068\uff0c\u5909\u7570\u30df\u30aa\u30b7\u30f3\u306b\u3088\u308b\u7dda\u7dad\u306e\u4e71\u308c\u304c\u6291\u5236\u3055\u308c\u308b\u3068\u3068\u3082\u306b\uff0c\u904b\u52d5\u80fd\u3082\u6539\u5584\u3059\u308b\uff0e\u3053\u308c\u306f\u7b4b\u8089\u7d30\u80de\u306e\u4e2d\u3067\u5b8c\u7d50\u3059\u308b\u53cd\u5fdc\u306a\u306e\u3067cell-autonomous(\u7d30\u80de\u81ea\u5f8b)\u5236\u5fa1\u3067\u3042\u308b\uff0e\u3068\u3053\u308d\u304c\u9a5a\u304f\u3079\u304d\u3053\u3068\u306b\uff0c\u7b4b\u8089\u7d44\u7e54\u306b\u304a\u3044\u3066\u5909\u7570\u30df\u30aa\u30b7\u30f3\u3092\u767a\u73fe\u3057\u305f\u7dda\u866b\u3067\uff0c\u5c0f\u8178\u3084\u795e\u7d4c\u7d44\u7e54\u3067Hsp90\u3092\u9ad8\u767a\u73fe\u3057\u3066\u3082\u7b4b\u8089\u7d44\u7e54\u3067\u306e\u7dda\u7dad\u306e\u4e71\u308c\u304c\u6291\u5236\u3055\u308c\uff0c\u3055\u3089\u306b\uff0c\u904b\u52d5\u80fd\u3082\u6539\u5584\u3059\u308b\u3068\u3044\u3046\u306e\u3067\u3042\u308b\uff0e\u3053\u308c\u306f\u4e00\u3064\u306e\u7d44\u7e54(\u305f\u3068\u3048\u3070\u5c0f\u8178)\u3067\u306e\u30b7\u30e3\u30da\u30ed\u30f3\u767a\u73fe\u306e\u30b7\u30b0\u30ca\u30eb\u304c\u4ed6\u306e\u7d44\u7e54(\u3053\u3053\u3067\u306f\u7b4b\u8089)\u306b\u3082\u4f1d\u3048\u3089\u308c\u3066\uff0c\u305d\u306e\u7d44\u7e54\u3067\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u6052\u5e38\u6027\u304c\u7dad\u6301\u3055\u308c\u308b\u3053\u3068\u3092\u610f\u5473\u3059\u308b\uff0e\u3053\u306e\u3088\u3046\u306b\uff0c\u500b\u4f53\u306e\u4e2d\u306e\u7d44\u7e54\u9593\u3067\uff0c\u71b1\u30b7\u30e7\u30c3\u30af\u5fdc\u7b54\u306e\u60c5\u5831\u304c\u304a\u4e92\u3044\u306b\u4f1d\u9054\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\uff0e\u3053\u306e\u3053\u3068\u3092\u3053\u306e\u8ad6\u6587\u306e\u8457\u8005\u3089\u306fcell-nonautonomous\u5236\u5fa1\u306b\u3088\u308b\u7d30\u80de\u9593\u30b7\u30e3\u30da\u30ed\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054(transcellular chaperone signaling)\u3068\u547c\u3093\u3067\u3044\u308b\uff0e \u795e\u7d4c\u304b\u3089\u306e\u30b7\u30b0\u30ca\u30eb\u3067\u6a19\u7684\u7d30\u80de\u306b\u71b1\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3053\u3068\u304c\uff0c\u6587\u732e1\u306ePrahlad\u3089\u306e\u7814\u7a76\u3067cell-nonautonomous\u5236\u5fa1\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3068\uff0c\u6ce8\u76ee\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u3063\u305f\uff0e\u3057\u304b\u3057\uff0c\u5b9f\u306f20\u6570\u5e74\u524d\u306e1991\u5e74\u306b\u30e9\u30c3\u30c8\u3067\u540c\u3058\u3088\u3046\u306a\u7814\u7a76\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<\/p>\n\n\n\n
4\uff09\uff0e\u305d\u308c\u306b\u3088\u308b\u3068\uff0c\u30e9\u30c3\u30c8\u3092\u62d8\u675f\u30b9\u30c8\u30ec\u30b9\u6761\u4ef6\u4e0b\u306b\u304a\u304f\u3068\uff0c\u8996\u5e8a\u4e0b\u90e8\u3092\u4ecb\u3057\u3066\u8133\u4e0b\u5782\u4f53\u304b\u3089\u526f\u814e\u76ae\u8cea\u523a\u6fc0\u30db\u30eb\u30e2\u30f3(ACTH\uff0cadrenocorticotropic hormone)\u304c\u5206\u6ccc\u3055\u308c\uff0c\u526f\u814e\u76ae\u8cea\u306e\u7d30\u80de\u3067Hsp70\u304c\u767a\u73fe\u3059\u308b\u3068\u3044\u3046\uff0e\u3053\u306e\u53cd\u5fdc\u306f\u8133\u4e0b\u5782\u4f53\u3092 \u5207\u9664\u3059\u308b\u3068\u898b\u3089\u308c\u306a\u304f\u306a\u308b\u304c\uff0cACTH\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u56de\u5fa9\u3059\u308b\u3053\u3068\u304b\u3089\uff0cACTH\u4f9d\u5b58\u7684\u306bHsp70\u304c\u8a98\u5c0e\u3055\u308c\u305f\u3053\u3068\u3092\u610f\u5473\u3059\u308b\uff0e\u307e\u305f\uff0c\u62d8\u675f\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u526f\u814e\u76ae\u8cea\u3067\u306eHsp70\u306e\u767a\u73fe\u306f\u8001\u5316\u30e9\u30c3\u30c8\u3067\u306f\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304b\u3089\uff0c\u8001\u5316\u3059\u308b\u3053\u3068\u3067\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3082\u793a\u5506\u3055\u308c\u305f\uff0e\u306a\u304a\uff0c\u526f\u814e\u76ae\u8cea\u3067\u306eHsp70\u306e\u767a\u73fe\u306fHSF1\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b<\/p>\n\n\n\n
