\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c6
\u201d\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c\u3000Int J Hyperthermia\u306e\u7dcf\u8aac\u3088\u308a\u201d
(\u4eac\u90fd\u5927\u5b66\u539f\u5b50\u7089\u5b9f\u9a13\u6240\u653e\u5c04\u7dda\u751f\u547d\u79d1\u5b66\u7814\u7a76\u90e8\u9580 \u5897\u6c38\u614e\u4e00\u90ce)<\/p>\n\n\n\n
2000\u5e74\u306b\u3001Hanahan\u3068Weinberg\u306b\u3088\u3063\u3066\u63d0\u5531\u3055\u308c\u305f6\u3064\u306e\u201dThe hallmarks of cancer\u201d\u306f\u30012011\u5e74\u306b\u6539\u8a02\u3055\u308c\u3001\u3055\u3089\u306b4\u3064\u306e\u7279\u6027 (\u4ee3\u8b1d\u7570\u5e38\u3001\u816b\u760d\u514d\u75ab\u6a5f\u69cb\u306e\u7834\u7dbb\u3001\u816b\u760d\u767a\u751f\u3092\u4fc3\u3059\u708e\u75c7\u3001\u7d30\u80de\u5fae\u5c0f\u74b0\u5883)\u304c\u52a0\u3048\u3089\u308c\u305f\u304c\u3001\u4f4e\u9178\u7d20\u3084pH\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u7d44\u7e54\u5185\u5fae\u5c0f\u74b0\u5883\u306b\u306f\u3001\u7279\u6bb5\u8a00\u53ca\u3055\u308c\u306a\u304b\u3063\u305f\u3002\u3053\u306e\u7dcf\u8aac\u3067\u306f\u3001Hyperthermia\u306e\u751f\u7269\u5b66\u306b\u5927\u304d\u304f\u5f71\u97ff\u3059\u308b\u4e0a\u8a184\u3064\u306e\u7279\u6027\u306b\u7126\u70b9\u3092\u5f53\u3066\u3001\u524d\u81e8\u5e8a\u7684\u306a\u52d5\u7269\u3092\u7528\u3044\u305f\u7814\u7a76\u6210\u679c\u3092\u6982\u89b3\u3057\u3001Hyperthermia\u306e\u751f\u7269\u7814\u7a76\u9818\u57df\u306b\u304a\u3051\u308b\u5148\u898b\u7684\u840c\u82bd\u7684\u306a\u7814\u7a76\u9818\u57df\u306b\u8a00\u53ca\u3057\u3066\u3044\u308b\u3002\u2460 \u751f\u7406\u5b66\u7684\u7d44\u7e54\u5185\u5fae\u5c0f\u74b0\u5883\u9818\u57df\u3067\u306f\u3001\u9178\u6027\u5316\u85ac\u5264\u3068\u6bba\u816b\u760d\u7d30\u80de\u52b9\u679c\u3092\u671f\u5f85\u3067\u304d\u308b\u6cbb\u7642\u9818\u57df\u6e29\u5ea6\u306b\u52a0\u6e29\u3059\u308bHyperthermia (HTM)\u3068\u306e\u4f75\u7528\u52b9\u679c\u306e\u66f4\u306a\u308b\u89e3\u6790\u3001Ablation\u306b\u304a\u3051\u308b\u85ac\u5264\u53d6\u308a\u8fbc\u307f\u6a5f\u69cb\u306e\u89e3\u6790\u3001\u767a\u71b1\u7a0b\u5ea6\u306e\u4f4e\u6e29\u5ea6\u52a0\u6e29\u7642\u6cd5Mild temperature hyperthermia (MTH)\u306e\u6709\u7528\u6027\u3092\u652f\u3048\u308b\u57fa\u76e4\u7684\u6a5f\u69cb\u306e\u89e3\u6790\u3001\u2461 \u816b\u760d\u514d\u75ab\u30fb\u708e\u75c7\u30fb\u81ea\u5df1\u514d\u75ab\u30fb\u9178\u7d20\u30e9\u30b8\u30ab\u30eb\u30b9\u30c8\u30ec\u30b9\u7814\u7a76\u9818\u57df\u3067\u306f\u3001Heat shock protein (HSP)\u3068Abscopal effect\u3068\u306e\u95a2\u4fc2\u306e\u89e3\u6790\u3001Ablation\u306b\u304a\u3051\u308b\u816b\u760d\u306e\u4fb5\u8972\u6027\u306e\u4ea2\u9032\u3068\u6297\u816b\u760d\u514d\u75ab\u306e\u4ea2\u9032\u3068\u306e\u76f8\u6bba\u6027\u306b\u95a2\u3059\u308b\u89e3\u6790\u3084\u3055\u3089\u306b\u306f\u85ac\u5264\u4f75\u7528\u6642\u306e\u89e3\u6790\u3001MTH\u6642\u306e\u6297\u816b\u760d\u514d\u75ab\u4ea2\u9032\u306e\u6a5f\u69cb\u89e3\u6790\u3001\u52a0\u6e29\u6642\u4e00\u822c\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u30fb\u597d\u4e2d\u7403\u30fb\u81ea\u5df1\u514d\u75ab\u6a5f\u69cb\u3078\u306e\u5f71\u97ff\u89e3\u6790\u3001HTM\u3084Ablation\u3068\u9178\u7d20\u30e9\u30b8\u30ab\u30eb\u53cd\u5fdc\u3068\u306e\u95a2\u4fc2\u89e3\u6790\u3001\u2462 \u8840\u7ba1\u65b0\u751f\u9818\u57df\u3067\u306f\u3001HTM\u30fbAblation\u30fbMTH\u6642\u306e\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u5264\u4f7f\u7528\u610f\u7fa9\u306e\u89e3\u6790\u3001\u2463 \u5e79\u7d30\u80de\u7814\u7a76\u9818\u57df\u3067\u306f\u3001HTM\u30fbAblation\u30fbMTH\u304c\u816b\u760d\u3068\u6b63\u5e38\u7d44\u7e54\u306e\u5e79\u7d30\u80de\u306b\u53ca\u307c\u3059\u5f71\u97ff\u89e3\u6790\u3001\u2464 \u7d30\u80de\u4ee3\u8b1d\u7814\u7a76\u9818\u57df\u3067\u306f\u3001HTM\u6642\u306e\u89e3\u6790\u306f\u5341\u5206\u306b\u6a5f\u304c\u719f\u3057\u3066\u304a\u308a\u3001MTH\u6642\u306e\u89e3\u6790\u3067\u3082\u7814\u7a76\u6210\u679c\u304c\u51fa\u3064\u3064\u3042\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u308b\u3002\u7d50\u8ad6\u3068\u3057\u3066\u306f\u3001\u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u9818\u57df\u3068\u708e\u75c7\u7814\u7a76\u9818\u57df\u3067\u306f\u3001\u52a0\u6e29\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u5c11\u306a\u304f\u3001\u306a\u304a\u4e00\u5c64\u884c\u308f\u308c\u308b\u3079\u304d\u3067\u3042\u308b\u3068\u8ff0\u3079\u3066\u3044\u308b (1)\u3002<\/p>\n\n\n\n
\u6e29\u71b1\u4f75\u7528\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u6539\u5584\u306e\u305f\u3081\u306e\u73fe\u5b9f\u7684\u306a\u751f\u7269\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u95a2\u3059\u308b\u7dcf\u8aac(2)\u3067\u306f\u3001\u2460 \u816b\u760d\u5185\u306e\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308b\u5834\u5408\u306b\u306f\u3001\u751f\u4f53\u9084\u5143\u7269\u8cea\u3001\u9178\u6027\u5316\u85ac\u5264\u3001DNA\u4fee\u5fa9\u963b\u5bb3\u5264\u3001\u30ca\u30ce\u7c92\u5b50\u3001\u514d\u75ab\u4fee\u98fe\u5264\u3001HSP90\u963b\u5bb3\u5264\u306e\u6295\u4e0e\u304c\u53d6\u308a\u6319\u3052\u3089\u308c\u305f\u3002\u4f4e\u9178\u7d20\u7d30\u80de\u3001\u7279\u306b\u6804\u990a\u4e0d\u8db3\u72b6\u614b\u3067\u3082\u3042\u308b\u6162\u6027\u4f4e\u9178\u7d20\u7d30\u80de\u306f\u3001\u57fa\u672c\u7684\u306b\u306f\u6804\u990a\u4e0d\u8db3\u72b6\u614b\u3067\u306f\u306a\u3044\u6025\u6027\u4f4e\u9178\u7d20\u7d30\u80de\u3088\u308a\u3082DNA\u4fee\u5fa9\u80fd\u304c\u4f4e\u3044\u3002\u3053\u306e\u7279\u6027\u306f\u3001DNA\u4fee\u5fa9\u963b\u5bb3\u5264\u3092\u4f4e\u7dda\u91cf\u306e\u653e\u5c04\u7dda\u7167\u5c04\u3068\u3068\u3082\u306b\u4f7f\u7528\u3059\u308b\u3068\u3001\u6b63\u5e38\u7d30\u80de\u3067\u306f\u5927\u304d\u306a\u4fee\u5fa9\u80fd\u3092\u671f\u5f85\u3067\u304d\u308b\u305f\u3081\u306b\u3001\u6709\u5bb3\u4e8b\u8c61\u306e\u51fa\u73fe\u3092\u52b9\u7387\u3088\u304f\u4f4e\u6e1b\u3067\u304d\u308b\u3002\u2461 \u816b\u760d\u5185\u8840\u7ba1\u3092\u6a19\u7684\u3068\u3059\u308b\u5834\u5408\u306b\u306f\u3001\u4e00\u6642\u7684\u8840\u7ba1\u4fee\u98fe\u5264\u3001\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u5264\u3001\u816b\u760d\u8840\u7ba1\u7834\u7dbb\u5264\u306e\u6295\u4e0e\u304c\u53d6\u308a\u4e0a\u3052\u3089\u308c\u3001\u653e\u5c04\u7dda\u7167\u5c04\u3068\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u306e\u91cd\u8981\u6027\u304c\u5f37\u8abf\u3055\u308c\u305f\u3002\u2462 \u6700\u5f8c\u306b\u2460\u53c8\u306f\u2461\u306e\u6cbb\u7642\u6642\u306b\u304a\u3051\u308b\u6b63\u5e38\u7d44\u7e54\u3078\u306e\u5f71\u97ff\u7814\u7a76\u306b\u8a00\u53ca\u3055\u308c\u305f\u304c\u3001\u5831\u544a\u304c\u6975\u3081\u3066\u5c11\u306a\u304f\u3001\u66f4\u306a\u308b\u7814\u7a76\u304c\u671f\u5f85\u3055\u308c\u308b\u4e8b\u304c\u6307\u6458\u3055\u308c\u305f (2)\u3002\u3053\u306e\u7dcf\u8aac\u304c\u89e6\u308c\u305f\u816b\u760d\u5185\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308bDNA\u4fee\u5fa9\u963b\u5bb3\u5264\u3092\u7528\u3044\u308bHTM\u9818\u57df\u6e29\u71b1\u7642\u6cd5\u306b\u306f\u3001\u30d7\u30e9\u30c1\u30ca\u5264\u3084PARP\u963b\u5bb3\u5264\u6295\u4e0e\u6642\u306e\u52b9\u679c\u3092\u5897\u5f37\u3055\u305b\u3001\u52a0\u6e29\u9818\u57df\u3092\u6a19\u7684\u75c5\u5909\u3068\u3059\u308b\u4e00\u7a2e\u306e\u6a19\u7684\u6cbb\u7642\u3068\u3057\u3066\u306e\u6f5c\u5728\u7684\u6709\u7528\u6027\u304c\u5341\u5206\u306b\u8a8d\u3081\u3089\u308c\u308b\u4e8b\u3092\u793a\u3059\u7dcf\u8aac(3)\u3082\u63b2\u8f09\u3055\u308c\u3066\u3044\u305f\u3002<\/p>\n\n\n\n
<<\/strong>\u6587\u732e><\/strong><\/p>\n\n\n\n (1) Mark W. Dewhirst<\/u><\/a>, Chen-Ting Lee<\/u><\/a>, Kathleen A. Ashcraft<\/u><\/a>. The future of biology in driving the field of hyperthermia. Int J Hyperthermia 2016, 32(1): 4-13.<\/p>\n\n\n\n (2) Michael R. Horsman<\/u><\/a>. Realistic biological approaches for improving thermoradiotherapy. Int J Hyperthermia 2016, 32(1): 14-22.<\/p>\n\n\n\n (3) Rolf Issels<\/u><\/a>, Eric Kampmann<\/u><\/a>, Roland Kanaar<\/u><\/a>, Lars H. Lindner<\/u><\/a>. Hallmarks of hyperthermia in driving the future of clinical hyperthermia as targeted therapy: translation into clinical application. Int J Hyperthermia 2016, 32(1): 89-95.<\/p>\n","protected":false},"excerpt":{"rendered":" \u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c6 \u201d\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c\u3000Int J Hyperthermia\u306e\u7dcf\u8aac\u3088\u308a\u201d (\u4eac\u90fd\u5927\u5b66\u539f\u5b50\u7089\u5b9f\u9a13\u6240\u653e\u5c04\u7dda\u751f\u547d\u79d1\u5b66 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-622","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/622","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=622"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/622\/revisions"}],"predecessor-version":[{"id":623,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/622\/revisions\/623"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=622"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=622"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=622"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}