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\u3000\u3068\u3053\u308d\u304c\uff0c\u6700\u8fd1\u767a\u8868\u3055\u308c\u305fSingh\u3089\u306e\u5831\u544a\u306b\u3088\u308b\u3068\uff0c\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u76ae\u819a\u306b\u3042\u3089\u304b\u3058\u3081Hsp90\u963b\u5bb3\u5264\u3067\u3042\u308b17AAG\u3092\u5857\u3063\u3066\u304a\u304f\u3068\uff0c\u7d2b\u5916\u7dda\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u76ae\u819a\u304c\u3093\uff08squamous cell carcinoma, SCC\uff09\u306e\u767a\u751f\u304c\u6291\u5236\u3055\u308c\u308b\u3068\u3044\u30461)<\/sup>\uff0e\u3064\u307e\u308a\uff0c17AAG\u306b\u306f\u304c\u3093\u767a\u751f\u306e\u4e88\u9632\u52b9\u679c\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\uff0e\u3055\u3089\u306b\uff0c\u7d2b\u5916\u7dda\u306b\u3088\u308b\u76ae\u819a\u306e\u5149\u8001\u5316\uff08\u30b7\u30ef\u3084\u305f\u308b\u307f\uff09\u306b\u5bfe\u3057\u3066\u3082\u9632\u8b77\u52b9\u679c\u304c\u3042\u308b\u3068\u3044\u3046\uff0e<\/p>\n\n\n\n

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\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

1) Singh A, et al<\/em>. Topically applied Hsp90 inhibitor 17AAG inhibits UVR-induced cutaneous squamous cell carcinoma. J Invest Dermatol. 135: 1098-107, 2015.<\/p>\n\n\n\n

2) Aziz, MH, et al<\/em>. Protein kinase C epsilon, which sensitizes skin to sun’s UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. Cancer Res. 67: 1385-94, 2007.<\/p>\n\n\n\n

3) Katiyar SK. Hsp90 inhibitor can inhibit UV carcinogenesis. J Invest Dermatol. 135: 945-7, 2015.<\/p>\n\n\n\n

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