5)\uff0e \u3088\u304f\u8003\u3048\u3066\u307f\u308b\u3068\uff0c\u795e\u7d4c\u7cfb\u3084\u5185\u5206\u6ccc\u7cfb\uff0c\u307e\u305f\u5897\u6b96\u56e0\u5b50\u306a\u3069\u306b\u3088\u308b\u751f\u4f53\u6a5f\u80fd\u5236\u5fa1\u306e\u307b\u3068\u3093\u3069\u306f\uff0ccell-nonautonomous\u5236\u5fa1\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\uff0e\u3064\u307e\u308a\uff0c\u4ed6\u306e\u7d30\u80de(\u795e\u7d4c\u7d30\u80de\u3084\u5185\u5206\u6ccc\u817a\uff0c\u5897\u6b96\u56e0\u5b50\u751f\u7523\u7d30\u80de\u306a\u3069)\u304b\u3089\u306e\u30b7\u30b0\u30ca\u30eb\u306b\u5fdc\u7b54\u3057\u3066\u6a19\u7684\u7d30\u80de\u3067\u3055\u307e\u3056\u307e\u306a\u4e8b\u8c61\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u304b\u3089\u3067\u3042\u308b\uff0e\u305f\u3060\uff0c\u30b7\u30b0\u30ca\u30eb\u306e\u9001\u308a\u624b\u3068\u53d7\u3051\u624b\u306e\u7d30\u80de\u3067\u306f\u5168\u304f\u9055\u3046\u73fe\u8c61\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u591a\u3044\uff0e\u3057\u304b\u3057\uff0c\u672c\u7a3f\u3067\u7d39\u4ecb\u3057\u305f\u306e\u306f(\u7279\u306b\u6587\u732e3)\uff0c\u4e00\u3064\u306e\u7d44\u7e54\u3067\u306e\u71b1\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306e\u60c5\u5831\u304c\u4f55\u3089\u304b\u306e\u65b9\u6cd5\u3067\u4f1d\u3048\u3089\u308c\u3066\uff0c\u4ed6\u306e\u7d44\u7e54\u3067\u3082\u540c\u3058\u71b1\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3053\u3068\u3067\u3042\u308b\uff0e\u3053\u308c\u306f\u5168\u304f\u65b0\u3057\u3044\u30bf\u30a4\u30d7\u306e\u300c\u7d30\u80de\u9593\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u300d\u306a\u306e\u304b\u3082\u3057\u308c\u306a\u3044\uff0e \u6700\u8fd1\uff0c\u5225\u306e\u5b9f\u9a13\u7cfb\u3067\u3082\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u30b7\u30b0\u30ca\u30eb\u304c\u7d30\u80de\u9593\u3067\u4f1d\u9054\u3055\u308c\u308b\u4e8b\u4f8b\u304c\u5831\u544a\u3055\u308c\u3066\u304d\u3066\u3044\u308b\u304c\uff0c\u305d\u306e\u3053\u3068\u306b\u3064\u3044\u3066\u306f\uff0c\u307e\u305f\uff0c\u7a3f\u3092\u6539\u3081\u3066\u7d39\u4ecb\u3057\u305f\u3044\uff0e<\/p>\n\n\n\n
\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n
1) Prahlad V., et al. Regulation of cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science, 320: 811-814, 2008.<\/p>\n\n\n\n
2) Tatum M.C., et al. Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase. Curr Biol, 25: 163-174, 2015.<\/p>\n\n\n\n
3) van Oosten-Hawle P., et al. Regulation of organismal proteostasis by transcellular chaperone signaling. Cell, 153: 1366-1378, 2013.<\/p>\n\n\n\n
4) Blake M.J., et al. Stress-induced heat shock protein 70 expression in adrenal cortex: An adrenocorticotropic hormone-sensitive, age-dependent response. Proc Natl Acad Sci USA, 88: 9873-9877, 1991.<\/p>\n\n\n\n
5) Fawcett T.W., et al. Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1. J Biol Chem, 269: 32272-32278, 1994.<\/p>\n","protected":false},"excerpt":{"rendered":"
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