{"id":629,"date":"2016-05-24T19:12:00","date_gmt":"2016-05-24T10:12:00","guid":{"rendered":"https:\/\/idsc-gunma.jp\/congress\/jstm\/?p=629"},"modified":"2022-05-26T20:49:53","modified_gmt":"2022-05-26T11:49:53","slug":"%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc%e3%83%9f%e3%82%a2%e3%81%8chpv%e3%81%ab%e3%82%88%e3%82%8bp53%e3%81%ae%e5%88%86%e8%a7%a3%e3%82%92%e9%98%b2%e3%81%90","status":"publish","type":"post","link":"https:\/\/idsc-gunma.jp\/congress\/jstm\/%e3%83%8f%e3%82%a4%e3%83%91%e3%83%bc%e3%82%b5%e3%83%bc%e3%83%9f%e3%82%a2%e3%81%8chpv%e3%81%ab%e3%82%88%e3%82%8bp53%e3%81%ae%e5%88%86%e8%a7%a3%e3%82%92%e9%98%b2%e3%81%90\/","title":{"rendered":"\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u304cHPV\u306b\u3088\u308bp53\u306e\u5206\u89e3\u3092\u9632\u3050"},"content":{"rendered":"\n<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c3<br><br>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u304cHPV\u306b\u3088\u308bp53\u306e\u5206\u89e3\u3092\u9632\u3050\u3000<br>\uff08\u7fa4\u99ac\u5927\u5b66\uff1a\u9ad8\u6a4b\u662d\u4e45\uff09<\/p>\n\n\n\n<p>\u4eca\u56de\u3001Amsterdam\u5927\u5b66Academic Medical Center\u306eOei AL\u6c0f\u306e\u696d\u7e3e\u306b\u3064\u3044\u3066\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u3001\u300cDNA\u4fee\u5fa9\u7d4c\u8def\u306b\u5bfe\u3059\u308b\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306e\u52b9\u679c\u300d\u306b\u3064\u3044\u3066\u306e\u7dcf\u8aac[1]\u3092\u3001\u6211\u3005\u306e\u696d\u7e3e\u3082\u542b\u3081\u3066\u4e16\u754c\u306e\u52d5\u5411\u3092\u7684\u78ba\u304a\u3088\u3073\u516c\u5e73\u306bRadiat Oncol\u306b\u307e\u3068\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u7b46\u982d\u8457\u8005\u306eOei\u6c0f\u304c\u3069\u306e\u3088\u3046\u306a\u65b9\u306a\u306e\u304b\u95a2\u5fc3\u3092\u62b1\u3044\u3066\u304a\u308a\u307e\u3057\u305f\u3002ICHO2016\u306b\u3066President\u2019s Symposia Lecture\u306e\u6f14\u8005\u306bOei\u6c0f\u304c\u9078\u3070\u308c\u3001\u7c21\u5358\u306a\u5c65\u6b74\u304c\u5927\u4f1aHP[2]\u306b\u63b2\u8f09\u3055\u308c\u3001\u535a\u58eb\u8ab2\u7a0b\u306e\u82e5\u3044\u5b66\u751f\u3055\u3093\u3067\u3042\u308b\u3053\u3068\u3092\u77e5\u308a\u3001\u9a5a\u304d\u3092\u96a0\u305b\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3055\u3089\u306b\u3001ICHO2016\u3067\u8b1b\u6f14\u3092\u62dd\u8074\u3057\u3001\u305d\u306e\u7814\u7a76\u5185\u5bb9\u306b\u3082\u611f\u5fc3\u3055\u305b\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u3053\u3067\u7d39\u4ecb\u3059\u308b\u306e\u306f\u305d\u306e\u8b1b\u6f14\u306e\u3082\u3068\u306b\u306a\u3063\u305f\u300c\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306f<em>p53<\/em>\u4f9d\u5b58\u7684\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u4ecb\u3057\u3066\u5b50\u5bae\u9838\u304c\u3093\u306e\u30d2\u30c8\u30d1\u30d4\u30ed\u30fc\u30de\u30a6\u30a4\u30eb\u30b9(HPV)\u3092\u9078\u629e\u7684\u306b\u6a19\u7684\u3068\u3059\u308b\u300d\u3068\u3044\u3046Cancer Res\u306b\u5831\u544a\u3055\u308c\u305f\u8ad6\u6587\u3067\u3059[3]\u3002HPV\u306f\u3001\u5b50\u5bae\u9838\u304c\u3093\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u30ea\u30b9\u30af\u306e\u9ad8\u3044HPV\u30bf\u30a4\u30d716\u306818\u304c\u5b50\u5bae\u9838\u304c\u3093\u306e70%\u4ee5\u4e0a\u3067\u898b\u3064\u304b\u3063\u3066\u304a\u308a\u3001\u816b\u760d\u6027E6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7523\u751f\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001E6\u306f\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u7523\u7269p53\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7d50\u5408\u3057\u3066\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u306e\u7d50\u5408\u3092\u4ecb\u3057\u3066p53\u306e\u5206\u89e3\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001E6\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u304c\u3001HPV\u967d\u6027\u306e\u816b\u760d\u7d30\u80de\u3092\u9664\u53bb\u3059\u308b\u6709\u671b\u306a\u6cbb\u7642\u306e\u9078\u629e\u80a2\u3067\u3042\u308b\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u653e\u5c04\u7dda\u3068\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306e\u4f75\u7528\u306f\u3001\u5b50\u5bae\u9838\u304c\u3093\u306b\u5bfe\u3059\u308b\u975e\u5e38\u306b\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6226\u7565\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3053\u3067\u3001Oei\u6c0f\u3089\u306f\u3001\u5b50\u5bae\u9838\u304c\u3093\u7d30\u80deSiHa (HPV16\u611f\u67d3\u578b)\u304a\u3088\u3073HeLa (HPV18\u611f\u67d3\u578b)\u3001\u305d\u308c\u305e\u308c\u306e\u79fb\u690d\u816b\u760d\u3001\u60a3\u8005\u306e\u751f\u691c\u30b5\u30f3\u30d7\u30eb\u3092\u7528\u3044\u3001\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306e\u5f71\u97ff\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u81e8\u5e8a\u3067\u7528\u3044\u3089\u308c\u308b\u3088\u3046\u306a42\u2103\u306e1\u6642\u9593\u51e6\u7406\u306b\u3088\u3063\u3066\u3001E6\u306b\u3088\u308bp53\u306e\u5206\u89e3\u3092\u9632\u3050\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u6e29\u71b1\u51e6\u7406\u306f\u3001E6\u2013p53\u8907\u5408\u4f53\u306e\u5f62\u6210\u3092\u59a8\u3052\u3066\u3001p53\u4f9d\u5b58\u7684\u306a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3068G<sub>2<\/sub>-\u30a2\u30ec\u30b9\u30c8\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u898b\u3044\u51fa\u3057\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001HPV\u967d\u6027\u306e\u5b50\u5bae\u9838\u304c\u3093\u306b\u5bfe\u3057\u3066\u3001\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u304c\u6cbb\u7642\u52b9\u679c\u5411\u4e0a\u306b\u9069\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u6b8b\u5ff5\u306a\u304c\u3089Oei\u6c0f\u3089\u306e\u8ad6\u6587\u306b\u306f\u5f15\u7528\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u30012000\u5e74\u306b\u64ad\u78e8\u5148\u751f(\u95a2\u897f\u533b\u5927)\u3089\u304c\u3001\u5b50\u5bae\u9838\u304c\u3093\u3067\u653e\u5c04\u7dda\u5358\u72ec\u306b\u6bd4\u3079\u3066\u3001\u653e\u5c04\u7dda\u3068\u6e29\u71b1\u306e\u4f75\u7528\u3067p53\u306e\u4e0b\u6d41\u907a\u4f1d\u5b50\u7523\u7269\u3067\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u8a98\u5c0e\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308bBax\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u983b\u5ea6\u304c\u9ad8\u3044\u3053\u3068\u3092\u5831\u544a\u3055\u308c\u3066\u304a\u308a[4]\u3001\u305d\u306e\u7d50\u679c\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3057\u305f\u3002\u306a\u305c\u3001\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u3088\u3063\u3066E6\u3068p53\u306e\u7d50\u5408\u304c\u59a8\u3052\u3089\u308c\u308b\u306e\u304b\u3001HSP\u306a\u3069\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u306e\u95a2\u4fc2\u306f\u3069\u3046\u304b\u306a\u3069\u3001\u8208\u5473\u306f\u5c3d\u304d\u307e\u305b\u3093\u3002\u5e78\u3044\u306b\u3082\u3001\u6b21\u56de\u306eICHO2020\u306fAmsterdam\u3067\u306e\u958b\u50ac\u4e88\u5b9a\u3067\u3059\u3002\u65b0\u9032\u6c17\u92ed\u306eOei\u6c0f\u306b\u518d\u4f1a\u3067\u304d\u308b\u3053\u3068\u3092\u697d\u3057\u307f\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Oei AL,&nbsp;<em>et al<\/em>. Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all. Radiat Oncol. 10:165, 2015.<\/li><li>http:\/\/www.thermaltherapy.org\/ebusSFTM\/InvitedLecturers.aspx<\/li><li>Oei AL,&nbsp;<em>et al<\/em>. Hyperthermia selectively targets human papillomavirus in cervical tumors via p53-dependent apoptosis. Cancer Res. 75:5120-9, 2015.<\/li><li>Harima Y,&nbsp;<em>et al<\/em>. Bax and Bcl-2 protein expression following radiation therapy versus radiation plus thermoradiotherapy in stage IIIB cervical carcinoma. Cancer. 88:132-8, 2000.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c3 \u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u304cHPV\u306b\u3088\u308bp53\u306e\u5206\u89e3\u3092\u9632\u3050\u3000\uff08\u7fa4\u99ac\u5927\u5b66\uff1a\u9ad8\u6a4b\u662d\u4e45\uff09 \u4eca\u56de\u3001Amsterdam\u5927\u5b66Academic Medical Center\u306eOei AL\u6c0f\u306e\u696d\u7e3e\u306b\u3064\u3044\u3066\u7d39\u4ecb [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"vkexunit_cta_each_option":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-629","post","type-post","status-publish","format-standard","hentry","category-report"],"_links":{"self":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/629","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/comments?post=629"}],"version-history":[{"count":1,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/629\/revisions"}],"predecessor-version":[{"id":630,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/posts\/629\/revisions\/630"}],"wp:attachment":[{"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/media?parent=629"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/categories?post=629"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idsc-gunma.jp\/congress\/jstm\/wp-json\/wp\/v2\/tags?post=629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}